Reviewed, UniProtKB/Swiss-Prot Q9Y277 (VDAC3_HUMAN)

Names and origin

Protein names

Recommended name:
    Voltage-dependent anion-selective channel protein 3
      Short name=VDAC-3
      Short name=hVDAC3
Alternative name(s):
    Outer mitochondrial membrane protein porin 3

Gene names

Name:

VDAC3

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules By similarity.
Subcellular location	Mitochondrion outer membrane.
Tissue specificity	Widely expressed. Highest in testis.
Domain	Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands By similarity.
Sequence similarities	Belongs to the eukaryotic mitochondrial porin family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane Mitochondrion Mitochondrion outer membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane
Ligand	NAD Nucleotide-binding
Molecular function	Porin
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine transport Ref.1 Traceable author statement. Source: ProtInc anion transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial outer membrane Ref.1 Traceable author statement. Source: ProtInc
Molecular function	nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct voltage-gated anion channel activity Ref.1 Traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CASP4	P49662	1	EBI-354196,EBI-1057327

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y277-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y277-2)

The sequence of this isoform differs from the canonical sequence as follows:
     39-39: V → VM

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	Voltage-dependent anion-selective channel protein 3		PRO_0000050512
Regions
	Transmembrane	26 – 35	10	Transmembrane beta-strand By similarity
	Transmembrane	39 – 47	9	Transmembrane beta-strand By similarity
	Transmembrane	54 – 64	11	Transmembrane beta-strand By similarity
	Transmembrane	69 – 76	8	Transmembrane beta-strand By similarity
	Transmembrane	80 – 89	10	Transmembrane beta-strand By similarity
	Transmembrane	95 – 104	10	Transmembrane beta-strand By similarity
	Transmembrane	111 – 120	10	Transmembrane beta-strand By similarity
	Transmembrane	123 – 130	8	Transmembrane beta-strand By similarity
	Transmembrane	137 – 145	9	Transmembrane beta-strand By similarity
	Transmembrane	150 – 158	9	Transmembrane beta-strand By similarity
	Transmembrane	163 – 175	13	Transmembrane beta-strand By similarity
	Transmembrane	178 – 185	8	Transmembrane beta-strand By similarity
	Transmembrane	189 – 198	10	Transmembrane beta-strand By similarity
	Transmembrane	202 – 211	10	Transmembrane beta-strand By similarity
	Transmembrane	218 – 227	10	Transmembrane beta-strand By similarity
	Transmembrane	231 – 238	8	Transmembrane beta-strand By similarity
	Transmembrane	242 – 251	10	Transmembrane beta-strand By similarity
	Transmembrane	254 – 263	10	Transmembrane beta-strand By similarity
	Transmembrane	273 – 282	10	Transmembrane beta-strand By similarity
	Nucleotide binding	242 – 244	3	NAD By similarity
	Nucleotide binding	260 – 264	5	NAD By similarity
Amino acid modifications
	Modified residue	20	1	N6-acetyllysine By similarity
	Modified residue	33	1	Phosphothreonine By similarity
	Modified residue	48	1	Phosphotyrosine By similarity
	Modified residue	61	1	N6-acetyllysine By similarity
	Modified residue	195	1	Phosphotyrosine Ref.6
	Modified residue	241	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	39	1	V → VM in isoform 2.		VSP_005079

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: E03CBCEDA72A9783	FASTA	283	30,659
	10 20 30 40 50 60 MCNTPTYCDL GKAAKDVFNK GYGFGMVKID LKTKSCSGVE FSTSGHAYTD TGKASGNLET 70 80 90 100 110 120 KYKVCNYGLT FTQKWNTDNT LGTEISWENK LAEGLKLTLD TIFVPNTGKK SGKLKASYKR 130 140 150 160 170 180 DCFSVGSNVD IDFSGPTIYG WAVLAFEGWL AGYQMSFDTA KSKLSQNNFA LGYKAADFQL 190 200 210 220 230 240 HTHVNDGTEF GGSIYQKVNE KIETSINLAW TAGSNNTRFG IAAKYMLDCR TSLSAKVNNA 250 260 270 280 SLIGLGYTQT LRPGVKLTLS ALIDGKNFSA GGHKVGLGFE LEA
	Isoform 2. Checksum: 7AD0EBC72F3C1112	FASTA	284	30,790
	10 20 30 40 50 60 MCNTPTYCDL GKAAKDVFNK GYGFGMVKID LKTKSCSGVM EFSTSGHAYT DTGKASGNLE 70 80 90 100 110 120 TKYKVCNYGL TFTQKWNTDN TLGTEISWEN KLAEGLKLTL DTIFVPNTGK KSGKLKASYK 130 140 150 160 170 180 RDCFSVGSNV DIDFSGPTIY GWAVLAFEGW LAGYQMSFDT AKSKLSQNNF ALGYKAADFQ 190 200 210 220 230 240 LHTHVNDGTE FGGSIYQKVN EKIETSINLA WTAGSNNTRF GIAAKYMLDC RTSLSAKVNN 250 260 270 280 ASLIGLGYTQ TLRPGVKLTL SALIDGKNFS AGGHKVGLGF ELEA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a novel human voltage-dependent anion channel gene." Rahmani Z., Maunoury C., Siddiqui A. Eur. J. Hum. Genet. 6:337-340(1998) [PubMed: 9781040] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning." Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z. Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed: 9653160] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Skin.
[4]	"Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis." Decker W.K., Bowles K.R., Schatte E.C., Towbin J.A., Craigen W.J. Mamm. Genome 10:1041-1042(1999) [PubMed: 10501981] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-253.
[5]	"The tissue-specific, alternatively spliced single ATG exon of the type 3 voltage-dependent anion channel gene does not create a truncated protein isoform in vivo." Decker W.K., Craigen W.J. Mol. Genet. Metab. 70:69-74(2000) [PubMed: 10833333] [Abstract] Cited for: ALTERNATIVE SPLICING.
[6]	"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-195, MASS SPECTROMETRY.
[7]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U90943 mRNA. Translation: AAB93872.1. AF038962 mRNA. Translation: AAC39876.1. BC056870 mRNA. Translation: AAH56870.1. AF151682, AF151679, AF151681 Genomic DNA. Translation: AAD49610.1.
IPI	IPI00031804. IPI00294779.
RefSeq	NP_001129166.1. NP_005653.3.
UniGene	Hs.699301
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y277. 9 interactions.
PTM databases
PhosphoSite	Q9Y277.
Proteomic databases
PeptideAtlas	Q9Y277.
PRIDE	Q9Y277.
Genome annotation databases
Ensembl	ENSG00000078668. Homo sapiens. [Contig view]
GeneID	7419.
KEGG	hsa:7419.
UCSC	uc003xpc.1. human.
Organism-specific databases
GeneCards	GC08P042368.
H-InvDB	HIX0007479.
HGNC	HGNC:12674. VDAC3.
MIM	610029. gene.
PharmGKB	PA37297.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9Y277.
HOVERGEN	Q9Y277.
OMA	Q9Y277. CFSLGSN.
Gene expression databases
ArrayExpress	Q9Y277.
Bgee	Q9Y277.
CleanEx	HS_VDAC3.
GermOnline	ENSG00000078668. Homo sapiens.
Family and domain databases
InterPro	IPR001925. Porin_Euk. [Graphical view]
Pfam	PF01459. Porin_3. 1 hit. [Graphical view]
PRINTS	PR00185. EUKARYTPORIN.
PROSITE	PS00558. EUKARYOTIC_PORIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB01375. Dihydroxyaluminium.
NextBio	29048.
SOURCE	Search...

Entry information

Entry name

VDAC3_HUMAN

Accession

Primary (citable) accession number: Q9Y277
Secondary accession number(s): Q9UIS0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	July 7, 2009
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)