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Protein

Endoplasmic reticulum-Golgi intermediate compartment protein 3

Gene

ERGIC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possible role in transport between endoplasmic reticulum and Golgi.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum-Golgi intermediate compartment protein 3
Alternative name(s):
Serologically defined breast cancer antigen NY-BR-84
Gene namesi
Name:ERGIC3
Synonyms:C20orf47, ERV46, SDBCAG84
ORF Names:CGI-54, PRO0989
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15927. ERGIC3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Topological domaini47 – 341LumenalSequence analysisAdd BLAST295
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 383CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51614.
OpenTargetsiENSG00000125991.
PharmGKBiPA38050.

Polymorphism and mutation databases

BioMutaiERGIC3.
DMDMi37999823.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000976401 – 383Endoplasmic reticulum-Golgi intermediate compartment protein 3Add BLAST383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Glycosylationi241N-linked (GlcNAc...)1 Publication1
Glycosylationi266N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9Y282.
PaxDbiQ9Y282.
PeptideAtlasiQ9Y282.
PRIDEiQ9Y282.

PTM databases

iPTMnetiQ9Y282.
PhosphoSitePlusiQ9Y282.
SwissPalmiQ9Y282.

Expressioni

Gene expression databases

BgeeiENSG00000125991.
CleanExiHS_ERGIC3.
ExpressionAtlasiQ9Y282. baseline and differential.
GenevisibleiQ9Y282. HS.

Organism-specific databases

HPAiHPA015242.
HPA015968.

Interactioni

Subunit structurei

Interacts with ERGIC1/ERGIC32.1 Publication

Protein-protein interaction databases

BioGridi119638. 66 interactors.
IntActiQ9Y282. 5 interactors.
STRINGi9606.ENSP00000349970.

Structurei

3D structure databases

ProteinModelPortaliQ9Y282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ERGIC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2667. Eukaryota.
ENOG410XP7X. LUCA.
GeneTreeiENSGT00530000063113.
HOGENOMiHOG000210954.
HOVERGENiHBG105706.
InParanoidiQ9Y282.
KOiK20367.
PhylomeDBiQ9Y282.
TreeFamiTF300739.

Family and domain databases

InterProiIPR012936. Erv_C.
[Graphical view]
PfamiPF07970. COPIIcoated_ERV. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y282-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEALGKLKQF DAYPKTLEDF RVKTCGGATV TIVSGLLMLL LFLSELQYYL
60 70 80 90 100
TTEVHPELYV DKSRGDKLKI NIDVLFPHMP CAYLSIDAMD VAGEQQLDVE
110 120 130 140 150
HNLFKQRLDK DGIPVSSEAE RHELGKVEVT VFDPDSLDPD RCESCYGAEA
160 170 180 190 200
EDIKCCNTCE DVREAYRRRG WAFKNPDTIE QCRREGFSQK MQEQKNEGCQ
210 220 230 240 250
VYGFLEVNKV AGNFHFAPGK SFQQSHVHVH DLQSFGLDNI NMTHYIQHLS
260 270 280 290 300
FGEDYPGIVN PLDHTNVTAP QASMMFQYFV KVVPTVYMKV DGEVLRTNQF
310 320 330 340 350
SVTRHEKVAN GLLGDQGLPG VFVLYELSPM MVKLTEKHRS FTHFLTGVCA
360 370 380
IIGGMFTVAG LIDSLIYHSA RAIQKKIDLG KTT
Length:383
Mass (Da):43,222
Last modified:November 1, 1999 - v1
Checksum:i8370FB3067AD95CE
GO
Isoform 2 (identifier: Q9Y282-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-230: VH → GE
     231-383: Missing.

Note: No experimental confirmation available.
Show »
Length:230
Mass (Da):26,155
Checksum:i11727EE72A9A2587
GO
Isoform 3 (identifier: Q9Y282-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-229: V → VHAVEI

Show »
Length:388
Mass (Da):43,772
Checksum:i54AE001D4A66DAF4
GO

Sequence cautioni

The sequence AAF71038 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG48265 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239N → D in BAC11054 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048939113I → L.Corresponds to variant rs35505616dbSNPEnsembl.1
Natural variantiVAR_036553297T → K in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008652229 – 230VH → GE in isoform 2. 1 Publication2
Alternative sequenceiVSP_019208229V → VHAVEI in isoform 3. 1 Publication1
Alternative sequenceiVSP_008653231 – 383Missing in isoform 2. 1 PublicationAdd BLAST153

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF308298 mRNA. Translation: AAG48265.1. Different initiation.
AF151812 mRNA. Translation: AAD34049.1.
AK074550 mRNA. Translation: BAC11054.1.
AF077030 mRNA. Translation: AAD27763.1.
AL121586 Genomic DNA. Translation: CAB89412.1.
AL121586 Genomic DNA. Translation: CAI42842.1.
BC009765 mRNA. Translation: AAH09765.1.
BC014014 mRNA. Translation: AAH14014.1.
AF116614 mRNA. Translation: AAF71038.1. Different initiation.
CCDSiCCDS13257.1. [Q9Y282-1]
CCDS13258.1. [Q9Y282-3]
RefSeqiNP_057050.1. NM_015966.2. [Q9Y282-1]
NP_938408.1. NM_198398.1. [Q9Y282-3]
UniGeneiHs.472558.

Genome annotation databases

EnsembliENST00000348547; ENSP00000341358; ENSG00000125991. [Q9Y282-1]
ENST00000357394; ENSP00000349970; ENSG00000125991. [Q9Y282-3]
GeneIDi51614.
KEGGihsa:51614.
UCSCiuc002xcs.4. human. [Q9Y282-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF308298 mRNA. Translation: AAG48265.1. Different initiation.
AF151812 mRNA. Translation: AAD34049.1.
AK074550 mRNA. Translation: BAC11054.1.
AF077030 mRNA. Translation: AAD27763.1.
AL121586 Genomic DNA. Translation: CAB89412.1.
AL121586 Genomic DNA. Translation: CAI42842.1.
BC009765 mRNA. Translation: AAH09765.1.
BC014014 mRNA. Translation: AAH14014.1.
AF116614 mRNA. Translation: AAF71038.1. Different initiation.
CCDSiCCDS13257.1. [Q9Y282-1]
CCDS13258.1. [Q9Y282-3]
RefSeqiNP_057050.1. NM_015966.2. [Q9Y282-1]
NP_938408.1. NM_198398.1. [Q9Y282-3]
UniGeneiHs.472558.

3D structure databases

ProteinModelPortaliQ9Y282.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119638. 66 interactors.
IntActiQ9Y282. 5 interactors.
STRINGi9606.ENSP00000349970.

PTM databases

iPTMnetiQ9Y282.
PhosphoSitePlusiQ9Y282.
SwissPalmiQ9Y282.

Polymorphism and mutation databases

BioMutaiERGIC3.
DMDMi37999823.

Proteomic databases

EPDiQ9Y282.
PaxDbiQ9Y282.
PeptideAtlasiQ9Y282.
PRIDEiQ9Y282.

Protocols and materials databases

DNASUi51614.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348547; ENSP00000341358; ENSG00000125991. [Q9Y282-1]
ENST00000357394; ENSP00000349970; ENSG00000125991. [Q9Y282-3]
GeneIDi51614.
KEGGihsa:51614.
UCSCiuc002xcs.4. human. [Q9Y282-1]

Organism-specific databases

CTDi51614.
DisGeNETi51614.
GeneCardsiERGIC3.
HGNCiHGNC:15927. ERGIC3.
HPAiHPA015242.
HPA015968.
neXtProtiNX_Q9Y282.
OpenTargetsiENSG00000125991.
PharmGKBiPA38050.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2667. Eukaryota.
ENOG410XP7X. LUCA.
GeneTreeiENSGT00530000063113.
HOGENOMiHOG000210954.
HOVERGENiHBG105706.
InParanoidiQ9Y282.
KOiK20367.
PhylomeDBiQ9Y282.
TreeFamiTF300739.

Miscellaneous databases

ChiTaRSiERGIC3. human.
GeneWikiiERGIC3.
GenomeRNAii51614.
PROiQ9Y282.

Gene expression databases

BgeeiENSG00000125991.
CleanExiHS_ERGIC3.
ExpressionAtlasiQ9Y282. baseline and differential.
GenevisibleiQ9Y282. HS.

Family and domain databases

InterProiIPR012936. Erv_C.
[Graphical view]
PfamiPF07970. COPIIcoated_ERV. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERGI3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y282
Secondary accession number(s): Q5JWS3
, Q6ZWP7, Q9H276, Q9P1L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.