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Q9Y267

- S22AE_HUMAN

UniProt

Q9Y267 - S22AE_HUMAN

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Protein

Solute carrier family 22 member 14

Gene

SLC22A14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. organic cation transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. organic cation transport Source: UniProtKB
Complete GO annotation...

Protein family/group databases

TCDBi2.A.1.19.22. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 14
Alternative name(s):
Organic cation transporter-like 4
Short name:
ORCTL-4
Gene namesi
Name:SLC22A14
Synonyms:OCTL2, ORCTL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:8495. SLC22A14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7070CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence AnalysisAdd
BLAST
Topological domaini92 – 18493ExtracellularSequence AnalysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence AnalysisAdd
BLAST
Topological domaini206 – 2105CytoplasmicSequence Analysis
Transmembranei211 – 23121HelicalSequence AnalysisAdd
BLAST
Topological domaini232 – 2354ExtracellularSequence Analysis
Transmembranei236 – 25621HelicalSequence AnalysisAdd
BLAST
Topological domaini257 – 27014CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei271 – 29121HelicalSequence AnalysisAdd
BLAST
Topological domaini292 – 2976ExtracellularSequence Analysis
Transmembranei298 – 31821HelicalSequence AnalysisAdd
BLAST
Topological domaini319 – 37961CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei380 – 40021HelicalSequence AnalysisAdd
BLAST
Topological domaini401 – 4088ExtracellularSequence Analysis
Transmembranei409 – 43123HelicalSequence AnalysisAdd
BLAST
Topological domaini432 – 4376CytoplasmicSequence Analysis
Transmembranei438 – 45821HelicalSequence AnalysisAdd
BLAST
Topological domaini459 – 48830ExtracellularSequence AnalysisAdd
BLAST
Transmembranei489 – 50921HelicalSequence AnalysisAdd
BLAST
Topological domaini510 – 5123CytoplasmicSequence Analysis
Transmembranei513 – 53321HelicalSequence AnalysisAdd
BLAST
Topological domaini534 – 5385ExtracellularSequence Analysis
Transmembranei539 – 55921HelicalSequence AnalysisAdd
BLAST
Topological domaini560 – 59435CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32815.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594Solute carrier family 22 member 14PRO_0000230784Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y267.
PRIDEiQ9Y267.

PTM databases

PhosphoSiteiQ9Y267.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiQ9Y267.
CleanExiHS_SLC22A14.
ExpressionAtlasiQ9Y267. baseline and differential.
GenevestigatoriQ9Y267.

Organism-specific databases

HPAiHPA037556.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000273173.

Structurei

3D structure databases

ProteinModelPortaliQ9Y267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00770000120546.
HOGENOMiHOG000234569.
HOVERGENiHBG108434.
InParanoidiQ9Y267.
KOiK08210.
OMAiSAFFMFA.
OrthoDBiEOG7C8GH9.
PhylomeDBiQ9Y267.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y267-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGEENFKEE LRSQDASRNL NQHEVAGHPH SWSLEMLLRR LRAVHTKQDD
60 70 80 90 100
KFANLLDAVG EFGTFQQRLV ALTFIPSIMS AFFMFADHFV FTAQKPYCNT
110 120 130 140 150
SWILAVGPHL SKAEQLNLTI PQAPNGSFLT CFMYLPVPWN LDSIIQFGLN
160 170 180 190 200
DTDTCQDGWI YPDAKKRSLI NEFDLVCGME TKKDTAQIMF MAGLPIGSLI
210 220 230 240 250
FRLITDKMGR YPAILLSLLG LIIFGFGTAF MNSFHLYLFF RFGISQSVVG
260 270 280 290 300
YAISSISLAT EWLVGEHRAH AIILGHCFFA VGAVLLTGIA YSLPHWQLLF
310 320 330 340 350
LVGGILVIPF ISYIWILPES PRWLMMKGKV KEAKQVLCYA ASVNKKTIPS
360 370 380 390 400
NLLDELQLPR KKVTRASVLD FCKNRQLCKV TLVMSCVWFT VSYTYFTLSL
410 420 430 440 450
RMRELGVSVH FRHVVPSIME VPARLCCIFL LQQIGRKWSL AVTLLQAIIW
460 470 480 490 500
CLLLLFLPEG EDGLRLKWPR CPATELKSMT ILVLMLREFS LAATVTVFFL
510 520 530 540 550
YTAELLPTVL RATGLGLVSL ASVAGAILSL TIISQTPSLL PIFLCCVLAI
560 570 580 590
VAFSLSSLLP ETRDQPLSES LNHSSQIRNK VKDMKTKETS SDDV
Length:594
Mass (Da):66,684
Last modified:November 30, 2010 - v4
Checksum:i7EA290B06222B681
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti282 – 2821G → W in BAA76351. (PubMed:10072596)Curated
Sequence conflicti282 – 2821G → W in BAA77626. (PubMed:10231028)Curated
Sequence conflicti470 – 4701R → H in BAG37720. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti108 – 1081P → H.
Corresponds to variant rs9847584 [ dbSNP | Ensembl ].
VAR_055108
Natural varianti112 – 1121K → E.
Corresponds to variant rs2073714 [ dbSNP | Ensembl ].
VAR_055109
Natural varianti144 – 1441I → T.2 Publications
Corresponds to variant rs194685 [ dbSNP | Ensembl ].
VAR_055110
Natural varianti245 – 2451S → L.
Corresponds to variant rs1078846 [ dbSNP | Ensembl ].
VAR_055111
Natural varianti284 – 2841V → M.5 Publications
Corresponds to variant rs818818 [ dbSNP | Ensembl ].
VAR_055112
Natural varianti292 – 2921S → G.5 Publications
Corresponds to variant rs818817 [ dbSNP | Ensembl ].
VAR_055113
Natural varianti466 – 4661L → P.
Corresponds to variant rs34256819 [ dbSNP | Ensembl ].
VAR_055114
Natural varianti512 – 5121A → V.
Corresponds to variant rs2070492 [ dbSNP | Ensembl ].
VAR_055115
Natural varianti560 – 5601P → R.2 Publications
Corresponds to variant rs240033 [ dbSNP | Ensembl ].
VAR_055116

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011082 mRNA. Translation: BAA76351.1.
AB026898 Genomic DNA. Translation: BAA77626.1.
AK315317 mRNA. Translation: BAG37720.1.
AP006193 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64529.1.
BC075070 mRNA. Translation: AAH75070.1.
BC075071 mRNA. Translation: AAH75071.1.
BC126482 mRNA. Translation: AAI26483.1.
BC130543 mRNA. Translation: AAI30544.1.
CCDSiCCDS2677.1.
RefSeqiNP_004794.2. NM_004803.3.
XP_005265641.1. XM_005265584.1.
XP_005265642.1. XM_005265585.2.
UniGeneiHs.165559.

Genome annotation databases

EnsembliENST00000273173; ENSP00000273173; ENSG00000144671.
ENST00000448498; ENSP00000396283; ENSG00000144671.
GeneIDi9389.
KEGGihsa:9389.
UCSCiuc003cib.2. human.

Polymorphism databases

DMDMi313104317.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011082 mRNA. Translation: BAA76351.1 .
AB026898 Genomic DNA. Translation: BAA77626.1 .
AK315317 mRNA. Translation: BAG37720.1 .
AP006193 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64529.1 .
BC075070 mRNA. Translation: AAH75070.1 .
BC075071 mRNA. Translation: AAH75071.1 .
BC126482 mRNA. Translation: AAI26483.1 .
BC130543 mRNA. Translation: AAI30544.1 .
CCDSi CCDS2677.1.
RefSeqi NP_004794.2. NM_004803.3.
XP_005265641.1. XM_005265584.1.
XP_005265642.1. XM_005265585.2.
UniGenei Hs.165559.

3D structure databases

ProteinModelPortali Q9Y267.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000273173.

Protein family/group databases

TCDBi 2.A.1.19.22. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei Q9Y267.

Polymorphism databases

DMDMi 313104317.

Proteomic databases

PaxDbi Q9Y267.
PRIDEi Q9Y267.

Protocols and materials databases

DNASUi 9389.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000273173 ; ENSP00000273173 ; ENSG00000144671 .
ENST00000448498 ; ENSP00000396283 ; ENSG00000144671 .
GeneIDi 9389.
KEGGi hsa:9389.
UCSCi uc003cib.2. human.

Organism-specific databases

CTDi 9389.
GeneCardsi GC03P038322.
H-InvDB HIX0024265.
HGNCi HGNC:8495. SLC22A14.
HPAi HPA037556.
MIMi 604048. gene.
neXtProti NX_Q9Y267.
PharmGKBi PA32815.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00770000120546.
HOGENOMi HOG000234569.
HOVERGENi HBG108434.
InParanoidi Q9Y267.
KOi K08210.
OMAi SAFFMFA.
OrthoDBi EOG7C8GH9.
PhylomeDBi Q9Y267.
TreeFami TF315847.

Miscellaneous databases

GenomeRNAii 9389.
NextBioi 35179.
PROi Q9Y267.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y267.
CleanExi HS_SLC22A14.
ExpressionAtlasi Q9Y267. baseline and differential.
Genevestigatori Q9Y267.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters."
    Nishiwaki T., Daigo Y., Tamari M., Fujii Y., Nakamura Y.
    Cytogenet. Cell Genet. 83:251-255(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS THR-144; MET-284 AND GLY-292.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-144; MET-284 AND GLY-292.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS MET-284; GLY-292 AND ARG-560.
    Tissue: Testis.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS MET-284 AND GLY-292.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS MET-284; GLY-292 AND ARG-560.
    Tissue: Brain.

Entry informationi

Entry nameiS22AE_HUMAN
AccessioniPrimary (citable) accession number: Q9Y267
Secondary accession number(s): A0AVS9
, A1L4H6, B2RCX3, Q6DJT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 30, 2010
Last modified: November 26, 2014
This is version 99 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3