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Q9Y261

- FOXA2_HUMAN

UniProt

Q9Y261 - FOXA2_HUMAN

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Protein
Hepatocyte nuclear factor 3-beta
Gene
FOXA2, HNF3B, TCF3B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' By similarity. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi159 – 25294Fork-head
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. DNA binding, bending Source: RefGenome
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: BHF-UCL
  4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: RefGenome
  5. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  6. double-stranded DNA binding Source: RefGenome
  7. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  8. transcription factor binding Source: RefGenome
  9. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. cell development Source: Ensembl
  3. cell differentiation in hindbrain Source: Ensembl
  4. chromatin modification Source: UniProtKB-KW
  5. connective tissue development Source: Ensembl
  6. dopaminergic neuron differentiation Source: Ensembl
  7. dorsal/ventral neural tube patterning Source: Ensembl
  8. ectoderm formation Source: Ensembl
  9. endocrine pancreas development Source: BHF-UCL
  10. epithelial tube branching involved in lung morphogenesis Source: Ensembl
  11. glucose homeostasis Source: RefGenome
  12. in utero embryonic development Source: RefGenome
  13. lung epithelial cell differentiation Source: Ensembl
  14. negative regulation of detection of glucose Source: BHF-UCL
  15. negative regulation of epithelial to mesenchymal transition Source: BHF-UCL
  16. negative regulation of glucokinase activity Source: BHF-UCL
  17. negative regulation of neuron differentiation Source: Ensembl
  18. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  19. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
  20. negative regulation of transcription from RNA polymerase II promoter by glucose Source: BHF-UCL
  21. neuron fate specification Source: RefGenome
  22. pattern specification process Source: RefGenome
  23. positive regulation of cell-cell adhesion mediated by cadherin Source: BHF-UCL
  24. positive regulation of embryonic development Source: UniProtKB
  25. positive regulation of gastrulation Source: UniProtKB
  26. positive regulation of neuron differentiation Source: RefGenome
  27. positive regulation of smoothened signaling pathway Source: Ensembl
  28. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  29. positive regulation of transcription from RNA polymerase II promoter by glucose Source: BHF-UCL
  30. positive regulation of transcription from RNA polymerase III promoter Source: Ensembl
  31. positive regulation of transcription, DNA-templated Source: UniProtKB
  32. primitive streak formation Source: UniProtKB
  33. regulation of blood coagulation Source: UniProtKB
  34. regulation of hormone levels Source: RefGenome
  35. regulation of insulin secretion involved in cellular response to glucose stimulus Source: BHF-UCL
  36. regulation of steroid metabolic process Source: Ensembl
  37. regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  38. regulation of transcription from RNA polymerase II promoter involved in detection of glucose Source: BHF-UCL
  39. response to interleukin-6 Source: UniProtKB
  40. signal transduction involved in regulation of gene expression Source: Ensembl
  41. somite rostral/caudal axis specification Source: Ensembl
  42. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_13819. Regulation of gene expression in beta cells.
SignaLinkiQ9Y261.

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte nuclear factor 3-beta
Short name:
HNF-3-beta
Short name:
HNF-3B
Alternative name(s):
Forkhead box protein A2
Transcription factor 3B
Short name:
TCF-3B
Gene namesi
Name:FOXA2
Synonyms:HNF3B, TCF3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:5022. FOXA2.

Subcellular locationi

Nucleus. Cytoplasm
Note: Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB
  3. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA201091.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Hepatocyte nuclear factor 3-beta
PRO_0000091795Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei156 – 1561Phosphothreonine By similarity
Modified residuei212 – 2121Phosphoserine By similarity
Modified residuei283 – 2831Phosphoserine By similarity
Modified residuei303 – 3031Phosphoserine By similarity
Modified residuei306 – 3061Phosphoserine By similarity
Modified residuei307 – 3071Phosphoserine By similarity
Modified residuei309 – 3091Phosphoserine By similarity
Modified residuei436 – 4361Phosphoserine By similarity
Modified residuei457 – 4571Phosphoserine By similarity

Post-translational modificationi

Phosphorylation on Thr-156 abolishes binding to target promoters and subsequent transcription activation upon insulin stimulation By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y261.
PaxDbiQ9Y261.
PRIDEiQ9Y261.

PTM databases

PhosphoSiteiQ9Y261.

Expressioni

Gene expression databases

ArrayExpressiQ9Y261.
BgeeiQ9Y261.
CleanExiHS_FOXA2.
GenevestigatoriQ9Y261.

Organism-specific databases

HPAiCAB001388.

Interactioni

Subunit structurei

Binds DNA as a monomer. Binds TLE1 By similarity. Interacts with FOXA1 and FOXA3. Interacts with PRKDC.2 Publications

Protein-protein interaction databases

BioGridi109412. 10 interactions.
IntActiQ9Y261. 1 interaction.
MINTiMINT-6610868.
STRINGi9606.ENSP00000315955.

Structurei

3D structure databases

ProteinModelPortaliQ9Y261.
SMRiQ9Y261. Positions 157-256.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni14 – 9380Transactivation domain 1 By similarity
Add
BLAST
Regioni361 – 45797Transactivation domain 2 By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi106 – 1138Nuclear localization signal By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000231817.
HOVERGENiHBG006621.
InParanoidiQ9Y261.
KOiK08035.
OMAiTYEQVMH.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ9Y261.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR013638. Fork-head_N.
IPR018533. Forkhead_box_C.
IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
PF08430. Fork_head_N. 1 hit.
PF09354. HNF_C. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y261-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLGAVKMEGH EPSDWSSYYA EPEGYSSVSN MNAGLGMNGM NTYMSMSAAA    50
MGSGSGNMSA GSMNMSSYVG AGMSPSLAGM SPGAGAMAGM GGSAGAAGVA 100
GMGPHLSPSL SPLGGQAAGA MGGLAPYANM NSMSPMYGQA GLSRARDPKT 150
YRRSYTHAKP PYSYISLITM AIQQSPNKML TLSEIYQWIM DLFPFYRQNQ 200
QRWQNSIRHS LSFNDCFLKV PRSPDKPGKG SFWTLHPDSG NMFENGCYLR 250
RQKRFKCEKQ LALKEAAGAA GSGKKAAAGA QASQAQLGEA AGPASETPAG 300
TESPHSSASP CQEHKRGGLG ELKGTPAAAL SPPEPAPSPG QQQQAAAHLL 350
GPPHHPGLPP EAHLKPEHHY AFNHPFSINN LMSSEQQHHH SHHHHQPHKM 400
DLKAYEQVMH YPGYGSPMPG SLAMGPVTNK TGLDASPLAA DTSYYQGVYS 450
RPIMNSS 457
Length:457
Mass (Da):48,306
Last modified:November 1, 1999 - v1
Checksum:i61DDE4C75C70680A
GO
Isoform 2 (identifier: Q9Y261-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHSASSM

Show »
Length:463
Mass (Da):48,907
Checksum:i726495A18CAE1677
GO

Sequence cautioni

The sequence AAH11780.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti328 – 3281A → V in Japanese subjects with maturity-onset diabetes of the young; pathological significance unknown. 1 Publication
Corresponds to variant rs199796119 [ dbSNP | Ensembl ].
VAR_008858

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MHSASSM in isoform 2.
VSP_041212

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028021 mRNA. Translation: BAA78106.1.
AF147787 Genomic DNA. Translation: AAD41081.1.
AF176110 Genomic DNA. Translation: AAD51978.1.
AL121722 Genomic DNA. Translation: CAB89773.1.
BC006545 mRNA. Translation: AAH06545.2.
BC011780 mRNA. Translation: AAH11780.1. Different initiation.
BC019288 mRNA. Translation: AAH19288.1.
CCDSiCCDS13147.1. [Q9Y261-1]
CCDS46585.1. [Q9Y261-2]
RefSeqiNP_068556.2. NM_021784.4. [Q9Y261-2]
NP_710141.1. NM_153675.2. [Q9Y261-1]
XP_006723625.1. XM_006723562.1. [Q9Y261-1]
UniGeneiHs.155651.

Genome annotation databases

EnsembliENST00000377115; ENSP00000366319; ENSG00000125798. [Q9Y261-1]
ENST00000419308; ENSP00000400341; ENSG00000125798. [Q9Y261-2]
GeneIDi3170.
KEGGihsa:3170.
UCSCiuc002wsn.3. human. [Q9Y261-1]

Polymorphism databases

DMDMi8134491.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Hepatocyte nuclear factors entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028021 mRNA. Translation: BAA78106.1 .
AF147787 Genomic DNA. Translation: AAD41081.1 .
AF176110 Genomic DNA. Translation: AAD51978.1 .
AL121722 Genomic DNA. Translation: CAB89773.1 .
BC006545 mRNA. Translation: AAH06545.2 .
BC011780 mRNA. Translation: AAH11780.1 . Different initiation.
BC019288 mRNA. Translation: AAH19288.1 .
CCDSi CCDS13147.1. [Q9Y261-1 ]
CCDS46585.1. [Q9Y261-2 ]
RefSeqi NP_068556.2. NM_021784.4. [Q9Y261-2 ]
NP_710141.1. NM_153675.2. [Q9Y261-1 ]
XP_006723625.1. XM_006723562.1. [Q9Y261-1 ]
UniGenei Hs.155651.

3D structure databases

ProteinModelPortali Q9Y261.
SMRi Q9Y261. Positions 157-256.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109412. 10 interactions.
IntActi Q9Y261. 1 interaction.
MINTi MINT-6610868.
STRINGi 9606.ENSP00000315955.

PTM databases

PhosphoSitei Q9Y261.

Polymorphism databases

DMDMi 8134491.

Proteomic databases

MaxQBi Q9Y261.
PaxDbi Q9Y261.
PRIDEi Q9Y261.

Protocols and materials databases

DNASUi 3170.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377115 ; ENSP00000366319 ; ENSG00000125798 . [Q9Y261-1 ]
ENST00000419308 ; ENSP00000400341 ; ENSG00000125798 . [Q9Y261-2 ]
GeneIDi 3170.
KEGGi hsa:3170.
UCSCi uc002wsn.3. human. [Q9Y261-1 ]

Organism-specific databases

CTDi 3170.
GeneCardsi GC20M022561.
HGNCi HGNC:5022. FOXA2.
HPAi CAB001388.
MIMi 600288. gene.
neXtProti NX_Q9Y261.
PharmGKBi PA201091.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5025.
HOGENOMi HOG000231817.
HOVERGENi HBG006621.
InParanoidi Q9Y261.
KOi K08035.
OMAi TYEQVMH.
OrthoDBi EOG7C8GHD.
PhylomeDBi Q9Y261.
TreeFami TF316127.

Enzyme and pathway databases

Reactomei REACT_13819. Regulation of gene expression in beta cells.
SignaLinki Q9Y261.

Miscellaneous databases

ChiTaRSi FOXA2. human.
GeneWikii FOXA2.
GenomeRNAii 3170.
NextBioi 12568.
PROi Q9Y261.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y261.
Bgeei Q9Y261.
CleanExi HS_FOXA2.
Genevestigatori Q9Y261.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR013638. Fork-head_N.
IPR018533. Forkhead_box_C.
IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
PF08430. Fork_head_N. 1 hit.
PF09354. HNF_C. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3 beta and mutation screening in Japanese subjects with maturity-onset diabetes of the young."
    Yamada S., Zhu Q., Aihara Y., Onda H., Zhang Z., Yu L., Jin L., Si Y.J., Nishigori H., Tomura H., Inoue I., Morikawa A., Yamagata K., Hanafusa T., Matsuzawa Y., Takeda J.
    Diabetologia 43:121-124(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), VARIANT VAL-328.
    Tissue: Liver.
  2. "No evidence for diabetes-associated mutations in the hepatocyte nuclear factor-3 beta gene in Japanese patients with MODY."
    Hinokio Y., Horikawa Y., Furuta H., Cox N.J., Iwasaki N., Honda M., Ogata M., Iwamoto Y., Bell G.I.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis."
    Navas M.A., Vaisse C., Boger S., Heimesaat M., Kollee L.A., Stoffel M.
    Hum. Hered. 50:370-381(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung.
  6. "Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization."
    Wolfrum C., Besser D., Luca E., Stoffel M.
    Proc. Natl. Acad. Sci. U.S.A. 100:11624-11629(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. "A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism."
    Verschuur M., de Jong M., Felida L., de Maat M.P., Vos H.L.
    J. Biol. Chem. 280:16763-16771(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROMOTER-BINDING.
  8. "Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq."
    Motallebipour M., Ameur A., Reddy Bysani M.S., Patra K., Wallerman O., Mangion J., Barker M.A., McKernan K.J., Komorowski J., Wadelius C.
    Genome Biol. 10:R129.0-R129.0(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FOXA1 AND FOXA3.
  9. "Identification of DNA-dependent protein kinase as a cofactor for the forkhead transcription factor FoxA2."
    Nock A., Ascano J.M., Jones T., Barrero M.J., Sugiyama N., Tomita M., Ishihama Y., Malik S.
    J. Biol. Chem. 284:19915-19926(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PRKDC.

Entry informationi

Entry nameiFOXA2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y261
Secondary accession number(s): Q8WUW4, Q96DF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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