Reviewed, UniProtKB/Swiss-Prot Q9Y263 (PLAP_HUMAN)

Names and origin

Protein names

Recommended name:
    Phospholipase A-2-activating protein
      Short name=PLA2P
      Short name=PLAP

Gene names

Name:	PLAA
Synonyms:	PLAP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	795 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Plays an important role in the regulation of specific inflammatory disease processes By similarity.
Sequence similarities	Belongs to the WD repeat PLAP family. Contains 1 PFU domain. Contains 1 PUL domain. Contains 7 WD repeats.
Sequence caution	The sequence AAD42075.1 differs from that shown. Reason: Frameshift at position 698. The sequence BAA92105.1 differs from that shown. Reason: Erroneous termination at position 545. Translated as Gln. The sequence CAH72641.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Domain	Repeat WD repeat
Gene Ontology (GO)
Biological process	phospholipid metabolic process Ref.8 Traceable author statement. Source: ProtInc signal transduction Ref.8 Traceable author statement. Source: ProtInc
Molecular function	phospholipase A2 activator activity Ref.8 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 795	795	Phospholipase A-2-activating protein		PRO_0000051130
Regions
	Repeat	17 – 56	40	WD 1
	Repeat	63 – 107	45	WD 2
	Repeat	110 – 148	39	WD 3
	Repeat	149 – 188	40	WD 4
	Repeat	190 – 227	38	WD 5
	Repeat	229 – 268	40	WD 6
	Repeat	270 – 307	38	WD 7
	Domain	366 – 465	100	PFU
	Domain	533 – 794	262	PUL
Experimental info
	Sequence conflict	14	1	L → F Ref.5
	Sequence conflict	57	1	E → D Ref.5
	Sequence conflict	86	1	A → F in AAD42075. Ref.5
	Sequence conflict	97	1	F → L in AAD42075. Ref.5
	Sequence conflict	172	1	D → G in BAA91803. Ref.2
	Sequence conflict	363	1	E → K in BAD97264. Ref.6
	Sequence conflict	422	1	T → A in AAD42075. Ref.5
	Sequence conflict	520	1	N → S in BAA92105. Ref.2
	Sequence conflict	531	1	M → L in AAD42075. Ref.5
	Sequence conflict	541	1	V → L in AAD42075. Ref.5
	Sequence conflict	746	1	L → P Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q9Y263-1 [UniParc]. Last modified June 13, 2006. Version 2. Checksum: D6E7330AC9891637	FASTA	795	87,157
	10 20 30 40 50 60 MTSGATRYRL SCSLRGHELD VRGLVCCAYP PGAFVSVSRD RTTRLWAPDS PNRSFTEMHC 70 80 90 100 110 120 MSGHSNFVSC VCIIPSSDIY PHGLIATGGN DHNICIFSLD SPMPLYILKG HKNTVCSLSS 130 140 150 160 170 180 GKFGTLLSGS WDTTAKVWLN DKCMMTLQGH TAAVWAVKIL PEQGLMLTGS ADKTVKLWKA 190 200 210 220 230 240 GRCERTFSGH EDCVRGLAIL SETEFLSCAN DASIRRWQIT GECLEVYYGH TNYIYSISVF 250 260 270 280 290 300 PNCRDFVTTA EDRSLRIWKH GECAQTIRLP AQSIWCCCVL DNGDIVVGAS DGIIRVFTES 310 320 330 340 350 360 EDRTASAEEI KAFEKELSHA TIDSKTGDLG DINAEQLPGR EHLNEPGTRE GQTRLIRDGE 370 380 390 400 410 420 KVEAYQWSVS EGRWIKIGDV VGSSGANQQT SGKVLYEGKE FDYVFSIDVN EGGPSYKLPY 430 440 450 460 470 480 NTSDDPWLTA YNFLQKNDLN PMFLDQVAKF IIDNTKGQML GLGNPSFSDP FTGGGRYVPG 490 500 510 520 530 540 SSGSSNTLPT ADPFTGAGRY VPGSASMGTT MAGVDPFTGN SAYRSAASKT MNIYFPKKEA 550 560 570 580 590 600 VTFDQANPTQ ILGKLKELNG TAPEEKKLTE DDLILLEKIL SLICNSSSEK PTVQQLQILW 610 620 630 640 650 660 KAINCPEDIV FPALDILRLS IKHPSVNENF CNEKEGAQFS SHLINLLNPK GKPANQLLAL 670 680 690 700 710 720 RTFCNCFVGQ AGQKLMMSQR ESLMSHAIEL KSGSNKNIHI ALATLALNYS VCFHKDHNIE 730 740 750 760 770 780 GKAQCLSLIS TILEVVQDLE ATFRLLVALG TLISDDSNAV QLAKSLGVDS QIKKYSSVSE 790 PAKVSECCRF ILNLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	The German cDNA consortium Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[5]	"Chromosomal localization of phospholipase A2 activating protein, an ets2 target gene, to 9p21." Beatty B., Qi S., Pienkowska M., Scherer S.W., Testa J.R., Cheng J.Q., Herbrick J.-A., Scheidl T., Zhang Z., Kola I., Seth A. Genomics 62:529-532(1999) [PubMed: 10644453] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-795.
[6]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 48-795. Tissue: Kidney.
[7]	"Cloning of the human phospholipase A2 activating protein (hPLAP) gene on the chromosome 9p21 melanoma deleted region." Ruiz A., Nadal M., Puig S., Estivill X. Gene 239:155-161(1999) [PubMed: 10571045] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-795. Tissue: Fetal brain.
[8]	"Molecular characterization of cDNA for phospholipase A2-activating protein." Chopra A.K., Ribardo D.A., Wood T.G., Prusak D.J., Xu X.-J., Peterson J.W. Biochim. Biophys. Acta 1444:125-130(1999) [PubMed: 9931468] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 58-795.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL133608 mRNA. Translation: CAB63739.1. AK001642 mRNA. Translation: BAA91803.1. AK002143 mRNA. Translation: BAA92105.1. AL356133 Genomic DNA. Translation: CAH72641.1. Sequence problems. BC032551 mRNA. Translation: AAH32551.1. AF145020 mRNA. Translation: AAD42075.1. Sequence problems. AK223544 mRNA. Translation: BAD97264.1. AJ238243 mRNA. Translation: CAB42881.1. Different initiation. AF083395 mRNA. Translation: AAD03030.1. Different initiation.
PIR	T43447.
RefSeq	NP_001026859.1. NP_004244.1.
UniGene	Hs.27182
3D structure databases
HSSP	HSSP built from PDB template 1NEX based on UniProtKB P07834.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000137055. Homo sapiens. [Contig view]
GeneID	9373.
KEGG	hsa:9373.
Organism-specific databases
H-InvDB	HIX0007960.
HGNC	HGNC:9043. PLAA.
HPA	CAB005035.
MIM	603873. gene.
PharmGKB	PA33370.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q9Y263.
Gene expression databases
ArrayExpress	Q9Y263.
CleanEx	HS_PLAA.
GermOnline	ENSG00000137055. Homo sapiens.
Family and domain databases
InterPro	IPR015155. PFU. IPR013535. PUL. IPR015943. WD40/YVTN_repeat-like. IPR001680. WD40_repeat. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF09070. PFU. 1 hit. PF08324. PUL. 1 hit. PF00400. WD40. 7 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
ProDom	PD000018. WD40. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00320. WD40. 7 hits. [Graphical view]
PROSITE	PS51394. PFU. 1 hit. PS51396. PUL. 1 hit. PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. 3 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...
Other Resources
NextBio	35110.
SOURCE	Search...

Entry information

Entry name

PLAP_HUMAN

Accession

Primary (citable) accession number: Q9Y263
Secondary accession number(s): Q53EU5 , Q5VY33, Q9NUL8, Q9NVE9, Q9UF53, Q9Y5L1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	June 13, 2006
Last modified:	November 4, 2008
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)