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Q9Y257

- KCNK6_HUMAN

UniProt

Q9Y257 - KCNK6_HUMAN

Protein

Potassium channel subfamily K member 6

Gene

KCNK6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Exhibits outward rectification in a physiological K+ gradient and mild inward rectification in symmetrical K+ conditions.

    GO - Molecular functioni

    1. inward rectifier potassium channel activity Source: ProtInc

    GO - Biological processi

    1. negative regulation of systemic arterial blood pressure Source: Ensembl
    2. potassium ion transport Source: ProtInc
    3. regulation of resting membrane potential Source: Ensembl
    4. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75779. Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK).

    Protein family/group databases

    TCDBi1.A.1.8.3. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel subfamily K member 6
    Alternative name(s):
    Inward rectifying potassium channel protein TWIK-2
    TWIK-originated similarity sequence
    Gene namesi
    Name:KCNK6
    Synonyms:TOSS, TWIK2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6281. KCNK6.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: Reactome
    2. voltage-gated potassium channel complex Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi53 – 531C → A: No channel activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA30063.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Potassium channel subfamily K member 6PRO_0000101750Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9Y257.
    PRIDEiQ9Y257.

    PTM databases

    PhosphoSiteiQ9Y257.

    Expressioni

    Tissue specificityi

    Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression detected in brain.

    Gene expression databases

    ArrayExpressiQ9Y257.
    BgeeiQ9Y257.
    CleanExiHS_KCNK6.
    GenevestigatoriQ9Y257.

    Organism-specific databases

    HPAiCAB022637.
    HPA040184.

    Interactioni

    Subunit structurei

    Homodimer.Curated

    Protein-protein interaction databases

    STRINGi9606.ENSP00000263372.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y257.
    SMRiQ9Y257. Positions 20-262.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 44CytoplasmicSequence Analysis
    Topological domaini142 – 17231CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini257 – 31357CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei90 – 11526Pore-forming; Name=Pore-forming 1Sequence AnalysisAdd
    BLAST
    Intramembranei199 – 22325Pore-forming; Name=Pore-forming 2Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei121 – 14121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG290832.
    HOGENOMiHOG000286014.
    HOVERGENiHBG052237.
    InParanoidiQ9Y257.
    KOiK04917.
    OMAiPAVIFAH.
    OrthoDBiEOG7TTQ85.
    PhylomeDBiQ9Y257.
    TreeFamiTF313947.

    Family and domain databases

    InterProiIPR003280. 2pore_dom_K_chnl.
    IPR013099. 2pore_dom_K_chnl_dom.
    IPR003092. 2pore_dom_K_chnl_TASK.
    IPR005408. 2pore_dom_K_chnl_TWIK.
    IPR005409. 2pore_dom_K_chnl_TWIK2.
    [Graphical view]
    PfamiPF07885. Ion_trans_2. 2 hits.
    [Graphical view]
    PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
    PRINTSiPR01333. 2POREKCHANEL.
    PR01587. TWIK2CHANNEL.
    PR01586. TWIKCHANNEL.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y257-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRRGALLAGA LAAYAAYLVL GALLVARLEG PHEARLRAEL ETLRAQLLQR    50
    SPCVAAPALD AFVERVLAAG RLGRVVLANA SGSANASDPA WDFASALFFA 100
    STLITTVGYG YTTPLTDAGK AFSIAFALLG VPTTMLLLTA SAQRLSLLLT 150
    HVPLSWLSMR WGWDPRRAAC WHLVALLGVV VTVCFLVPAV IFAHLEEAWS 200
    FLDAFYFCFI SLSTIGLGDY VPGEAPGQPY RALYKVLVTV YLFLGLVAMV 250
    LVLQTFRHVS DLHGLTELIL LPPPCPASFN ADEDDRVDIL GPQPESHQQL 300
    SASSHTDYAS IPR 313
    Length:313
    Mass (Da):33,747
    Last modified:November 1, 1999 - v1
    Checksum:i1379382DFB0575DE
    GO
    Isoform 2 (identifier: Q9Y257-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-134: Missing.

    Show »
    Length:179
    Mass (Da):19,903
    Checksum:i21805E679C6A83F6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti150 – 1501T → I.
    Corresponds to variant rs35762773 [ dbSNP | Ensembl ].
    VAR_052426
    Natural varianti240 – 2401V → I.
    Corresponds to variant rs35496032 [ dbSNP | Ensembl ].
    VAR_059842
    Natural varianti259 – 2591V → M.
    Corresponds to variant rs34989303 [ dbSNP | Ensembl ].
    VAR_052427

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 134134Missing in isoform 2. 1 PublicationVSP_006692Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF134149 mRNA. Translation: AAD22980.1.
    AF117708 mRNA. Translation: AAD24000.1.
    AF281302 mRNA. Translation: AAG10506.1.
    AF281303 mRNA. Translation: AAG10507.1.
    AJ297404, AJ297405 Genomic DNA. Translation: CAC15489.1.
    BC004367 mRNA. Translation: AAH04367.1.
    CCDSiCCDS12513.1. [Q9Y257-1]
    RefSeqiNP_004814.1. NM_004823.1. [Q9Y257-1]
    XP_005259488.1. XM_005259431.2. [Q9Y257-2]
    XP_006723572.1. XM_006723509.1. [Q9Y257-1]
    XP_006723573.1. XM_006723510.1. [Q9Y257-2]
    UniGeneiHs.240395.

    Genome annotation databases

    EnsembliENST00000263372; ENSP00000263372; ENSG00000099337. [Q9Y257-1]
    GeneIDi9424.
    KEGGihsa:9424.
    UCSCiuc002oic.3. human. [Q9Y257-1]

    Polymorphism databases

    DMDMi13124108.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF134149 mRNA. Translation: AAD22980.1 .
    AF117708 mRNA. Translation: AAD24000.1 .
    AF281302 mRNA. Translation: AAG10506.1 .
    AF281303 mRNA. Translation: AAG10507.1 .
    AJ297404 , AJ297405 Genomic DNA. Translation: CAC15489.1 .
    BC004367 mRNA. Translation: AAH04367.1 .
    CCDSi CCDS12513.1. [Q9Y257-1 ]
    RefSeqi NP_004814.1. NM_004823.1. [Q9Y257-1 ]
    XP_005259488.1. XM_005259431.2. [Q9Y257-2 ]
    XP_006723572.1. XM_006723509.1. [Q9Y257-1 ]
    XP_006723573.1. XM_006723510.1. [Q9Y257-2 ]
    UniGenei Hs.240395.

    3D structure databases

    ProteinModelPortali Q9Y257.
    SMRi Q9Y257. Positions 20-262.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000263372.

    Chemistry

    DrugBanki DB00308. Ibutilide.
    DB00908. Quinidine.

    Protein family/group databases

    TCDBi 1.A.1.8.3. the voltage-gated ion channel (vic) superfamily.

    PTM databases

    PhosphoSitei Q9Y257.

    Polymorphism databases

    DMDMi 13124108.

    Proteomic databases

    PaxDbi Q9Y257.
    PRIDEi Q9Y257.

    Protocols and materials databases

    DNASUi 9424.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263372 ; ENSP00000263372 ; ENSG00000099337 . [Q9Y257-1 ]
    GeneIDi 9424.
    KEGGi hsa:9424.
    UCSCi uc002oic.3. human. [Q9Y257-1 ]

    Organism-specific databases

    CTDi 9424.
    GeneCardsi GC19P038810.
    H-InvDB HIX0202814.
    HGNCi HGNC:6281. KCNK6.
    HPAi CAB022637.
    HPA040184.
    MIMi 603939. gene.
    neXtProti NX_Q9Y257.
    PharmGKBi PA30063.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG290832.
    HOGENOMi HOG000286014.
    HOVERGENi HBG052237.
    InParanoidi Q9Y257.
    KOi K04917.
    OMAi PAVIFAH.
    OrthoDBi EOG7TTQ85.
    PhylomeDBi Q9Y257.
    TreeFami TF313947.

    Enzyme and pathway databases

    Reactomei REACT_75779. Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK).

    Miscellaneous databases

    GeneWikii KCNK6.
    GenomeRNAii 9424.
    NextBioi 35302.
    PROi Q9Y257.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y257.
    Bgeei Q9Y257.
    CleanExi HS_KCNK6.
    Genevestigatori Q9Y257.

    Family and domain databases

    InterProi IPR003280. 2pore_dom_K_chnl.
    IPR013099. 2pore_dom_K_chnl_dom.
    IPR003092. 2pore_dom_K_chnl_TASK.
    IPR005408. 2pore_dom_K_chnl_TWIK.
    IPR005409. 2pore_dom_K_chnl_TWIK2.
    [Graphical view ]
    Pfami PF07885. Ion_trans_2. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF038061. K_channel_subfamily_K_type. 1 hit.
    PRINTSi PR01333. 2POREKCHANEL.
    PR01587. TWIK2CHANNEL.
    PR01586. TWIKCHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit."
      Pountney D.J., Gulkarov I., Vega-Saenz de Miera E., Holmes D., Saganich M., Rudy B., Artman M., Coetzee W.A.
      FEBS Lett. 450:191-196(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. "TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family."
      Chavez R.A., Gray A.T., Zhao B.B., Kindler C.H., Mazurek M.J., Mehta Y., Forsayeth J.R., Yost C.S.
      J. Biol. Chem. 274:7887-7892(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), MUTAGENESIS OF CYS-53.
      Tissue: Brain.
    3. Erratum
      Chavez R.A., Gray A.T., Zhao B.B., Kindler C.H., Mazurek M.J., Mehta Y., Forsayeth J.R., Yost C.S.
      J. Biol. Chem. 274:24440-24440(1999)
    4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), CHARACTERIZATION.
    5. "Genomic structure and mutation screening of the TWIK-2 gene."
      Chen A.F., Gray A.T., Chen A.H., Kindler C.H., Mhatre A.N., Yost C.S., Lalwani A.K., Smith R.J.H.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Pancreas.

    Entry informationi

    Entry nameiKCNK6_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y257
    Secondary accession number(s): Q9HB47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Inhibited by internal acidification and, to a small degree, by zinc. Not inhibited by quinine, quinidine or barium.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3