Q9Y258 (CCL26_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C motif chemokine 26

Alternative name(s):
CC chemokine IMAC
Eotaxin-3
Macrophage inflammatory protein 4-alpha
Short name=MIP-4-alpha
Small-inducible cytokine A26
Thymic stroma chemokine-1
Short name=TSC-1

Gene names

Name:	CCL26
Synonyms:	SCYA26
ORF Names:	UNQ216/PRO242

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	94 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Chemotactic for eosinophils and basophils. Binds to CCR3.
Subunit structure	Monomer.
Subcellular location	Secreted.
Tissue specificity	Ubiquitously expressed at low levels in various tissues including heart and ovary.
Sequence similarities	Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
Biological process	Chemotaxis Inflammatory response
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cell-cell signaling Traceable author statement Ref.1. Source: ProtInc chemotaxis Traceable author statement Ref.1. Source: ProtInc immune response Traceable author statement Ref.1. Source: ProtInc inflammatory response Traceable author statement Ref.1. Source: ProtInc positive regulation of Rac GTPase activity Inferred from direct assay PubMed 19525930. Source: BHF-UCL positive regulation of actin filament polymerization Inferred from direct assay PubMed 19525930. Source: BHF-UCL positive regulation of cell migration Inferred from direct assay PubMed 19525930. Source: BHF-UCL positive regulation of endothelial cell proliferation Inferred from direct assay PubMed 19525930. Source: BHF-UCL signal transduction Non-traceable author statement Ref.1. Source: ProtInc
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	chemokine activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 23

23

Ref.3

Chain

24 – 94

71

C-C motif chemokine 26

PRO_0000005238

Amino acid modifications

Disulfide bond

33 ↔ 57

Disulfide bond

34 ↔ 73

Natural variations

Natural variant

18

1

L → R.
Corresponds to variant rs11465333 [ dbSNP | Ensembl ].

VAR_029192

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

94

Helix Strand Turn

Details...

Helix

44 – 46

3

Beta strand

47 – 52

6

Beta strand

55 – 59

5

Beta strand

62 – 66

5

Beta strand

71 – 74

4

Beta strand

76 – 78

3

Helix

79 – 88

10

Sequences

	Sequence		Length	Mass (Da)
	Q9Y258 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 8525B1E4BDD39A5F	FASTA	94	10,648
	10 20 30 40 50 60 MMGLSLASAV LLASLLSLHL GTATRGSDIS KTCCFQYSHK PLPWTWVRSY EFTSNSCSQR 70 80 90 AVIFTTKRGK KVCTHPRKKW VQKYISLLKT PKQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a novel human CC chemokine, SCYA26." Guo R.F., Ward P.A., Hu S.M., McDuffie J.E., Huber-Lang M., Shi M.M. Genomics 58:313-317(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[2]	"A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils." Shinkai A., Yoshisue H., Koike M., Shoji E., Nakagawa S., Saito A., Takeda T., Imabeppu S., Kato Y., Hanai N., Anazawa H., Kuga T., Nishi T. J. Immunol. 163:1602-1610(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[3]	"Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3." Kitaura M., Suzuki N., Imai T., Takagi S., Suzuki R., Nakajima T., Hirai K., Nomiyama H., Yoshie O. J. Biol. Chem. 274:27975-27980(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS. Tissue: Lung.
[4]	"A novel CC chemokine expressed in thymic stroma." Wang Z., Scadden D.T. Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"Molecular cloning and characterization of a new human CC chemokine IMAC." Berg E.L., Melrose J., Fu H., Tsurushita N. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]	Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[11]	"NMR solution structure and backbone dynamics of the CC chemokine eotaxin-3." Ye J., Mayer K.L., Mayer M.R., Stone M.J. Biochemistry 40:7820-7831(2001) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR.
+	Additional computationally mapped references.

Web resources

Wikipedia

CCL26 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF124601 mRNA. Translation: AAD22197.1.
AB016542 mRNA. Translation: BAA36704.1.
AB010447 mRNA. Translation: BAA84579.1.
AF096296 mRNA. Translation: AAF09265.1.
AF142434 mRNA. Translation: AAD46495.1.
EF064763 Genomic DNA. Translation: ABK41946.1.
AY358893 mRNA. Translation: AAQ89252.1.
AC005102 Genomic DNA. Translation: AAD15411.1.
CH471220 Genomic DNA. Translation: EAW71771.1.
BC069394 mRNA. Translation: AAH69394.1.
BC093773 mRNA. Translation: AAH93773.1.
BC101665 mRNA. Translation: AAI01666.1.

IPI

IPI00031757.

RefSeq

NP_006063.1. NM_006072.4.

UniGene

Hs.131342.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1G2S	NMR	-	A	24-94	[»]
1G2T	NMR	-	A	24-94	[»]

ProteinModelPortal

Q9Y258.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-5877N.

MINT

MINT-105215.

STRING

9606.ENSP00000005180.

Polymorphism databases

DMDM

6685990.

Proteomic databases

PaxDb

Q9Y258.

PRIDE

Q9Y258.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000005180; ENSP00000005180; ENSG00000006606.
ENST00000394905; ENSP00000378365; ENSG00000006606.
ENST00000575353; ENSP00000458182; ENSG00000262029.
ENST00000576539; ENSP00000461652; ENSG00000262029.

GeneID

10344.

KEGG

hsa:10344.

UCSC

uc003udt.1. human.

Organism-specific databases

CTD

10344.

GeneCards

GC07M075398.

HGNC

HGNC:10625. CCL26.

MIM

604697. gene.

neXtProt

NX_Q9Y258.

PharmGKB

PA35557.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG69247.

HOGENOM

HOG000036685.

HOVERGEN

HBG017871.

InParanoid

Q9Y258.

KO

K05514.

OMA

CSQQAVI.

OrthoDB

EOG43TZX5.

PhylomeDB

Q9Y258.

Enzyme and pathway databases

Pathway_Interaction_DB

il4_2pathway. IL4-mediated signaling events.

Gene expression databases

Bgee

Q9Y258.

CleanEx

HS_CCL26.

Genevestigator

Q9Y258.

GermOnline

ENSG00000006606. Homo sapiens.

Family and domain databases

InterPro

IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]

Pfam

PF00048. IL8. 1 hit.
[Graphical view]

SMART

SM00199. SCY. 1 hit.
[Graphical view]

SUPFAM

SSF54117. Chemokine_IL8. 1 hit.

PROSITE

PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9Y258.

GenomeRNAi

10344.

NextBio

39227.

SOURCE

Search...

Entry information

Entry name

CCL26_HUMAN

Accession

Primary (citable) accession number: Q9Y258
Secondary accession number(s): A0N0Q5, Q52LV8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 118 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.