Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9Y258 (CCL26_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 26
Alternative name(s):
CC chemokine IMAC
Eotaxin-3
Macrophage inflammatory protein 4-alpha
Short name=MIP-4-alpha
Small-inducible cytokine A26
Thymic stroma chemokine-1
Short name=TSC-1
Gene names
Name:CCL26
Synonyms:SCYA26
ORF Names:UNQ216/PRO242
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length94 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Chemotactic for eosinophils and basophils. Binds to CCR3.

Subunit structure

Monomer.

Subcellular location

Secreted.

Tissue specificity

Ubiquitously expressed at low levels in various tissues including heart and ovary.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.3
Chain24 – 9471C-C motif chemokine 26
PRO_0000005238

Amino acid modifications

Disulfide bond33 ↔ 57
Disulfide bond34 ↔ 73

Natural variations

Natural variant181L → R.
Corresponds to variant rs11465333 [ dbSNP | Ensembl ].
VAR_029192

Secondary structure

............. 94
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9Y258 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 8525B1E4BDD39A5F

FASTA9410,648
        10         20         30         40         50         60 
MMGLSLASAV LLASLLSLHL GTATRGSDIS KTCCFQYSHK PLPWTWVRSY EFTSNSCSQR 

        70         80         90 
AVIFTTKRGK KVCTHPRKKW VQKYISLLKT PKQL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a novel human CC chemokine, SCYA26."
Guo R.F., Ward P.A., Hu S.M., McDuffie J.E., Huber-Lang M., Shi M.M.
Genomics 58:313-317(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[2]"A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils."
Shinkai A., Yoshisue H., Koike M., Shoji E., Nakagawa S., Saito A., Takeda T., Imabeppu S., Kato Y., Hanai N., Anazawa H., Kuga T., Nishi T.
J. Immunol. 163:1602-1610(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[3]"Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3."
Kitaura M., Suzuki N., Imai T., Takagi S., Suzuki R., Nakajima T., Hirai K., Nomiyama H., Yoshie O.
J. Biol. Chem. 274:27975-27980(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
Tissue: Lung.
[4]"A novel CC chemokine expressed in thymic stroma."
Wang Z., Scadden D.T.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Molecular cloning and characterization of a new human CC chemokine IMAC."
Berg E.L., Melrose J., Fu H., Tsurushita N.
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
[11]"NMR solution structure and backbone dynamics of the CC chemokine eotaxin-3."
Ye J., Mayer K.L., Mayer M.R., Stone M.J.
Biochemistry 40:7820-7831(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR.
+Additional computationally mapped references.

Web resources

Wikipedia

CCL26 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF124601 mRNA. Translation: AAD22197.1.
AB016542 mRNA. Translation: BAA36704.1.
AB010447 mRNA. Translation: BAA84579.1.
AF096296 mRNA. Translation: AAF09265.1.
AF142434 mRNA. Translation: AAD46495.1.
EF064763 Genomic DNA. Translation: ABK41946.1.
AY358893 mRNA. Translation: AAQ89252.1.
AC005102 Genomic DNA. Translation: AAD15411.1.
CH471220 Genomic DNA. Translation: EAW71771.1.
BC069394 mRNA. Translation: AAH69394.1.
BC093773 mRNA. Translation: AAH93773.1.
BC101665 mRNA. Translation: AAI01666.1.
RefSeqNP_006063.1. NM_006072.4.
UniGeneHs.131342.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1G2SNMR-A24-94[»]
1G2TNMR-A24-94[»]
DisProtDP00696.
ProteinModelPortalQ9Y258.
SMRQ9Y258. Positions 24-94.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115626. 1 interaction.
DIPDIP-5877N.
IntActQ9Y258. 1 interaction.
MINTMINT-105215.
STRING9606.ENSP00000005180.

Polymorphism databases

DMDM6685990.

Proteomic databases

PaxDbQ9Y258.
PRIDEQ9Y258.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000005180; ENSP00000005180; ENSG00000006606.
ENST00000394905; ENSP00000378365; ENSG00000006606.
ENST00000575353; ENSP00000458182; ENSG00000262029.
ENST00000576539; ENSP00000461652; ENSG00000262029.
GeneID10344.
KEGGhsa:10344.
UCSCuc003udt.1. human.

Organism-specific databases

CTD10344.
GeneCardsGC07M075398.
HGNCHGNC:10625. CCL26.
MIM604697. gene.
neXtProtNX_Q9Y258.
PharmGKBPA35557.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG69247.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidQ9Y258.
KOK05514.
OMACSQQAVI.
OrthoDBEOG7CVQ1F.
PhylomeDBQ9Y258.
TreeFamTF334888.

Gene expression databases

BgeeQ9Y258.
CleanExHS_CCL26.
GenevestigatorQ9Y258.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9Y258.
GenomeRNAi10344.
NextBio39227.
PROQ9Y258.
SOURCESearch...

Entry information

Entry nameCCL26_HUMAN
AccessionPrimary (citable) accession number: Q9Y258
Secondary accession number(s): A0N0Q5, Q52LV8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM