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Q9Y256

- FACE2_HUMAN

UniProt

Q9Y256 - FACE2_HUMAN

Protein

CAAX prenyl protease 2

Gene

RCE1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1.

    Enzyme regulationi

    Deubiquitination by USP17L2/USP17 negatively regulates the proteolytic activity toward Ras GTPases.1 Publication

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: UniProtKB
    2. metalloendopeptidase activity Source: ProtInc

    GO - Biological processi

    1. CAAX-box protein processing Source: UniProtKB
    2. proteolysis Source: ProtInc

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BRENDAi3.4.22.22. 2681.

    Protein family/group databases

    MEROPSiM79.002.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CAAX prenyl protease 2 (EC:3.4.22.-)
    Alternative name(s):
    Farnesylated proteins-converting enzyme 2
    Short name:
    FACE-2
    Prenyl protein-specific endoprotease 2
    RCE1 homolog
    Short name:
    hRCE1
    Gene namesi
    Name:RCE1
    Synonyms:FACE2, RCE1A, RCE1B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:13721. RCE1.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB
    2. integral component of plasma membrane Source: ProtInc
    3. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34302.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 329328CAAX prenyl protease 2PRO_0000194830Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Post-translational modificationi

    Ubiquitinated. Undergoes 'Lys-48'-and 'Lys-63'-linked ubiquitination. 'Lys-48' ubiquitination induces its degradation. Deubiquitinated by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains.1 Publication

    Keywords - PTMi

    Acetylation, Ubl conjugation

    Proteomic databases

    MaxQBiQ9Y256.
    PaxDbiQ9Y256.
    PRIDEiQ9Y256.

    PTM databases

    PhosphoSiteiQ9Y256.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ9Y256.
    BgeeiQ9Y256.
    CleanExiHS_RCE1.
    GenevestigatoriQ9Y256.

    Interactioni

    Protein-protein interaction databases

    BioGridi115307. 1 interaction.
    STRINGi9606.ENSP00000309163.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y256.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei75 – 9521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei112 – 13221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei186 – 20621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei229 – 24921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei254 – 27421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei283 – 30321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase U48 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG264307.
    HOGENOMiHOG000006037.
    HOVERGENiHBG002541.
    InParanoidiQ9Y256.
    KOiK08658.
    OMAiYSAFLFA.
    OrthoDBiEOG7F24TC.
    PhylomeDBiQ9Y256.
    TreeFamiTF313800.

    Family and domain databases

    InterProiIPR003675. CAAX_protease.
    [Graphical view]
    PfamiPF02517. Abi. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y256-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAALGGDGLR LLSVSRPERP PESAALGGLG PGLCCWVSVF SCLSLACSYV    50
    GSLYVWKSEL PRDHPAVIKR RFTSVLVVSS LSPLCVLLWR ELTGIQPGTS 100
    LLTLMGFRLE GIFPAALLPL LLTMILFLGP LMQLSMDCPC DLADGLKVVL 150
    APRSWARCLT DMRWLRNQVI APLTEELVFR ACMLPMLAPC MGLGPAVFTC 200
    PLFFGVAHFH HIIEQLRFRQ SSVGNIFLSA AFQFSYTAVF GAYTAFLFIR 250
    TGHLIGPVLC HSFCNYMGFP AVCAALEHPQ RRPLLAGYAL GVGLFLLLLQ 300
    PLTDPKLYGS LPLCVLLERA GDSEAPLCS 329
    Length:329
    Mass (Da):35,833
    Last modified:November 1, 1999 - v1
    Checksum:iBA8F764651172BFA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti326 – 3261P → A in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036407

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13835 mRNA. Translation: CAB46278.1.
    AF121951 mRNA. Translation: AAD22632.1.
    BC093726 mRNA. Translation: AAH93726.1.
    BC093728 mRNA. Translation: AAH93728.1.
    CCDSiCCDS8151.1.
    RefSeqiNP_001027450.1. NM_001032279.1.
    NP_005124.1. NM_005133.2.
    UniGeneiHs.654972.

    Genome annotation databases

    EnsembliENST00000309657; ENSP00000309163; ENSG00000173653.
    GeneIDi9986.
    KEGGihsa:9986.
    UCSCiuc001ojk.1. human.

    Polymorphism databases

    DMDMi13431529.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13835 mRNA. Translation: CAB46278.1 .
    AF121951 mRNA. Translation: AAD22632.1 .
    BC093726 mRNA. Translation: AAH93726.1 .
    BC093728 mRNA. Translation: AAH93728.1 .
    CCDSi CCDS8151.1.
    RefSeqi NP_001027450.1. NM_001032279.1.
    NP_005124.1. NM_005133.2.
    UniGenei Hs.654972.

    3D structure databases

    ProteinModelPortali Q9Y256.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115307. 1 interaction.
    STRINGi 9606.ENSP00000309163.

    Chemistry

    BindingDBi Q9Y256.
    ChEMBLi CHEMBL3411.

    Protein family/group databases

    MEROPSi M79.002.

    PTM databases

    PhosphoSitei Q9Y256.

    Polymorphism databases

    DMDMi 13431529.

    Proteomic databases

    MaxQBi Q9Y256.
    PaxDbi Q9Y256.
    PRIDEi Q9Y256.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309657 ; ENSP00000309163 ; ENSG00000173653 .
    GeneIDi 9986.
    KEGGi hsa:9986.
    UCSCi uc001ojk.1. human.

    Organism-specific databases

    CTDi 9986.
    GeneCardsi GC11P066611.
    HGNCi HGNC:13721. RCE1.
    MIMi 605385. gene.
    neXtProti NX_Q9Y256.
    PharmGKBi PA34302.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG264307.
    HOGENOMi HOG000006037.
    HOVERGENi HBG002541.
    InParanoidi Q9Y256.
    KOi K08658.
    OMAi YSAFLFA.
    OrthoDBi EOG7F24TC.
    PhylomeDBi Q9Y256.
    TreeFami TF313800.

    Enzyme and pathway databases

    BRENDAi 3.4.22.22. 2681.

    Miscellaneous databases

    GeneWikii RCE1.
    NextBioi 37706.
    PROi Q9Y256.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y256.
    Bgeei Q9Y256.
    CleanExi HS_RCE1.
    Genevestigatori Q9Y256.

    Family and domain databases

    InterProi IPR003675. CAAX_protease.
    [Graphical view ]
    Pfami PF02517. Abi. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins."
      Freije J.M.P., Blay P., Pendas A.M., Cadinanos J., Crespo P., Lopez-Otin C.
      Genomics 58:270-280(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.
    2. "Cloning and characterization of a mammalian prenyl protein-specific protease."
      Otto J.C., Kim E., Young S.G., Casey P.J.
      J. Biol. Chem. 274:8379-8382(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Human ras-converting enzyme (hRCE1) endoproteolytic activity on K-ras-derived peptides."
      Hollander I., Frommer E., Mallon R.
      Anal. Biochem. 286:129-137(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    5. Cited for: UBIQUITINATION, DEUBIQUITINATION BY USP17L2, SUBCELLULAR LOCATION, ENZYME REGULATION.
    6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    7. Cited for: VARIANT [LARGE SCALE ANALYSIS] ALA-326.

    Entry informationi

    Entry nameiFACE2_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y256
    Secondary accession number(s): Q52LZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3