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Q9Y264 (ANGP4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Angiopoietin-4

Short name=ANG-4
Alternative name(s):
Angiopoietin-3
Short name=ANG-3
Gene names
Name:ANGPT4
Synonyms:ANG3, ANG4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. Ref.5

Subunit structure

Homodimer; disulfide-linked. Interacts with TEK/TIE2. Ref.5

Subcellular location

Secreted Probable.

Tissue specificity

Highly expressed in the lung with much lower levels found in other tissues.

Sequence similarities

Contains 1 fibrinogen C-terminal domain.

Ontologies

Keywords
   Biological processAngiogenesis
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainCoiled coil
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of transmembrane receptor protein tyrosine kinase activity

Inferred from direct assay Ref.2PubMed 15851516. Source: GOC

angiogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

blood coagulation

Traceable author statement. Source: Reactome

cellular response to hypoxia

Inferred from expression pattern PubMed 12958144. Source: UniProtKB

leukocyte migration

Traceable author statement. Source: Reactome

negative regulation of angiogenesis

Inferred from direct assay PubMed 16790085. Source: UniProtKB

negative regulation of apoptotic process

Inferred from direct assay PubMed 12958144Ref.5. Source: UniProtKB

negative regulation of blood vessel endothelial cell migration

Inferred from direct assay PubMed 16790085. Source: UniProtKB

positive regulation of angiogenesis

Inferred from direct assay Ref.5. Source: UniProtKB

positive regulation of blood vessel endothelial cell migration

Inferred from direct assay Ref.5. Source: UniProtKB

positive regulation of endothelial cell migration

Inferred from direct assay PubMed 12958144. Source: UniProtKB

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from direct assay PubMed 15851516. Source: UniProtKB

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from direct assay PubMed 10025962. Source: UniProtKB

   Molecular_functionreceptor tyrosine kinase binding

Inferred from direct assay Ref.2. Source: UniProtKB

transmembrane receptor protein tyrosine kinase activator activity

Inferred from direct assay Ref.2PubMed 15851516. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 503479Angiopoietin-4
PRO_0000009116

Regions

Domain282 – 502221Fibrinogen C-terminal
Coiled coil84 – 238155 Potential

Amino acid modifications

Glycosylation961N-linked (GlcNAc...) Potential
Glycosylation1261N-linked (GlcNAc...) Potential
Glycosylation1401N-linked (GlcNAc...) Potential
Glycosylation1581N-linked (GlcNAc...) Potential
Glycosylation2471N-linked (GlcNAc...) Potential
Glycosylation2741N-linked (GlcNAc...) Potential
Glycosylation3111N-linked (GlcNAc...) Potential
Glycosylation3371N-linked (GlcNAc...) Potential
Glycosylation4271N-linked (GlcNAc...) Potential
Disulfide bond291 ↔ 320 By similarity
Disulfide bond444 ↔ 457 By similarity

Natural variations

Natural variant3951E → K.
Corresponds to variant rs869171 [ dbSNP | Ensembl ].
VAR_049070

Sequences

Sequence LengthMass (Da)Tools
Q9Y264 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 79CE52F66B532340

FASTA50356,849
        10         20         30         40         50         60 
MLSQLAMLQG SLLLVVATMS VAQQTRQEAD RGCETLVVQH GHCSYTFLLP KSEPCPPGPE 

        70         80         90        100        110        120 
VSRDSNTLQR ESLANPLHLG KLPTQQVKQL EQALQNNTQW LKKLERAIKT ILRSKLEQVQ 

       130        140        150        160        170        180 
QQMAQNQTAP MLELGTSLLN QTTAQIRKLT DMEAQLLNQT SRMDAQMPET FLSTNKLENQ 

       190        200        210        220        230        240 
LLLQRQKLQQ LQGQNSALEK RLQALETKQQ EELASILSKK AKLLNTLSRQ SAALTNIERG 

       250        260        270        280        290        300 
LRGVRHNSSL LQDQQHSLRQ LLVLLRHLVQ ERANASAPAF IMAGEQVFQD CAEIQRSGAS 

       310        320        330        340        350        360 
ASGVYTIQVS NATKPRKVFC DLQSSGGRWT LIQRRENGTV NFQRNWKDYK QGFGDPAGEH 

       370        380        390        400        410        420 
WLGNEVVHQL TRRAAYSLRV ELQDWEGHEA YAQYEHFHLG SENQLYRLSV VGYSGSAGRQ 

       430        440        450        460        470        480 
SSLVLQNTSF STLDSDNDHC LCKCAQVMSG GWWFDACGLS NLNGVYYHAP DNKYKMDGIR 

       490        500 
WHYFKGPSYS LRASRMMIRP LDI 

« Hide

References

« Hide 'large scale' references
[1]"Angiopoietin-3, a novel member of the angiopoietin family."
Nishimura M., Miki T., Yashima R., Yokoi N., Yano H., Sato Y., Seino S.
FEBS Lett. 448:254-256(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Aorta.
[2]"Angiopoietins 3 and 4: diverging gene counterparts in mice and humans."
Valenzuela D.M., Griffiths J.A., Rojas J., Aldrich T.H., Jones P.F., Zhou H., McClain J., Copeland N.G., Gilbert D.J., Jenkins N.A., Huang T., Papadopoulos N., Maisonpierre P.C., Davis S., Yancopoulos G.D.
Proc. Natl. Acad. Sci. U.S.A. 96:1904-1909(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.
[3]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Biological characterization of angiopoietin-3 and angiopoietin-4."
Lee H.J., Cho C.H., Hwang S.J., Choi H.H., Kim K.T., Ahn S.Y., Kim J.H., Oh J.L., Lee G.M., Koh G.Y.
FASEB J. 18:1200-1208(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN REGULATION OF ANGIOGENESIS; CELL SURVIVAL; CELL MIGRATION AND ACTIVATION OF AKT1, SUBUNIT, INTERACTION WITH TEK/TIE2.
[6]"Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system."
Augustin H.G., Koh G.Y., Thurston G., Alitalo K.
Nat. Rev. Mol. Cell Biol. 10:165-177(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF074332 mRNA. Translation: AAD31728.1.
AF113708 mRNA. Translation: AAD21587.1.
AL161939, AL050325 Genomic DNA. Translation: CAC09933.2.
AL050325, AL161939 Genomic DNA. Translation: CAI22922.1.
BC111976 mRNA. Translation: AAI11977.1.
BC111978 mRNA. Translation: AAI11979.1.
RefSeqNP_057069.1. NM_015985.2.
UniGeneHs.278973.

3D structure databases

ProteinModelPortalQ9Y264.
SMRQ9Y264. Positions 171-502.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119510. 2 interactions.
IntActQ9Y264. 1 interaction.
STRING9606.ENSP00000371347.

PTM databases

PhosphoSiteQ9Y264.

Polymorphism databases

DMDM17433288.

Proteomic databases

PaxDbQ9Y264.
PRIDEQ9Y264.

Protocols and materials databases

DNASU51378.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381922; ENSP00000371347; ENSG00000101280.
GeneID51378.
KEGGhsa:51378.
UCSCuc002wei.3. human.

Organism-specific databases

CTD51378.
GeneCardsGC20M000853.
HGNCHGNC:487. ANGPT4.
HPACAB013260.
CAB013305.
MIM603705. gene.
neXtProtNX_Q9Y264.
PharmGKBPA24793.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG273522.
HOGENOMHOG000037128.
HOVERGENHBG001644.
InParanoidQ9Y264.
KOK05467.
OMAYYPARHH.
OrthoDBEOG7X9G60.
PhylomeDBQ9Y264.
TreeFamTF336658.

Enzyme and pathway databases

ReactomeREACT_604. Hemostasis.
SignaLinkQ9Y264.

Gene expression databases

ArrayExpressQ9Y264.
BgeeQ9Y264.
CleanExHS_ANGPT4.
GenevestigatorQ9Y264.

Family and domain databases

Gene3D3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProIPR028845. Ang-4.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PANTHERPTHR19143:SF31. PTHR19143:SF31. 1 hit.
PfamPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMSSF56496. SSF56496. 1 hit.
PROSITEPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiANGPT4.
GenomeRNAi51378.
NextBio54879.
PROQ9Y264.
SOURCESearch...

Entry information

Entry nameANGP4_HUMAN
AccessionPrimary (citable) accession number: Q9Y264
Secondary accession number(s): Q5TFF4, Q9H4Z4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM