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Q9Y267

- S22AE_HUMAN

UniProt

Q9Y267 - S22AE_HUMAN

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Protein
Solute carrier family 22 member 14
Gene
SLC22A14, ORCTL4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. organic cation transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. organic cation transport Source: UniProtKB
Complete GO annotation...

Protein family/group databases

TCDBi2.A.1.19.22. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 14
Alternative name(s):
Organic cation transporter-like 4
Short name:
ORCTL-4
Gene namesi
Synonyms:ORCTL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:8495. SLC22A14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7070Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei71 – 9121Helical; Reviewed prediction
Add
BLAST
Topological domaini92 – 18493Extracellular Reviewed prediction
Add
BLAST
Transmembranei185 – 20521Helical; Reviewed prediction
Add
BLAST
Topological domaini206 – 2105Cytoplasmic Reviewed prediction
Transmembranei211 – 23121Helical; Reviewed prediction
Add
BLAST
Topological domaini232 – 2354Extracellular Reviewed prediction
Transmembranei236 – 25621Helical; Reviewed prediction
Add
BLAST
Topological domaini257 – 27014Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei271 – 29121Helical; Reviewed prediction
Add
BLAST
Topological domaini292 – 2976Extracellular Reviewed prediction
Transmembranei298 – 31821Helical; Reviewed prediction
Add
BLAST
Topological domaini319 – 37961Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei380 – 40021Helical; Reviewed prediction
Add
BLAST
Topological domaini401 – 4088Extracellular Reviewed prediction
Transmembranei409 – 43123Helical; Reviewed prediction
Add
BLAST
Topological domaini432 – 4376Cytoplasmic Reviewed prediction
Transmembranei438 – 45821Helical; Reviewed prediction
Add
BLAST
Topological domaini459 – 48830Extracellular Reviewed prediction
Add
BLAST
Transmembranei489 – 50921Helical; Reviewed prediction
Add
BLAST
Topological domaini510 – 5123Cytoplasmic Reviewed prediction
Transmembranei513 – 53321Helical; Reviewed prediction
Add
BLAST
Topological domaini534 – 5385Extracellular Reviewed prediction
Transmembranei539 – 55921Helical; Reviewed prediction
Add
BLAST
Topological domaini560 – 59435Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32815.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594Solute carrier family 22 member 14
PRO_0000230784Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi117 – 1171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi125 – 1251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi150 – 1501N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y267.
PRIDEiQ9Y267.

PTM databases

PhosphoSiteiQ9Y267.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

ArrayExpressiQ9Y267.
BgeeiQ9Y267.
CleanExiHS_SLC22A14.
GenevestigatoriQ9Y267.

Organism-specific databases

HPAiHPA037556.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000273173.

Structurei

3D structure databases

ProteinModelPortaliQ9Y267.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
HOGENOMiHOG000234569.
HOVERGENiHBG108434.
InParanoidiQ9Y267.
KOiK08210.
OMAiSAFFMFA.
OrthoDBiEOG7C8GH9.
PhylomeDBiQ9Y267.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y267-1 [UniParc]FASTAAdd to Basket

« Hide

MAGEENFKEE LRSQDASRNL NQHEVAGHPH SWSLEMLLRR LRAVHTKQDD    50
KFANLLDAVG EFGTFQQRLV ALTFIPSIMS AFFMFADHFV FTAQKPYCNT 100
SWILAVGPHL SKAEQLNLTI PQAPNGSFLT CFMYLPVPWN LDSIIQFGLN 150
DTDTCQDGWI YPDAKKRSLI NEFDLVCGME TKKDTAQIMF MAGLPIGSLI 200
FRLITDKMGR YPAILLSLLG LIIFGFGTAF MNSFHLYLFF RFGISQSVVG 250
YAISSISLAT EWLVGEHRAH AIILGHCFFA VGAVLLTGIA YSLPHWQLLF 300
LVGGILVIPF ISYIWILPES PRWLMMKGKV KEAKQVLCYA ASVNKKTIPS 350
NLLDELQLPR KKVTRASVLD FCKNRQLCKV TLVMSCVWFT VSYTYFTLSL 400
RMRELGVSVH FRHVVPSIME VPARLCCIFL LQQIGRKWSL AVTLLQAIIW 450
CLLLLFLPEG EDGLRLKWPR CPATELKSMT ILVLMLREFS LAATVTVFFL 500
YTAELLPTVL RATGLGLVSL ASVAGAILSL TIISQTPSLL PIFLCCVLAI 550
VAFSLSSLLP ETRDQPLSES LNHSSQIRNK VKDMKTKETS SDDV 594
Length:594
Mass (Da):66,684
Last modified:November 30, 2010 - v4
Checksum:i7EA290B06222B681
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti108 – 1081P → H.
Corresponds to variant rs9847584 [ dbSNP | Ensembl ].
VAR_055108
Natural varianti112 – 1121K → E.
Corresponds to variant rs2073714 [ dbSNP | Ensembl ].
VAR_055109
Natural varianti144 – 1441I → T.2 Publications
Corresponds to variant rs194685 [ dbSNP | Ensembl ].
VAR_055110
Natural varianti245 – 2451S → L.
Corresponds to variant rs1078846 [ dbSNP | Ensembl ].
VAR_055111
Natural varianti284 – 2841V → M.5 Publications
Corresponds to variant rs818818 [ dbSNP | Ensembl ].
VAR_055112
Natural varianti292 – 2921S → G.5 Publications
Corresponds to variant rs818817 [ dbSNP | Ensembl ].
VAR_055113
Natural varianti466 – 4661L → P.
Corresponds to variant rs34256819 [ dbSNP | Ensembl ].
VAR_055114
Natural varianti512 – 5121A → V.
Corresponds to variant rs2070492 [ dbSNP | Ensembl ].
VAR_055115
Natural varianti560 – 5601P → R.2 Publications
Corresponds to variant rs240033 [ dbSNP | Ensembl ].
VAR_055116

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti282 – 2821G → W in BAA76351. 1 Publication
Sequence conflicti282 – 2821G → W in BAA77626. 1 Publication
Sequence conflicti470 – 4701R → H in BAG37720. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011082 mRNA. Translation: BAA76351.1.
AB026898 Genomic DNA. Translation: BAA77626.1.
AK315317 mRNA. Translation: BAG37720.1.
AP006193 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64529.1.
BC075070 mRNA. Translation: AAH75070.1.
BC075071 mRNA. Translation: AAH75071.1.
BC126482 mRNA. Translation: AAI26483.1.
BC130543 mRNA. Translation: AAI30544.1.
CCDSiCCDS2677.1.
RefSeqiNP_004794.2. NM_004803.3.
XP_005265641.1. XM_005265584.1.
XP_005265642.1. XM_005265585.2.
UniGeneiHs.165559.

Genome annotation databases

EnsembliENST00000273173; ENSP00000273173; ENSG00000144671.
ENST00000448498; ENSP00000396283; ENSG00000144671.
GeneIDi9389.
KEGGihsa:9389.
UCSCiuc003cib.2. human.

Polymorphism databases

DMDMi313104317.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011082 mRNA. Translation: BAA76351.1 .
AB026898 Genomic DNA. Translation: BAA77626.1 .
AK315317 mRNA. Translation: BAG37720.1 .
AP006193 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64529.1 .
BC075070 mRNA. Translation: AAH75070.1 .
BC075071 mRNA. Translation: AAH75071.1 .
BC126482 mRNA. Translation: AAI26483.1 .
BC130543 mRNA. Translation: AAI30544.1 .
CCDSi CCDS2677.1.
RefSeqi NP_004794.2. NM_004803.3.
XP_005265641.1. XM_005265584.1.
XP_005265642.1. XM_005265585.2.
UniGenei Hs.165559.

3D structure databases

ProteinModelPortali Q9Y267.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000273173.

Protein family/group databases

TCDBi 2.A.1.19.22. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei Q9Y267.

Polymorphism databases

DMDMi 313104317.

Proteomic databases

PaxDbi Q9Y267.
PRIDEi Q9Y267.

Protocols and materials databases

DNASUi 9389.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000273173 ; ENSP00000273173 ; ENSG00000144671 .
ENST00000448498 ; ENSP00000396283 ; ENSG00000144671 .
GeneIDi 9389.
KEGGi hsa:9389.
UCSCi uc003cib.2. human.

Organism-specific databases

CTDi 9389.
GeneCardsi GC03P038322.
H-InvDB HIX0024265.
HGNCi HGNC:8495. SLC22A14.
HPAi HPA037556.
MIMi 604048. gene.
neXtProti NX_Q9Y267.
PharmGKBi PA32815.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
HOGENOMi HOG000234569.
HOVERGENi HBG108434.
InParanoidi Q9Y267.
KOi K08210.
OMAi SAFFMFA.
OrthoDBi EOG7C8GH9.
PhylomeDBi Q9Y267.
TreeFami TF315847.

Miscellaneous databases

GenomeRNAii 9389.
NextBioi 35179.
PROi Q9Y267.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y267.
Bgeei Q9Y267.
CleanExi HS_SLC22A14.
Genevestigatori Q9Y267.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters."
    Nishiwaki T., Daigo Y., Tamari M., Fujii Y., Nakamura Y.
    Cytogenet. Cell Genet. 83:251-255(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS THR-144; MET-284 AND GLY-292.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-144; MET-284 AND GLY-292.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS MET-284; GLY-292 AND ARG-560.
    Tissue: Testis.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS MET-284 AND GLY-292.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS MET-284; GLY-292 AND ARG-560.
    Tissue: Brain.

Entry informationi

Entry nameiS22AE_HUMAN
AccessioniPrimary (citable) accession number: Q9Y267
Secondary accession number(s): A0AVS9
, A1L4H6, B2RCX3, Q6DJT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 96 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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