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Q9Y261

- FOXA2_HUMAN

UniProt

Q9Y261 - FOXA2_HUMAN

Protein

Hepatocyte nuclear factor 3-beta

Gene

FOXA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' By similarity. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi159 – 25294Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: BHF-UCL
    3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    5. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. adult locomotory behavior Source: Ensembl
    2. cell development Source: Ensembl
    3. cell differentiation in hindbrain Source: Ensembl
    4. chromatin modification Source: UniProtKB-KW
    5. connective tissue development Source: Ensembl
    6. dopaminergic neuron differentiation Source: Ensembl
    7. dorsal/ventral neural tube patterning Source: Ensembl
    8. ectoderm formation Source: Ensembl
    9. endocrine pancreas development Source: BHF-UCL
    10. epithelial tube branching involved in lung morphogenesis Source: Ensembl
    11. in utero embryonic development Source: Ensembl
    12. lung epithelial cell differentiation Source: Ensembl
    13. negative regulation of detection of glucose Source: BHF-UCL
    14. negative regulation of epithelial to mesenchymal transition Source: BHF-UCL
    15. negative regulation of glucokinase activity Source: BHF-UCL
    16. negative regulation of neuron differentiation Source: Ensembl
    17. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    18. negative regulation of transcription from RNA polymerase II promoter by glucose Source: BHF-UCL
    19. neuron fate specification Source: Ensembl
    20. positive regulation of cell-cell adhesion mediated by cadherin Source: BHF-UCL
    21. positive regulation of embryonic development Source: UniProtKB
    22. positive regulation of gastrulation Source: UniProtKB
    23. positive regulation of neuron differentiation Source: Ensembl
    24. positive regulation of smoothened signaling pathway Source: Ensembl
    25. positive regulation of transcription, DNA-templated Source: UniProtKB
    26. positive regulation of transcription from RNA polymerase III promoter Source: Ensembl
    27. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    28. positive regulation of transcription from RNA polymerase II promoter by glucose Source: BHF-UCL
    29. primitive streak formation Source: UniProtKB
    30. regulation of blood coagulation Source: UniProtKB
    31. regulation of insulin secretion involved in cellular response to glucose stimulus Source: BHF-UCL
    32. regulation of steroid metabolic process Source: Ensembl
    33. regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    34. regulation of transcription from RNA polymerase II promoter involved in detection of glucose Source: BHF-UCL
    35. response to interleukin-6 Source: UniProtKB
    36. signal transduction involved in regulation of gene expression Source: Ensembl
    37. somite rostral/caudal axis specification Source: Ensembl

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_13819. Regulation of gene expression in beta cells.
    SignaLinkiQ9Y261.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hepatocyte nuclear factor 3-beta
    Short name:
    HNF-3-beta
    Short name:
    HNF-3B
    Alternative name(s):
    Forkhead box protein A2
    Transcription factor 3B
    Short name:
    TCF-3B
    Gene namesi
    Name:FOXA2
    Synonyms:HNF3B, TCF3B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:5022. FOXA2.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation. Cytoplasm 1 Publication
    Note: Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA201091.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 457457Hepatocyte nuclear factor 3-betaPRO_0000091795Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei156 – 1561PhosphothreonineBy similarity
    Modified residuei212 – 2121PhosphoserineBy similarity
    Modified residuei283 – 2831PhosphoserineBy similarity
    Modified residuei303 – 3031PhosphoserineBy similarity
    Modified residuei306 – 3061PhosphoserineBy similarity
    Modified residuei307 – 3071PhosphoserineBy similarity
    Modified residuei309 – 3091PhosphoserineBy similarity
    Modified residuei436 – 4361PhosphoserineBy similarity
    Modified residuei457 – 4571PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylation on Thr-156 abolishes binding to target promoters and subsequent transcription activation upon insulin stimulation.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y261.
    PaxDbiQ9Y261.
    PRIDEiQ9Y261.

    PTM databases

    PhosphoSiteiQ9Y261.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y261.
    BgeeiQ9Y261.
    CleanExiHS_FOXA2.
    GenevestigatoriQ9Y261.

    Organism-specific databases

    HPAiCAB001388.

    Interactioni

    Subunit structurei

    Binds DNA as a monomer. Binds TLE1 By similarity. Interacts with FOXA1 and FOXA3. Interacts with PRKDC.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi109412. 10 interactions.
    IntActiQ9Y261. 1 interaction.
    MINTiMINT-6610868.
    STRINGi9606.ENSP00000315955.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y261.
    SMRiQ9Y261. Positions 157-256.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni14 – 9380Transactivation domain 1By similarityAdd
    BLAST
    Regioni361 – 45797Transactivation domain 2By similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi106 – 1138Nuclear localization signalBy similarity

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    HOGENOMiHOG000231817.
    HOVERGENiHBG006621.
    InParanoidiQ9Y261.
    KOiK08035.
    OMAiTYEQVMH.
    OrthoDBiEOG7C8GHD.
    PhylomeDBiQ9Y261.
    TreeFamiTF316127.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR013638. Fork-head_N.
    IPR018533. Forkhead_box_C.
    IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    PF08430. Fork_head_N. 1 hit.
    PF09354. HNF_C. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y261-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLGAVKMEGH EPSDWSSYYA EPEGYSSVSN MNAGLGMNGM NTYMSMSAAA    50
    MGSGSGNMSA GSMNMSSYVG AGMSPSLAGM SPGAGAMAGM GGSAGAAGVA 100
    GMGPHLSPSL SPLGGQAAGA MGGLAPYANM NSMSPMYGQA GLSRARDPKT 150
    YRRSYTHAKP PYSYISLITM AIQQSPNKML TLSEIYQWIM DLFPFYRQNQ 200
    QRWQNSIRHS LSFNDCFLKV PRSPDKPGKG SFWTLHPDSG NMFENGCYLR 250
    RQKRFKCEKQ LALKEAAGAA GSGKKAAAGA QASQAQLGEA AGPASETPAG 300
    TESPHSSASP CQEHKRGGLG ELKGTPAAAL SPPEPAPSPG QQQQAAAHLL 350
    GPPHHPGLPP EAHLKPEHHY AFNHPFSINN LMSSEQQHHH SHHHHQPHKM 400
    DLKAYEQVMH YPGYGSPMPG SLAMGPVTNK TGLDASPLAA DTSYYQGVYS 450
    RPIMNSS 457
    Length:457
    Mass (Da):48,306
    Last modified:November 1, 1999 - v1
    Checksum:i61DDE4C75C70680A
    GO
    Isoform 2 (identifier: Q9Y261-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MHSASSM

    Show »
    Length:463
    Mass (Da):48,907
    Checksum:i726495A18CAE1677
    GO

    Sequence cautioni

    The sequence AAH11780.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti328 – 3281A → V in Japanese subjects with maturity-onset diabetes of the young; pathological significance unknown. 1 Publication
    Corresponds to variant rs199796119 [ dbSNP | Ensembl ].
    VAR_008858

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MHSASSM in isoform 2. 1 PublicationVSP_041212

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028021 mRNA. Translation: BAA78106.1.
    AF147787 Genomic DNA. Translation: AAD41081.1.
    AF176110 Genomic DNA. Translation: AAD51978.1.
    AL121722 Genomic DNA. Translation: CAB89773.1.
    BC006545 mRNA. Translation: AAH06545.2.
    BC011780 mRNA. Translation: AAH11780.1. Different initiation.
    BC019288 mRNA. Translation: AAH19288.1.
    CCDSiCCDS13147.1. [Q9Y261-1]
    CCDS46585.1. [Q9Y261-2]
    RefSeqiNP_068556.2. NM_021784.4. [Q9Y261-2]
    NP_710141.1. NM_153675.2. [Q9Y261-1]
    XP_006723625.1. XM_006723562.1. [Q9Y261-1]
    UniGeneiHs.155651.

    Genome annotation databases

    EnsembliENST00000377115; ENSP00000366319; ENSG00000125798. [Q9Y261-1]
    ENST00000419308; ENSP00000400341; ENSG00000125798. [Q9Y261-2]
    GeneIDi3170.
    KEGGihsa:3170.
    UCSCiuc002wsn.3. human. [Q9Y261-1]

    Polymorphism databases

    DMDMi8134491.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Hepatocyte nuclear factors entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028021 mRNA. Translation: BAA78106.1 .
    AF147787 Genomic DNA. Translation: AAD41081.1 .
    AF176110 Genomic DNA. Translation: AAD51978.1 .
    AL121722 Genomic DNA. Translation: CAB89773.1 .
    BC006545 mRNA. Translation: AAH06545.2 .
    BC011780 mRNA. Translation: AAH11780.1 . Different initiation.
    BC019288 mRNA. Translation: AAH19288.1 .
    CCDSi CCDS13147.1. [Q9Y261-1 ]
    CCDS46585.1. [Q9Y261-2 ]
    RefSeqi NP_068556.2. NM_021784.4. [Q9Y261-2 ]
    NP_710141.1. NM_153675.2. [Q9Y261-1 ]
    XP_006723625.1. XM_006723562.1. [Q9Y261-1 ]
    UniGenei Hs.155651.

    3D structure databases

    ProteinModelPortali Q9Y261.
    SMRi Q9Y261. Positions 157-256.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109412. 10 interactions.
    IntActi Q9Y261. 1 interaction.
    MINTi MINT-6610868.
    STRINGi 9606.ENSP00000315955.

    PTM databases

    PhosphoSitei Q9Y261.

    Polymorphism databases

    DMDMi 8134491.

    Proteomic databases

    MaxQBi Q9Y261.
    PaxDbi Q9Y261.
    PRIDEi Q9Y261.

    Protocols and materials databases

    DNASUi 3170.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377115 ; ENSP00000366319 ; ENSG00000125798 . [Q9Y261-1 ]
    ENST00000419308 ; ENSP00000400341 ; ENSG00000125798 . [Q9Y261-2 ]
    GeneIDi 3170.
    KEGGi hsa:3170.
    UCSCi uc002wsn.3. human. [Q9Y261-1 ]

    Organism-specific databases

    CTDi 3170.
    GeneCardsi GC20M022561.
    HGNCi HGNC:5022. FOXA2.
    HPAi CAB001388.
    MIMi 600288. gene.
    neXtProti NX_Q9Y261.
    PharmGKBi PA201091.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5025.
    HOGENOMi HOG000231817.
    HOVERGENi HBG006621.
    InParanoidi Q9Y261.
    KOi K08035.
    OMAi TYEQVMH.
    OrthoDBi EOG7C8GHD.
    PhylomeDBi Q9Y261.
    TreeFami TF316127.

    Enzyme and pathway databases

    Reactomei REACT_13819. Regulation of gene expression in beta cells.
    SignaLinki Q9Y261.

    Miscellaneous databases

    ChiTaRSi FOXA2. human.
    GeneWikii FOXA2.
    GenomeRNAii 3170.
    NextBioi 12568.
    PROi Q9Y261.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y261.
    Bgeei Q9Y261.
    CleanExi HS_FOXA2.
    Genevestigatori Q9Y261.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR013638. Fork-head_N.
    IPR018533. Forkhead_box_C.
    IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    PF08430. Fork_head_N. 1 hit.
    PF09354. HNF_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3 beta and mutation screening in Japanese subjects with maturity-onset diabetes of the young."
      Yamada S., Zhu Q., Aihara Y., Onda H., Zhang Z., Yu L., Jin L., Si Y.J., Nishigori H., Tomura H., Inoue I., Morikawa A., Yamagata K., Hanafusa T., Matsuzawa Y., Takeda J.
      Diabetologia 43:121-124(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), VARIANT VAL-328.
      Tissue: Liver.
    2. "No evidence for diabetes-associated mutations in the hepatocyte nuclear factor-3 beta gene in Japanese patients with MODY."
      Hinokio Y., Horikawa Y., Furuta H., Cox N.J., Iwasaki N., Honda M., Ogata M., Iwamoto Y., Bell G.I.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis."
      Navas M.A., Vaisse C., Boger S., Heimesaat M., Kollee L.A., Stoffel M.
      Hum. Hered. 50:370-381(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Lung.
    6. "Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization."
      Wolfrum C., Besser D., Luca E., Stoffel M.
      Proc. Natl. Acad. Sci. U.S.A. 100:11624-11629(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    7. "A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism."
      Verschuur M., de Jong M., Felida L., de Maat M.P., Vos H.L.
      J. Biol. Chem. 280:16763-16771(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROMOTER-BINDING.
    8. "Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq."
      Motallebipour M., Ameur A., Reddy Bysani M.S., Patra K., Wallerman O., Mangion J., Barker M.A., McKernan K.J., Komorowski J., Wadelius C.
      Genome Biol. 10:R129.0-R129.0(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FOXA1 AND FOXA3.
    9. "Identification of DNA-dependent protein kinase as a cofactor for the forkhead transcription factor FoxA2."
      Nock A., Ascano J.M., Jones T., Barrero M.J., Sugiyama N., Tomita M., Ishihama Y., Malik S.
      J. Biol. Chem. 284:19915-19926(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PRKDC.

    Entry informationi

    Entry nameiFOXA2_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y261
    Secondary accession number(s): Q8WUW4, Q96DF7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 145 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3