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Protein

Type 2 lactosamine alpha-2,3-sialyltransferase

Gene

ST3GAL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1.

GO - Molecular functioni

GO - Biological processi

  • cellular protein modification process Source: UniProtKB
  • cellular response to interleukin-6 Source: UniProtKB
  • ganglioside biosynthetic process Source: GO_Central
  • glycolipid metabolic process Source: UniProtKB
  • keratan sulfate biosynthetic process Source: Reactome
  • oligosaccharide metabolic process Source: UniProtKB
  • protein N-linked glycosylation via asparagine Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciZFISH:ENSG00000064225-MONOMER.
BRENDAi2.4.99.10. 2681.
2.4.99.6. 2681.
ReactomeiR-HSA-1912420. Pre-NOTCH Processing in Golgi.
R-HSA-2022854. Keratan sulfate biosynthesis.
R-HSA-4085001. Sialic acid metabolism.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Type 2 lactosamine alpha-2,3-sialyltransferase (EC:2.4.99.-)
Alternative name(s):
CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI
ST3Gal VI
Short name:
ST3GalVI
Sialyltransferase 10
Gene namesi
Name:ST3GAL6
Synonyms:SIAT10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:18080. ST3GAL6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicSequence analysis4
Transmembranei5 – 25Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini26 – 331LumenalSequence analysisAdd BLAST306

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • Golgi membrane Source: Reactome
  • integral component of Golgi membrane Source: InterPro
  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10402.
OpenTargetsiENSG00000064225.
PharmGKBiPA134958548.

Polymorphism and mutation databases

DMDMi54039605.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001493051 – 331Type 2 lactosamine alpha-2,3-sialyltransferaseAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi129N-linked (GlcNAc...)Sequence analysis1
Glycosylationi181N-linked (GlcNAc...)Sequence analysis1
Glycosylationi282N-linked (GlcNAc...)Sequence analysis1
Glycosylationi295N-linked (GlcNAc...)Sequence analysis1
Glycosylationi308N-linked (GlcNAc...)1 Publication1
Glycosylationi327N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y274.
PaxDbiQ9Y274.
PeptideAtlasiQ9Y274.
PRIDEiQ9Y274.

PTM databases

iPTMnetiQ9Y274.
PhosphoSitePlusiQ9Y274.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000064225.
CleanExiHS_ST3GAL6.
ExpressionAtlasiQ9Y274. baseline and differential.
GenevisibleiQ9Y274. HS.

Organism-specific databases

HPAiHPA018792.

Interactioni

Protein-protein interaction databases

BioGridi115674. 6 interactors.
STRINGi9606.ENSP00000377717.

Structurei

3D structure databases

ProteinModelPortaliQ9Y274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000000682.
HOVERGENiHBG056676.
InParanoidiQ9Y274.
KOiK03792.
PhylomeDBiQ9Y274.
TreeFamiTF354325.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y274-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGYLVAIFL SAVFLYYVLH CILWGTNVYW VAPVEMKRRN KIQPCLSKPA
60 70 80 90 100
FASLLRFHQF HPFLCAADFR KIASLYGSDK FDLPYGMRTS AEYFRLALSK
110 120 130 140 150
LQSCDLFDEF DNIPCKKCVV VGNGGVLKNK TLGEKIDSYD VIIRMNNGPV
160 170 180 190 200
LGHEEEVGRR TTFRLFYPES VFSDPIHNDP NTTVILTAFK PHDLRWLLEL
210 220 230 240 250
LMGDKINTNG FWKKPALNLI YKPYQIRILD PFIIRTAAYE LLHFPKVFPK
260 270 280 290 300
NQKPKHPTTG IIAITLAFYI CHEVHLAGFK YNFSDLKSPL HYYGNATMSL
310 320 330
MNKNAYHNVT AEQLFLKDII EKNLVINLTQ D
Length:331
Mass (Da):38,214
Last modified:November 1, 1999 - v1
Checksum:iDD2B3D88D3D0A055
GO
Isoform 2 (identifier: Q9Y274-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.
     112-144: NIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIR → K

Show »
Length:213
Mass (Da):24,782
Checksum:i6AC0FDF802B3D8AF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti271C → S in BAG50993 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049227311A → T.Corresponds to variant rs28489284dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0470091 – 86Missing in isoform 2. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_047010112 – 144NIPCK…DVIIR → K in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022918 mRNA. Translation: BAA77609.1.
AF119391 mRNA. Translation: AAD39131.1.
AK315111 mRNA. Translation: BAG37569.1.
AK001922 mRNA. Translation: BAG50993.1.
AC106728 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79849.1.
CH471052 Genomic DNA. Translation: EAW79850.1.
CH471052 Genomic DNA. Translation: EAW79852.1.
BC023312 mRNA. Translation: AAH23312.1.
CCDSiCCDS2933.1. [Q9Y274-1]
CCDS59452.1. [Q9Y274-2]
RefSeqiNP_001258074.1. NM_001271145.1.
NP_001258075.1. NM_001271146.1. [Q9Y274-1]
NP_001258076.1. NM_001271147.1. [Q9Y274-2]
NP_001310281.1. NM_001323352.1. [Q9Y274-1]
NP_001310294.1. NM_001323365.1. [Q9Y274-1]
NP_001310297.1. NM_001323368.1. [Q9Y274-1]
NP_006091.1. NM_006100.3. [Q9Y274-1]
UniGeneiHs.148716.

Genome annotation databases

EnsembliENST00000265261; ENSP00000265261; ENSG00000064225. [Q9Y274-2]
ENST00000394162; ENSP00000377717; ENSG00000064225. [Q9Y274-1]
ENST00000483910; ENSP00000417376; ENSG00000064225. [Q9Y274-1]
GeneIDi10402.
KEGGihsa:10402.
UCSCiuc003dsz.5. human. [Q9Y274-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

ST3Gal VI

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022918 mRNA. Translation: BAA77609.1.
AF119391 mRNA. Translation: AAD39131.1.
AK315111 mRNA. Translation: BAG37569.1.
AK001922 mRNA. Translation: BAG50993.1.
AC106728 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79849.1.
CH471052 Genomic DNA. Translation: EAW79850.1.
CH471052 Genomic DNA. Translation: EAW79852.1.
BC023312 mRNA. Translation: AAH23312.1.
CCDSiCCDS2933.1. [Q9Y274-1]
CCDS59452.1. [Q9Y274-2]
RefSeqiNP_001258074.1. NM_001271145.1.
NP_001258075.1. NM_001271146.1. [Q9Y274-1]
NP_001258076.1. NM_001271147.1. [Q9Y274-2]
NP_001310281.1. NM_001323352.1. [Q9Y274-1]
NP_001310294.1. NM_001323365.1. [Q9Y274-1]
NP_001310297.1. NM_001323368.1. [Q9Y274-1]
NP_006091.1. NM_006100.3. [Q9Y274-1]
UniGeneiHs.148716.

3D structure databases

ProteinModelPortaliQ9Y274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115674. 6 interactors.
STRINGi9606.ENSP00000377717.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

PTM databases

iPTMnetiQ9Y274.
PhosphoSitePlusiQ9Y274.

Polymorphism and mutation databases

DMDMi54039605.

Proteomic databases

EPDiQ9Y274.
PaxDbiQ9Y274.
PeptideAtlasiQ9Y274.
PRIDEiQ9Y274.

Protocols and materials databases

DNASUi10402.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265261; ENSP00000265261; ENSG00000064225. [Q9Y274-2]
ENST00000394162; ENSP00000377717; ENSG00000064225. [Q9Y274-1]
ENST00000483910; ENSP00000417376; ENSG00000064225. [Q9Y274-1]
GeneIDi10402.
KEGGihsa:10402.
UCSCiuc003dsz.5. human. [Q9Y274-1]

Organism-specific databases

CTDi10402.
DisGeNETi10402.
GeneCardsiST3GAL6.
HGNCiHGNC:18080. ST3GAL6.
HPAiHPA018792.
MIMi607156. gene.
neXtProtiNX_Q9Y274.
OpenTargetsiENSG00000064225.
PharmGKBiPA134958548.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000000682.
HOVERGENiHBG056676.
InParanoidiQ9Y274.
KOiK03792.
PhylomeDBiQ9Y274.
TreeFamiTF354325.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000064225-MONOMER.
BRENDAi2.4.99.10. 2681.
2.4.99.6. 2681.
ReactomeiR-HSA-1912420. Pre-NOTCH Processing in Golgi.
R-HSA-2022854. Keratan sulfate biosynthesis.
R-HSA-4085001. Sialic acid metabolism.

Miscellaneous databases

GenomeRNAii10402.
PROiQ9Y274.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000064225.
CleanExiHS_ST3GAL6.
ExpressionAtlasiQ9Y274. baseline and differential.
GenevisibleiQ9Y274. HS.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSIA10_HUMAN
AccessioniPrimary (citable) accession number: Q9Y274
Secondary accession number(s): B2RCH2
, B3KMI1, D3DN39, F8W6U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.