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Q9Y267 (S22AE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 22 member 14
Alternative name(s):
Organic cation transporter-like 4
Short name=ORCTL-4
Gene names
Name:SLC22A14
Synonyms:ORCTL4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length594 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Ubiquitous. Ref.1

Sequence similarities

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processorganic cation transport

Non-traceable author statement Ref.1. Source: UniProtKB

   Cellular_componentintegral component of plasma membrane

Non-traceable author statement Ref.1. Source: UniProtKB

   Molecular_functionorganic cation transmembrane transporter activity

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 594594Solute carrier family 22 member 14
PRO_0000230784

Regions

Topological domain1 – 7070Cytoplasmic Potential
Transmembrane71 – 9121Helical; Potential
Topological domain92 – 18493Extracellular Potential
Transmembrane185 – 20521Helical; Potential
Topological domain206 – 2105Cytoplasmic Potential
Transmembrane211 – 23121Helical; Potential
Topological domain232 – 2354Extracellular Potential
Transmembrane236 – 25621Helical; Potential
Topological domain257 – 27014Cytoplasmic Potential
Transmembrane271 – 29121Helical; Potential
Topological domain292 – 2976Extracellular Potential
Transmembrane298 – 31821Helical; Potential
Topological domain319 – 37961Cytoplasmic Potential
Transmembrane380 – 40021Helical; Potential
Topological domain401 – 4088Extracellular Potential
Transmembrane409 – 43123Helical; Potential
Topological domain432 – 4376Cytoplasmic Potential
Transmembrane438 – 45821Helical; Potential
Topological domain459 – 48830Extracellular Potential
Transmembrane489 – 50921Helical; Potential
Topological domain510 – 5123Cytoplasmic Potential
Transmembrane513 – 53321Helical; Potential
Topological domain534 – 5385Extracellular Potential
Transmembrane539 – 55921Helical; Potential
Topological domain560 – 59435Cytoplasmic Potential

Amino acid modifications

Glycosylation991N-linked (GlcNAc...) Potential
Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation1251N-linked (GlcNAc...) Potential
Glycosylation1501N-linked (GlcNAc...) Potential

Natural variations

Natural variant1081P → H.
Corresponds to variant rs9847584 [ dbSNP | Ensembl ].
VAR_055108
Natural variant1121K → E.
Corresponds to variant rs2073714 [ dbSNP | Ensembl ].
VAR_055109
Natural variant1441I → T. Ref.1 Ref.2
Corresponds to variant rs194685 [ dbSNP | Ensembl ].
VAR_055110
Natural variant2451S → L.
Corresponds to variant rs1078846 [ dbSNP | Ensembl ].
VAR_055111
Natural variant2841V → M. Ref.1 Ref.2 Ref.3 Ref.5 Ref.6
Corresponds to variant rs818818 [ dbSNP | Ensembl ].
VAR_055112
Natural variant2921S → G. Ref.1 Ref.2 Ref.3 Ref.5 Ref.6
Corresponds to variant rs818817 [ dbSNP | Ensembl ].
VAR_055113
Natural variant4661L → P.
Corresponds to variant rs34256819 [ dbSNP | Ensembl ].
VAR_055114
Natural variant5121A → V.
Corresponds to variant rs2070492 [ dbSNP | Ensembl ].
VAR_055115
Natural variant5601P → R. Ref.3 Ref.6
Corresponds to variant rs240033 [ dbSNP | Ensembl ].
VAR_055116

Experimental info

Sequence conflict2821G → W in BAA76351. Ref.1
Sequence conflict2821G → W in BAA77626. Ref.2
Sequence conflict4701R → H in BAG37720. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9Y267 [UniParc].

Last modified November 30, 2010. Version 4.
Checksum: 7EA290B06222B681

FASTA59466,684
        10         20         30         40         50         60 
MAGEENFKEE LRSQDASRNL NQHEVAGHPH SWSLEMLLRR LRAVHTKQDD KFANLLDAVG 

        70         80         90        100        110        120 
EFGTFQQRLV ALTFIPSIMS AFFMFADHFV FTAQKPYCNT SWILAVGPHL SKAEQLNLTI 

       130        140        150        160        170        180 
PQAPNGSFLT CFMYLPVPWN LDSIIQFGLN DTDTCQDGWI YPDAKKRSLI NEFDLVCGME 

       190        200        210        220        230        240 
TKKDTAQIMF MAGLPIGSLI FRLITDKMGR YPAILLSLLG LIIFGFGTAF MNSFHLYLFF 

       250        260        270        280        290        300 
RFGISQSVVG YAISSISLAT EWLVGEHRAH AIILGHCFFA VGAVLLTGIA YSLPHWQLLF 

       310        320        330        340        350        360 
LVGGILVIPF ISYIWILPES PRWLMMKGKV KEAKQVLCYA ASVNKKTIPS NLLDELQLPR 

       370        380        390        400        410        420 
KKVTRASVLD FCKNRQLCKV TLVMSCVWFT VSYTYFTLSL RMRELGVSVH FRHVVPSIME 

       430        440        450        460        470        480 
VPARLCCIFL LQQIGRKWSL AVTLLQAIIW CLLLLFLPEG EDGLRLKWPR CPATELKSMT 

       490        500        510        520        530        540 
ILVLMLREFS LAATVTVFFL YTAELLPTVL RATGLGLVSL ASVAGAILSL TIISQTPSLL 

       550        560        570        580        590 
PIFLCCVLAI VAFSLSSLLP ETRDQPLSES LNHSSQIRNK VKDMKTKETS SDDV 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters."
Nishiwaki T., Daigo Y., Tamari M., Fujii Y., Nakamura Y.
Cytogenet. Cell Genet. 83:251-255(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS THR-144; MET-284 AND GLY-292.
[2]"Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3."
Daigo Y., Isomura M., Nishiwaki T., Tamari M., Ishikawa S., Kai M., Takeuchi K., Yamane Y., Hayashi R., Minami M., Fujino M.A., Hojo Y., Uchiyama I., Takagi T., Nakamura Y.
DNA Res. 6:37-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-144; MET-284 AND GLY-292.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS MET-284; GLY-292 AND ARG-560.
Tissue: Testis.
[4]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS MET-284 AND GLY-292.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS MET-284; GLY-292 AND ARG-560.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB011082 mRNA. Translation: BAA76351.1.
AB026898 Genomic DNA. Translation: BAA77626.1.
AK315317 mRNA. Translation: BAG37720.1.
AP006193 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64529.1.
BC075070 mRNA. Translation: AAH75070.1.
BC075071 mRNA. Translation: AAH75071.1.
BC126482 mRNA. Translation: AAI26483.1.
BC130543 mRNA. Translation: AAI30544.1.
CCDSCCDS2677.1.
RefSeqNP_004794.2. NM_004803.3.
XP_005265641.1. XM_005265584.1.
XP_005265642.1. XM_005265585.2.
UniGeneHs.165559.

3D structure databases

ProteinModelPortalQ9Y267.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000273173.

Protein family/group databases

TCDB2.A.1.19.22. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteQ9Y267.

Polymorphism databases

DMDM313104317.

Proteomic databases

PaxDbQ9Y267.
PRIDEQ9Y267.

Protocols and materials databases

DNASU9389.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000273173; ENSP00000273173; ENSG00000144671.
ENST00000448498; ENSP00000396283; ENSG00000144671.
GeneID9389.
KEGGhsa:9389.
UCSCuc003cib.2. human.

Organism-specific databases

CTD9389.
GeneCardsGC03P038322.
H-InvDBHIX0024265.
HGNCHGNC:8495. SLC22A14.
HPAHPA037556.
MIM604048. gene.
neXtProtNX_Q9Y267.
PharmGKBPA32815.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0477.
HOGENOMHOG000234569.
HOVERGENHBG108434.
InParanoidQ9Y267.
KOK08210.
OMASAFFMFA.
OrthoDBEOG7C8GH9.
PhylomeDBQ9Y267.
TreeFamTF315847.

Gene expression databases

ArrayExpressQ9Y267.
BgeeQ9Y267.
CleanExHS_SLC22A14.
GenevestigatorQ9Y267.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi9389.
NextBio35179.
PROQ9Y267.
SOURCESearch...

Entry information

Entry nameS22AE_HUMAN
AccessionPrimary (citable) accession number: Q9Y267
Secondary accession number(s): A0AVS9 expand/collapse secondary AC list , A1L4H6, B2RCX3, Q6DJT3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 96 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM