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Q9Y258

- CCL26_HUMAN

UniProt

Q9Y258 - CCL26_HUMAN

Protein

C-C motif chemokine 26

Gene

CCL26

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Chemotactic for eosinophils and basophils. Binds to CCR3.

    GO - Molecular functioni

    1. chemokine activity Source: ProtInc

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. cell chemotaxis Source: GOC
    3. chemotaxis Source: ProtInc
    4. immune response Source: ProtInc
    5. inflammatory response Source: ProtInc
    6. positive regulation of actin filament polymerization Source: BHF-UCL
    7. positive regulation of cell migration Source: BHF-UCL
    8. positive regulation of endothelial cell proliferation Source: BHF-UCL
    9. positive regulation of Rac GTPase activity Source: BHF-UCL
    10. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 26
    Alternative name(s):
    CC chemokine IMAC
    Eotaxin-3
    Macrophage inflammatory protein 4-alpha
    Short name:
    MIP-4-alpha
    Small-inducible cytokine A26
    Thymic stroma chemokine-1
    Short name:
    TSC-1
    Gene namesi
    Name:CCL26
    Synonyms:SCYA26
    ORF Names:UNQ216/PRO242
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:10625. CCL26.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35557.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationAdd
    BLAST
    Chaini24 – 9471C-C motif chemokine 26PRO_0000005238Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 57
    Disulfide bondi34 ↔ 73

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ9Y258.
    PRIDEiQ9Y258.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed at low levels in various tissues including heart and ovary.

    Gene expression databases

    BgeeiQ9Y258.
    CleanExiHS_CCL26.
    GenevestigatoriQ9Y258.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    BioGridi115626. 1 interaction.
    DIPiDIP-5877N.
    IntActiQ9Y258. 1 interaction.
    MINTiMINT-105215.
    STRINGi9606.ENSP00000005180.

    Structurei

    Secondary structure

    1
    94
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi44 – 463
    Beta strandi47 – 526
    Beta strandi55 – 595
    Beta strandi62 – 665
    Beta strandi71 – 744
    Beta strandi76 – 783
    Helixi79 – 8810

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1G2SNMR-A24-94[»]
    1G2TNMR-A24-94[»]
    DisProtiDP00696.
    ProteinModelPortaliQ9Y258.
    SMRiQ9Y258. Positions 24-94.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y258.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG69247.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiQ9Y258.
    KOiK05514.
    OMAiQRAVIFT.
    OrthoDBiEOG7CVQ1F.
    PhylomeDBiQ9Y258.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y258-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMGLSLASAV LLASLLSLHL GTATRGSDIS KTCCFQYSHK PLPWTWVRSY   50
    EFTSNSCSQR AVIFTTKRGK KVCTHPRKKW VQKYISLLKT PKQL 94
    Length:94
    Mass (Da):10,648
    Last modified:November 1, 1999 - v1
    Checksum:i8525B1E4BDD39A5F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti18 – 181L → R.
    Corresponds to variant rs11465333 [ dbSNP | Ensembl ].
    VAR_029192

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF124601 mRNA. Translation: AAD22197.1.
    AB016542 mRNA. Translation: BAA36704.1.
    AB010447 mRNA. Translation: BAA84579.1.
    AF096296 mRNA. Translation: AAF09265.1.
    AF142434 mRNA. Translation: AAD46495.1.
    EF064763 Genomic DNA. Translation: ABK41946.1.
    AY358893 mRNA. Translation: AAQ89252.1.
    AC005102 Genomic DNA. Translation: AAD15411.1.
    CH471220 Genomic DNA. Translation: EAW71771.1.
    BC069394 mRNA. Translation: AAH69394.1.
    BC093773 mRNA. Translation: AAH93773.1.
    BC101665 mRNA. Translation: AAI01666.1.
    CCDSiCCDS5578.1.
    RefSeqiNP_006063.1. NM_006072.4.
    UniGeneiHs.131342.

    Genome annotation databases

    EnsembliENST00000005180; ENSP00000005180; ENSG00000006606.
    ENST00000394905; ENSP00000378365; ENSG00000006606.
    GeneIDi10344.
    KEGGihsa:10344.
    UCSCiuc003udt.1. human.

    Polymorphism databases

    DMDMi6685990.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CCL26 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF124601 mRNA. Translation: AAD22197.1 .
    AB016542 mRNA. Translation: BAA36704.1 .
    AB010447 mRNA. Translation: BAA84579.1 .
    AF096296 mRNA. Translation: AAF09265.1 .
    AF142434 mRNA. Translation: AAD46495.1 .
    EF064763 Genomic DNA. Translation: ABK41946.1 .
    AY358893 mRNA. Translation: AAQ89252.1 .
    AC005102 Genomic DNA. Translation: AAD15411.1 .
    CH471220 Genomic DNA. Translation: EAW71771.1 .
    BC069394 mRNA. Translation: AAH69394.1 .
    BC093773 mRNA. Translation: AAH93773.1 .
    BC101665 mRNA. Translation: AAI01666.1 .
    CCDSi CCDS5578.1.
    RefSeqi NP_006063.1. NM_006072.4.
    UniGenei Hs.131342.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1G2S NMR - A 24-94 [» ]
    1G2T NMR - A 24-94 [» ]
    DisProti DP00696.
    ProteinModelPortali Q9Y258.
    SMRi Q9Y258. Positions 24-94.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115626. 1 interaction.
    DIPi DIP-5877N.
    IntActi Q9Y258. 1 interaction.
    MINTi MINT-105215.
    STRINGi 9606.ENSP00000005180.

    Polymorphism databases

    DMDMi 6685990.

    Proteomic databases

    PaxDbi Q9Y258.
    PRIDEi Q9Y258.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000005180 ; ENSP00000005180 ; ENSG00000006606 .
    ENST00000394905 ; ENSP00000378365 ; ENSG00000006606 .
    GeneIDi 10344.
    KEGGi hsa:10344.
    UCSCi uc003udt.1. human.

    Organism-specific databases

    CTDi 10344.
    GeneCardsi GC07M075398.
    HGNCi HGNC:10625. CCL26.
    MIMi 604697. gene.
    neXtProti NX_Q9Y258.
    PharmGKBi PA35557.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG69247.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi Q9Y258.
    KOi K05514.
    OMAi QRAVIFT.
    OrthoDBi EOG7CVQ1F.
    PhylomeDBi Q9Y258.
    TreeFami TF334888.

    Miscellaneous databases

    EvolutionaryTracei Q9Y258.
    GenomeRNAii 10344.
    NextBioi 39227.
    PROi Q9Y258.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y258.
    CleanExi HS_CCL26.
    Genevestigatori Q9Y258.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a novel human CC chemokine, SCYA26."
      Guo R.F., Ward P.A., Hu S.M., McDuffie J.E., Huber-Lang M., Shi M.M.
      Genomics 58:313-317(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. "A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils."
      Shinkai A., Yoshisue H., Koike M., Shoji E., Nakagawa S., Saito A., Takeda T., Imabeppu S., Kato Y., Hanai N., Anazawa H., Kuga T., Nishi T.
      J. Immunol. 163:1602-1610(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    3. "Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3."
      Kitaura M., Suzuki N., Imai T., Takagi S., Suzuki R., Nakajima T., Hirai K., Nomiyama H., Yoshie O.
      J. Biol. Chem. 274:27975-27980(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
      Tissue: Lung.
    4. "A novel CC chemokine expressed in thymic stroma."
      Wang Z., Scadden D.T.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Molecular cloning and characterization of a new human CC chemokine IMAC."
      Berg E.L., Melrose J., Fu H., Tsurushita N.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    11. "NMR solution structure and backbone dynamics of the CC chemokine eotaxin-3."
      Ye J., Mayer K.L., Mayer M.R., Stone M.J.
      Biochemistry 40:7820-7831(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.

    Entry informationi

    Entry nameiCCL26_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y258
    Secondary accession number(s): A0N0Q5, Q52LV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3