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Protein

C-C motif chemokine 26

Gene

CCL26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemoattractant for eosinophils and basophils (PubMed:10415065, PubMed:10488147). Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca2+ mobilization in eosinophils (PubMed:10415065, PubMed:10488147, PubMed:11425309).3 Publications

GO - Molecular functioni

  • CCR3 chemokine receptor binding Source: CAFA
  • chemokine activity Source: CAFA
  • receptor agonist activity Source: CAFA

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • cellular response to interferon-gamma Source: GO_Central
  • cellular response to interleukin-1 Source: GO_Central
  • cellular response to tumor necrosis factor Source: GO_Central
  • chemokine-mediated signaling pathway Source: CAFA
  • chemotaxis Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • inflammatory response Source: GO_Central
  • monocyte chemotaxis Source: CAFA
  • neutrophil chemotaxis Source: GO_Central
  • positive regulation of actin filament polymerization Source: BHF-UCL
  • positive regulation of cell migration Source: BHF-UCL
  • positive regulation of chemotaxis Source: CAFA
  • positive regulation of endothelial cell proliferation Source: BHF-UCL
  • positive regulation of ERK1 and ERK2 cascade Source: GO_Central
  • positive regulation of GTPase activity Source: BHF-UCL
  • response to organonitrogen compound Source: Ensembl
  • signal transduction Source: ProtInc
  • T cell chemotaxis Source: CAFA

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 26
Alternative name(s):
CC chemokine IMAC
Eotaxin-3
Macrophage inflammatory protein 4-alpha
Short name:
MIP-4-alpha
Small-inducible cytokine A26
Thymic stroma chemokine-1
Short name:
TSC-1
Gene namesi
Name:CCL26
Synonyms:SCYA26
ORF Names:UNQ216/PRO242
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:10625. CCL26.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: CAFA

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10344.
OpenTargetsiENSG00000006606.
PharmGKBiPA35557.

Polymorphism and mutation databases

BioMutaiCCL26.
DMDMi6685990.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000000523824 – 94C-C motif chemokine 26Add BLAST71

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 57
Disulfide bondi34 ↔ 73

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9Y258.
PeptideAtlasiQ9Y258.
PRIDEiQ9Y258.

PTM databases

iPTMnetiQ9Y258.
PhosphoSitePlusiQ9Y258.

Expressioni

Tissue specificityi

Ubiquitously expressed at low levels in various tissues including heart and ovary.2 Publications

Gene expression databases

BgeeiENSG00000006606.
CleanExiHS_CCL26.
GenevisibleiQ9Y258. HS.

Interactioni

Subunit structurei

Monomer.1 Publication

GO - Molecular functioni

  • CCR3 chemokine receptor binding Source: CAFA
  • chemokine activity Source: CAFA
  • receptor agonist activity Source: CAFA

Protein-protein interaction databases

BioGridi115626. 1 interactor.
DIPiDIP-5877N.
IntActiQ9Y258. 4 interactors.
MINTiMINT-105215.
STRINGi9606.ENSP00000005180.

Structurei

Secondary structure

194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi44 – 46Combined sources3
Beta strandi47 – 52Combined sources6
Beta strandi55 – 59Combined sources5
Beta strandi62 – 66Combined sources5
Beta strandi71 – 74Combined sources4
Beta strandi76 – 78Combined sources3
Helixi79 – 88Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G2SNMR-A24-94[»]
1G2TNMR-A24-94[»]
DisProtiDP00696.
ProteinModelPortaliQ9Y258.
SMRiQ9Y258.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y258.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JIGC. Eukaryota.
ENOG41115YQ. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ9Y258.
KOiK21096.
OMAiCSQQAVI.
OrthoDBiEOG091G14Y2.
PhylomeDBiQ9Y258.
TreeFamiTF334888.

Family and domain databases

InterProiView protein in InterPro
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00472. SMALL_CYTOKINES_CC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y258-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGLSLASAV LLASLLSLHL GTATRGSDIS KTCCFQYSHK PLPWTWVRSY
60 70 80 90
EFTSNSCSQR AVIFTTKRGK KVCTHPRKKW VQKYISLLKT PKQL
Length:94
Mass (Da):10,648
Last modified:November 1, 1999 - v1
Checksum:i8525B1E4BDD39A5F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02919218L → R. Corresponds to variant dbSNP:rs11465333Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124601 mRNA. Translation: AAD22197.1.
AB016542 mRNA. Translation: BAA36704.1.
AB010447 mRNA. Translation: BAA84579.1.
AF096296 mRNA. Translation: AAF09265.1.
AF142434 mRNA. Translation: AAD46495.1.
EF064763 Genomic DNA. Translation: ABK41946.1.
AY358893 mRNA. Translation: AAQ89252.1.
AC005102 Genomic DNA. Translation: AAD15411.1.
CH471220 Genomic DNA. Translation: EAW71771.1.
BC069394 mRNA. Translation: AAH69394.1.
BC093773 mRNA. Translation: AAH93773.1.
BC101665 mRNA. Translation: AAI01666.1.
CCDSiCCDS5578.1.
RefSeqiNP_006063.1. NM_006072.4.
XP_016867161.1. XM_017011672.1.
UniGeneiHs.131342.

Genome annotation databases

EnsembliENST00000005180; ENSP00000005180; ENSG00000006606.
ENST00000394905; ENSP00000378365; ENSG00000006606.
GeneIDi10344.
KEGGihsa:10344.
UCSCiuc003udt.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCCL26_HUMAN
AccessioniPrimary (citable) accession number: Q9Y258
Secondary accession number(s): A0N0Q5, Q52LV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: July 5, 2017
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families