ID   ANGP4_HUMAN             Reviewed;         503 AA.
AC   Q9Y264; Q5TFF4; Q9H4Z4;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   07-JUL-2009, entry version 66.
DE   RecName: Full=Angiopoietin-4;
DE            Short=ANG-4;
DE   AltName: Full=ANG-3;
DE   Flags: Precursor;
GN   Name=ANGPT4; Synonyms=ANG3, ANG4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Aorta;
RX   MEDLINE=99232854; PubMed=10218486; DOI=10.1016/S0014-5793(99)00381-6;
RA   Nishimura M., Miki T., Yashima R., Yokoi N., Yano H., Sato Y.,
RA   Seino S.;
RT   "Angiopoietin-3, a novel member of the angiopoietin family.";
RL   FEBS Lett. 448:254-256(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RX   MEDLINE=99162530; PubMed=10051567; DOI=10.1073/pnas.96.5.1904;
RA   Valenzuela D.M., Griffiths J.A., Rojas J., Aldrich T.H., Jones P.F.,
RA   Zhou H., McClain J., Copeland N.G., Gilbert D.J., Jenkins N.A.,
RA   Huang T., Papadopoulos N., Maisonpierre P.C., Davis S.,
RA   Yancopoulos G.D.;
RT   "Angiopoietins 3 and 4: diverging gene counterparts in mice and
RT   humans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:1904-1909(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=21638749; PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Binds to tyrosine-protein kinase receptor TIE2 and
CC       activates it.
CC   -!- SUBCELLULAR LOCATION: Secreted (Probable).
CC   -!- TISSUE SPECIFICITY: Highly expressed in the lung with much lower
CC       levels found in other tissues.
CC   -!- SIMILARITY: Contains 1 fibrinogen C-terminal domain.
CC   -!- CAUTION: Was originally (PubMed:10218486) called angiopoietin-3.
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DR   EMBL; AF074332; AAD31728.1; -; mRNA.
DR   EMBL; AF113708; AAD21587.1; -; mRNA.
DR   EMBL; AL161939; CAC09933.2; -; Genomic_DNA.
DR   EMBL; AL050325; CAC09933.2; JOINED; Genomic_DNA.
DR   EMBL; AL050325; CAI22922.1; -; Genomic_DNA.
DR   EMBL; AL161939; CAI22922.1; JOINED; Genomic_DNA.
DR   EMBL; BC111976; AAI11977.1; -; mRNA.
DR   EMBL; BC111978; AAI11979.1; -; mRNA.
DR   IPI; IPI00031775; -.
DR   RefSeq; NP_057069.1; -.
DR   UniGene; Hs.278973; -.
DR   HSSP; P02671; 1FZD.
DR   PhosphoSite; Q9Y264; -.
DR   PRIDE; Q9Y264; -.
DR   Ensembl; ENSG00000101280; Homo sapiens.
DR   GeneID; 51378; -.
DR   KEGG; hsa:51378; -.
DR   UCSC; uc002wei.1; human.
DR   GeneCards; GC20M000801; -.
DR   H-InvDB; HIX0040505; -.
DR   HGNC; HGNC:487; ANGPT4.
DR   HPA; CAB013260; -.
DR   HPA; CAB013305; -.
DR   MIM; 603705; gene.
DR   PharmGKB; PA24793; -.
DR   HOGENOM; Q9Y264; -.
DR   HOVERGEN; Q9Y264; -.
DR   OMA; Q9Y264; LQGHELH.
DR   Pathway_Interaction_DB; angiopoietinreceptor_pathway; Angiopoietin receptor Tie2-mediated signaling.
DR   Reactome; REACT_604; Hemostasis.
DR   Reactome; REACT_6900; Signaling in Immune system.
DR   NextBio; 54879; -.
DR   ArrayExpress; Q9Y264; -.
DR   Bgee; Q9Y264; -.
DR   CleanEx; HS_ANGPT4; -.
DR   GermOnline; ENSG00000101280; Homo sapiens.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:receptor binding; IEA:InterPro.
DR   GO; GO:0030297; F:transmembrane receptor protein tyrosine kin...; NAS:UniProtKB.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C.
DR   InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR   Gene3D; G3DSA:3.90.215.10; Fibrinogen_a/b/g_C_1; 1.
DR   Pfam; PF00147; Fibrinogen_C; 1.
DR   SMART; SM00186; FBG; 1.
DR   PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Complete proteome; Disulfide bond; Glycoprotein;
KW   Polymorphism; Secreted; Signal.
FT   SIGNAL        1     24       Potential.
FT   CHAIN        25    503       Angiopoietin-4.
FT                                /FTId=PRO_0000009116.
FT   DOMAIN      282    502       Fibrinogen C-terminal.
FT   COILED       84    238       Potential.
FT   CARBOHYD     96     96       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    126    126       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    140    140       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    158    158       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    247    247       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    274    274       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    311    311       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    337    337       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    427    427       N-linked (GlcNAc...) (Potential).
FT   DISULFID    291    320       By similarity.
FT   DISULFID    444    457       By similarity.
FT   VARIANT     395    395       E -> K (in dbSNP:rs869171).
FT                                /FTId=VAR_049070.
SQ   SEQUENCE   503 AA;  56849 MW;  79CE52F66B532340 CRC64;
     MLSQLAMLQG SLLLVVATMS VAQQTRQEAD RGCETLVVQH GHCSYTFLLP KSEPCPPGPE
     VSRDSNTLQR ESLANPLHLG KLPTQQVKQL EQALQNNTQW LKKLERAIKT ILRSKLEQVQ
     QQMAQNQTAP MLELGTSLLN QTTAQIRKLT DMEAQLLNQT SRMDAQMPET FLSTNKLENQ
     LLLQRQKLQQ LQGQNSALEK RLQALETKQQ EELASILSKK AKLLNTLSRQ SAALTNIERG
     LRGVRHNSSL LQDQQHSLRQ LLVLLRHLVQ ERANASAPAF IMAGEQVFQD CAEIQRSGAS
     ASGVYTIQVS NATKPRKVFC DLQSSGGRWT LIQRRENGTV NFQRNWKDYK QGFGDPAGEH
     WLGNEVVHQL TRRAAYSLRV ELQDWEGHEA YAQYEHFHLG SENQLYRLSV VGYSGSAGRQ
     SSLVLQNTSF STLDSDNDHC LCKCAQVMSG GWWFDACGLS NLNGVYYHAP DNKYKMDGIR
     WHYFKGPSYS LRASRMMIRP LDI
//