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Protein

Angiopoietin-4

Gene

ANGPT4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.1 Publication

GO - Molecular functioni

  • receptor tyrosine kinase binding Source: UniProtKB
  • transmembrane receptor protein tyrosine kinase activator activity Source: UniProtKB

GO - Biological processi

  • angiogenesis Source: UniProtKB-KW
  • cellular response to hypoxia Source: UniProtKB
  • leukocyte migration Source: Reactome
  • negative regulation of angiogenesis Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of blood vessel endothelial cell migration Source: UniProtKB
  • Notch signaling pathway Source: Ensembl
  • positive regulation of angiogenesis Source: UniProtKB
  • positive regulation of blood vessel endothelial cell migration Source: UniProtKB
  • positive regulation of endothelial cell migration Source: UniProtKB
  • positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB

Keywordsi

Biological processAngiogenesis

Enzyme and pathway databases

ReactomeiR-HSA-210993 Tie2 Signaling
SignaLinkiQ9Y264
SIGNORiQ9Y264

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-4
Short name:
ANG-4
Alternative name(s):
Angiopoietin-3
Short name:
ANG-3
Gene namesi
Name:ANGPT4
Synonyms:ANG3, ANG4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101280.7
HGNCiHGNC:487 ANGPT4
MIMi603705 gene
neXtProtiNX_Q9Y264

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi51378
OpenTargetsiENSG00000101280
PharmGKBiPA24793

Polymorphism and mutation databases

BioMutaiANGPT4
DMDMi17433288

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000000911625 – 503Angiopoietin-4Add BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi247N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi291 ↔ 320PROSITE-ProRule annotation
Glycosylationi311N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi427N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi444 ↔ 457PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9Y264
PaxDbiQ9Y264
PeptideAtlasiQ9Y264
PRIDEiQ9Y264

PTM databases

iPTMnetiQ9Y264
PhosphoSitePlusiQ9Y264

Expressioni

Tissue specificityi

Highly expressed in the lung with much lower levels found in other tissues.

Gene expression databases

BgeeiENSG00000101280
CleanExiHS_ANGPT4
GenevisibleiQ9Y264 HS

Organism-specific databases

HPAiCAB013260
CAB013305

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with TEK/TIE2.1 Publication

GO - Molecular functioni

  • receptor tyrosine kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119510, 3 interactors
IntActiQ9Y264, 1 interactor
STRINGi9606.ENSP00000371347

Structurei

3D structure databases

ProteinModelPortaliQ9Y264
SMRiQ9Y264
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini282 – 502Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST221

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili84 – 238Sequence analysisAdd BLAST155

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00760000118809
HOGENOMiHOG000037128
HOVERGENiHBG001644
InParanoidiQ9Y264
KOiK05467
OMAiGIRWHYF
OrthoDBiEOG091G03M1
PhylomeDBiQ9Y264
TreeFamiTF336658

Family and domain databases

CDDicd00087 FReD, 1 hit
Gene3Di3.90.215.10, 2 hits
4.10.530.10, 1 hit
InterProiView protein in InterPro
IPR028845 Ang-4
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR014715 Fibrinogen_a/b/g_C_2
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PANTHERiPTHR19143:SF31 PTHR19143:SF31, 1 hit
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y264-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSQLAMLQG SLLLVVATMS VAQQTRQEAD RGCETLVVQH GHCSYTFLLP
60 70 80 90 100
KSEPCPPGPE VSRDSNTLQR ESLANPLHLG KLPTQQVKQL EQALQNNTQW
110 120 130 140 150
LKKLERAIKT ILRSKLEQVQ QQMAQNQTAP MLELGTSLLN QTTAQIRKLT
160 170 180 190 200
DMEAQLLNQT SRMDAQMPET FLSTNKLENQ LLLQRQKLQQ LQGQNSALEK
210 220 230 240 250
RLQALETKQQ EELASILSKK AKLLNTLSRQ SAALTNIERG LRGVRHNSSL
260 270 280 290 300
LQDQQHSLRQ LLVLLRHLVQ ERANASAPAF IMAGEQVFQD CAEIQRSGAS
310 320 330 340 350
ASGVYTIQVS NATKPRKVFC DLQSSGGRWT LIQRRENGTV NFQRNWKDYK
360 370 380 390 400
QGFGDPAGEH WLGNEVVHQL TRRAAYSLRV ELQDWEGHEA YAQYEHFHLG
410 420 430 440 450
SENQLYRLSV VGYSGSAGRQ SSLVLQNTSF STLDSDNDHC LCKCAQVMSG
460 470 480 490 500
GWWFDACGLS NLNGVYYHAP DNKYKMDGIR WHYFKGPSYS LRASRMMIRP

LDI
Length:503
Mass (Da):56,849
Last modified:November 1, 1999 - v1
Checksum:i79CE52F66B532340
GO
Isoform 2 (identifier: Q9Y264-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     408-503: LSVVGYSGSA...SRMMIRPLDI → VVV

Note: No experimental confirmation available.
Show »
Length:410
Mass (Da):46,416
Checksum:iD400123988B77BD8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049070395E → K. Corresponds to variant dbSNP:rs869171Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055091408 – 503LSVVG…RPLDI → VVV in isoform 2. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074332 mRNA Translation: AAD31728.1
AF113708 mRNA Translation: AAD21587.1
AK304756 mRNA Translation: BAG65511.1
AL050325 Genomic DNA No translation available.
AL161939 Genomic DNA No translation available.
BC111976 mRNA Translation: AAI11977.1
BC111978 mRNA Translation: AAI11979.1
CCDSiCCDS13009.1 [Q9Y264-1]
RefSeqiNP_001309738.1, NM_001322809.1 [Q9Y264-2]
NP_057069.1, NM_015985.3 [Q9Y264-1]
UniGeneiHs.278973
Hs.565714

Genome annotation databases

EnsembliENST00000381922; ENSP00000371347; ENSG00000101280 [Q9Y264-1]
GeneIDi51378
KEGGihsa:51378
UCSCiuc002wei.4 human [Q9Y264-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiANGP4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y264
Secondary accession number(s): B4E3J9, Q5TFF4, Q9H4Z4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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