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Protein

Cysteinyl leukotriene receptor 1

Gene

CYSLTR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173198-MONOMER.
ReactomeiR-HSA-391906. Leukotriene receptors.
R-HSA-416476. G alpha (q) signalling events.

Protein family/group databases

TCDBi9.A.14.13.2. the g-protein-coupled receptor (gpcr) family.

Chemistry databases

SwissLipidsiSLP:000001582.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 1
Short name:
CysLTR1
Alternative name(s):
Cysteinyl leukotriene D4 receptor
Short name:
LTD4 receptor
G-protein coupled receptor HG55
HMTMF81
Gene namesi
Name:CYSLTR1
Synonyms:CYSLT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:17451. CYSLTR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 106ExtracellularSequence analysisAdd BLAST28
Transmembranei107 – 127Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini128 – 141CytoplasmicSequence analysisAdd BLAST14
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 193ExtracellularSequence analysisAdd BLAST31
Transmembranei194 – 214Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini215 – 230CytoplasmicSequence analysisAdd BLAST16
Transmembranei231 – 251Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini252 – 276ExtracellularSequence analysisAdd BLAST25
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 337CytoplasmicSequence analysisAdd BLAST40

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10800.
OpenTargetsiENSG00000173198.
PharmGKBiPA38453.

Chemistry databases

ChEMBLiCHEMBL1798.
DrugBankiDB00587. Cinalukast.
DB00471. Montelukast.
DB00716. Nedocromil.
DB01411. Pranlukast.
DB00549. Zafirlukast.
GuidetoPHARMACOLOGYi269.

Polymorphism and mutation databases

DMDMi20138087.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692991 – 337Cysteinyl leukotriene receptor 1Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi96 ↔ 173PROSITE-ProRule annotation
Glycosylationi169N-linked (GlcNAc...)Sequence analysis1
Glycosylationi180N-linked (GlcNAc...)Sequence analysis1
Glycosylationi262N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y271.
PeptideAtlasiQ9Y271.
PRIDEiQ9Y271.

PTM databases

iPTMnetiQ9Y271.
PhosphoSitePlusiQ9Y271.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart.

Gene expression databases

BgeeiENSG00000173198.
CleanExiHS_CYSLTR1.
GenevisibleiQ9Y271. HS.

Organism-specific databases

HPAiHPA010546.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CYSLTR2Q9NS752EBI-9347754,EBI-3843579

Protein-protein interaction databases

BioGridi116014. 1 interactor.
IntActiQ9Y271. 1 interactor.
STRINGi9606.ENSP00000362401.

Chemistry databases

BindingDBiQ9Y271.

Structurei

3D structure databases

ProteinModelPortaliQ9Y271.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKK2. Eukaryota.
ENOG410XRU6. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ9Y271.
KOiK04322.
OMAiPQDNQAK.
OrthoDBiEOG091G0FE0.
PhylomeDBiQ9Y271.
TreeFamiTF350009.

Family and domain databases

InterProiIPR013310. CLT1_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01902. CYSLT1RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y271-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDETGNLTVS SATCHDTIDD FRNQVYSTLY SMISVVGFFG NGFVLYVLIK
60 70 80 90 100
TYHKKSAFQV YMINLAVADL LCVCTLPLRV VYYVHKGIWL FGDFLCRLST
110 120 130 140 150
YALYVNLYCS IFFMTAMSFF RCIAIVFPVQ NINLVTQKKA RFVCVGIWIF
160 170 180 190 200
VILTSSPFLM AKPQKDEKNN TKCFEPPQDN QTKNHVLVLH YVSLFVGFII
210 220 230 240 250
PFVIIIVCYT MIILTLLKKS MKKNLSSHKK AIGMIMVVTA AFLVSFMPYH
260 270 280 290 300
IQRTIHLHFL HNETKPCDSV LRMQKSVVIT LSLAASNCCF DPLLYFFSGG
310 320 330
NFRKRLSTFR KHSLSSVTYV PRKKASLPEK GEEICKV
Length:337
Mass (Da):38,541
Last modified:November 1, 1999 - v1
Checksum:iB9B53940F895F245
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti272R → T in AAH35750 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119711 mRNA. Translation: AAD42285.1.
AF133266 mRNA. Translation: AAD42778.1.
AY242130 Genomic DNA. Translation: AAO92297.1.
AK313643 mRNA. Translation: BAG36401.1.
AL445202 Genomic DNA. Translation: CAI40462.1.
CH471104 Genomic DNA. Translation: EAW98598.1.
CH471104 Genomic DNA. Translation: EAW98599.1.
BC035750 mRNA. Translation: AAH35750.1.
CCDSiCCDS14439.1.
RefSeqiNP_001269115.1. NM_001282186.1.
NP_001269116.1. NM_001282187.1.
NP_001269117.1. NM_001282188.1.
NP_006630.1. NM_006639.3.
UniGeneiHs.733809.

Genome annotation databases

EnsembliENST00000373304; ENSP00000362401; ENSG00000173198.
ENST00000614798; ENSP00000478492; ENSG00000173198.
GeneIDi10800.
KEGGihsa:10800.
UCSCiuc004edb.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119711 mRNA. Translation: AAD42285.1.
AF133266 mRNA. Translation: AAD42778.1.
AY242130 Genomic DNA. Translation: AAO92297.1.
AK313643 mRNA. Translation: BAG36401.1.
AL445202 Genomic DNA. Translation: CAI40462.1.
CH471104 Genomic DNA. Translation: EAW98598.1.
CH471104 Genomic DNA. Translation: EAW98599.1.
BC035750 mRNA. Translation: AAH35750.1.
CCDSiCCDS14439.1.
RefSeqiNP_001269115.1. NM_001282186.1.
NP_001269116.1. NM_001282187.1.
NP_001269117.1. NM_001282188.1.
NP_006630.1. NM_006639.3.
UniGeneiHs.733809.

3D structure databases

ProteinModelPortaliQ9Y271.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116014. 1 interactor.
IntActiQ9Y271. 1 interactor.
STRINGi9606.ENSP00000362401.

Chemistry databases

BindingDBiQ9Y271.
ChEMBLiCHEMBL1798.
DrugBankiDB00587. Cinalukast.
DB00471. Montelukast.
DB00716. Nedocromil.
DB01411. Pranlukast.
DB00549. Zafirlukast.
GuidetoPHARMACOLOGYi269.
SwissLipidsiSLP:000001582.

Protein family/group databases

TCDBi9.A.14.13.2. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiQ9Y271.
PhosphoSitePlusiQ9Y271.

Polymorphism and mutation databases

DMDMi20138087.

Proteomic databases

PaxDbiQ9Y271.
PeptideAtlasiQ9Y271.
PRIDEiQ9Y271.

Protocols and materials databases

DNASUi10800.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373304; ENSP00000362401; ENSG00000173198.
ENST00000614798; ENSP00000478492; ENSG00000173198.
GeneIDi10800.
KEGGihsa:10800.
UCSCiuc004edb.5. human.

Organism-specific databases

CTDi10800.
DisGeNETi10800.
GeneCardsiCYSLTR1.
HGNCiHGNC:17451. CYSLTR1.
HPAiHPA010546.
MIMi300201. gene.
neXtProtiNX_Q9Y271.
OpenTargetsiENSG00000173198.
PharmGKBiPA38453.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKK2. Eukaryota.
ENOG410XRU6. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000236328.
HOVERGENiHBG099611.
InParanoidiQ9Y271.
KOiK04322.
OMAiPQDNQAK.
OrthoDBiEOG091G0FE0.
PhylomeDBiQ9Y271.
TreeFamiTF350009.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173198-MONOMER.
ReactomeiR-HSA-391906. Leukotriene receptors.
R-HSA-416476. G alpha (q) signalling events.

Miscellaneous databases

GeneWikiiCysteinyl_leukotriene_receptor_1.
GenomeRNAii10800.
PROiQ9Y271.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173198.
CleanExiHS_CYSLTR1.
GenevisibleiQ9Y271. HS.

Family and domain databases

InterProiIPR013310. CLT1_recept.
IPR004071. Cyst_leuk_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01902. CYSLT1RECPTR.
PR01533. CYSLTRECPTR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLTR1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y271
Secondary accession number(s): B2R954
, D3DTE4, Q5JS94, Q8IV19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Selective antagonists, such as montelukast (Singulair), zafirlukast (Accolate) and pranlukast (Onon), are used in the treatment of the asthma crisis.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.