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Q9Y277 (VDAC3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Voltage-dependent anion-selective channel protein 3

Short name=VDAC-3
Short name=hVDAC3
Alternative name(s):
Outer mitochondrial membrane protein porin 3
Gene names
Name:VDAC3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules By similarity.

Subcellular location

Mitochondrion outer membrane.

Tissue specificity

Widely expressed. Highest in testis.

Domain

Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands By similarity.

Sequence similarities

Belongs to the eukaryotic mitochondrial porin family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y277-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y277-2)

The sequence of this isoform differs from the canonical sequence as follows:
     39-39: V → VM

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.6
Chain2 – 283282Voltage-dependent anion-selective channel protein 3
PRO_0000050512

Regions

Transmembrane26 – 3510Beta stranded; By similarity
Transmembrane39 – 479Beta stranded; By similarity
Transmembrane54 – 6411Beta stranded; By similarity
Transmembrane69 – 768Beta stranded; By similarity
Transmembrane80 – 8910Beta stranded; By similarity
Transmembrane95 – 10410Beta stranded; By similarity
Transmembrane111 – 12010Beta stranded; By similarity
Transmembrane123 – 1308Beta stranded; By similarity
Transmembrane137 – 1459Beta stranded; By similarity
Transmembrane150 – 1589Beta stranded; By similarity
Transmembrane163 – 17513Beta stranded; By similarity
Transmembrane178 – 1858Beta stranded; By similarity
Transmembrane189 – 19810Beta stranded; By similarity
Transmembrane202 – 21110Beta stranded; By similarity
Transmembrane218 – 22710Beta stranded; By similarity
Transmembrane231 – 2388Beta stranded; By similarity
Transmembrane242 – 25110Beta stranded; By similarity
Transmembrane254 – 26310Beta stranded; By similarity
Transmembrane273 – 28210Beta stranded; By similarity
Nucleotide binding242 – 2443NAD By similarity
Nucleotide binding260 – 2645NAD By similarity

Amino acid modifications

Modified residue21N-acetylcysteine Ref.6
Modified residue121N6-acetyllysine By similarity
Modified residue151N6-acetyllysine By similarity
Modified residue201N6-acetyllysine Ref.7
Modified residue901N6-acetyllysine Ref.7
Modified residue2411Phosphoserine By similarity
Modified residue2661N6-acetyllysine By similarity

Natural variations

Alternative sequence391V → VM in isoform 2.
VSP_005079

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: E03CBCEDA72A9783

FASTA28330,659
        10         20         30         40         50         60 
MCNTPTYCDL GKAAKDVFNK GYGFGMVKID LKTKSCSGVE FSTSGHAYTD TGKASGNLET 

        70         80         90        100        110        120 
KYKVCNYGLT FTQKWNTDNT LGTEISWENK LAEGLKLTLD TIFVPNTGKK SGKLKASYKR 

       130        140        150        160        170        180 
DCFSVGSNVD IDFSGPTIYG WAVLAFEGWL AGYQMSFDTA KSKLSQNNFA LGYKAADFQL 

       190        200        210        220        230        240 
HTHVNDGTEF GGSIYQKVNE KIETSINLAW TAGSNNTRFG IAAKYMLDCR TSLSAKVNNA 

       250        260        270        280 
SLIGLGYTQT LRPGVKLTLS ALIDGKNFSA GGHKVGLGFE LEA 

« Hide

Isoform 2 [UniParc].

Checksum: 7AD0EBC72F3C1112
Show »

FASTA28430,790

References

« Hide 'large scale' references
[1]"Isolation of a novel human voltage-dependent anion channel gene."
Rahmani Z., Maunoury C., Siddiqui A.
Eur. J. Hum. Genet. 6:337-340(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z.
Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Umbilical cord blood.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Skin.
[4]"Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis."
Decker W.K., Bowles K.R., Schatte E.C., Towbin J.A., Craigen W.J.
Mamm. Genome 10:1041-1042(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-253.
[5]"The tissue-specific, alternatively spliced single ATG exon of the type 3 voltage-dependent anion channel gene does not create a truncated protein isoform in vivo."
Decker W.K., Craigen W.J.
Mol. Genet. Metab. 70:69-74(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING.
[6]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT CYS-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
[7]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-20 AND LYS-90, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U90943 mRNA. Translation: AAB93872.1.
AF038962 mRNA. Translation: AAC39876.1.
BC056870 mRNA. Translation: AAH56870.1.
AH008073 Genomic DNA. Translation: AAD49610.1.
CCDSCCDS47850.1. [Q9Y277-2]
CCDS6131.1. [Q9Y277-1]
RefSeqNP_001129166.1. NM_001135694.2. [Q9Y277-2]
NP_005653.3. NM_005662.6. [Q9Y277-1]
UniGeneHs.699301.

3D structure databases

ProteinModelPortalQ9Y277.
SMRQ9Y277. Positions 1-283.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113262. 43 interactions.
IntActQ9Y277. 9 interactions.
MINTMINT-1395020.
STRING9606.ENSP00000388732.

Chemistry

DrugBankDB01375. Dihydroxyaluminium.

PTM databases

PhosphoSiteQ9Y277.

Polymorphism databases

DMDM12643945.

2D gel databases

UCD-2DPAGEQ9Y277.

Proteomic databases

MaxQBQ9Y277.
PaxDbQ9Y277.
PeptideAtlasQ9Y277.
PRIDEQ9Y277.

Protocols and materials databases

DNASU7419.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000022615; ENSP00000022615; ENSG00000078668. [Q9Y277-1]
ENST00000521158; ENSP00000428845; ENSG00000078668. [Q9Y277-2]
GeneID7419.
KEGGhsa:7419.
UCSCuc003xpc.3. human. [Q9Y277-1]
uc022aul.1. human. [Q9Y277-2]

Organism-specific databases

CTD7419.
GeneCardsGC08P042266.
HGNCHGNC:12674. VDAC3.
HPAHPA026864.
MIM610029. gene.
neXtProtNX_Q9Y277.
PharmGKBPA37297.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG243169.
HOGENOMHOG000188277.
HOVERGENHBG054036.
InParanoidQ9Y277.
KOK15041.
PhylomeDBQ9Y277.
TreeFamTF315091.

Gene expression databases

ArrayExpressQ9Y277.
BgeeQ9Y277.
CleanExHS_VDAC3.
GenevestigatorQ9Y277.

Family and domain databases

Gene3D2.40.160.10. 1 hit.
InterProIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
[Graphical view]
PfamPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSPR00185. EUKARYTPORIN.
PROSITEPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSVDAC3. human.
GeneWikiVDAC3.
GenomeRNAi7419.
NextBio29048.
PROQ9Y277.
SOURCESearch...

Entry information

Entry nameVDAC3_HUMAN
AccessionPrimary (citable) accession number: Q9Y277
Secondary accession number(s): Q9UIS0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM