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Q9Y256

- FACE2_HUMAN

UniProt

Q9Y256 - FACE2_HUMAN

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Protein

CAAX prenyl protease 2

Gene
RCE1, FACE2, RCE1A, RCE1B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1.

Enzyme regulationi

Deubiquitination by USP17L2/USP17 negatively regulates the proteolytic activity toward Ras GTPases.1 Publication

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. metalloendopeptidase activity Source: ProtInc

GO - Biological processi

  1. CAAX-box protein processing Source: UniProtKB
  2. proteolysis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BRENDAi3.4.22.22. 2681.

Protein family/group databases

MEROPSiM79.002.

Names & Taxonomyi

Protein namesi
Recommended name:
CAAX prenyl protease 2 (EC:3.4.22.-)
Alternative name(s):
Farnesylated proteins-converting enzyme 2
Short name:
FACE-2
Prenyl protein-specific endoprotease 2
RCE1 homolog
Short name:
hRCE1
Gene namesi
Name:RCE1
Synonyms:FACE2, RCE1A, RCE1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:13721. RCE1.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521Helical; Reviewed predictionAdd
BLAST
Transmembranei75 – 9521Helical; Reviewed predictionAdd
BLAST
Transmembranei112 – 13221Helical; Reviewed predictionAdd
BLAST
Transmembranei186 – 20621Helical; Reviewed predictionAdd
BLAST
Transmembranei229 – 24921Helical; Reviewed predictionAdd
BLAST
Transmembranei254 – 27421Helical; Reviewed predictionAdd
BLAST
Transmembranei283 – 30321Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34302.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 329328CAAX prenyl protease 2PRO_0000194830Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Post-translational modificationi

Ubiquitinated. Undergoes 'Lys-48'-and 'Lys-63'-linked ubiquitination. 'Lys-48' ubiquitination induces its degradation. Deubiquitinated by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains.1 Publication

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

MaxQBiQ9Y256.
PaxDbiQ9Y256.
PRIDEiQ9Y256.

PTM databases

PhosphoSiteiQ9Y256.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

ArrayExpressiQ9Y256.
BgeeiQ9Y256.
CleanExiHS_RCE1.
GenevestigatoriQ9Y256.

Interactioni

Protein-protein interaction databases

BioGridi115307. 1 interaction.
STRINGi9606.ENSP00000309163.

Structurei

3D structure databases

ProteinModelPortaliQ9Y256.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase U48 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG264307.
HOGENOMiHOG000006037.
HOVERGENiHBG002541.
InParanoidiQ9Y256.
KOiK08658.
OMAiYSAFLFA.
OrthoDBiEOG7F24TC.
PhylomeDBiQ9Y256.
TreeFamiTF313800.

Family and domain databases

InterProiIPR003675. CAAX_protease.
[Graphical view]
PfamiPF02517. Abi. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y256-1 [UniParc]FASTAAdd to Basket

« Hide

MAALGGDGLR LLSVSRPERP PESAALGGLG PGLCCWVSVF SCLSLACSYV    50
GSLYVWKSEL PRDHPAVIKR RFTSVLVVSS LSPLCVLLWR ELTGIQPGTS 100
LLTLMGFRLE GIFPAALLPL LLTMILFLGP LMQLSMDCPC DLADGLKVVL 150
APRSWARCLT DMRWLRNQVI APLTEELVFR ACMLPMLAPC MGLGPAVFTC 200
PLFFGVAHFH HIIEQLRFRQ SSVGNIFLSA AFQFSYTAVF GAYTAFLFIR 250
TGHLIGPVLC HSFCNYMGFP AVCAALEHPQ RRPLLAGYAL GVGLFLLLLQ 300
PLTDPKLYGS LPLCVLLERA GDSEAPLCS 329
Length:329
Mass (Da):35,833
Last modified:November 1, 1999 - v1
Checksum:iBA8F764651172BFA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti326 – 3261P → A in a breast cancer sample; somatic mutation. 1 Publication
VAR_036407

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13835 mRNA. Translation: CAB46278.1.
AF121951 mRNA. Translation: AAD22632.1.
BC093726 mRNA. Translation: AAH93726.1.
BC093728 mRNA. Translation: AAH93728.1.
CCDSiCCDS8151.1.
RefSeqiNP_001027450.1. NM_001032279.1.
NP_005124.1. NM_005133.2.
UniGeneiHs.654972.

Genome annotation databases

EnsembliENST00000309657; ENSP00000309163; ENSG00000173653.
GeneIDi9986.
KEGGihsa:9986.
UCSCiuc001ojk.1. human.

Polymorphism databases

DMDMi13431529.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13835 mRNA. Translation: CAB46278.1 .
AF121951 mRNA. Translation: AAD22632.1 .
BC093726 mRNA. Translation: AAH93726.1 .
BC093728 mRNA. Translation: AAH93728.1 .
CCDSi CCDS8151.1.
RefSeqi NP_001027450.1. NM_001032279.1.
NP_005124.1. NM_005133.2.
UniGenei Hs.654972.

3D structure databases

ProteinModelPortali Q9Y256.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115307. 1 interaction.
STRINGi 9606.ENSP00000309163.

Chemistry

BindingDBi Q9Y256.
ChEMBLi CHEMBL3411.

Protein family/group databases

MEROPSi M79.002.

PTM databases

PhosphoSitei Q9Y256.

Polymorphism databases

DMDMi 13431529.

Proteomic databases

MaxQBi Q9Y256.
PaxDbi Q9Y256.
PRIDEi Q9Y256.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309657 ; ENSP00000309163 ; ENSG00000173653 .
GeneIDi 9986.
KEGGi hsa:9986.
UCSCi uc001ojk.1. human.

Organism-specific databases

CTDi 9986.
GeneCardsi GC11P066611.
HGNCi HGNC:13721. RCE1.
MIMi 605385. gene.
neXtProti NX_Q9Y256.
PharmGKBi PA34302.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG264307.
HOGENOMi HOG000006037.
HOVERGENi HBG002541.
InParanoidi Q9Y256.
KOi K08658.
OMAi YSAFLFA.
OrthoDBi EOG7F24TC.
PhylomeDBi Q9Y256.
TreeFami TF313800.

Enzyme and pathway databases

BRENDAi 3.4.22.22. 2681.

Miscellaneous databases

GeneWikii RCE1.
NextBioi 37706.
PROi Q9Y256.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y256.
Bgeei Q9Y256.
CleanExi HS_RCE1.
Genevestigatori Q9Y256.

Family and domain databases

InterProi IPR003675. CAAX_protease.
[Graphical view ]
Pfami PF02517. Abi. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins."
    Freije J.M.P., Blay P., Pendas A.M., Cadinanos J., Crespo P., Lopez-Otin C.
    Genomics 58:270-280(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  2. "Cloning and characterization of a mammalian prenyl protein-specific protease."
    Otto J.C., Kim E., Young S.G., Casey P.J.
    J. Biol. Chem. 274:8379-8382(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Human ras-converting enzyme (hRCE1) endoproteolytic activity on K-ras-derived peptides."
    Hollander I., Frommer E., Mallon R.
    Anal. Biochem. 286:129-137(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  5. Cited for: UBIQUITINATION, DEUBIQUITINATION BY USP17L2, SUBCELLULAR LOCATION, ENZYME REGULATION.
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] ALA-326.

Entry informationi

Entry nameiFACE2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y256
Secondary accession number(s): Q52LZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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