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Protein

Solute carrier family 22 member 14

Gene

SLC22A14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • organic cation transport Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144671-MONOMER.

Protein family/group databases

TCDBi2.A.1.19.22. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 14
Alternative name(s):
Organic cation transporter-like 4
Short name:
ORCTL-4
Gene namesi
Name:SLC22A14
Synonyms:OCTL2, ORCTL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:8495. SLC22A14.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 70CytoplasmicSequence analysisAdd BLAST70
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Topological domaini92 – 184ExtracellularSequence analysisAdd BLAST93
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 210CytoplasmicSequence analysis5
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 235ExtracellularSequence analysis4
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 270CytoplasmicSequence analysisAdd BLAST14
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 297ExtracellularSequence analysis6
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Topological domaini319 – 379CytoplasmicSequence analysisAdd BLAST61
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Topological domaini401 – 408ExtracellularSequence analysis8
Transmembranei409 – 431HelicalSequence analysisAdd BLAST23
Topological domaini432 – 437CytoplasmicSequence analysis6
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 488ExtracellularSequence analysisAdd BLAST30
Transmembranei489 – 509HelicalSequence analysisAdd BLAST21
Topological domaini510 – 512CytoplasmicSequence analysis3
Transmembranei513 – 533HelicalSequence analysisAdd BLAST21
Topological domaini534 – 538ExtracellularSequence analysis5
Transmembranei539 – 559HelicalSequence analysisAdd BLAST21
Topological domaini560 – 594CytoplasmicSequence analysisAdd BLAST35

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9389.
OpenTargetsiENSG00000144671.
PharmGKBiPA32815.

Polymorphism and mutation databases

BioMutaiSLC22A14.
DMDMi313104317.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002307841 – 594Solute carrier family 22 member 14Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...)Sequence analysis1
Glycosylationi117N-linked (GlcNAc...)Sequence analysis1
Glycosylationi125N-linked (GlcNAc...)Sequence analysis1
Glycosylationi150N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y267.
PRIDEiQ9Y267.

PTM databases

iPTMnetiQ9Y267.
PhosphoSitePlusiQ9Y267.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000144671.
CleanExiHS_SLC22A14.
ExpressionAtlasiQ9Y267. baseline and differential.
GenevisibleiQ9Y267. HS.

Organism-specific databases

HPAiHPA037556.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000273173.

Structurei

3D structure databases

ProteinModelPortaliQ9Y267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRHZ. Eukaryota.
ENOG410XQIT. LUCA.
GeneTreeiENSGT00860000133730.
HOGENOMiHOG000234569.
HOVERGENiHBG108434.
InParanoidiQ9Y267.
KOiK08210.
OMAiSAFFMFA.
OrthoDBiEOG091G07EF.
PhylomeDBiQ9Y267.
TreeFamiTF315847.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y267-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEENFKEE LRSQDASRNL NQHEVAGHPH SWSLEMLLRR LRAVHTKQDD
60 70 80 90 100
KFANLLDAVG EFGTFQQRLV ALTFIPSIMS AFFMFADHFV FTAQKPYCNT
110 120 130 140 150
SWILAVGPHL SKAEQLNLTI PQAPNGSFLT CFMYLPVPWN LDSIIQFGLN
160 170 180 190 200
DTDTCQDGWI YPDAKKRSLI NEFDLVCGME TKKDTAQIMF MAGLPIGSLI
210 220 230 240 250
FRLITDKMGR YPAILLSLLG LIIFGFGTAF MNSFHLYLFF RFGISQSVVG
260 270 280 290 300
YAISSISLAT EWLVGEHRAH AIILGHCFFA VGAVLLTGIA YSLPHWQLLF
310 320 330 340 350
LVGGILVIPF ISYIWILPES PRWLMMKGKV KEAKQVLCYA ASVNKKTIPS
360 370 380 390 400
NLLDELQLPR KKVTRASVLD FCKNRQLCKV TLVMSCVWFT VSYTYFTLSL
410 420 430 440 450
RMRELGVSVH FRHVVPSIME VPARLCCIFL LQQIGRKWSL AVTLLQAIIW
460 470 480 490 500
CLLLLFLPEG EDGLRLKWPR CPATELKSMT ILVLMLREFS LAATVTVFFL
510 520 530 540 550
YTAELLPTVL RATGLGLVSL ASVAGAILSL TIISQTPSLL PIFLCCVLAI
560 570 580 590
VAFSLSSLLP ETRDQPLSES LNHSSQIRNK VKDMKTKETS SDDV
Length:594
Mass (Da):66,684
Last modified:November 30, 2010 - v4
Checksum:i7EA290B06222B681
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti282G → W in BAA76351 (PubMed:10072596).Curated1
Sequence conflicti282G → W in BAA77626 (PubMed:10231028).Curated1
Sequence conflicti470R → H in BAG37720 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055108108P → H.Corresponds to variant rs9847584dbSNPEnsembl.1
Natural variantiVAR_055109112K → E.Corresponds to variant rs2073714dbSNPEnsembl.1
Natural variantiVAR_055110144I → T.2 PublicationsCorresponds to variant rs194685dbSNPEnsembl.1
Natural variantiVAR_055111245S → L.Corresponds to variant rs1078846dbSNPEnsembl.1
Natural variantiVAR_055112284V → M.5 PublicationsCorresponds to variant rs818818dbSNPEnsembl.1
Natural variantiVAR_055113292S → G.5 PublicationsCorresponds to variant rs818817dbSNPEnsembl.1
Natural variantiVAR_055114466L → P.Corresponds to variant rs34256819dbSNPEnsembl.1
Natural variantiVAR_055115512A → V.Corresponds to variant rs2070492dbSNPEnsembl.1
Natural variantiVAR_055116560P → R.2 PublicationsCorresponds to variant rs240033dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011082 mRNA. Translation: BAA76351.1.
AB026898 Genomic DNA. Translation: BAA77626.1.
AK315317 mRNA. Translation: BAG37720.1.
AP006193 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64529.1.
BC075070 mRNA. Translation: AAH75070.1.
BC075071 mRNA. Translation: AAH75071.1.
BC126482 mRNA. Translation: AAI26483.1.
BC130543 mRNA. Translation: AAI30544.1.
CCDSiCCDS2677.1.
RefSeqiNP_001306962.1. NM_001320033.1.
NP_004794.2. NM_004803.4.
XP_005265642.1. XM_005265585.4.
XP_011532547.1. XM_011534245.2.
UniGeneiHs.165559.

Genome annotation databases

EnsembliENST00000273173; ENSP00000273173; ENSG00000144671.
ENST00000448498; ENSP00000396283; ENSG00000144671.
GeneIDi9389.
KEGGihsa:9389.
UCSCiuc003cib.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011082 mRNA. Translation: BAA76351.1.
AB026898 Genomic DNA. Translation: BAA77626.1.
AK315317 mRNA. Translation: BAG37720.1.
AP006193 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64529.1.
BC075070 mRNA. Translation: AAH75070.1.
BC075071 mRNA. Translation: AAH75071.1.
BC126482 mRNA. Translation: AAI26483.1.
BC130543 mRNA. Translation: AAI30544.1.
CCDSiCCDS2677.1.
RefSeqiNP_001306962.1. NM_001320033.1.
NP_004794.2. NM_004803.4.
XP_005265642.1. XM_005265585.4.
XP_011532547.1. XM_011534245.2.
UniGeneiHs.165559.

3D structure databases

ProteinModelPortaliQ9Y267.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000273173.

Protein family/group databases

TCDBi2.A.1.19.22. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ9Y267.
PhosphoSitePlusiQ9Y267.

Polymorphism and mutation databases

BioMutaiSLC22A14.
DMDMi313104317.

Proteomic databases

PaxDbiQ9Y267.
PRIDEiQ9Y267.

Protocols and materials databases

DNASUi9389.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273173; ENSP00000273173; ENSG00000144671.
ENST00000448498; ENSP00000396283; ENSG00000144671.
GeneIDi9389.
KEGGihsa:9389.
UCSCiuc003cib.3. human.

Organism-specific databases

CTDi9389.
DisGeNETi9389.
GeneCardsiSLC22A14.
H-InvDBHIX0024265.
HGNCiHGNC:8495. SLC22A14.
HPAiHPA037556.
MIMi604048. gene.
neXtProtiNX_Q9Y267.
OpenTargetsiENSG00000144671.
PharmGKBiPA32815.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRHZ. Eukaryota.
ENOG410XQIT. LUCA.
GeneTreeiENSGT00860000133730.
HOGENOMiHOG000234569.
HOVERGENiHBG108434.
InParanoidiQ9Y267.
KOiK08210.
OMAiSAFFMFA.
OrthoDBiEOG091G07EF.
PhylomeDBiQ9Y267.
TreeFamiTF315847.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144671-MONOMER.

Miscellaneous databases

GenomeRNAii9389.
PROiQ9Y267.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144671.
CleanExiHS_SLC22A14.
ExpressionAtlasiQ9Y267. baseline and differential.
GenevisibleiQ9Y267. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS22AE_HUMAN
AccessioniPrimary (citable) accession number: Q9Y267
Secondary accession number(s): A0AVS9
, A1L4H6, B2RCX3, Q6DJT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 118 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.