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Protein

C-C motif chemokine 26

Gene

CCL26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic for eosinophils and basophils. Binds to CCR3.

GO - Molecular functioni

  1. chemokine activity Source: ProtInc

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. cell chemotaxis Source: GOC
  3. chemotaxis Source: ProtInc
  4. immune response Source: ProtInc
  5. inflammatory response Source: ProtInc
  6. positive regulation of actin filament polymerization Source: BHF-UCL
  7. positive regulation of cell migration Source: BHF-UCL
  8. positive regulation of endothelial cell proliferation Source: BHF-UCL
  9. positive regulation of Rac GTPase activity Source: BHF-UCL
  10. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 26
Alternative name(s):
CC chemokine IMAC
Eotaxin-3
Macrophage inflammatory protein 4-alpha
Short name:
MIP-4-alpha
Small-inducible cytokine A26
Thymic stroma chemokine-1
Short name:
TSC-1
Gene namesi
Name:CCL26
Synonyms:SCYA26
ORF Names:UNQ216/PRO242
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:10625. CCL26.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35557.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 9471C-C motif chemokine 26PRO_0000005238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57
Disulfide bondi34 ↔ 73

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9Y258.
PRIDEiQ9Y258.

Expressioni

Tissue specificityi

Ubiquitously expressed at low levels in various tissues including heart and ovary.

Gene expression databases

BgeeiQ9Y258.
CleanExiHS_CCL26.
GenevestigatoriQ9Y258.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi115626. 1 interaction.
DIPiDIP-5877N.
IntActiQ9Y258. 1 interaction.
MINTiMINT-105215.
STRINGi9606.ENSP00000005180.

Structurei

Secondary structure

1
94
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi44 – 463Combined sources
Beta strandi47 – 526Combined sources
Beta strandi55 – 595Combined sources
Beta strandi62 – 665Combined sources
Beta strandi71 – 744Combined sources
Beta strandi76 – 783Combined sources
Helixi79 – 8810Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G2SNMR-A24-94[»]
1G2TNMR-A24-94[»]
DisProtiDP00696.
ProteinModelPortaliQ9Y258.
SMRiQ9Y258. Positions 24-94.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y258.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG69247.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ9Y258.
KOiK05514.
OMAiCSQQAVI.
OrthoDBiEOG7CVQ1F.
PhylomeDBiQ9Y258.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y258-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGLSLASAV LLASLLSLHL GTATRGSDIS KTCCFQYSHK PLPWTWVRSY
60 70 80 90
EFTSNSCSQR AVIFTTKRGK KVCTHPRKKW VQKYISLLKT PKQL
Length:94
Mass (Da):10,648
Last modified:October 31, 1999 - v1
Checksum:i8525B1E4BDD39A5F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181L → R.
Corresponds to variant rs11465333 [ dbSNP | Ensembl ].
VAR_029192

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124601 mRNA. Translation: AAD22197.1.
AB016542 mRNA. Translation: BAA36704.1.
AB010447 mRNA. Translation: BAA84579.1.
AF096296 mRNA. Translation: AAF09265.1.
AF142434 mRNA. Translation: AAD46495.1.
EF064763 Genomic DNA. Translation: ABK41946.1.
AY358893 mRNA. Translation: AAQ89252.1.
AC005102 Genomic DNA. Translation: AAD15411.1.
CH471220 Genomic DNA. Translation: EAW71771.1.
BC069394 mRNA. Translation: AAH69394.1.
BC093773 mRNA. Translation: AAH93773.1.
BC101665 mRNA. Translation: AAI01666.1.
CCDSiCCDS5578.1.
RefSeqiNP_006063.1. NM_006072.4.
UniGeneiHs.131342.

Genome annotation databases

EnsembliENST00000005180; ENSP00000005180; ENSG00000006606.
ENST00000394905; ENSP00000378365; ENSG00000006606.
GeneIDi10344.
KEGGihsa:10344.
UCSCiuc003udt.1. human.

Polymorphism databases

DMDMi6685990.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CCL26 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124601 mRNA. Translation: AAD22197.1.
AB016542 mRNA. Translation: BAA36704.1.
AB010447 mRNA. Translation: BAA84579.1.
AF096296 mRNA. Translation: AAF09265.1.
AF142434 mRNA. Translation: AAD46495.1.
EF064763 Genomic DNA. Translation: ABK41946.1.
AY358893 mRNA. Translation: AAQ89252.1.
AC005102 Genomic DNA. Translation: AAD15411.1.
CH471220 Genomic DNA. Translation: EAW71771.1.
BC069394 mRNA. Translation: AAH69394.1.
BC093773 mRNA. Translation: AAH93773.1.
BC101665 mRNA. Translation: AAI01666.1.
CCDSiCCDS5578.1.
RefSeqiNP_006063.1. NM_006072.4.
UniGeneiHs.131342.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G2SNMR-A24-94[»]
1G2TNMR-A24-94[»]
DisProtiDP00696.
ProteinModelPortaliQ9Y258.
SMRiQ9Y258. Positions 24-94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115626. 1 interaction.
DIPiDIP-5877N.
IntActiQ9Y258. 1 interaction.
MINTiMINT-105215.
STRINGi9606.ENSP00000005180.

Polymorphism databases

DMDMi6685990.

Proteomic databases

PaxDbiQ9Y258.
PRIDEiQ9Y258.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000005180; ENSP00000005180; ENSG00000006606.
ENST00000394905; ENSP00000378365; ENSG00000006606.
GeneIDi10344.
KEGGihsa:10344.
UCSCiuc003udt.1. human.

Organism-specific databases

CTDi10344.
GeneCardsiGC07M075398.
HGNCiHGNC:10625. CCL26.
MIMi604697. gene.
neXtProtiNX_Q9Y258.
PharmGKBiPA35557.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG69247.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ9Y258.
KOiK05514.
OMAiCSQQAVI.
OrthoDBiEOG7CVQ1F.
PhylomeDBiQ9Y258.
TreeFamiTF334888.

Miscellaneous databases

EvolutionaryTraceiQ9Y258.
GenomeRNAii10344.
NextBioi39227.
PROiQ9Y258.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y258.
CleanExiHS_CCL26.
GenevestigatoriQ9Y258.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel human CC chemokine, SCYA26."
    Guo R.F., Ward P.A., Hu S.M., McDuffie J.E., Huber-Lang M., Shi M.M.
    Genomics 58:313-317(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils."
    Shinkai A., Yoshisue H., Koike M., Shoji E., Nakagawa S., Saito A., Takeda T., Imabeppu S., Kato Y., Hanai N., Anazawa H., Kuga T., Nishi T.
    J. Immunol. 163:1602-1610(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  3. "Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3."
    Kitaura M., Suzuki N., Imai T., Takagi S., Suzuki R., Nakajima T., Hirai K., Nomiyama H., Yoshie O.
    J. Biol. Chem. 274:27975-27980(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
    Tissue: Lung.
  4. "A novel CC chemokine expressed in thymic stroma."
    Wang Z., Scadden D.T.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Molecular cloning and characterization of a new human CC chemokine IMAC."
    Berg E.L., Melrose J., Fu H., Tsurushita N.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  11. "NMR solution structure and backbone dynamics of the CC chemokine eotaxin-3."
    Ye J., Mayer K.L., Mayer M.R., Stone M.J.
    Biochemistry 40:7820-7831(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiCCL26_HUMAN
AccessioniPrimary (citable) accession number: Q9Y258
Secondary accession number(s): A0N0Q5, Q52LV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2000
Last sequence update: October 31, 1999
Last modified: January 6, 2015
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.