Reviewed, UniProtKB/Swiss-Prot Q9Y264 (ANGP4_HUMAN)

Names and origin

Protein names

Recommended name:
    Angiopoietin-4
      Short name=ANG-4
Alternative name(s):
    ANG-3

Gene names

Name:	ANGPT4
Synonyms:	ANG3, ANG4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds to tyrosine-protein kinase receptor TIE2 and activates it.
Subcellular location	SecretedProbable.
Tissue specificity	Highly expressed in the lung with much lower levels found in other tissues.
Sequence similarities	Contains 1 fibrinogen C-terminal domain.
Caution	Was originally (Ref.1) called angiopoietin-3.

Ontologies

Keywords
Cellular component	Secreted
Domain	Coiled coil Signal
PTM	Glycoprotein
Gene Ontology (GO)
Molecular function	transmembrane receptor protein tyrosine kinase activator activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 503	479	Angiopoietin-4		PRO_0000009116
Regions
	Domain	282 – 502	221	Fibrinogen C-terminal
	Coiled coil	84 – 238	155	Potential
Amino acid modifications
	Glycosylation	96	1	N-linked (GlcNAc...) Potential
	Glycosylation	126	1	N-linked (GlcNAc...) Potential
	Glycosylation	140	1	N-linked (GlcNAc...) Potential
	Glycosylation	158	1	N-linked (GlcNAc...) Potential
	Glycosylation	247	1	N-linked (GlcNAc...) Potential
	Glycosylation	274	1	N-linked (GlcNAc...) Potential
	Glycosylation	311	1	N-linked (GlcNAc...) Potential
	Glycosylation	337	1	N-linked (GlcNAc...) Potential
	Glycosylation	427	1	N-linked (GlcNAc...) Potential
	Disulfide bond	291 ↔ 320		By similarity
	Disulfide bond	444 ↔ 457		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9Y264-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 79CE52F66B532340	FASTA	503	56,849
	10 20 30 40 50 60 MLSQLAMLQG SLLLVVATMS VAQQTRQEAD RGCETLVVQH GHCSYTFLLP KSEPCPPGPE 70 80 90 100 110 120 VSRDSNTLQR ESLANPLHLG KLPTQQVKQL EQALQNNTQW LKKLERAIKT ILRSKLEQVQ 130 140 150 160 170 180 QQMAQNQTAP MLELGTSLLN QTTAQIRKLT DMEAQLLNQT SRMDAQMPET FLSTNKLENQ 190 200 210 220 230 240 LLLQRQKLQQ LQGQNSALEK RLQALETKQQ EELASILSKK AKLLNTLSRQ SAALTNIERG 250 260 270 280 290 300 LRGVRHNSSL LQDQQHSLRQ LLVLLRHLVQ ERANASAPAF IMAGEQVFQD CAEIQRSGAS 310 320 330 340 350 360 ASGVYTIQVS NATKPRKVFC DLQSSGGRWT LIQRRENGTV NFQRNWKDYK QGFGDPAGEH 370 380 390 400 410 420 WLGNEVVHQL TRRAAYSLRV ELQDWEGHEA YAQYEHFHLG SENQLYRLSV VGYSGSAGRQ 430 440 450 460 470 480 SSLVLQNTSF STLDSDNDHC LCKCAQVMSG GWWFDACGLS NLNGVYYHAP DNKYKMDGIR 490 500 WHYFKGPSYS LRASRMMIRP LDI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Angiopoietin-3, a novel member of the angiopoietin family." Nishimura M., Miki T., Yashima R., Yokoi N., Yano H., Sato Y., Seino S. FEBS Lett. 448:254-256(1999) [PubMed: 10218486] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Aorta.
[2]	"Angiopoietins 3 and 4: diverging gene counterparts in mice and humans." Valenzuela D.M., Griffiths J.A., Rojas J., Aldrich T.H., Jones P.F., Zhou H., McClain J., Copeland N.G., Gilbert D.J., Jenkins N.A., Huang T., Papadopoulos N., Maisonpierre P.C., Davis S., Yancopoulos G.D. Proc. Natl. Acad. Sci. U.S.A. 96:1904-1909(1999) [PubMed: 10051567] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF074332 mRNA. Translation: AAD31728.1. AF113708 mRNA. Translation: AAD21587.1. AL161939, AL050325 Genomic DNA. Translation: CAC09933.2. AL050325, AL161939 Genomic DNA. Translation: CAI22922.1. BC111976 mRNA. Translation: AAI11977.1. BC111978 mRNA. Translation: AAI11979.1.
RefSeq	NP_057069.1.
UniGene	Hs.278973
3D structure databases
HSSP	HSSP built from PDB template 1FZD based on UniProtKB P02671.
ModBase	Search...
PTM databases
PhosphoSite	Q9Y264.
Genome annotation databases
Ensembl	ENSG00000101280. Homo sapiens. [Contig view]
GeneID	51378.
KEGG	hsa:51378.
Organism-specific databases
H-InvDB	HIX0040505.
HGNC	HGNC:487. ANGPT4.
HPA	CAB013260. CAB013305.
MIM	603705. gene.
PharmGKB	PA24793.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q9Y264.
HOVERGEN	Q9Y264.
Gene expression databases
ArrayExpress	Q9Y264.
CleanEx	HS_ANGPT4.
GermOnline	ENSG00000101280. Homo sapiens.
Family and domain databases
InterPro	IPR002181. Fibrinogen_a/b/g_C. IPR014716. Fibrinogen_a/b/g_C_1. [Graphical view]
Gene3D	G3DSA:3.90.215.10. Fibrinogen_a/b/g_C_1. 1 hit.
Pfam	PF00147. Fibrinogen_C. 1 hit. [Graphical view]
SMART	SM00186. FBG. 1 hit. [Graphical view]
PROSITE	PS00514. FIBRINOGEN_C_1. 1 hit. PS51406. FIBRINOGEN_C_2. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...
Other Resources
NextBio	54879.
SOURCE	Search...

Entry information

Entry name

ANGP4_HUMAN

Accession

Primary (citable) accession number: Q9Y264
Secondary accession number(s): Q5TFF4, Q9H4Z4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
Last sequence update:	November 1, 1999
Last modified:	November 4, 2008
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)