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Q9Y267

- S22AE_HUMAN

UniProt

Q9Y267 - S22AE_HUMAN

Protein

Solute carrier family 22 member 14

Gene

SLC22A14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 4 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. organic cation transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. organic cation transport Source: UniProtKB

    Protein family/group databases

    TCDBi2.A.1.19.22. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 22 member 14
    Alternative name(s):
    Organic cation transporter-like 4
    Short name:
    ORCTL-4
    Gene namesi
    Name:SLC22A14
    Synonyms:OCTL2, ORCTL4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:8495. SLC22A14.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32815.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 594594Solute carrier family 22 member 14PRO_0000230784Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9Y267.
    PRIDEiQ9Y267.

    PTM databases

    PhosphoSiteiQ9Y267.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiQ9Y267.
    BgeeiQ9Y267.
    CleanExiHS_SLC22A14.
    GenevestigatoriQ9Y267.

    Organism-specific databases

    HPAiHPA037556.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000273173.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y267.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7070CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini92 – 18493ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini206 – 2105CytoplasmicSequence Analysis
    Topological domaini232 – 2354ExtracellularSequence Analysis
    Topological domaini257 – 27014CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini292 – 2976ExtracellularSequence Analysis
    Topological domaini319 – 37961CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini401 – 4088ExtracellularSequence Analysis
    Topological domaini432 – 4376CytoplasmicSequence Analysis
    Topological domaini459 – 48830ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini510 – 5123CytoplasmicSequence Analysis
    Topological domaini534 – 5385ExtracellularSequence Analysis
    Topological domaini560 – 59435CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei71 – 9121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei185 – 20521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei211 – 23121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei298 – 31821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei380 – 40021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei409 – 43123HelicalSequence AnalysisAdd
    BLAST
    Transmembranei438 – 45821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei489 – 50921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei513 – 53321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei539 – 55921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000234569.
    HOVERGENiHBG108434.
    InParanoidiQ9Y267.
    KOiK08210.
    OMAiSAFFMFA.
    OrthoDBiEOG7C8GH9.
    PhylomeDBiQ9Y267.
    TreeFamiTF315847.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y267-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGEENFKEE LRSQDASRNL NQHEVAGHPH SWSLEMLLRR LRAVHTKQDD    50
    KFANLLDAVG EFGTFQQRLV ALTFIPSIMS AFFMFADHFV FTAQKPYCNT 100
    SWILAVGPHL SKAEQLNLTI PQAPNGSFLT CFMYLPVPWN LDSIIQFGLN 150
    DTDTCQDGWI YPDAKKRSLI NEFDLVCGME TKKDTAQIMF MAGLPIGSLI 200
    FRLITDKMGR YPAILLSLLG LIIFGFGTAF MNSFHLYLFF RFGISQSVVG 250
    YAISSISLAT EWLVGEHRAH AIILGHCFFA VGAVLLTGIA YSLPHWQLLF 300
    LVGGILVIPF ISYIWILPES PRWLMMKGKV KEAKQVLCYA ASVNKKTIPS 350
    NLLDELQLPR KKVTRASVLD FCKNRQLCKV TLVMSCVWFT VSYTYFTLSL 400
    RMRELGVSVH FRHVVPSIME VPARLCCIFL LQQIGRKWSL AVTLLQAIIW 450
    CLLLLFLPEG EDGLRLKWPR CPATELKSMT ILVLMLREFS LAATVTVFFL 500
    YTAELLPTVL RATGLGLVSL ASVAGAILSL TIISQTPSLL PIFLCCVLAI 550
    VAFSLSSLLP ETRDQPLSES LNHSSQIRNK VKDMKTKETS SDDV 594
    Length:594
    Mass (Da):66,684
    Last modified:November 30, 2010 - v4
    Checksum:i7EA290B06222B681
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti282 – 2821G → W in BAA76351. (PubMed:10072596)Curated
    Sequence conflicti282 – 2821G → W in BAA77626. (PubMed:10231028)Curated
    Sequence conflicti470 – 4701R → H in BAG37720. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti108 – 1081P → H.
    Corresponds to variant rs9847584 [ dbSNP | Ensembl ].
    VAR_055108
    Natural varianti112 – 1121K → E.
    Corresponds to variant rs2073714 [ dbSNP | Ensembl ].
    VAR_055109
    Natural varianti144 – 1441I → T.2 Publications
    Corresponds to variant rs194685 [ dbSNP | Ensembl ].
    VAR_055110
    Natural varianti245 – 2451S → L.
    Corresponds to variant rs1078846 [ dbSNP | Ensembl ].
    VAR_055111
    Natural varianti284 – 2841V → M.5 Publications
    Corresponds to variant rs818818 [ dbSNP | Ensembl ].
    VAR_055112
    Natural varianti292 – 2921S → G.5 Publications
    Corresponds to variant rs818817 [ dbSNP | Ensembl ].
    VAR_055113
    Natural varianti466 – 4661L → P.
    Corresponds to variant rs34256819 [ dbSNP | Ensembl ].
    VAR_055114
    Natural varianti512 – 5121A → V.
    Corresponds to variant rs2070492 [ dbSNP | Ensembl ].
    VAR_055115
    Natural varianti560 – 5601P → R.2 Publications
    Corresponds to variant rs240033 [ dbSNP | Ensembl ].
    VAR_055116

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011082 mRNA. Translation: BAA76351.1.
    AB026898 Genomic DNA. Translation: BAA77626.1.
    AK315317 mRNA. Translation: BAG37720.1.
    AP006193 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64529.1.
    BC075070 mRNA. Translation: AAH75070.1.
    BC075071 mRNA. Translation: AAH75071.1.
    BC126482 mRNA. Translation: AAI26483.1.
    BC130543 mRNA. Translation: AAI30544.1.
    CCDSiCCDS2677.1.
    RefSeqiNP_004794.2. NM_004803.3.
    XP_005265641.1. XM_005265584.1.
    XP_005265642.1. XM_005265585.2.
    UniGeneiHs.165559.

    Genome annotation databases

    EnsembliENST00000273173; ENSP00000273173; ENSG00000144671.
    ENST00000448498; ENSP00000396283; ENSG00000144671.
    GeneIDi9389.
    KEGGihsa:9389.
    UCSCiuc003cib.2. human.

    Polymorphism databases

    DMDMi313104317.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011082 mRNA. Translation: BAA76351.1 .
    AB026898 Genomic DNA. Translation: BAA77626.1 .
    AK315317 mRNA. Translation: BAG37720.1 .
    AP006193 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64529.1 .
    BC075070 mRNA. Translation: AAH75070.1 .
    BC075071 mRNA. Translation: AAH75071.1 .
    BC126482 mRNA. Translation: AAI26483.1 .
    BC130543 mRNA. Translation: AAI30544.1 .
    CCDSi CCDS2677.1.
    RefSeqi NP_004794.2. NM_004803.3.
    XP_005265641.1. XM_005265584.1.
    XP_005265642.1. XM_005265585.2.
    UniGenei Hs.165559.

    3D structure databases

    ProteinModelPortali Q9Y267.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000273173.

    Protein family/group databases

    TCDBi 2.A.1.19.22. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei Q9Y267.

    Polymorphism databases

    DMDMi 313104317.

    Proteomic databases

    PaxDbi Q9Y267.
    PRIDEi Q9Y267.

    Protocols and materials databases

    DNASUi 9389.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000273173 ; ENSP00000273173 ; ENSG00000144671 .
    ENST00000448498 ; ENSP00000396283 ; ENSG00000144671 .
    GeneIDi 9389.
    KEGGi hsa:9389.
    UCSCi uc003cib.2. human.

    Organism-specific databases

    CTDi 9389.
    GeneCardsi GC03P038322.
    H-InvDB HIX0024265.
    HGNCi HGNC:8495. SLC22A14.
    HPAi HPA037556.
    MIMi 604048. gene.
    neXtProti NX_Q9Y267.
    PharmGKBi PA32815.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000234569.
    HOVERGENi HBG108434.
    InParanoidi Q9Y267.
    KOi K08210.
    OMAi SAFFMFA.
    OrthoDBi EOG7C8GH9.
    PhylomeDBi Q9Y267.
    TreeFami TF315847.

    Miscellaneous databases

    GenomeRNAii 9389.
    NextBioi 35179.
    PROi Q9Y267.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y267.
    Bgeei Q9Y267.
    CleanExi HS_SLC22A14.
    Genevestigatori Q9Y267.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters."
      Nishiwaki T., Daigo Y., Tamari M., Fujii Y., Nakamura Y.
      Cytogenet. Cell Genet. 83:251-255(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS THR-144; MET-284 AND GLY-292.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-144; MET-284 AND GLY-292.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS MET-284; GLY-292 AND ARG-560.
      Tissue: Testis.
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS MET-284 AND GLY-292.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS MET-284; GLY-292 AND ARG-560.
      Tissue: Brain.

    Entry informationi

    Entry nameiS22AE_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y267
    Secondary accession number(s): A0AVS9
    , A1L4H6, B2RCX3, Q6DJT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 97 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3