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Protein

PRELI domain-containing protein 1, mitochondrial

Gene

PRELID1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs.3 Publications

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • immune response Source: ProtInc
  • multicellular organism development Source: ProtInc
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of mitochondrial membrane potential Source: UniProtKB
  • negative regulation of release of cytochrome c from mitochondria Source: UniProtKB
  • phospholipid transport Source: GOC
  • positive regulation of cellular respiration Source: UniProtKB
  • positive regulation of endopeptidase activity Source: UniProtKB
  • positive regulation of phospholipid transport Source: UniProtKB
  • positive regulation of T cell apoptotic process Source: UniProtKB
  • regulation of apoptotic process Source: Reactome
  • regulation of membrane lipid distribution Source: UniProtKB
  • regulation of mitochondrial membrane potential Source: UniProtKB
  • regulation of T cell differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Lipid transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6803204. TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.

Names & Taxonomyi

Protein namesi
Recommended name:
PRELI domain-containing protein 1, mitochondrial
Alternative name(s):
25 kDa protein of relevant evolutionary and lymphoid interest
Px19-like protein
Gene namesi
Name:PRELID1
Synonyms:PRELI
ORF Names:CGI-106, SBBI12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:30255. PRELID1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial intermembrane space Source: UniProtKB
  • mitochondrion Source: UniProtKB
  • nucleoplasm Source: HPA
  • protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400040.

Polymorphism and mutation databases

DMDMi29839690.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 219PRELI domain-containing protein 1, mitochondrialPRO_0000097119
Transit peptidei1 – ?Mitochondrion1 Publication

Proteomic databases

EPDiQ9Y255.
MaxQBiQ9Y255.
PaxDbiQ9Y255.
PRIDEiQ9Y255.

PTM databases

iPTMnetiQ9Y255.
PhosphoSiteiQ9Y255.

Expressioni

Tissue specificityi

Highly expressed in fetal liver; less expressed in fetal brain, lung, and kidney. At the adult stage, expression is drastically reduced in the liver but highly expressed in the spleen, brain, lung, lymph nodes and peripheral blood leukocytes.

Inductioni

Up-regulated in response to activation in primary T helper cells.1 Publication

Gene expression databases

BgeeiQ9Y255.
CleanExiHS_PRELID1.
ExpressionAtlasiQ9Y255. baseline and differential.
GenevisibleiQ9Y255. HS.

Organism-specific databases

HPAiHPA005701.

Interactioni

Subunit structurei

Forms a complex with TRIAP1 in the mitochondrion intermembrane space. Interacts with OPA1 and AIFM1.2 Publications

Protein-protein interaction databases

BioGridi118045. 3 interactions.
IntActiQ9Y255. 1 interaction.
STRINGi9606.ENSP00000302114.

Structurei

3D structure databases

ProteinModelPortaliQ9Y255.
SMRiQ9Y255. Positions 1-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 174139PRELI/MSF1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PRELI/MSF1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3337. Eukaryota.
ENOG411110V. LUCA.
GeneTreeiENSGT00550000074825.
HOGENOMiHOG000185150.
HOVERGENiHBG105096.
InParanoidiQ9Y255.
OMAiWNITHAR.
OrthoDBiEOG7F512Z.
PhylomeDBiQ9Y255.
TreeFamiTF313119.

Family and domain databases

InterProiIPR006797. PRELI/MSF1_dom.
[Graphical view]
PfamiPF04707. PRELI. 1 hit.
[Graphical view]
PROSITEiPS50904. PRELI_MSF1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y255-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVKYFLGQSV LRSSWDQVFA AFWQRYPNPY SKHVLTEDIV HREVTPDQKL
60 70 80 90 100
LSRRLLTKTN RMPRWAERLF PANVAHSVYV LEDSIVDPQN QTMTTFTWNI
110 120 130 140 150
NHARLMVVEE RCVYCVNSDN SGWTEIRREA WVSSSLFGVS RAVQEFGLAR
160 170 180 190 200
FKSNVTKTMK GFEYILAKLQ GEAPSKTLVE TAKEAKEKAK ETALAATEKA
210
KDLASKAATK KQQQQQQFV
Length:219
Mass (Da):25,181
Last modified:November 1, 1999 - v1
Checksum:iCCDBF54FA573509F
GO
Isoform 2 (identifier: Q9Y255-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-181: Missing.

Note: No experimental confirmation available.
Show »
Length:208
Mass (Da):24,068
Checksum:i523B720DB5C4AF77
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271R → H in AAF09255 (PubMed:10784606).Curated
Sequence conflicti142 – 1421A → T in AAF17191 (PubMed:10931946).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei171 – 18111Missing in isoform 2. 1 PublicationVSP_054731Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201925 mRNA. Translation: AAF09255.1.
AF087858 mRNA. Translation: AAP97168.1.
AF151864 mRNA. Translation: AAD34101.1.
AF153607 mRNA. Translation: AAD41089.1.
AF111112 mRNA. Translation: AAF27195.1.
AF112203 mRNA. Translation: AAF17191.1.
AK312170 mRNA. Translation: BAG35104.1.
AC146507 Genomic DNA. No translation available.
CH471195 Genomic DNA. Translation: EAW85022.1.
CH471195 Genomic DNA. Translation: EAW85023.1.
BC000007 mRNA. Translation: AAH00007.1.
BC007268 mRNA. Translation: AAH07268.1.
BC008307 mRNA. Translation: AAH08307.1.
BC008866 mRNA. Translation: AAH08866.1.
BC013733 mRNA. Translation: AAH13733.1.
BC013748 mRNA. Translation: AAH13748.1.
BC078182 mRNA. Translation: AAH78182.1.
CCDSiCCDS4415.1. [Q9Y255-1]
CCDS64328.1. [Q9Y255-2]
RefSeqiNP_001258757.1. NM_001271828.1. [Q9Y255-2]
NP_037369.1. NM_013237.3. [Q9Y255-1]
UniGeneiHs.744904.

Genome annotation databases

EnsembliENST00000303204; ENSP00000302114; ENSG00000169230. [Q9Y255-1]
ENST00000503216; ENSP00000427097; ENSG00000169230. [Q9Y255-2]
GeneIDi27166.
KEGGihsa:27166.
UCSCiuc003mfx.5. human. [Q9Y255-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201925 mRNA. Translation: AAF09255.1.
AF087858 mRNA. Translation: AAP97168.1.
AF151864 mRNA. Translation: AAD34101.1.
AF153607 mRNA. Translation: AAD41089.1.
AF111112 mRNA. Translation: AAF27195.1.
AF112203 mRNA. Translation: AAF17191.1.
AK312170 mRNA. Translation: BAG35104.1.
AC146507 Genomic DNA. No translation available.
CH471195 Genomic DNA. Translation: EAW85022.1.
CH471195 Genomic DNA. Translation: EAW85023.1.
BC000007 mRNA. Translation: AAH00007.1.
BC007268 mRNA. Translation: AAH07268.1.
BC008307 mRNA. Translation: AAH08307.1.
BC008866 mRNA. Translation: AAH08866.1.
BC013733 mRNA. Translation: AAH13733.1.
BC013748 mRNA. Translation: AAH13748.1.
BC078182 mRNA. Translation: AAH78182.1.
CCDSiCCDS4415.1. [Q9Y255-1]
CCDS64328.1. [Q9Y255-2]
RefSeqiNP_001258757.1. NM_001271828.1. [Q9Y255-2]
NP_037369.1. NM_013237.3. [Q9Y255-1]
UniGeneiHs.744904.

3D structure databases

ProteinModelPortaliQ9Y255.
SMRiQ9Y255. Positions 1-170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118045. 3 interactions.
IntActiQ9Y255. 1 interaction.
STRINGi9606.ENSP00000302114.

PTM databases

iPTMnetiQ9Y255.
PhosphoSiteiQ9Y255.

Polymorphism and mutation databases

DMDMi29839690.

Proteomic databases

EPDiQ9Y255.
MaxQBiQ9Y255.
PaxDbiQ9Y255.
PRIDEiQ9Y255.

Protocols and materials databases

DNASUi27166.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303204; ENSP00000302114; ENSG00000169230. [Q9Y255-1]
ENST00000503216; ENSP00000427097; ENSG00000169230. [Q9Y255-2]
GeneIDi27166.
KEGGihsa:27166.
UCSCiuc003mfx.5. human. [Q9Y255-1]

Organism-specific databases

CTDi27166.
GeneCardsiPRELID1.
H-InvDBHIX0028820.
HGNCiHGNC:30255. PRELID1.
HPAiHPA005701.
MIMi605733. gene.
neXtProtiNX_Q9Y255.
PharmGKBiPA162400040.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3337. Eukaryota.
ENOG411110V. LUCA.
GeneTreeiENSGT00550000074825.
HOGENOMiHOG000185150.
HOVERGENiHBG105096.
InParanoidiQ9Y255.
OMAiWNITHAR.
OrthoDBiEOG7F512Z.
PhylomeDBiQ9Y255.
TreeFamiTF313119.

Enzyme and pathway databases

ReactomeiR-HSA-6803204. TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.

Miscellaneous databases

ChiTaRSiPRELID1. human.
GenomeRNAii27166.
PROiQ9Y255.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y255.
CleanExiHS_PRELID1.
ExpressionAtlasiQ9Y255. baseline and differential.
GenevisibleiQ9Y255. HS.

Family and domain databases

InterProiIPR006797. PRELI/MSF1_dom.
[Graphical view]
PfamiPF04707. PRELI. 1 hit.
[Graphical view]
PROSITEiPS50904. PRELI_MSF1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PRELI, the human homologue of the avian px19, is expressed by germinal center B lymphocytes."
    Guzman-Rojas L., Sims J.C., Rangel R., Guret C., Sun Y., Alcocer J.M., Martinez-Valdez H.
    Int. Immunol. 12:607-612(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Tonsil.
  2. "Cloning of a new human cDNA homologous to chicken px19 mRNA."
    Zhang X.N., Yu L., Cui W.C., Zhang H.L., Xin Y.R., Zhao S.Y.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "A catalogue of genes in the human dermal papilla cells as identified by expressed sequence tags."
    Kim M.K., Kim Y.H., Seo J.M., Lee H.M., Chung H.J., Sohn M.Y., Hwang S.Y., Im S.U., Jung E.J., Lee J.H., Kim J.C.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hair follicle dermal papilla.
  5. Zhang W., He L., Wan T., Zhu X., Cao X.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Adrenal gland.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  8. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain, Eye, Ovary, Placenta and Uterus.
  11. "PRELI (protein of relevant evolutionary and lymphoid interest) is located within an evolutionarily conserved gene cluster on chromosome 5q34-q35 and encodes a novel mitochondrial protein."
    Fox E.J., Stubbs S.A., Kyaw Tun J., Leek J.P., Markham A.F., Wright S.C.
    Biochem. J. 378:817-825(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, PRESENCE OF N-TERMINAL TRANSIT PEPTIDE.
  12. "PRELI is a mitochondrial regulator of human primary T-helper cell apoptosis, STAT6, and Th2-cell differentiation."
    Tahvanainen J., Kallonen T., Lahteenmaki H., Heiskanen K.M., Westermarck J., Rao K.V., Lahesmaa R.
    Blood 113:1268-1277(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
  13. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH OPA1 AND AIFM1.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid."
    Potting C., Tatsuta T., Konig T., Haag M., Wai T., Aaltonen M.J., Langer T.
    Cell Metab. 18:287-295(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiPRLD1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y255
Secondary accession number(s): B2R5F7
, D6RD25, Q549N2, Q9UI13, Q9UJS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: November 1, 1999
Last modified: June 8, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.