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Q9Y264

- ANGP4_HUMAN

UniProt

Q9Y264 - ANGP4_HUMAN

Protein

Angiopoietin-4

Gene

ANGPT4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.1 Publication

    GO - Molecular functioni

    1. receptor tyrosine kinase binding Source: UniProtKB
    2. transmembrane receptor protein tyrosine kinase activator activity Source: UniProtKB

    GO - Biological processi

    1. activation of transmembrane receptor protein tyrosine kinase activity Source: GOC
    2. angiogenesis Source: UniProtKB-KW
    3. blood coagulation Source: Reactome
    4. cellular response to hypoxia Source: UniProtKB
    5. leukocyte migration Source: Reactome
    6. negative regulation of angiogenesis Source: UniProtKB
    7. negative regulation of apoptotic process Source: UniProtKB
    8. negative regulation of blood vessel endothelial cell migration Source: UniProtKB
    9. positive regulation of angiogenesis Source: UniProtKB
    10. positive regulation of blood vessel endothelial cell migration Source: UniProtKB
    11. positive regulation of endothelial cell migration Source: UniProtKB
    12. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB

    Keywords - Biological processi

    Angiogenesis

    Enzyme and pathway databases

    ReactomeiREACT_12621. Tie2 Signaling.
    SignaLinkiQ9Y264.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Angiopoietin-4
    Short name:
    ANG-4
    Alternative name(s):
    Angiopoietin-3
    Short name:
    ANG-3
    Gene namesi
    Name:ANGPT4
    Synonyms:ANG3, ANG4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:487. ANGPT4.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24793.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 503479Angiopoietin-4PRO_0000009116Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi291 ↔ 320PROSITE-ProRule annotation
    Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi337 – 3371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi427 – 4271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi444 ↔ 457PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9Y264.
    PRIDEiQ9Y264.

    PTM databases

    PhosphoSiteiQ9Y264.

    Expressioni

    Tissue specificityi

    Highly expressed in the lung with much lower levels found in other tissues.

    Gene expression databases

    ArrayExpressiQ9Y264.
    BgeeiQ9Y264.
    CleanExiHS_ANGPT4.
    GenevestigatoriQ9Y264.

    Organism-specific databases

    HPAiCAB013260.
    CAB013305.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Interacts with TEK/TIE2.1 Publication

    Protein-protein interaction databases

    BioGridi119510. 2 interactions.
    IntActiQ9Y264. 1 interaction.
    STRINGi9606.ENSP00000371347.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y264.
    SMRiQ9Y264. Positions 171-502.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini282 – 502221Fibrinogen C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili84 – 238155Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Signal

    Phylogenomic databases

    eggNOGiNOG273522.
    HOGENOMiHOG000037128.
    HOVERGENiHBG001644.
    InParanoidiQ9Y264.
    KOiK05467.
    OMAiYYPARHH.
    OrthoDBiEOG7X9G60.
    PhylomeDBiQ9Y264.
    TreeFamiTF336658.

    Family and domain databases

    Gene3Di3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProiIPR028845. Ang-4.
    IPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR020837. Fibrinogen_CS.
    [Graphical view]
    PANTHERiPTHR19143:SF31. PTHR19143:SF31. 1 hit.
    PfamiPF00147. Fibrinogen_C. 1 hit.
    [Graphical view]
    SMARTiSM00186. FBG. 1 hit.
    [Graphical view]
    SUPFAMiSSF56496. SSF56496. 1 hit.
    PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y264-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLSQLAMLQG SLLLVVATMS VAQQTRQEAD RGCETLVVQH GHCSYTFLLP    50
    KSEPCPPGPE VSRDSNTLQR ESLANPLHLG KLPTQQVKQL EQALQNNTQW 100
    LKKLERAIKT ILRSKLEQVQ QQMAQNQTAP MLELGTSLLN QTTAQIRKLT 150
    DMEAQLLNQT SRMDAQMPET FLSTNKLENQ LLLQRQKLQQ LQGQNSALEK 200
    RLQALETKQQ EELASILSKK AKLLNTLSRQ SAALTNIERG LRGVRHNSSL 250
    LQDQQHSLRQ LLVLLRHLVQ ERANASAPAF IMAGEQVFQD CAEIQRSGAS 300
    ASGVYTIQVS NATKPRKVFC DLQSSGGRWT LIQRRENGTV NFQRNWKDYK 350
    QGFGDPAGEH WLGNEVVHQL TRRAAYSLRV ELQDWEGHEA YAQYEHFHLG 400
    SENQLYRLSV VGYSGSAGRQ SSLVLQNTSF STLDSDNDHC LCKCAQVMSG 450
    GWWFDACGLS NLNGVYYHAP DNKYKMDGIR WHYFKGPSYS LRASRMMIRP 500
    LDI 503
    Length:503
    Mass (Da):56,849
    Last modified:November 1, 1999 - v1
    Checksum:i79CE52F66B532340
    GO
    Isoform 2 (identifier: Q9Y264-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         408-503: LSVVGYSGSA...SRMMIRPLDI → VVV

    Note: No experimental confirmation available.

    Show »
    Length:410
    Mass (Da):46,416
    Checksum:iD400123988B77BD8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti395 – 3951E → K.
    Corresponds to variant rs869171 [ dbSNP | Ensembl ].
    VAR_049070

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei408 – 50396LSVVG…RPLDI → VVV in isoform 2. 1 PublicationVSP_055091Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF074332 mRNA. Translation: AAD31728.1.
    AF113708 mRNA. Translation: AAD21587.1.
    AK304756 mRNA. Translation: BAG65511.1.
    AL161939, AL050325 Genomic DNA. Translation: CAC09933.2.
    AL050325, AL161939 Genomic DNA. Translation: CAI22922.1.
    BC111976 mRNA. Translation: AAI11977.1.
    BC111978 mRNA. Translation: AAI11979.1.
    CCDSiCCDS13009.1. [Q9Y264-1]
    RefSeqiNP_057069.1. NM_015985.2.
    XP_005260777.1. XM_005260720.1.
    UniGeneiHs.278973.

    Genome annotation databases

    EnsembliENST00000381922; ENSP00000371347; ENSG00000101280. [Q9Y264-1]
    GeneIDi51378.
    KEGGihsa:51378.
    UCSCiuc002wei.3. human. [Q9Y264-1]

    Polymorphism databases

    DMDMi17433288.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF074332 mRNA. Translation: AAD31728.1 .
    AF113708 mRNA. Translation: AAD21587.1 .
    AK304756 mRNA. Translation: BAG65511.1 .
    AL161939 , AL050325 Genomic DNA. Translation: CAC09933.2 .
    AL050325 , AL161939 Genomic DNA. Translation: CAI22922.1 .
    BC111976 mRNA. Translation: AAI11977.1 .
    BC111978 mRNA. Translation: AAI11979.1 .
    CCDSi CCDS13009.1. [Q9Y264-1 ]
    RefSeqi NP_057069.1. NM_015985.2.
    XP_005260777.1. XM_005260720.1.
    UniGenei Hs.278973.

    3D structure databases

    ProteinModelPortali Q9Y264.
    SMRi Q9Y264. Positions 171-502.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119510. 2 interactions.
    IntActi Q9Y264. 1 interaction.
    STRINGi 9606.ENSP00000371347.

    PTM databases

    PhosphoSitei Q9Y264.

    Polymorphism databases

    DMDMi 17433288.

    Proteomic databases

    PaxDbi Q9Y264.
    PRIDEi Q9Y264.

    Protocols and materials databases

    DNASUi 51378.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381922 ; ENSP00000371347 ; ENSG00000101280 . [Q9Y264-1 ]
    GeneIDi 51378.
    KEGGi hsa:51378.
    UCSCi uc002wei.3. human. [Q9Y264-1 ]

    Organism-specific databases

    CTDi 51378.
    GeneCardsi GC20M000853.
    HGNCi HGNC:487. ANGPT4.
    HPAi CAB013260.
    CAB013305.
    MIMi 603705. gene.
    neXtProti NX_Q9Y264.
    PharmGKBi PA24793.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG273522.
    HOGENOMi HOG000037128.
    HOVERGENi HBG001644.
    InParanoidi Q9Y264.
    KOi K05467.
    OMAi YYPARHH.
    OrthoDBi EOG7X9G60.
    PhylomeDBi Q9Y264.
    TreeFami TF336658.

    Enzyme and pathway databases

    Reactomei REACT_12621. Tie2 Signaling.
    SignaLinki Q9Y264.

    Miscellaneous databases

    GeneWikii ANGPT4.
    GenomeRNAii 51378.
    NextBioi 35477558.
    PROi Q9Y264.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y264.
    Bgeei Q9Y264.
    CleanExi HS_ANGPT4.
    Genevestigatori Q9Y264.

    Family and domain databases

    Gene3Di 3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProi IPR028845. Ang-4.
    IPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR020837. Fibrinogen_CS.
    [Graphical view ]
    PANTHERi PTHR19143:SF31. PTHR19143:SF31. 1 hit.
    Pfami PF00147. Fibrinogen_C. 1 hit.
    [Graphical view ]
    SMARTi SM00186. FBG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56496. SSF56496. 1 hit.
    PROSITEi PS00514. FIBRINOGEN_C_1. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Angiopoietin-3, a novel member of the angiopoietin family."
      Nishimura M., Miki T., Yashima R., Yokoi N., Yano H., Sato Y., Seino S.
      FEBS Lett. 448:254-256(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Aorta.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Ovary.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Uterus.
    4. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Biological characterization of angiopoietin-3 and angiopoietin-4."
      Lee H.J., Cho C.H., Hwang S.J., Choi H.H., Kim K.T., Ahn S.Y., Kim J.H., Oh J.L., Lee G.M., Koh G.Y.
      FASEB J. 18:1200-1208(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF ANGIOGENESIS; CELL SURVIVAL; CELL MIGRATION AND ACTIVATION OF AKT1, SUBUNIT, INTERACTION WITH TEK/TIE2.
    7. "Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system."
      Augustin H.G., Koh G.Y., Thurston G., Alitalo K.
      Nat. Rev. Mol. Cell Biol. 10:165-177(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiANGP4_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y264
    Secondary accession number(s): B4E3J9, Q5TFF4, Q9H4Z4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3