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Protein

Potassium channel subfamily K member 6

Gene

KCNK6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits outward rectification in a physiological K+ gradient and mild inward rectification in symmetrical K+ conditions.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000099337-MONOMER.
ReactomeiR-HSA-1299308. Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK).
R-HSA-5576886. Phase 4 - resting membrane potential.

Protein family/group databases

TCDBi1.A.1.8.3. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 6
Alternative name(s):
Inward rectifying potassium channel protein TWIK-2
TWIK-originated similarity sequence
Gene namesi
Name:KCNK6
Synonyms:TOSS, TWIK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6281. KCNK6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicSequence analysis4
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Intramembranei90 – 115Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST26
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 172CytoplasmicSequence analysisAdd BLAST31
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Intramembranei199 – 223Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST25
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 313CytoplasmicSequence analysisAdd BLAST57

GO - Cellular componenti

  • plasma membrane Source: Reactome
  • voltage-gated potassium channel complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi53C → A: No channel activity. 1 Publication1

Organism-specific databases

DisGeNETi9424.
OpenTargetsiENSG00000099337.
PharmGKBiPA30063.

Chemistry databases

DrugBankiDB00308. Ibutilide.
DB00908. Quinidine.

Polymorphism and mutation databases

BioMutaiKCNK6.
DMDMi13124108.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017501 – 313Potassium channel subfamily K member 6Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...)Sequence analysis1
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y257.
PaxDbiQ9Y257.
PeptideAtlasiQ9Y257.
PRIDEiQ9Y257.

PTM databases

iPTMnetiQ9Y257.
PhosphoSitePlusiQ9Y257.

Expressioni

Tissue specificityi

Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression detected in brain.

Gene expression databases

BgeeiENSG00000099337.
CleanExiHS_KCNK6.
ExpressionAtlasiQ9Y257. baseline and differential.
GenevisibleiQ9Y257. HS.

Organism-specific databases

HPAiCAB022637.
HPA040184.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi9606.ENSP00000263372.

Structurei

3D structure databases

ProteinModelPortaliQ9Y257.
SMRiQ9Y257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000286014.
HOVERGENiHBG052237.
InParanoidiQ9Y257.
KOiK04917.
OMAiPAVIFAH.
OrthoDBiEOG091G0DIX.
PhylomeDBiQ9Y257.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR005409. 2pore_dom_K_chnl_TWIK2.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01587. TWIK2CHANNEL.
PR01586. TWIKCHANNEL.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y257-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRGALLAGA LAAYAAYLVL GALLVARLEG PHEARLRAEL ETLRAQLLQR
60 70 80 90 100
SPCVAAPALD AFVERVLAAG RLGRVVLANA SGSANASDPA WDFASALFFA
110 120 130 140 150
STLITTVGYG YTTPLTDAGK AFSIAFALLG VPTTMLLLTA SAQRLSLLLT
160 170 180 190 200
HVPLSWLSMR WGWDPRRAAC WHLVALLGVV VTVCFLVPAV IFAHLEEAWS
210 220 230 240 250
FLDAFYFCFI SLSTIGLGDY VPGEAPGQPY RALYKVLVTV YLFLGLVAMV
260 270 280 290 300
LVLQTFRHVS DLHGLTELIL LPPPCPASFN ADEDDRVDIL GPQPESHQQL
310
SASSHTDYAS IPR
Length:313
Mass (Da):33,747
Last modified:November 1, 1999 - v1
Checksum:i1379382DFB0575DE
GO
Isoform 2 (identifier: Q9Y257-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.

Show »
Length:179
Mass (Da):19,903
Checksum:i21805E679C6A83F6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052426150T → I.Corresponds to variant rs35762773dbSNPEnsembl.1
Natural variantiVAR_059842240V → I.Corresponds to variant rs35496032dbSNPEnsembl.1
Natural variantiVAR_052427259V → M.Corresponds to variant rs34989303dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0066921 – 134Missing in isoform 2. 1 PublicationAdd BLAST134

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134149 mRNA. Translation: AAD22980.1.
AF117708 mRNA. Translation: AAD24000.1.
AF281302 mRNA. Translation: AAG10506.1.
AF281303 mRNA. Translation: AAG10507.1.
AJ297404, AJ297405 Genomic DNA. Translation: CAC15489.1.
BC004367 mRNA. Translation: AAH04367.1.
CCDSiCCDS12513.1. [Q9Y257-1]
RefSeqiNP_004814.1. NM_004823.1. [Q9Y257-1]
XP_011525828.1. XM_011527526.1. [Q9Y257-2]
UniGeneiHs.240395.

Genome annotation databases

EnsembliENST00000263372; ENSP00000263372; ENSG00000099337. [Q9Y257-1]
GeneIDi9424.
KEGGihsa:9424.
UCSCiuc002oic.4. human. [Q9Y257-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134149 mRNA. Translation: AAD22980.1.
AF117708 mRNA. Translation: AAD24000.1.
AF281302 mRNA. Translation: AAG10506.1.
AF281303 mRNA. Translation: AAG10507.1.
AJ297404, AJ297405 Genomic DNA. Translation: CAC15489.1.
BC004367 mRNA. Translation: AAH04367.1.
CCDSiCCDS12513.1. [Q9Y257-1]
RefSeqiNP_004814.1. NM_004823.1. [Q9Y257-1]
XP_011525828.1. XM_011527526.1. [Q9Y257-2]
UniGeneiHs.240395.

3D structure databases

ProteinModelPortaliQ9Y257.
SMRiQ9Y257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000263372.

Chemistry databases

DrugBankiDB00308. Ibutilide.
DB00908. Quinidine.

Protein family/group databases

TCDBi1.A.1.8.3. the voltage-gated ion channel (vic) superfamily.

PTM databases

iPTMnetiQ9Y257.
PhosphoSitePlusiQ9Y257.

Polymorphism and mutation databases

BioMutaiKCNK6.
DMDMi13124108.

Proteomic databases

EPDiQ9Y257.
PaxDbiQ9Y257.
PeptideAtlasiQ9Y257.
PRIDEiQ9Y257.

Protocols and materials databases

DNASUi9424.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263372; ENSP00000263372; ENSG00000099337. [Q9Y257-1]
GeneIDi9424.
KEGGihsa:9424.
UCSCiuc002oic.4. human. [Q9Y257-1]

Organism-specific databases

CTDi9424.
DisGeNETi9424.
GeneCardsiKCNK6.
H-InvDBHIX0202814.
HGNCiHGNC:6281. KCNK6.
HPAiCAB022637.
HPA040184.
MIMi603939. gene.
neXtProtiNX_Q9Y257.
OpenTargetsiENSG00000099337.
PharmGKBiPA30063.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000286014.
HOVERGENiHBG052237.
InParanoidiQ9Y257.
KOiK04917.
OMAiPAVIFAH.
OrthoDBiEOG091G0DIX.
PhylomeDBiQ9Y257.
TreeFamiTF313947.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000099337-MONOMER.
ReactomeiR-HSA-1299308. Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK).
R-HSA-5576886. Phase 4 - resting membrane potential.

Miscellaneous databases

ChiTaRSiKCNK6. human.
GeneWikiiKCNK6.
GenomeRNAii9424.
PROiQ9Y257.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099337.
CleanExiHS_KCNK6.
ExpressionAtlasiQ9Y257. baseline and differential.
GenevisibleiQ9Y257. HS.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR005409. 2pore_dom_K_chnl_TWIK2.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01587. TWIK2CHANNEL.
PR01586. TWIKCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNK6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y257
Secondary accession number(s): Q9HB47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Inhibited by internal acidification and, to a small degree, by zinc. Not inhibited by quinine, quinidine or barium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.