Q9Y264 (ANGP4_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 88.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Angiopoietin-4 Short name=ANG-4 Alternative name(s): Angiopoietin-3 Short name=ANG-3 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 503 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. Ref.5 |
| Subunit structure | Homodimer; disulfide-linked. Interacts with TEK/TIE2. Ref.5 |
| Subcellular location | Secreted Probable. |
| Tissue specificity | Highly expressed in the lung with much lower levels found in other tissues. |
| Sequence similarities | Contains 1 fibrinogen C-terminal domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 24 | 24 | Potential | ||||||||
| Chain | 25 – 503 | 479 | Angiopoietin-4 | PRO_0000009116 | |||||||
Regions | |||||||||||
| Domain | 282 – 502 | 221 | Fibrinogen C-terminal | ||||||||
| Coiled coil | 84 – 238 | 155 | Potential | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 96 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 126 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 140 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 158 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 247 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 274 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 311 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 337 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 427 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 291 ↔ 320 | By similarity | |||||||||
| Disulfide bond | 444 ↔ 457 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 395 | 1 | E → K. Corresponds to variant rs869171 [ dbSNP | Ensembl ]. | VAR_049070 | |||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF074332 mRNA. Translation: AAD31728.1. AF113708 mRNA. Translation: AAD21587.1. AL161939, AL050325 Genomic DNA. Translation: CAC09933.2. AL050325, AL161939 Genomic DNA. Translation: CAI22922.1. BC111976 mRNA. Translation: AAI11977.1. BC111978 mRNA. Translation: AAI11979.1. |
| IPI | IPI00031775. |
| RefSeq | NP_057069.1. NM_015985.2. |
| UniGene | Hs.278973. |
3D structure databases | |
| ProteinModelPortal | Q9Y264. |
| SMR | Q9Y264. Positions 287-502. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9Y264. 1 interaction. |
| STRING | Q9Y264. |
PTM databases | |
| PhosphoSite | Q9Y264. |
Polymorphism databases | |
| DMDM | 17433288. |
Proteomic databases | |
| PRIDE | Q9Y264. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000381922; ENSP00000371347; ENSG00000101280. |
| GeneID | 51378. |
| KEGG | hsa:51378. |
| UCSC | uc002wei.1. human. |
Organism-specific databases | |
| CTD | 51378. |
| GeneCards | GC20M000853. |
| H-InvDB | HIX0040505. |
| HGNC | HGNC:487. ANGPT4. |
| HPA | CAB013260. CAB013305. |
| MIM | 603705. gene. |
| neXtProt | NX_Q9Y264. |
| PharmGKB | PA24793. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG10211. |
| GeneTree | ENSGT00560000076679. |
| HOGENOM | HBG444111. |
| HOVERGEN | HBG001644. |
| InParanoid | Q9Y264. |
| OMA | QGHELHR. |
| OrthoDB | EOG4640C3. |
| PhylomeDB | Q9Y264. |
Enzyme and pathway databases | |
| Pathway_Interaction_DB | angiopoietinreceptor_pathway. Angiopoietin receptor Tie2-mediated signaling. |
| Reactome | REACT_604. Hemostasis. |
Gene expression databases | |
| ArrayExpress | Q9Y264. |
| Bgee | Q9Y264. |
| CleanEx | HS_ANGPT4. |
| Genevestigator | Q9Y264. |
| GermOnline | ENSG00000101280. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002181. Fibrinogen_a/b/g_C. IPR014716. Fibrinogen_a/b/g_C_1. IPR014715. Fibrinogen_a/b/g_C_2. IPR020837. Fibrinogen_CS. [Graphical view] |
| Gene3D | G3DSA:3.90.215.10. Fibrinogen_a/b/g_C_1. 1 hit. G3DSA:4.10.530.10. Fibrinogen_a/b/g_C_2. 1 hit. |
| KO | K05467. |
| Pfam | PF00147. Fibrinogen_C. 1 hit. [Graphical view] |
| SMART | SM00186. FBG. 1 hit. [Graphical view] |
| SUPFAM | SSF56496. Fibrinogen_a/b/g_C. 1 hit. |
| PROSITE | PS00514. FIBRINOGEN_C_1. 1 hit. PS51406. FIBRINOGEN_C_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 54879. |
| SOURCE | Search... |
Entry information
| Entry name | ANGP4_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9Y264 Secondary accession number(s): Q5TFF4, Q9H4Z4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 20 Human chromosome 20: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with