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Protein

Voltage-dependent anion-selective channel protein 3

Gene

VDAC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi242 – 244NADBy similarity3
Nucleotide bindingi260 – 264NADBy similarity5

GO - Molecular functioni

  • nucleotide binding Source: UniProtKB-KW
  • porin activity Source: UniProtKB-KW
  • voltage-gated anion channel activity Source: UniProtKB

GO - Biological processi

  • adenine transport Source: ProtInc
  • regulation of cilium assembly Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

NAD, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000078668-MONOMER.
ReactomeiR-HSA-5689880. Ub-specific processing proteases.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent anion-selective channel protein 3
Short name:
VDAC-3
Short name:
hVDAC3
Alternative name(s):
Outer mitochondrial membrane protein porin 3
Gene namesi
Name:VDAC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:12674. VDAC3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 35Beta strandedBy similarity10
Transmembranei39 – 47Beta strandedBy similarity9
Transmembranei54 – 64Beta strandedBy similarityAdd BLAST11
Transmembranei69 – 76Beta strandedBy similarity8
Transmembranei80 – 89Beta strandedBy similarity10
Transmembranei95 – 104Beta strandedBy similarity10
Transmembranei111 – 120Beta strandedBy similarity10
Transmembranei123 – 130Beta strandedBy similarity8
Transmembranei137 – 145Beta strandedBy similarity9
Transmembranei150 – 158Beta strandedBy similarity9
Transmembranei163 – 175Beta strandedBy similarityAdd BLAST13
Transmembranei178 – 185Beta strandedBy similarity8
Transmembranei189 – 198Beta strandedBy similarity10
Transmembranei202 – 211Beta strandedBy similarity10
Transmembranei218 – 227Beta strandedBy similarity10
Transmembranei231 – 238Beta strandedBy similarity8
Transmembranei242 – 251Beta strandedBy similarity10
Transmembranei254 – 263Beta strandedBy similarity10
Transmembranei273 – 282Beta strandedBy similarity10

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • mitochondrial outer membrane Source: ProtInc
  • mitochondrion Source: UniProtKB
  • nucleus Source: UniProtKB
  • pore complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000078668.
PharmGKBiPA37297.

Chemistry databases

DrugBankiDB01375. Dihydroxyaluminium.

Polymorphism and mutation databases

BioMutaiVDAC3.
DMDMi12643945.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000505122 – 283Voltage-dependent anion-selective channel protein 3Add BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylcysteineCombined sources1
Modified residuei4PhosphothreonineCombined sources1
Modified residuei20N6-acetyllysine; alternateCombined sources1
Modified residuei20N6-succinyllysine; alternateBy similarity1
Cross-linki53Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei67PhosphotyrosineBy similarity1
Modified residuei90N6-acetyllysineCombined sources1
Modified residuei107PhosphothreonineBy similarity1
Modified residuei109N6-acetyllysine; alternateBy similarity1
Cross-linki109Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Cross-linki110Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki161Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki163Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei241PhosphoserineBy similarity1
Modified residuei266N6-acetyllysine; alternateBy similarity1
Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Cross-linki274Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Post-translational modificationi

Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Y277.
PaxDbiQ9Y277.
PeptideAtlasiQ9Y277.
PRIDEiQ9Y277.

2D gel databases

UCD-2DPAGEQ9Y277.

PTM databases

iPTMnetiQ9Y277.
PhosphoSitePlusiQ9Y277.
SwissPalmiQ9Y277.

Expressioni

Tissue specificityi

Widely expressed. Highest in testis.

Gene expression databases

BgeeiENSG00000078668.
CleanExiHS_VDAC3.
ExpressionAtlasiQ9Y277. baseline and differential.
GenevisibleiQ9Y277. HS.

Organism-specific databases

HPAiHPA026864.

Interactioni

Protein-protein interaction databases

BioGridi113262. 109 interactors.
IntActiQ9Y277. 16 interactors.
MINTiMINT-1395020.
STRINGi9606.ENSP00000428845.

Structurei

3D structure databases

ProteinModelPortaliQ9Y277.
SMRiQ9Y277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3126. Eukaryota.
ENOG410ZBK1. LUCA.
GeneTreeiENSGT00390000011336.
HOGENOMiHOG000188277.
HOVERGENiHBG054036.
InParanoidiQ9Y277.
KOiK15041.
OMAiICNYGLT.
OrthoDBiEOG091G0F0O.
PhylomeDBiQ9Y277.
TreeFamiTF315091.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
IPR030271. VDAC3.
[Graphical view]
PANTHERiPTHR11743:SF28. PTHR11743:SF28. 1 hit.
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSiPR00185. EUKARYTPORIN.
PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y277-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCNTPTYCDL GKAAKDVFNK GYGFGMVKID LKTKSCSGVE FSTSGHAYTD
60 70 80 90 100
TGKASGNLET KYKVCNYGLT FTQKWNTDNT LGTEISWENK LAEGLKLTLD
110 120 130 140 150
TIFVPNTGKK SGKLKASYKR DCFSVGSNVD IDFSGPTIYG WAVLAFEGWL
160 170 180 190 200
AGYQMSFDTA KSKLSQNNFA LGYKAADFQL HTHVNDGTEF GGSIYQKVNE
210 220 230 240 250
KIETSINLAW TAGSNNTRFG IAAKYMLDCR TSLSAKVNNA SLIGLGYTQT
260 270 280
LRPGVKLTLS ALIDGKNFSA GGHKVGLGFE LEA
Length:283
Mass (Da):30,659
Last modified:November 1, 1999 - v1
Checksum:iE03CBCEDA72A9783
GO
Isoform 2 (identifier: Q9Y277-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-39: V → VM

Show »
Length:284
Mass (Da):30,790
Checksum:i7AD0EBC72F3C1112
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00507939V → VM in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90943 mRNA. Translation: AAB93872.1.
AF038962 mRNA. Translation: AAC39876.1.
BC056870 mRNA. Translation: AAH56870.1.
AH008073 Genomic DNA. Translation: AAD49610.1.
CCDSiCCDS47850.1. [Q9Y277-2]
CCDS6131.1. [Q9Y277-1]
RefSeqiNP_001129166.1. NM_001135694.2. [Q9Y277-2]
NP_005653.3. NM_005662.6. [Q9Y277-1]
UniGeneiHs.699301.

Genome annotation databases

EnsembliENST00000022615; ENSP00000022615; ENSG00000078668. [Q9Y277-1]
ENST00000521158; ENSP00000428845; ENSG00000078668. [Q9Y277-2]
GeneIDi7419.
KEGGihsa:7419.
UCSCiuc003xpc.4. human. [Q9Y277-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90943 mRNA. Translation: AAB93872.1.
AF038962 mRNA. Translation: AAC39876.1.
BC056870 mRNA. Translation: AAH56870.1.
AH008073 Genomic DNA. Translation: AAD49610.1.
CCDSiCCDS47850.1. [Q9Y277-2]
CCDS6131.1. [Q9Y277-1]
RefSeqiNP_001129166.1. NM_001135694.2. [Q9Y277-2]
NP_005653.3. NM_005662.6. [Q9Y277-1]
UniGeneiHs.699301.

3D structure databases

ProteinModelPortaliQ9Y277.
SMRiQ9Y277.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113262. 109 interactors.
IntActiQ9Y277. 16 interactors.
MINTiMINT-1395020.
STRINGi9606.ENSP00000428845.

Chemistry databases

DrugBankiDB01375. Dihydroxyaluminium.

PTM databases

iPTMnetiQ9Y277.
PhosphoSitePlusiQ9Y277.
SwissPalmiQ9Y277.

Polymorphism and mutation databases

BioMutaiVDAC3.
DMDMi12643945.

2D gel databases

UCD-2DPAGEQ9Y277.

Proteomic databases

EPDiQ9Y277.
PaxDbiQ9Y277.
PeptideAtlasiQ9Y277.
PRIDEiQ9Y277.

Protocols and materials databases

DNASUi7419.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000022615; ENSP00000022615; ENSG00000078668. [Q9Y277-1]
ENST00000521158; ENSP00000428845; ENSG00000078668. [Q9Y277-2]
GeneIDi7419.
KEGGihsa:7419.
UCSCiuc003xpc.4. human. [Q9Y277-1]

Organism-specific databases

CTDi7419.
GeneCardsiVDAC3.
HGNCiHGNC:12674. VDAC3.
HPAiHPA026864.
MIMi610029. gene.
neXtProtiNX_Q9Y277.
OpenTargetsiENSG00000078668.
PharmGKBiPA37297.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3126. Eukaryota.
ENOG410ZBK1. LUCA.
GeneTreeiENSGT00390000011336.
HOGENOMiHOG000188277.
HOVERGENiHBG054036.
InParanoidiQ9Y277.
KOiK15041.
OMAiICNYGLT.
OrthoDBiEOG091G0F0O.
PhylomeDBiQ9Y277.
TreeFamiTF315091.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000078668-MONOMER.
ReactomeiR-HSA-5689880. Ub-specific processing proteases.

Miscellaneous databases

ChiTaRSiVDAC3. human.
GeneWikiiVDAC3.
GenomeRNAii7419.
PROiQ9Y277.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000078668.
CleanExiHS_VDAC3.
ExpressionAtlasiQ9Y277. baseline and differential.
GenevisibleiQ9Y277. HS.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
IPR030271. VDAC3.
[Graphical view]
PANTHERiPTHR11743:SF28. PTHR11743:SF28. 1 hit.
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSiPR00185. EUKARYTPORIN.
PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVDAC3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y277
Secondary accession number(s): Q9UIS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.