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Protein

Phospholipase A-2-activating protein

Gene

PLAA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the maintenance of ubiquitin levels.By similarity

GO - Molecular functioni

  • phospholipase A2 activator activity Source: ProtInc
  • ubiquitin binding Source: GO_Central

GO - Biological processi

  • inflammatory response Source: Ensembl
  • phospholipid metabolic process Source: ProtInc
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
  • signal transduction Source: ProtInc
  • ubiquitin homeostasis Source: GO_Central
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137055-MONOMER.
SignaLinkiQ9Y263.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase A-2-activating protein
Short name:
PLA2P
Short name:
PLAP
Gene namesi
Name:PLAA
Synonyms:PLAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:9043. PLAA.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • nucleus Source: GO_Central
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi9373.
OpenTargetsiENSG00000137055.
PharmGKBiPA33370.

Chemistry databases

ChEMBLiCHEMBL6114.

Polymorphism and mutation databases

BioMutaiPLAA.
DMDMi108935868.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511301 – 795Phospholipase A-2-activating proteinAdd BLAST795

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50PhosphoserineCombined sources1
Modified residuei529N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y263.
MaxQBiQ9Y263.
PaxDbiQ9Y263.
PeptideAtlasiQ9Y263.
PRIDEiQ9Y263.

PTM databases

iPTMnetiQ9Y263.
PhosphoSitePlusiQ9Y263.

Expressioni

Gene expression databases

BgeeiENSG00000137055.
CleanExiHS_PLAA.
ExpressionAtlasiQ9Y263. baseline and differential.
GenevisibleiQ9Y263. HS.

Organism-specific databases

HPAiCAB005035.
HPA020994.
HPA020996.

Interactioni

Subunit structurei

Interacts with ubiquitin. Interacts with VCP.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Q763533EBI-1994037,EBI-6248077From a different organism.
HEL-S-70V9HW803EBI-1994037,EBI-10175326
KPNA4O006293EBI-1994037,EBI-396343
UBXN1Q043235EBI-1994037,EBI-1058647

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114774. 37 interactors.
IntActiQ9Y263. 16 interactors.
MINTiMINT-3084225.
STRINGi9606.ENSP00000380460.

Chemistry databases

BindingDBiQ9Y263.

Structurei

Secondary structure

1795
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi390 – 392Combined sources3
Beta strandi394 – 396Combined sources3
Beta strandi399 – 407Combined sources9
Beta strandi410 – 412Combined sources3
Beta strandi416 – 420Combined sources5
Helixi426 – 437Combined sources12
Helixi443 – 455Combined sources13
Turni457 – 460Combined sources4
Helixi548 – 559Combined sources12
Helixi564 – 566Combined sources3
Helixi571 – 584Combined sources14
Helixi593 – 603Combined sources11
Turni607 – 609Combined sources3
Helixi611 – 620Combined sources10
Helixi624 – 631Combined sources8
Turni633 – 635Combined sources3
Helixi636 – 645Combined sources10
Helixi653 – 665Combined sources13
Helixi666 – 668Combined sources3
Helixi670 – 678Combined sources9
Helixi680 – 688Combined sources9
Helixi689 – 691Combined sources3
Helixi696 – 715Combined sources20
Helixi719 – 733Combined sources15
Helixi739 – 753Combined sources15
Helixi757 – 765Combined sources9
Helixi768 – 771Combined sources4
Helixi772 – 777Combined sources6
Helixi782 – 792Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K89NMR-A386-465[»]
2K8ANMR-A386-465[»]
2K8BNMR-B386-465[»]
2K8CNMR-B386-465[»]
3EBBX-ray1.90A/B/C/D511-795[»]
ProteinModelPortaliQ9Y263.
SMRiQ9Y263.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y263.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati17 – 56WD 1Add BLAST40
Repeati63 – 107WD 2Add BLAST45
Repeati110 – 148WD 3Add BLAST39
Repeati149 – 188WD 4Add BLAST40
Repeati190 – 227WD 5Add BLAST38
Repeati229 – 268WD 6Add BLAST40
Repeati270 – 307WD 7Add BLAST38
Domaini366 – 465PFUPROSITE-ProRule annotationAdd BLAST100
Domaini533 – 794PULPROSITE-ProRule annotationAdd BLAST262
Repeati546 – 588ARM 1Add BLAST43
Repeati589 – 620ARM 2Add BLAST32
Repeati621 – 669ARM 3Add BLAST49
Repeati670 – 715ARM 4Add BLAST46
Repeati716 – 755ARM 5Add BLAST40
Repeati756 – 795ARM 6Add BLAST40

Domaini

The PUL domain is composed of 6 armadillo-like repeats and mediates the interaction with VCP C-terminus.1 Publication
The PFU domain mediates interaction with ubiquitin.1 Publication

Sequence similaritiesi

Belongs to the WD repeat PLAP family.Curated
Contains 6 ARM repeats.Curated
Contains 1 PFU domain.PROSITE-ProRule annotation
Contains 1 PUL domain.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0301. Eukaryota.
ENOG410XS67. LUCA.
GeneTreeiENSGT00550000074944.
HOGENOMiHOG000174247.
HOVERGENiHBG008204.
InParanoidiQ9Y263.
KOiK14018.
OMAiIPSSDMY.
OrthoDBiEOG091G06FX.
PhylomeDBiQ9Y263.
TreeFamiTF105944.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR016024. ARM-type_fold.
IPR033510. PLAA/Doa1/Lub1.
IPR015155. PLAA_fam_Ub-bd_PFU.
IPR013535. PUL_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19849:SF0. PTHR19849:SF0. 1 hit.
PfamiPF09070. PFU. 1 hit.
PF08324. PUL. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS51394. PFU. 1 hit.
PS51396. PUL. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y263-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSGATRYRL SCSLRGHELD VRGLVCCAYP PGAFVSVSRD RTTRLWAPDS
60 70 80 90 100
PNRSFTEMHC MSGHSNFVSC VCIIPSSDIY PHGLIATGGN DHNICIFSLD
110 120 130 140 150
SPMPLYILKG HKNTVCSLSS GKFGTLLSGS WDTTAKVWLN DKCMMTLQGH
160 170 180 190 200
TAAVWAVKIL PEQGLMLTGS ADKTVKLWKA GRCERTFSGH EDCVRGLAIL
210 220 230 240 250
SETEFLSCAN DASIRRWQIT GECLEVYYGH TNYIYSISVF PNCRDFVTTA
260 270 280 290 300
EDRSLRIWKH GECAQTIRLP AQSIWCCCVL DNGDIVVGAS DGIIRVFTES
310 320 330 340 350
EDRTASAEEI KAFEKELSHA TIDSKTGDLG DINAEQLPGR EHLNEPGTRE
360 370 380 390 400
GQTRLIRDGE KVEAYQWSVS EGRWIKIGDV VGSSGANQQT SGKVLYEGKE
410 420 430 440 450
FDYVFSIDVN EGGPSYKLPY NTSDDPWLTA YNFLQKNDLN PMFLDQVAKF
460 470 480 490 500
IIDNTKGQML GLGNPSFSDP FTGGGRYVPG SSGSSNTLPT ADPFTGAGRY
510 520 530 540 550
VPGSASMGTT MAGVDPFTGN SAYRSAASKT MNIYFPKKEA VTFDQANPTQ
560 570 580 590 600
ILGKLKELNG TAPEEKKLTE DDLILLEKIL SLICNSSSEK PTVQQLQILW
610 620 630 640 650
KAINCPEDIV FPALDILRLS IKHPSVNENF CNEKEGAQFS SHLINLLNPK
660 670 680 690 700
GKPANQLLAL RTFCNCFVGQ AGQKLMMSQR ESLMSHAIEL KSGSNKNIHI
710 720 730 740 750
ALATLALNYS VCFHKDHNIE GKAQCLSLIS TILEVVQDLE ATFRLLVALG
760 770 780 790
TLISDDSNAV QLAKSLGVDS QIKKYSSVSE PAKVSECCRF ILNLL
Length:795
Mass (Da):87,157
Last modified:June 13, 2006 - v2
Checksum:iD6E7330AC9891637
GO

Sequence cautioni

The sequence AAD03030 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAD42075 differs from that shown. Reason: Frameshift at position 698.Curated
The sequence AAD42075 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA92105 differs from that shown. Reason: Erroneous termination at position 545. Translated as Gln.Curated
The sequence BAD97264 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB42881 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAH72641 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14L → F in AAD42075 (PubMed:10644453).Curated1
Sequence conflicti57E → D in AAD42075 (PubMed:10644453).Curated1
Sequence conflicti86A → F in AAD42075 (PubMed:10644453).Curated1
Sequence conflicti97F → L in AAD42075 (PubMed:10644453).Curated1
Sequence conflicti172D → G in BAA91803 (PubMed:14702039).Curated1
Sequence conflicti363E → K in BAD97264 (Ref. 6) Curated1
Sequence conflicti422T → A in AAD42075 (PubMed:10644453).Curated1
Sequence conflicti520N → S in BAA92105 (PubMed:14702039).Curated1
Sequence conflicti531M → L in AAD42075 (PubMed:10644453).Curated1
Sequence conflicti541V → L in AAD42075 (PubMed:10644453).Curated1
Sequence conflicti746L → P in AAD42075 (PubMed:10644453).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001642 mRNA. Translation: BAA91803.1.
AK002143 mRNA. Translation: BAA92105.1. Sequence problems.
AL133608 mRNA. Translation: CAB63739.1.
AL356133 Genomic DNA. Translation: CAH72641.1. Sequence problems.
BC032551 mRNA. Translation: AAH32551.1.
AF145020 mRNA. Translation: AAD42075.1. Sequence problems.
AK223544 mRNA. Translation: BAD97264.1. Different initiation.
AJ238243 mRNA. Translation: CAB42881.1. Different initiation.
AF083395 mRNA. Translation: AAD03030.1. Different initiation.
CCDSiCCDS35000.1.
PIRiT43447.
RefSeqiNP_001026859.1. NM_001031689.2.
UniGeneiHs.27182.

Genome annotation databases

EnsembliENST00000397292; ENSP00000380460; ENSG00000137055.
GeneIDi9373.
KEGGihsa:9373.
UCSCiuc003zqd.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001642 mRNA. Translation: BAA91803.1.
AK002143 mRNA. Translation: BAA92105.1. Sequence problems.
AL133608 mRNA. Translation: CAB63739.1.
AL356133 Genomic DNA. Translation: CAH72641.1. Sequence problems.
BC032551 mRNA. Translation: AAH32551.1.
AF145020 mRNA. Translation: AAD42075.1. Sequence problems.
AK223544 mRNA. Translation: BAD97264.1. Different initiation.
AJ238243 mRNA. Translation: CAB42881.1. Different initiation.
AF083395 mRNA. Translation: AAD03030.1. Different initiation.
CCDSiCCDS35000.1.
PIRiT43447.
RefSeqiNP_001026859.1. NM_001031689.2.
UniGeneiHs.27182.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K89NMR-A386-465[»]
2K8ANMR-A386-465[»]
2K8BNMR-B386-465[»]
2K8CNMR-B386-465[»]
3EBBX-ray1.90A/B/C/D511-795[»]
ProteinModelPortaliQ9Y263.
SMRiQ9Y263.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114774. 37 interactors.
IntActiQ9Y263. 16 interactors.
MINTiMINT-3084225.
STRINGi9606.ENSP00000380460.

Chemistry databases

BindingDBiQ9Y263.
ChEMBLiCHEMBL6114.

PTM databases

iPTMnetiQ9Y263.
PhosphoSitePlusiQ9Y263.

Polymorphism and mutation databases

BioMutaiPLAA.
DMDMi108935868.

Proteomic databases

EPDiQ9Y263.
MaxQBiQ9Y263.
PaxDbiQ9Y263.
PeptideAtlasiQ9Y263.
PRIDEiQ9Y263.

Protocols and materials databases

DNASUi9373.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397292; ENSP00000380460; ENSG00000137055.
GeneIDi9373.
KEGGihsa:9373.
UCSCiuc003zqd.4. human.

Organism-specific databases

CTDi9373.
DisGeNETi9373.
GeneCardsiPLAA.
HGNCiHGNC:9043. PLAA.
HPAiCAB005035.
HPA020994.
HPA020996.
MIMi603873. gene.
neXtProtiNX_Q9Y263.
OpenTargetsiENSG00000137055.
PharmGKBiPA33370.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0301. Eukaryota.
ENOG410XS67. LUCA.
GeneTreeiENSGT00550000074944.
HOGENOMiHOG000174247.
HOVERGENiHBG008204.
InParanoidiQ9Y263.
KOiK14018.
OMAiIPSSDMY.
OrthoDBiEOG091G06FX.
PhylomeDBiQ9Y263.
TreeFamiTF105944.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137055-MONOMER.
SignaLinkiQ9Y263.

Miscellaneous databases

ChiTaRSiPLAA. human.
EvolutionaryTraceiQ9Y263.
GeneWikiiPLAA_(gene).
GenomeRNAii9373.
PROiQ9Y263.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137055.
CleanExiHS_PLAA.
ExpressionAtlasiQ9Y263. baseline and differential.
GenevisibleiQ9Y263. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR016024. ARM-type_fold.
IPR033510. PLAA/Doa1/Lub1.
IPR015155. PLAA_fam_Ub-bd_PFU.
IPR013535. PUL_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19849:SF0. PTHR19849:SF0. 1 hit.
PfamiPF09070. PFU. 1 hit.
PF08324. PUL. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS51394. PFU. 1 hit.
PS51396. PUL. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLAP_HUMAN
AccessioniPrimary (citable) accession number: Q9Y263
Secondary accession number(s): Q53EU5
, Q5VY33, Q9NUL8, Q9NVE9, Q9UF53, Q9Y5L1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 13, 2006
Last modified: November 30, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.