Angiopoietin-4 precursor - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q9Y264 (ANGP4_HUMAN)

Last modified June 16, 2009. Version 65. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Angiopoietin-4
      Short name=ANG-4
Alternative name(s):
    ANG-3

Gene names

Name:	ANGPT4
Synonyms:	ANG3, ANG4

Organism

Homo sapiens (Human)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds to tyrosine-protein kinase receptor TIE2 and activates it.
Subcellular location	Secreted Probable.
Tissue specificity	Highly expressed in the lung with much lower levels found in other tissues.
Sequence similarities	Contains 1 fibrinogen C-terminal domain.
Caution	Was originally (Ref.1) called angiopoietin-3.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Coiled coil Signal
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	receptor binding Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase activator activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

24

Potential

Chain

479

Angiopoietin-4

PRO_0000009116

Regions

Domain

221

Fibrinogen C-terminal

Coiled coil

155

Potential

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Disulfide bond

By similarity

Disulfide bond

By similarity

Natural variations

Natural variant

1

E → K: dbSNP rs869171.

VAR_049070

Sequences

Sequence

Length

Mass (Da)

Tools

Q9Y264-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 79CE52F66B532340
Show »

503

56,849

        10         20         30         40         50         60 
MLSQLAMLQG SLLLVVATMS VAQQTRQEAD RGCETLVVQH GHCSYTFLLP KSEPCPPGPE 

        70         80         90        100        110        120 
VSRDSNTLQR ESLANPLHLG KLPTQQVKQL EQALQNNTQW LKKLERAIKT ILRSKLEQVQ 

       130        140        150        160        170        180 
QQMAQNQTAP MLELGTSLLN QTTAQIRKLT DMEAQLLNQT SRMDAQMPET FLSTNKLENQ 

       190        200        210        220        230        240 
LLLQRQKLQQ LQGQNSALEK RLQALETKQQ EELASILSKK AKLLNTLSRQ SAALTNIERG 

       250        260        270        280        290        300 
LRGVRHNSSL LQDQQHSLRQ LLVLLRHLVQ ERANASAPAF IMAGEQVFQD CAEIQRSGAS 

       310        320        330        340        350        360 
ASGVYTIQVS NATKPRKVFC DLQSSGGRWT LIQRRENGTV NFQRNWKDYK QGFGDPAGEH 

       370        380        390        400        410        420 
WLGNEVVHQL TRRAAYSLRV ELQDWEGHEA YAQYEHFHLG SENQLYRLSV VGYSGSAGRQ 

       430        440        450        460        470        480 
SSLVLQNTSF STLDSDNDHC LCKCAQVMSG GWWFDACGLS NLNGVYYHAP DNKYKMDGIR 

       490        500 
WHYFKGPSYS LRASRMMIRP LDI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Angiopoietin-3, a novel member of the angiopoietin family." Nishimura M., Miki T., Yashima R., Yokoi N., Yano H., Sato Y., Seino S. FEBS Lett. 448:254-256(1999) [PubMed: 10218486] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Aorta.
[2]	"Angiopoietins 3 and 4: diverging gene counterparts in mice and humans." Valenzuela D.M., Griffiths J.A., Rojas J., Aldrich T.H., Jones P.F., Zhou H., McClain J., Copeland N.G., Gilbert D.J., Jenkins N.A., Huang T., Papadopoulos N., Maisonpierre P.C., Davis S., Yancopoulos G.D. Proc. Natl. Acad. Sci. U.S.A. 96:1904-1909(1999) [PubMed: 10051567] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
	AF074332 mRNA. Translation: AAD31728.1. AF113708 mRNA. Translation: AAD21587.1. AL161939, AL050325 Genomic DNA. Translation: CAC09933.2. AL050325, AL161939 Genomic DNA. Translation: CAI22922.1. BC111976 mRNA. Translation: AAI11977.1. BC111978 mRNA. Translation: AAI11979.1.
IPI	IPI00031775.
RefSeq	NP_057069.1.
UniGene	Hs.278973
3D structure databases
HSSP	HSSP built from PDB template 1FZD based on UniProtKB P02671.
ModBase	Search...
PTM databases
PhosphoSite	Q9Y264.
Proteomic databases
PRIDE	Q9Y264.
Genome annotation databases
Ensembl	ENSG00000101280. Homo sapiens. [Contig view]
GeneID	51378.
KEGG	hsa:51378.
Organism-specific databases
GeneCards	GC20M000801.
H-InvDB	HIX0040505.
HGNC	HGNC:487. ANGPT4.
HPA	CAB013260. CAB013305.
MIM	603705. gene.
PharmGKB	PA24793.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9Y264.
HOVERGEN	Q9Y264.
OMA	Q9Y264. LQGHELH.
Enzyme and pathway databases
Pathway_Interaction_DB	angiopoietinreceptor_pathway. Angiopoietin receptor Tie2-mediated signaling.
Reactome	REACT_604. Hemostasis. REACT_6900. Signaling in Immune system.
Gene expression databases
ArrayExpress	Q9Y264.
Bgee	Q9Y264.
CleanEx	HS_ANGPT4.
GermOnline	ENSG00000101280. Homo sapiens.
Family and domain databases
InterPro	IPR002181. Fibrinogen_a/b/g_C. IPR014716. Fibrinogen_a/b/g_C_1. [Graphical view]
Gene3D	G3DSA:3.90.215.10. Fibrinogen_a/b/g_C_1. 1 hit.
Pfam	PF00147. Fibrinogen_C. 1 hit. [Graphical view]
SMART	SM00186. FBG. 1 hit. [Graphical view]
PROSITE	PS00514. FIBRINOGEN_C_1. 1 hit. PS51406. FIBRINOGEN_C_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	54879.
SOURCE	Search...

Entry information

Entry name

ANGP4_HUMAN

Accession

Primary (citable) accession number: Q9Y264
Secondary accession number(s): Q5TFF4, Q9H4Z4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
Last sequence update:	November 1, 1999
Last modified:	June 16, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Relevant documents

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents