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Q9Y277

- VDAC3_HUMAN

UniProt

Q9Y277 - VDAC3_HUMAN

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Protein

Voltage-dependent anion-selective channel protein 3

Gene

VDAC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi242 – 2443NADBy similarity
Nucleotide bindingi260 – 2645NADBy similarity

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. porin activity Source: UniProtKB-KW
  3. voltage-gated anion channel activity Source: UniProtKB

GO - Biological processi

  1. adenine transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

NAD, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent anion-selective channel protein 3
Short name:
VDAC-3
Short name:
hVDAC3
Alternative name(s):
Outer mitochondrial membrane protein porin 3
Gene namesi
Name:VDAC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:12674. VDAC3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 3510Beta strandedBy similarity
Transmembranei39 – 479Beta strandedBy similarity
Transmembranei54 – 6411Beta strandedBy similarityAdd
BLAST
Transmembranei69 – 768Beta strandedBy similarity
Transmembranei80 – 8910Beta strandedBy similarity
Transmembranei95 – 10410Beta strandedBy similarity
Transmembranei111 – 12010Beta strandedBy similarity
Transmembranei123 – 1308Beta strandedBy similarity
Transmembranei137 – 1459Beta strandedBy similarity
Transmembranei150 – 1589Beta strandedBy similarity
Transmembranei163 – 17513Beta strandedBy similarityAdd
BLAST
Transmembranei178 – 1858Beta strandedBy similarity
Transmembranei189 – 19810Beta strandedBy similarity
Transmembranei202 – 21110Beta strandedBy similarity
Transmembranei218 – 22710Beta strandedBy similarity
Transmembranei231 – 2388Beta strandedBy similarity
Transmembranei242 – 25110Beta strandedBy similarity
Transmembranei254 – 26310Beta strandedBy similarity
Transmembranei273 – 28210Beta strandedBy similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. mitochondrial outer membrane Source: ProtInc
  3. mitochondrion Source: UniProt
  4. nucleus Source: UniProt
  5. pore complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37297.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 283282Voltage-dependent anion-selective channel protein 3PRO_0000050512Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylcysteine1 Publication
Modified residuei12 – 121N6-acetyllysineBy similarity
Modified residuei15 – 151N6-acetyllysineBy similarity
Modified residuei20 – 201N6-acetyllysine1 Publication
Modified residuei90 – 901N6-acetyllysine1 Publication
Modified residuei241 – 2411PhosphoserineBy similarity
Modified residuei266 – 2661N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9Y277.
PaxDbiQ9Y277.
PeptideAtlasiQ9Y277.
PRIDEiQ9Y277.

2D gel databases

UCD-2DPAGEQ9Y277.

PTM databases

PhosphoSiteiQ9Y277.

Expressioni

Tissue specificityi

Widely expressed. Highest in testis.

Gene expression databases

BgeeiQ9Y277.
CleanExiHS_VDAC3.
ExpressionAtlasiQ9Y277. baseline and differential.
GenevestigatoriQ9Y277.

Organism-specific databases

HPAiHPA026864.

Interactioni

Protein-protein interaction databases

BioGridi113262. 45 interactions.
IntActiQ9Y277. 9 interactions.
MINTiMINT-1395020.
STRINGi9606.ENSP00000388732.

Structurei

3D structure databases

ProteinModelPortaliQ9Y277.
SMRiQ9Y277. Positions 1-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiNOG243169.
GeneTreeiENSGT00390000011336.
HOGENOMiHOG000188277.
HOVERGENiHBG054036.
InParanoidiQ9Y277.
KOiK15041.
PhylomeDBiQ9Y277.
TreeFamiTF315091.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
[Graphical view]
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSiPR00185. EUKARYTPORIN.
PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y277-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCNTPTYCDL GKAAKDVFNK GYGFGMVKID LKTKSCSGVE FSTSGHAYTD
60 70 80 90 100
TGKASGNLET KYKVCNYGLT FTQKWNTDNT LGTEISWENK LAEGLKLTLD
110 120 130 140 150
TIFVPNTGKK SGKLKASYKR DCFSVGSNVD IDFSGPTIYG WAVLAFEGWL
160 170 180 190 200
AGYQMSFDTA KSKLSQNNFA LGYKAADFQL HTHVNDGTEF GGSIYQKVNE
210 220 230 240 250
KIETSINLAW TAGSNNTRFG IAAKYMLDCR TSLSAKVNNA SLIGLGYTQT
260 270 280
LRPGVKLTLS ALIDGKNFSA GGHKVGLGFE LEA
Length:283
Mass (Da):30,659
Last modified:November 1, 1999 - v1
Checksum:iE03CBCEDA72A9783
GO
Isoform 2 (identifier: Q9Y277-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-39: V → VM

Show »
Length:284
Mass (Da):30,790
Checksum:i7AD0EBC72F3C1112
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei39 – 391V → VM in isoform 2. CuratedVSP_005079

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90943 mRNA. Translation: AAB93872.1.
AF038962 mRNA. Translation: AAC39876.1.
BC056870 mRNA. Translation: AAH56870.1.
AH008073 Genomic DNA. Translation: AAD49610.1.
CCDSiCCDS47850.1. [Q9Y277-2]
CCDS6131.1. [Q9Y277-1]
RefSeqiNP_001129166.1. NM_001135694.2. [Q9Y277-2]
NP_005653.3. NM_005662.6. [Q9Y277-1]
UniGeneiHs.699301.

Genome annotation databases

EnsembliENST00000022615; ENSP00000022615; ENSG00000078668. [Q9Y277-1]
ENST00000521158; ENSP00000428845; ENSG00000078668. [Q9Y277-2]
GeneIDi7419.
KEGGihsa:7419.
UCSCiuc003xpc.3. human. [Q9Y277-1]
uc022aul.1. human. [Q9Y277-2]

Polymorphism databases

DMDMi12643945.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90943 mRNA. Translation: AAB93872.1 .
AF038962 mRNA. Translation: AAC39876.1 .
BC056870 mRNA. Translation: AAH56870.1 .
AH008073 Genomic DNA. Translation: AAD49610.1 .
CCDSi CCDS47850.1. [Q9Y277-2 ]
CCDS6131.1. [Q9Y277-1 ]
RefSeqi NP_001129166.1. NM_001135694.2. [Q9Y277-2 ]
NP_005653.3. NM_005662.6. [Q9Y277-1 ]
UniGenei Hs.699301.

3D structure databases

ProteinModelPortali Q9Y277.
SMRi Q9Y277. Positions 1-283.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113262. 45 interactions.
IntActi Q9Y277. 9 interactions.
MINTi MINT-1395020.
STRINGi 9606.ENSP00000388732.

Chemistry

DrugBanki DB01375. Dihydroxyaluminium.

PTM databases

PhosphoSitei Q9Y277.

Polymorphism databases

DMDMi 12643945.

2D gel databases

UCD-2DPAGE Q9Y277.

Proteomic databases

MaxQBi Q9Y277.
PaxDbi Q9Y277.
PeptideAtlasi Q9Y277.
PRIDEi Q9Y277.

Protocols and materials databases

DNASUi 7419.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000022615 ; ENSP00000022615 ; ENSG00000078668 . [Q9Y277-1 ]
ENST00000521158 ; ENSP00000428845 ; ENSG00000078668 . [Q9Y277-2 ]
GeneIDi 7419.
KEGGi hsa:7419.
UCSCi uc003xpc.3. human. [Q9Y277-1 ]
uc022aul.1. human. [Q9Y277-2 ]

Organism-specific databases

CTDi 7419.
GeneCardsi GC08P042249.
HGNCi HGNC:12674. VDAC3.
HPAi HPA026864.
MIMi 610029. gene.
neXtProti NX_Q9Y277.
PharmGKBi PA37297.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG243169.
GeneTreei ENSGT00390000011336.
HOGENOMi HOG000188277.
HOVERGENi HBG054036.
InParanoidi Q9Y277.
KOi K15041.
PhylomeDBi Q9Y277.
TreeFami TF315091.

Miscellaneous databases

ChiTaRSi VDAC3. human.
GeneWikii VDAC3.
GenomeRNAii 7419.
NextBioi 29048.
PROi Q9Y277.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y277.
CleanExi HS_VDAC3.
ExpressionAtlasi Q9Y277. baseline and differential.
Genevestigatori Q9Y277.

Family and domain databases

Gene3Di 2.40.160.10. 1 hit.
InterProi IPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
[Graphical view ]
Pfami PF01459. Porin_3. 1 hit.
[Graphical view ]
PRINTSi PR00185. EUKARYTPORIN.
PROSITEi PS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a novel human voltage-dependent anion channel gene."
    Rahmani Z., Maunoury C., Siddiqui A.
    Eur. J. Hum. Genet. 6:337-340(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
    Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z.
    Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  4. "Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis."
    Decker W.K., Bowles K.R., Schatte E.C., Towbin J.A., Craigen W.J.
    Mamm. Genome 10:1041-1042(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-253.
  5. "The tissue-specific, alternatively spliced single ATG exon of the type 3 voltage-dependent anion channel gene does not create a truncated protein isoform in vivo."
    Decker W.K., Craigen W.J.
    Mol. Genet. Metab. 70:69-74(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT CYS-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-20 AND LYS-90, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiVDAC3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y277
Secondary accession number(s): Q9UIS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3