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Reviewed, UniProtKB/Swiss-Prot Q9Y277 (VDAC3_HUMAN)

Last modified July 7, 2009. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Voltage-dependent anion-selective channel protein 3
      Short name=VDAC-3
      Short name=hVDAC3
Alternative name(s):
    Outer mitochondrial membrane protein porin 3
Gene names
Name: VDAC3
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules By similarity.

Subcellular location

Mitochondrion outer membrane.

Tissue specificity

Widely expressed. Highest in testis.

Domain

Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands By similarity.

Sequence similarities

Belongs to the eukaryotic mitochondrial porin family.

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentMembrane
Mitochondrion
Mitochondrion outer membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
   LigandNAD
Nucleotide-binding
   Molecular functionPorin
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processadenine transport Ref.1

Traceable author statement. Source: ProtInc

anion transport

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial outer membrane Ref.1

Traceable author statement. Source: ProtInc

   Molecular functionnucleotide binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction. Source: IntAct

voltage-gated anion channel activity Ref.1

Traceable author statement. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CASP4P496621EBI-354196,EBI-1057327

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y277-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y277-2)

The sequence of this isoform differs from the canonical sequence as follows:
     39-39: V → VM

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 283283Voltage-dependent anion-selective channel protein 3
PRO_0000050512

Regions

Transmembrane26 – 3510Transmembrane beta-strand By similarity
Transmembrane39 – 479Transmembrane beta-strand By similarity
Transmembrane54 – 6411Transmembrane beta-strand By similarity
Transmembrane69 – 768Transmembrane beta-strand By similarity
Transmembrane80 – 8910Transmembrane beta-strand By similarity
Transmembrane95 – 10410Transmembrane beta-strand By similarity
Transmembrane111 – 12010Transmembrane beta-strand By similarity
Transmembrane123 – 1308Transmembrane beta-strand By similarity
Transmembrane137 – 1459Transmembrane beta-strand By similarity
Transmembrane150 – 1589Transmembrane beta-strand By similarity
Transmembrane163 – 17513Transmembrane beta-strand By similarity
Transmembrane178 – 1858Transmembrane beta-strand By similarity
Transmembrane189 – 19810Transmembrane beta-strand By similarity
Transmembrane202 – 21110Transmembrane beta-strand By similarity
Transmembrane218 – 22710Transmembrane beta-strand By similarity
Transmembrane231 – 2388Transmembrane beta-strand By similarity
Transmembrane242 – 25110Transmembrane beta-strand By similarity
Transmembrane254 – 26310Transmembrane beta-strand By similarity
Transmembrane273 – 28210Transmembrane beta-strand By similarity
Nucleotide binding242 – 2443NAD By similarity
Nucleotide binding260 – 2645NAD By similarity

Amino acid modifications

Modified residue201N6-acetyllysine By similarity
Modified residue331Phosphothreonine By similarity
Modified residue481Phosphotyrosine By similarity
Modified residue611N6-acetyllysine By similarity
Modified residue1951Phosphotyrosine Ref.6
Modified residue2411Phosphoserine By similarity

Natural variations

Alternative sequence391V → VM in isoform 2.
VSP_005079

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: E03CBCEDA72A9783

FASTA28330,659
        10         20         30         40         50         60 
MCNTPTYCDL GKAAKDVFNK GYGFGMVKID LKTKSCSGVE FSTSGHAYTD TGKASGNLET 

        70         80         90        100        110        120 
KYKVCNYGLT FTQKWNTDNT LGTEISWENK LAEGLKLTLD TIFVPNTGKK SGKLKASYKR 

       130        140        150        160        170        180 
DCFSVGSNVD IDFSGPTIYG WAVLAFEGWL AGYQMSFDTA KSKLSQNNFA LGYKAADFQL 

       190        200        210        220        230        240 
HTHVNDGTEF GGSIYQKVNE KIETSINLAW TAGSNNTRFG IAAKYMLDCR TSLSAKVNNA 

       250        260        270        280 
SLIGLGYTQT LRPGVKLTLS ALIDGKNFSA GGHKVGLGFE LEA 

« Hide

Isoform 2.

Checksum: 7AD0EBC72F3C1112
Show »

FASTA28430,790

References

« Hide 'large scale' references
[1]"Isolation of a novel human voltage-dependent anion channel gene."
Rahmani Z., Maunoury C., Siddiqui A.
Eur. J. Hum. Genet. 6:337-340(1998) [PubMed: 9781040] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z.
Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed: 9653160] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Umbilical cord blood.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Skin.
[4]"Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis."
Decker W.K., Bowles K.R., Schatte E.C., Towbin J.A., Craigen W.J.
Mamm. Genome 10:1041-1042(1999) [PubMed: 10501981] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-253.
[5]"The tissue-specific, alternatively spliced single ATG exon of the type 3 voltage-dependent anion channel gene does not create a truncated protein isoform in vivo."
Decker W.K., Craigen W.J.
Mol. Genet. Metab. 70:69-74(2000) [PubMed: 10833333] [Abstract]
Cited for: ALTERNATIVE SPLICING.
[6]"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-195, MASS SPECTROMETRY.
[7]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

U90943 mRNA. Translation: AAB93872.1.
AF038962 mRNA. Translation: AAC39876.1.
BC056870 mRNA. Translation: AAH56870.1.
AF151682, AF151679, AF151681 Genomic DNA. Translation: AAD49610.1.
IPIIPI00031804.
IPI00294779.
RefSeqNP_001129166.1.
NP_005653.3.
UniGeneHs.699301

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ9Y277. 9 interactions.

PTM databases

PhosphoSiteQ9Y277.

Proteomic databases

PeptideAtlasQ9Y277.
PRIDEQ9Y277.

Genome annotation databases

EnsemblENSG00000078668. Homo sapiens. [Contig view]
GeneID7419.
KEGGhsa:7419.
UCSCuc003xpc.1. human.

Organism-specific databases

GeneCardsGC08P042368.
H-InvDBHIX0007479.
HGNCHGNC:12674. VDAC3.
MIM610029. gene.
PharmGKBPA37297.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9Y277.
HOVERGENQ9Y277.
OMAQ9Y277. CFSLGSN.

Gene expression databases

ArrayExpressQ9Y277.
BgeeQ9Y277.
CleanExHS_VDAC3.
GermOnlineENSG00000078668. Homo sapiens.

Family and domain databases

InterProIPR001925. Porin_Euk.
[Graphical view]
PfamPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSPR00185. EUKARYTPORIN.
PROSITEPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB01375. Dihydroxyaluminium.
NextBio29048.
SOURCESearch...

Entry information

Entry nameVDAC3_HUMAN
AccessionPrimary (citable) accession number: Q9Y277
Secondary accession number(s): Q9UIS0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: July 7, 2009
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents