ID   ANGP4_HUMAN             Reviewed;         503 AA.
AC   Q9Y264; Q9H4Z4;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   12-DEC-2006, entry version 45.
DE   Angiopoietin-4 precursor (ANG-4) (ANG-3).
GN   Name=ANGPT4; Synonyms=ANG3, ANG4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Aorta;
RX   MEDLINE=99232854; PubMed=10218486; DOI=10.1016/S0014-5793(99)00381-6;
RA   Nishimura M., Miki T., Yashima R., Yokoi N., Yano H., Sato Y.,
RA   Seino S.;
RT   "Angiopoietin-3, a novel member of the angiopoietin family.";
RL   FEBS Lett. 448:254-256(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RX   MEDLINE=99162530; PubMed=10051567; DOI=10.1073/pnas.96.5.1904;
RA   Valenzuela D.M., Griffiths J.A., Rojas J., Aldrich T.H., Jones P.F.,
RA   Zhou H., McClain J., Copeland N.G., Gilbert D.J., Jenkins N.A.,
RA   Huang T., Papadopoulos N., Maisonpierre P.C., Davis S.,
RA   Yancopoulos G.D.;
RT   "Angiopoietins 3 and 4: diverging gene counterparts in mice and
RT   humans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:1904-1909(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=21638749; PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
CC   -!- FUNCTION: Binds to tyrosine-protein kinase receptor TIE2 and
CC       activates it.
CC   -!- SUBCELLULAR LOCATION: Secreted protein (Probable).
CC   -!- TISSUE SPECIFICITY: Highly expressed in the lung with much lower
CC       levels found in other tissues.
CC   -!- SIMILARITY: Contains 1 fibrinogen C-terminal domain.
CC   -!- CAUTION: Was originally (Ref.1) called angiopoietin-3.
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DR   EMBL; AF074332; AAD31728.1; -; mRNA.
DR   EMBL; AF113708; AAD21587.1; -; mRNA.
DR   EMBL; AL161939; CAC09933.2; -; Genomic_DNA.
DR   EMBL; AL050325; CAC09933.2; JOINED; Genomic_DNA.
DR   UniGene; Hs.278973; -.
DR   HSSP; P02671; 1FZD.
DR   GermOnline; ENSG00000101280; Homo sapiens.
DR   Ensembl; ENSG00000101280; Homo sapiens.
DR   KEGG; hsa:51378; -.
DR   HGNC; HGNC:487; ANGPT4.
DR   MIM; 603705; gene.
DR   ArrayExpress; Q9Y264; -.
DR   GO; GO:0030297; F:transmembrane receptor protein tyrosine kin...; NAS:UniProtKB.
DR   InterPro; IPR002181; Fibrinogen_C.
DR   Pfam; PF00147; Fibrinogen_C; 1.
DR   SMART; SM00186; FBG; 1.
DR   PROSITE; PS00514; FIBRIN_AG_C_DOMAIN; 1.
KW   Coiled coil; Signal.
FT   SIGNAL        1     24       Potential.
FT   CHAIN        25    503       Angiopoietin-4.
FT                                /FTId=PRO_0000009116.
FT   DOMAIN      287    474       Fibrinogen C-terminal.
FT   COILED       84    238       Potential.
FT   DISULFID    291    320       By similarity.
FT   DISULFID    444    457       By similarity.
SQ   SEQUENCE   503 AA;  56849 MW;  79CE52F66B532340 CRC64;
     MLSQLAMLQG SLLLVVATMS VAQQTRQEAD RGCETLVVQH GHCSYTFLLP KSEPCPPGPE
     VSRDSNTLQR ESLANPLHLG KLPTQQVKQL EQALQNNTQW LKKLERAIKT ILRSKLEQVQ
     QQMAQNQTAP MLELGTSLLN QTTAQIRKLT DMEAQLLNQT SRMDAQMPET FLSTNKLENQ
     LLLQRQKLQQ LQGQNSALEK RLQALETKQQ EELASILSKK AKLLNTLSRQ SAALTNIERG
     LRGVRHNSSL LQDQQHSLRQ LLVLLRHLVQ ERANASAPAF IMAGEQVFQD CAEIQRSGAS
     ASGVYTIQVS NATKPRKVFC DLQSSGGRWT LIQRRENGTV NFQRNWKDYK QGFGDPAGEH
     WLGNEVVHQL TRRAAYSLRV ELQDWEGHEA YAQYEHFHLG SENQLYRLSV VGYSGSAGRQ
     SSLVLQNTSF STLDSDNDHC LCKCAQVMSG GWWFDACGLS NLNGVYYHAP DNKYKMDGIR
     WHYFKGPSYS LRASRMMIRP LDI
//