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Q9Y277

- VDAC3_HUMAN

UniProt

Q9Y277 - VDAC3_HUMAN

Protein

Voltage-dependent anion-selective channel protein 3

Gene

VDAC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi242 – 2443NADBy similarity
    Nucleotide bindingi260 – 2645NADBy similarity

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. porin activity Source: UniProtKB-KW
    3. voltage-gated anion channel activity Source: UniProtKB

    GO - Biological processi

    1. adenine transport Source: ProtInc

    Keywords - Molecular functioni

    Porin

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    NAD, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent anion-selective channel protein 3
    Short name:
    VDAC-3
    Short name:
    hVDAC3
    Alternative name(s):
    Outer mitochondrial membrane protein porin 3
    Gene namesi
    Name:VDAC3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:12674. VDAC3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. mitochondrial outer membrane Source: ProtInc
    3. mitochondrion Source: UniProt
    4. nucleus Source: UniProt
    5. pore complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37297.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 283282Voltage-dependent anion-selective channel protein 3PRO_0000050512Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylcysteine1 Publication
    Modified residuei12 – 121N6-acetyllysineBy similarity
    Modified residuei15 – 151N6-acetyllysineBy similarity
    Modified residuei20 – 201N6-acetyllysine1 Publication
    Modified residuei90 – 901N6-acetyllysine1 Publication
    Modified residuei241 – 2411PhosphoserineBy similarity
    Modified residuei266 – 2661N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y277.
    PaxDbiQ9Y277.
    PeptideAtlasiQ9Y277.
    PRIDEiQ9Y277.

    2D gel databases

    UCD-2DPAGEQ9Y277.

    PTM databases

    PhosphoSiteiQ9Y277.

    Expressioni

    Tissue specificityi

    Widely expressed. Highest in testis.

    Gene expression databases

    ArrayExpressiQ9Y277.
    BgeeiQ9Y277.
    CleanExiHS_VDAC3.
    GenevestigatoriQ9Y277.

    Organism-specific databases

    HPAiHPA026864.

    Interactioni

    Protein-protein interaction databases

    BioGridi113262. 43 interactions.
    IntActiQ9Y277. 9 interactions.
    MINTiMINT-1395020.
    STRINGi9606.ENSP00000388732.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y277.
    SMRiQ9Y277. Positions 1-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 3510Beta strandedBy similarity
    Transmembranei39 – 479Beta strandedBy similarity
    Transmembranei54 – 6411Beta strandedBy similarityAdd
    BLAST
    Transmembranei69 – 768Beta strandedBy similarity
    Transmembranei80 – 8910Beta strandedBy similarity
    Transmembranei95 – 10410Beta strandedBy similarity
    Transmembranei111 – 12010Beta strandedBy similarity
    Transmembranei123 – 1308Beta strandedBy similarity
    Transmembranei137 – 1459Beta strandedBy similarity
    Transmembranei150 – 1589Beta strandedBy similarity
    Transmembranei163 – 17513Beta strandedBy similarityAdd
    BLAST
    Transmembranei178 – 1858Beta strandedBy similarity
    Transmembranei189 – 19810Beta strandedBy similarity
    Transmembranei202 – 21110Beta strandedBy similarity
    Transmembranei218 – 22710Beta strandedBy similarity
    Transmembranei231 – 2388Beta strandedBy similarity
    Transmembranei242 – 25110Beta strandedBy similarity
    Transmembranei254 – 26310Beta strandedBy similarity
    Transmembranei273 – 28210Beta strandedBy similarity

    Family & Domainsi

    Domaini

    Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane beta strand

    Phylogenomic databases

    eggNOGiNOG243169.
    HOGENOMiHOG000188277.
    HOVERGENiHBG054036.
    InParanoidiQ9Y277.
    KOiK15041.
    PhylomeDBiQ9Y277.
    TreeFamiTF315091.

    Family and domain databases

    Gene3Di2.40.160.10. 1 hit.
    InterProiIPR023614. Porin_dom.
    IPR001925. Porin_Euk.
    IPR027246. Porin_Euk/Tom40.
    [Graphical view]
    PfamiPF01459. Porin_3. 1 hit.
    [Graphical view]
    PRINTSiPR00185. EUKARYTPORIN.
    PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y277-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MCNTPTYCDL GKAAKDVFNK GYGFGMVKID LKTKSCSGVE FSTSGHAYTD    50
    TGKASGNLET KYKVCNYGLT FTQKWNTDNT LGTEISWENK LAEGLKLTLD 100
    TIFVPNTGKK SGKLKASYKR DCFSVGSNVD IDFSGPTIYG WAVLAFEGWL 150
    AGYQMSFDTA KSKLSQNNFA LGYKAADFQL HTHVNDGTEF GGSIYQKVNE 200
    KIETSINLAW TAGSNNTRFG IAAKYMLDCR TSLSAKVNNA SLIGLGYTQT 250
    LRPGVKLTLS ALIDGKNFSA GGHKVGLGFE LEA 283
    Length:283
    Mass (Da):30,659
    Last modified:November 1, 1999 - v1
    Checksum:iE03CBCEDA72A9783
    GO
    Isoform 2 (identifier: Q9Y277-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         39-39: V → VM

    Show »
    Length:284
    Mass (Da):30,790
    Checksum:i7AD0EBC72F3C1112
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei39 – 391V → VM in isoform 2. CuratedVSP_005079

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90943 mRNA. Translation: AAB93872.1.
    AF038962 mRNA. Translation: AAC39876.1.
    BC056870 mRNA. Translation: AAH56870.1.
    AH008073 Genomic DNA. Translation: AAD49610.1.
    CCDSiCCDS47850.1. [Q9Y277-2]
    CCDS6131.1. [Q9Y277-1]
    RefSeqiNP_001129166.1. NM_001135694.2. [Q9Y277-2]
    NP_005653.3. NM_005662.6. [Q9Y277-1]
    UniGeneiHs.699301.

    Genome annotation databases

    EnsembliENST00000022615; ENSP00000022615; ENSG00000078668. [Q9Y277-1]
    ENST00000521158; ENSP00000428845; ENSG00000078668. [Q9Y277-2]
    GeneIDi7419.
    KEGGihsa:7419.
    UCSCiuc003xpc.3. human. [Q9Y277-1]
    uc022aul.1. human. [Q9Y277-2]

    Polymorphism databases

    DMDMi12643945.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90943 mRNA. Translation: AAB93872.1 .
    AF038962 mRNA. Translation: AAC39876.1 .
    BC056870 mRNA. Translation: AAH56870.1 .
    AH008073 Genomic DNA. Translation: AAD49610.1 .
    CCDSi CCDS47850.1. [Q9Y277-2 ]
    CCDS6131.1. [Q9Y277-1 ]
    RefSeqi NP_001129166.1. NM_001135694.2. [Q9Y277-2 ]
    NP_005653.3. NM_005662.6. [Q9Y277-1 ]
    UniGenei Hs.699301.

    3D structure databases

    ProteinModelPortali Q9Y277.
    SMRi Q9Y277. Positions 1-283.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113262. 43 interactions.
    IntActi Q9Y277. 9 interactions.
    MINTi MINT-1395020.
    STRINGi 9606.ENSP00000388732.

    Chemistry

    DrugBanki DB01375. Dihydroxyaluminium.

    PTM databases

    PhosphoSitei Q9Y277.

    Polymorphism databases

    DMDMi 12643945.

    2D gel databases

    UCD-2DPAGE Q9Y277.

    Proteomic databases

    MaxQBi Q9Y277.
    PaxDbi Q9Y277.
    PeptideAtlasi Q9Y277.
    PRIDEi Q9Y277.

    Protocols and materials databases

    DNASUi 7419.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000022615 ; ENSP00000022615 ; ENSG00000078668 . [Q9Y277-1 ]
    ENST00000521158 ; ENSP00000428845 ; ENSG00000078668 . [Q9Y277-2 ]
    GeneIDi 7419.
    KEGGi hsa:7419.
    UCSCi uc003xpc.3. human. [Q9Y277-1 ]
    uc022aul.1. human. [Q9Y277-2 ]

    Organism-specific databases

    CTDi 7419.
    GeneCardsi GC08P042266.
    HGNCi HGNC:12674. VDAC3.
    HPAi HPA026864.
    MIMi 610029. gene.
    neXtProti NX_Q9Y277.
    PharmGKBi PA37297.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG243169.
    HOGENOMi HOG000188277.
    HOVERGENi HBG054036.
    InParanoidi Q9Y277.
    KOi K15041.
    PhylomeDBi Q9Y277.
    TreeFami TF315091.

    Miscellaneous databases

    ChiTaRSi VDAC3. human.
    GeneWikii VDAC3.
    GenomeRNAii 7419.
    NextBioi 29048.
    PROi Q9Y277.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y277.
    Bgeei Q9Y277.
    CleanExi HS_VDAC3.
    Genevestigatori Q9Y277.

    Family and domain databases

    Gene3Di 2.40.160.10. 1 hit.
    InterProi IPR023614. Porin_dom.
    IPR001925. Porin_Euk.
    IPR027246. Porin_Euk/Tom40.
    [Graphical view ]
    Pfami PF01459. Porin_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00185. EUKARYTPORIN.
    PROSITEi PS00558. EUKARYOTIC_PORIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a novel human voltage-dependent anion channel gene."
      Rahmani Z., Maunoury C., Siddiqui A.
      Eur. J. Hum. Genet. 6:337-340(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
      Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z.
      Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    4. "Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis."
      Decker W.K., Bowles K.R., Schatte E.C., Towbin J.A., Craigen W.J.
      Mamm. Genome 10:1041-1042(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-253.
    5. "The tissue-specific, alternatively spliced single ATG exon of the type 3 voltage-dependent anion channel gene does not create a truncated protein isoform in vivo."
      Decker W.K., Craigen W.J.
      Mol. Genet. Metab. 70:69-74(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT CYS-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-20 AND LYS-90, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiVDAC3_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y277
    Secondary accession number(s): Q9UIS0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3