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Q9Y257

- KCNK6_HUMAN

UniProt

Q9Y257 - KCNK6_HUMAN

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Protein

Potassium channel subfamily K member 6

Gene

KCNK6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Exhibits outward rectification in a physiological K+ gradient and mild inward rectification in symmetrical K+ conditions.

GO - Molecular functioni

  1. inward rectifier potassium channel activity Source: ProtInc

GO - Biological processi

  1. negative regulation of systemic arterial blood pressure Source: Ensembl
  2. potassium ion transport Source: ProtInc
  3. regulation of resting membrane potential Source: Ensembl
  4. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75779. Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK).

Protein family/group databases

TCDBi1.A.1.8.3. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 6
Alternative name(s):
Inward rectifying potassium channel protein TWIK-2
TWIK-originated similarity sequence
Gene namesi
Name:KCNK6
Synonyms:TOSS, TWIK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:6281. KCNK6.

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: Reactome
  2. voltage-gated potassium channel complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi53 – 531C → A: No channel activity. 1 Publication

Organism-specific databases

PharmGKBiPA30063.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Potassium channel subfamily K member 6PRO_0000101750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y257.
PRIDEiQ9Y257.

PTM databases

PhosphoSiteiQ9Y257.

Expressioni

Tissue specificityi

Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression detected in brain.

Gene expression databases

BgeeiQ9Y257.
CleanExiHS_KCNK6.
ExpressionAtlasiQ9Y257. baseline and differential.
GenevestigatoriQ9Y257.

Organism-specific databases

HPAiCAB022637.
HPA040184.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi9606.ENSP00000263372.

Structurei

3D structure databases

ProteinModelPortaliQ9Y257.
SMRiQ9Y257. Positions 20-262.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44CytoplasmicSequence Analysis
Topological domaini142 – 17231CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini257 – 31357CytoplasmicSequence AnalysisAdd
BLAST

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei90 – 11526Pore-forming; Name=Pore-forming 1Sequence AnalysisAdd
BLAST
Intramembranei199 – 22325Pore-forming; Name=Pore-forming 2Sequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence AnalysisAdd
BLAST
Transmembranei121 – 14121HelicalSequence AnalysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG290832.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000286014.
HOVERGENiHBG052237.
InParanoidiQ9Y257.
KOiK04917.
OMAiPAVIFAH.
OrthoDBiEOG7TTQ85.
PhylomeDBiQ9Y257.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR005409. 2pore_dom_K_chnl_TWIK2.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01587. TWIK2CHANNEL.
PR01586. TWIKCHANNEL.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y257) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRGALLAGA LAAYAAYLVL GALLVARLEG PHEARLRAEL ETLRAQLLQR
60 70 80 90 100
SPCVAAPALD AFVERVLAAG RLGRVVLANA SGSANASDPA WDFASALFFA
110 120 130 140 150
STLITTVGYG YTTPLTDAGK AFSIAFALLG VPTTMLLLTA SAQRLSLLLT
160 170 180 190 200
HVPLSWLSMR WGWDPRRAAC WHLVALLGVV VTVCFLVPAV IFAHLEEAWS
210 220 230 240 250
FLDAFYFCFI SLSTIGLGDY VPGEAPGQPY RALYKVLVTV YLFLGLVAMV
260 270 280 290 300
LVLQTFRHVS DLHGLTELIL LPPPCPASFN ADEDDRVDIL GPQPESHQQL
310
SASSHTDYAS IPR
Length:313
Mass (Da):33,747
Last modified:November 1, 1999 - v1
Checksum:i1379382DFB0575DE
GO
Isoform 2 (identifier: Q9Y257-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.

Show »
Length:179
Mass (Da):19,903
Checksum:i21805E679C6A83F6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti150 – 1501T → I.
Corresponds to variant rs35762773 [ dbSNP | Ensembl ].
VAR_052426
Natural varianti240 – 2401V → I.
Corresponds to variant rs35496032 [ dbSNP | Ensembl ].
VAR_059842
Natural varianti259 – 2591V → M.
Corresponds to variant rs34989303 [ dbSNP | Ensembl ].
VAR_052427

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 134134Missing in isoform 2. 1 PublicationVSP_006692Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF134149 mRNA. Translation: AAD22980.1.
AF117708 mRNA. Translation: AAD24000.1.
AF281302 mRNA. Translation: AAG10506.1.
AF281303 mRNA. Translation: AAG10507.1.
AJ297404, AJ297405 Genomic DNA. Translation: CAC15489.1.
BC004367 mRNA. Translation: AAH04367.1.
CCDSiCCDS12513.1. [Q9Y257-1]
RefSeqiNP_004814.1. NM_004823.1. [Q9Y257-1]
XP_005259488.1. XM_005259431.2. [Q9Y257-2]
XP_006723572.1. XM_006723509.1. [Q9Y257-1]
XP_006723573.1. XM_006723510.1. [Q9Y257-2]
UniGeneiHs.240395.

Genome annotation databases

EnsembliENST00000263372; ENSP00000263372; ENSG00000099337. [Q9Y257-1]
GeneIDi9424.
KEGGihsa:9424.
UCSCiuc002oic.3. human. [Q9Y257-1]

Polymorphism databases

DMDMi13124108.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF134149 mRNA. Translation: AAD22980.1 .
AF117708 mRNA. Translation: AAD24000.1 .
AF281302 mRNA. Translation: AAG10506.1 .
AF281303 mRNA. Translation: AAG10507.1 .
AJ297404 , AJ297405 Genomic DNA. Translation: CAC15489.1 .
BC004367 mRNA. Translation: AAH04367.1 .
CCDSi CCDS12513.1. [Q9Y257-1 ]
RefSeqi NP_004814.1. NM_004823.1. [Q9Y257-1 ]
XP_005259488.1. XM_005259431.2. [Q9Y257-2 ]
XP_006723572.1. XM_006723509.1. [Q9Y257-1 ]
XP_006723573.1. XM_006723510.1. [Q9Y257-2 ]
UniGenei Hs.240395.

3D structure databases

ProteinModelPortali Q9Y257.
SMRi Q9Y257. Positions 20-262.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000263372.

Chemistry

DrugBanki DB00308. Ibutilide.
DB00908. Quinidine.

Protein family/group databases

TCDBi 1.A.1.8.3. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei Q9Y257.

Polymorphism databases

DMDMi 13124108.

Proteomic databases

PaxDbi Q9Y257.
PRIDEi Q9Y257.

Protocols and materials databases

DNASUi 9424.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263372 ; ENSP00000263372 ; ENSG00000099337 . [Q9Y257-1 ]
GeneIDi 9424.
KEGGi hsa:9424.
UCSCi uc002oic.3. human. [Q9Y257-1 ]

Organism-specific databases

CTDi 9424.
GeneCardsi GC19P038810.
H-InvDB HIX0202814.
HGNCi HGNC:6281. KCNK6.
HPAi CAB022637.
HPA040184.
MIMi 603939. gene.
neXtProti NX_Q9Y257.
PharmGKBi PA30063.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG290832.
GeneTreei ENSGT00760000118858.
HOGENOMi HOG000286014.
HOVERGENi HBG052237.
InParanoidi Q9Y257.
KOi K04917.
OMAi PAVIFAH.
OrthoDBi EOG7TTQ85.
PhylomeDBi Q9Y257.
TreeFami TF313947.

Enzyme and pathway databases

Reactomei REACT_75779. Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK).

Miscellaneous databases

GeneWikii KCNK6.
GenomeRNAii 9424.
NextBioi 35302.
PROi Q9Y257.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y257.
CleanExi HS_KCNK6.
ExpressionAtlasi Q9Y257. baseline and differential.
Genevestigatori Q9Y257.

Family and domain databases

InterProi IPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR005409. 2pore_dom_K_chnl_TWIK2.
[Graphical view ]
Pfami PF07885. Ion_trans_2. 2 hits.
[Graphical view ]
PIRSFi PIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSi PR01333. 2POREKCHANEL.
PR01587. TWIK2CHANNEL.
PR01586. TWIKCHANNEL.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit."
    Pountney D.J., Gulkarov I., Vega-Saenz de Miera E., Holmes D., Saganich M., Rudy B., Artman M., Coetzee W.A.
    FEBS Lett. 450:191-196(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family."
    Chavez R.A., Gray A.T., Zhao B.B., Kindler C.H., Mazurek M.J., Mehta Y., Forsayeth J.R., Yost C.S.
    J. Biol. Chem. 274:7887-7892(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), MUTAGENESIS OF CYS-53.
    Tissue: Brain.
  3. Erratum
    Chavez R.A., Gray A.T., Zhao B.B., Kindler C.H., Mazurek M.J., Mehta Y., Forsayeth J.R., Yost C.S.
    J. Biol. Chem. 274:24440-24440(1999)
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), CHARACTERIZATION.
  5. "Genomic structure and mutation screening of the TWIK-2 gene."
    Chen A.F., Gray A.T., Chen A.H., Kindler C.H., Mhatre A.N., Yost C.S., Lalwani A.K., Smith R.J.H.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreas.

Entry informationi

Entry nameiKCNK6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y257
Secondary accession number(s): Q9HB47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Inhibited by internal acidification and, to a small degree, by zinc. Not inhibited by quinine, quinidine or barium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3