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Protein

Dexamethasone-induced Ras-related protein 1

Gene

RASD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 388GTPBy similarity
Nucleotide bindingi78 – 825GTPBy similarity
Nucleotide bindingi145 – 1484GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dexamethasone-induced Ras-related protein 1
Alternative name(s):
Activator of G-protein signaling 1
Gene namesi
Name:RASD1
Synonyms:AGS1, DEXRAS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:15828. RASD1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi11 – 111C → S: Suppresses NO-induced activation. 1 Publication

Organism-specific databases

PharmGKBiPA34236.

Polymorphism and mutation databases

BioMutaiRASD1.
DMDMi38258272.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Dexamethasone-induced Ras-related protein 1PRO_0000082717Add
BLAST
Propeptidei279 – 2813Removed in mature formBy similarityPRO_0000281372

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111S-nitrosocysteine1 Publication
Modified residuei278 – 2781Cysteine methyl esterBy similarity
Lipidationi278 – 2781S-farnesyl cysteineBy similarity

Post-translational modificationi

S-nitrosylation stimulates guanine-nucleotide exchange activity.1 Publication

Keywords - PTMi

Lipoprotein, Methylation, Prenylation, S-nitrosylation

Proteomic databases

MaxQBiQ9Y272.
PaxDbiQ9Y272.
PeptideAtlasiQ9Y272.
PRIDEiQ9Y272.

PTM databases

iPTMnetiQ9Y272.
PhosphoSiteiQ9Y272.

Expressioni

Tissue specificityi

Expressed in a variety of tissues including heart, cardiovascular tissues, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, gastrointestinal and reproductive tissues.2 Publications

Inductioni

By dexamethasone.1 Publication

Gene expression databases

BgeeiENSG00000108551.
CleanExiHS_RASD1.
GenevisibleiQ9Y272. HS.

Organism-specific databases

HPAiHPA047896.

Interactioni

Subunit structurei

Forms a ternary complex with CAPON and NOS1. Component of a complex, at least composed of APBB1, RASD1/DEXRAS1 and APP. Interacts with APBB1/FE65 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
HNRNPKP619783EBI-740818,EBI-304185
HNRPKQ6IBN13EBI-740818,EBI-3440248
MATR3P432433EBI-740818,EBI-352602
RBMY1JQ154153EBI-740818,EBI-8642021
TRIM37O949723EBI-740818,EBI-741602

Protein-protein interaction databases

BioGridi119662. 10 interactions.
IntActiQ9Y272. 9 interactions.
MINTiMINT-1437311.
STRINGi9606.ENSP00000225688.

Structurei

3D structure databases

ProteinModelPortaliQ9Y272.
SMRiQ9Y272. Positions 23-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi53 – 619Effector region

Sequence similaritiesi

Belongs to the small GTPase superfamily. RasD family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121857.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ9Y272.
KOiK07843.
OMAiFYREVEQ.
OrthoDBiEOG091G0U2W.
PhylomeDBiQ9Y272.
TreeFamiTF316238.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y272-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLAAMIKKM CPSDSELSIP AKNCYRMVIL GSSKVGKTAI VSRFLTGRFE
60 70 80 90 100
DAYTPTIEDF HRKFYSIRGE VYQLDILDTS GNHPFPAMRR LSILTGDVFI
110 120 130 140 150
LVFSLDNRDS FEEVQRLRQQ ILDTKSCLKN KTKENVDVPL VICGNKGDRD
160 170 180 190 200
FYREVDQREI EQLVGDDPQR CAYFEISAKK NSSLDQMFRA LFAMAKLPSE
210 220 230 240 250
MSPDLHRKVS VQYCDVLHKK ALRNKKLLRA GSGGGGGDPG DAFGIVAPFA
260 270 280
RRPSVHSDLM YIREKASAGS QAKDKERCVI S
Length:281
Mass (Da):31,642
Last modified:November 1, 1999 - v1
Checksum:i06C3C4417E4A69BD
GO
Isoform 2 (identifier: Q9Y272-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-122: GDVFILVFSLDNRDSFEEVQRLRQQIL → DPRHQVLPQEQNQGERGRAPGHLRQQG
     123-281: Missing.

Note: No experimental confirmation available.
Show »
Length:122
Mass (Da):13,848
Checksum:i5965158DC373053C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti118 – 1181R → K in AAF72997 (PubMed:12818426).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei96 – 12227GDVFI…RQQIL → DPRHQVLPQEQNQGERGRAP GHLRQQG in isoform 2. 1 PublicationVSP_046431Add
BLAST
Alternative sequencei123 – 281159Missing in isoform 2. 1 PublicationVSP_046432Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153192 mRNA. Translation: AAD34621.1.
AF172846 mRNA. Translation: AAF01364.1.
AF069506 mRNA. Translation: AAD34206.1.
AF222979 Genomic DNA. Translation: AAG44256.1.
AF262018 Genomic DNA. Translation: AAF72997.1.
AF498923 mRNA. Translation: AAM21071.1.
AK294073 mRNA. Translation: BAG57415.1.
AK312796 mRNA. Translation: BAG35656.1.
AC073621 Genomic DNA. No translation available.
CH471196 Genomic DNA. Translation: EAW55705.1.
BC018041 mRNA. Translation: AAH18041.1.
CCDSiCCDS11185.1. [Q9Y272-1]
CCDS58519.1. [Q9Y272-2]
RefSeqiNP_001186918.1. NM_001199989.1. [Q9Y272-2]
NP_057168.1. NM_016084.4. [Q9Y272-1]
UniGeneiHs.25829.

Genome annotation databases

EnsembliENST00000225688; ENSP00000225688; ENSG00000108551. [Q9Y272-1]
ENST00000579152; ENSP00000463388; ENSG00000108551. [Q9Y272-2]
GeneIDi51655.
KEGGihsa:51655.
UCSCiuc002gri.4. human. [Q9Y272-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153192 mRNA. Translation: AAD34621.1.
AF172846 mRNA. Translation: AAF01364.1.
AF069506 mRNA. Translation: AAD34206.1.
AF222979 Genomic DNA. Translation: AAG44256.1.
AF262018 Genomic DNA. Translation: AAF72997.1.
AF498923 mRNA. Translation: AAM21071.1.
AK294073 mRNA. Translation: BAG57415.1.
AK312796 mRNA. Translation: BAG35656.1.
AC073621 Genomic DNA. No translation available.
CH471196 Genomic DNA. Translation: EAW55705.1.
BC018041 mRNA. Translation: AAH18041.1.
CCDSiCCDS11185.1. [Q9Y272-1]
CCDS58519.1. [Q9Y272-2]
RefSeqiNP_001186918.1. NM_001199989.1. [Q9Y272-2]
NP_057168.1. NM_016084.4. [Q9Y272-1]
UniGeneiHs.25829.

3D structure databases

ProteinModelPortaliQ9Y272.
SMRiQ9Y272. Positions 23-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119662. 10 interactions.
IntActiQ9Y272. 9 interactions.
MINTiMINT-1437311.
STRINGi9606.ENSP00000225688.

PTM databases

iPTMnetiQ9Y272.
PhosphoSiteiQ9Y272.

Polymorphism and mutation databases

BioMutaiRASD1.
DMDMi38258272.

Proteomic databases

MaxQBiQ9Y272.
PaxDbiQ9Y272.
PeptideAtlasiQ9Y272.
PRIDEiQ9Y272.

Protocols and materials databases

DNASUi51655.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225688; ENSP00000225688; ENSG00000108551. [Q9Y272-1]
ENST00000579152; ENSP00000463388; ENSG00000108551. [Q9Y272-2]
GeneIDi51655.
KEGGihsa:51655.
UCSCiuc002gri.4. human. [Q9Y272-1]

Organism-specific databases

CTDi51655.
GeneCardsiRASD1.
HGNCiHGNC:15828. RASD1.
HPAiHPA047896.
MIMi605550. gene.
neXtProtiNX_Q9Y272.
PharmGKBiPA34236.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121857.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ9Y272.
KOiK07843.
OMAiFYREVEQ.
OrthoDBiEOG091G0U2W.
PhylomeDBiQ9Y272.
TreeFamiTF316238.

Miscellaneous databases

GeneWikiiRASD1.
GenomeRNAii51655.
PROiQ9Y272.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108551.
CleanExiHS_RASD1.
GenevisibleiQ9Y272. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRASD1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y272
Secondary accession number(s): B2R709, B4DFF4, Q9NYB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.