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Q9Y250

- LZTS1_HUMAN

UniProt

Q9Y250 - LZTS1_HUMAN

Protein

Leucine zipper putative tumor suppressor 1

Gene

LZTS1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor.3 Publications

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. gene expression Source: Reactome
    3. innate immune response Source: Reactome
    4. negative regulation of macroautophagy Source: BHF-UCL
    5. positive regulation of type I interferon production Source: Reactome
    6. regulation of dendrite morphogenesis Source: Ensembl
    7. regulation of transcription, DNA-templated Source: GOC
    8. termination of RNA polymerase III transcription Source: Reactome
    9. transcription, DNA-templated Source: UniProtKB
    10. transcription elongation from RNA polymerase III promoter Source: Reactome
    11. transcription from RNA polymerase III promoter Source: Reactome

    Keywords - Biological processi

    Cell cycle

    Enzyme and pathway databases

    ReactomeiREACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
    REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
    REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
    REACT_63. RNA Polymerase III Transcription Termination.
    REACT_756. RNA Polymerase III Chain Elongation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine zipper putative tumor suppressor 1
    Alternative name(s):
    F37/esophageal cancer-related gene-coding leucine-zipper motif
    Fez1
    Gene namesi
    Name:LZTS1
    Synonyms:FEZ1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:13861. LZTS1.

    Subcellular locationi

    Cytoplasm By similarity. Cell membrane By similarity. Cell projectiondendritic spine By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Cell junctionsynapse By similarity
    Note: Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density By similarity.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. cell body Source: Ensembl
    3. cell junction Source: UniProtKB-KW
    4. cytosol Source: Reactome
    5. dendritic shaft Source: Ensembl
    6. dendritic spine Source: UniProtKB-SubCell
    7. nucleoplasm Source: Reactome
    8. postsynaptic density Source: UniProtKB-SubCell
    9. postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Involvement in diseasei

    Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.1 Publication
    Note: The disease may be caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    MIMi133239. phenotype.
    PharmGKBiPA30507.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 596595Leucine zipper putative tumor suppressor 1PRO_0000182971Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity

    Post-translational modificationi

    Phorphorylated on serine residues. Hyperphosphorylated by the cAMP-dependent kinase PKA during cell-cycle progression.

    Keywords - PTMi

    Lipoprotein, Myristate, Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y250.
    PaxDbiQ9Y250.
    PRIDEiQ9Y250.

    PTM databases

    PhosphoSiteiQ9Y250.

    Expressioni

    Tissue specificityi

    Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas. Not detectable in primary tumors from breast and prostate and in many cancer cell lines.1 Publication

    Gene expression databases

    BgeeiQ9Y250.
    CleanExiHS_FEZ1.
    HS_LZTS1.
    GenevestigatoriQ9Y250.

    Organism-specific databases

    HPAiHPA006294.
    HPA022046.

    Interactioni

    Subunit structurei

    Binds EEF1G, TLK2 and CDK1.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDC25CP303072EBI-1216080,EBI-974439

    Protein-protein interaction databases

    BioGridi116348. 2 interactions.
    IntActiQ9Y250. 1 interaction.
    STRINGi9606.ENSP00000265801.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y250.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili256 – 374119Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the LZTS family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG137465.
    HOVERGENiHBG052381.
    InParanoidiQ9Y250.
    OMAiAMYQRNQ.
    OrthoDBiEOG7F7W8K.
    PhylomeDBiQ9Y250.
    TreeFamiTF331420.

    Sequences (7)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y250-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGSVSSLISG HSFHSKHCRA SQYKLRKSSH LKKLNRYSDG LLRFGFSQDS    50
    GHGKSSSKMG KSEDFFYIKV SQKARGSHHP DYTALSSGDL GGQAGVDFDP 100
    STPPKLMPFS NQLEMGSEKG AVRPTAFKPV LPRSGAILHS SPESASHQLH 150
    PAPPDKPKEQ ELKPGLCSGA LSDSGRNSMS SLPTHSTSSS YQLDPLVTPV 200
    GPTSRFGGSA HNITQGIVLQ DSNMMSLKAL SFSDGGSKLG HSNKADKGPS 250
    CVRSPISTDE CSIQELEQKL LEREGALQKL QRSFEEKELA SSLAYEERPR 300
    RCRDELEGPE PKGGNKLKQA SQKSQRAQQV LHLQVLQLQQ EKRQLRQELE 350
    SLMKEQDLLE TKLRSYEREK TSFGPALEET QWEVCQKSGE ISLLKQQLKE 400
    SQTEVNAKAS EILGLKAQLK DTRGKLEGLE LRTQDLEGAL RTKGLELEVC 450
    ENELQRKKNE AELLREKVNL LEQELQELRA QAALARDMGP PTFPEDVPAL 500
    QRELERLRAE LREERQGHDQ MSSGFQHERL VWKEEKEKVI QYQKQLQQSY 550
    VAMYQRNQRL EKALQQLARG DSAGEPLEVD LEGADIPYED IIATEI 596
    Length:596
    Mass (Da):66,613
    Last modified:January 23, 2007 - v3
    Checksum:i8ED96C707BA27659
    GO
    Isoform 2 (identifier: Q9Y250-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         505-527: Missing.

    Show »
    Length:573
    Mass (Da):63,834
    Checksum:i6360669E73603939
    GO
    Isoform 3 (identifier: Q9Y250-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         471-503: Missing.

    Show »
    Length:563
    Mass (Da):62,911
    Checksum:iE6EF5D260E41380C
    GO
    Isoform 4 (identifier: Q9Y250-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         468-526: Missing.

    Show »
    Length:537
    Mass (Da):59,829
    Checksum:iCE0F771B1629051B
    GO
    Isoform 5 (identifier: Q9Y250-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         454-545: Missing.

    Show »
    Length:504
    Mass (Da):55,611
    Checksum:i6665CACB72272BC0
    GO
    Isoform 6 (identifier: Q9Y250-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         186-571: Missing.

    Show »
    Length:210
    Mass (Da):22,529
    Checksum:iF6937560E3EB349C
    GO
    Isoform 7 (identifier: Q9Y250-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         55-76: SSSKMGKSEDFFYIKVSQKARG → AMTRCPRASSMSGSCGRRRRRR
         77-596: Missing.

    Show »
    Length:76
    Mass (Da):8,571
    Checksum:i9968B6605A104F27
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291S → P Found in an esophageal cancer sample; esophageal squamous cell carcinoma; somatic mutation. 1 Publication
    Corresponds to variant rs28937897 [ dbSNP | Ensembl ].
    VAR_018274
    Natural varianti50 – 501S → F.
    Corresponds to variant rs34620053 [ dbSNP | Ensembl ].
    VAR_053490
    Natural varianti119 – 1191K → E Found in an esophageal cancer sample; esophageal squamous cell carcinoma; somatic mutation. 1 Publication
    VAR_018275
    Natural varianti475 – 4751L → V.
    Corresponds to variant rs723874 [ dbSNP | Ensembl ].
    VAR_018276

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei55 – 7622SSSKM…QKARG → AMTRCPRASSMSGSCGRRRR RR in isoform 7. 1 PublicationVSP_009940Add
    BLAST
    Alternative sequencei77 – 596520Missing in isoform 7. 1 PublicationVSP_009941Add
    BLAST
    Alternative sequencei186 – 571386Missing in isoform 6. 1 PublicationVSP_009942Add
    BLAST
    Alternative sequencei454 – 54592Missing in isoform 5. 1 PublicationVSP_009943Add
    BLAST
    Alternative sequencei468 – 52659Missing in isoform 4. 1 PublicationVSP_009944Add
    BLAST
    Alternative sequencei471 – 50333Missing in isoform 3. 1 PublicationVSP_009945Add
    BLAST
    Alternative sequencei505 – 52723Missing in isoform 2. 1 PublicationVSP_009946Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF123652 mRNA. Translation: AAD23833.1.
    AF123653 Genomic DNA. Translation: AAD23834.1.
    AF123654 mRNA. Translation: AAD23835.1.
    AF123655 mRNA. Translation: AAD23836.1.
    AF123656 mRNA. Translation: AAD23837.1.
    AF123657 mRNA. Translation: AAD23838.1.
    AF123658 mRNA. Translation: AAD23839.1.
    AF123659 mRNA. Translation: AAD23840.1.
    CH471080 Genomic DNA. Translation: EAW63753.1.
    CH471080 Genomic DNA. Translation: EAW63755.1.
    BC075006 mRNA. Translation: AAH75006.1.
    BC075007 mRNA. Translation: AAH75007.1.
    CCDSiCCDS6015.1. [Q9Y250-1]
    RefSeqiNP_066300.1. NM_021020.3. [Q9Y250-1]
    XP_005273451.1. XM_005273394.2. [Q9Y250-1]
    UniGeneiHs.521432.

    Genome annotation databases

    EnsembliENST00000265801; ENSP00000265801; ENSG00000061337. [Q9Y250-1]
    ENST00000381569; ENSP00000370981; ENSG00000061337. [Q9Y250-1]
    ENST00000522290; ENSP00000429263; ENSG00000061337. [Q9Y250-4]
    GeneIDi11178.
    KEGGihsa:11178.
    UCSCiuc003wzr.3. human. [Q9Y250-1]
    uc010ltg.2. human. [Q9Y250-4]

    Polymorphism databases

    DMDMi46396556.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF123652 mRNA. Translation: AAD23833.1 .
    AF123653 Genomic DNA. Translation: AAD23834.1 .
    AF123654 mRNA. Translation: AAD23835.1 .
    AF123655 mRNA. Translation: AAD23836.1 .
    AF123656 mRNA. Translation: AAD23837.1 .
    AF123657 mRNA. Translation: AAD23838.1 .
    AF123658 mRNA. Translation: AAD23839.1 .
    AF123659 mRNA. Translation: AAD23840.1 .
    CH471080 Genomic DNA. Translation: EAW63753.1 .
    CH471080 Genomic DNA. Translation: EAW63755.1 .
    BC075006 mRNA. Translation: AAH75006.1 .
    BC075007 mRNA. Translation: AAH75007.1 .
    CCDSi CCDS6015.1. [Q9Y250-1 ]
    RefSeqi NP_066300.1. NM_021020.3. [Q9Y250-1 ]
    XP_005273451.1. XM_005273394.2. [Q9Y250-1 ]
    UniGenei Hs.521432.

    3D structure databases

    ProteinModelPortali Q9Y250.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116348. 2 interactions.
    IntActi Q9Y250. 1 interaction.
    STRINGi 9606.ENSP00000265801.

    PTM databases

    PhosphoSitei Q9Y250.

    Polymorphism databases

    DMDMi 46396556.

    Proteomic databases

    MaxQBi Q9Y250.
    PaxDbi Q9Y250.
    PRIDEi Q9Y250.

    Protocols and materials databases

    DNASUi 11178.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265801 ; ENSP00000265801 ; ENSG00000061337 . [Q9Y250-1 ]
    ENST00000381569 ; ENSP00000370981 ; ENSG00000061337 . [Q9Y250-1 ]
    ENST00000522290 ; ENSP00000429263 ; ENSG00000061337 . [Q9Y250-4 ]
    GeneIDi 11178.
    KEGGi hsa:11178.
    UCSCi uc003wzr.3. human. [Q9Y250-1 ]
    uc010ltg.2. human. [Q9Y250-4 ]

    Organism-specific databases

    CTDi 11178.
    GeneCardsi GC08M020147.
    HGNCi HGNC:13861. LZTS1.
    HPAi HPA006294.
    HPA022046.
    MIMi 133239. phenotype.
    606551. gene.
    neXtProti NX_Q9Y250.
    PharmGKBi PA30507.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG137465.
    HOVERGENi HBG052381.
    InParanoidi Q9Y250.
    OMAi AMYQRNQ.
    OrthoDBi EOG7F7W8K.
    PhylomeDBi Q9Y250.
    TreeFami TF331420.

    Enzyme and pathway databases

    Reactomei REACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
    REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
    REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
    REACT_63. RNA Polymerase III Transcription Termination.
    REACT_756. RNA Polymerase III Chain Elongation.

    Miscellaneous databases

    GeneWikii LZTS1.
    GenomeRNAii 11178.
    NextBioi 42535.
    PROi Q9Y250.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y250.
    CleanExi HS_FEZ1.
    HS_LZTS1.
    Genevestigatori Q9Y250.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors."
      Ishii H., Baffa R., Numata S., Murakumo Y., Rattan S., Inoue H., Mori M., Fidanza V., Alder H., Croce C.M.
      Proc. Natl. Acad. Sci. U.S.A. 96:3928-3933(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6 AND 7), INVOLVEMENT IN ESCR, VARIANTS PRO-29 AND GLU-119, FUNCTION, TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Fetal brain.
    4. "Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22."
      Cabeza-Arvelaiz Y., Sepulveda J.L., Lebovitz R.M., Thompson T.C., Chinault A.C.
      Oncogene 20:4169-4179(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ALTERNATIVE SPLICING.
    5. Cited for: FUNCTION, PHOSPHORYLATION, SUBCELLULAR LOCATION, INTERACTION WITH EEF1G AND CDK1.
    6. "FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region."
      Assmann E.M., Alborghetti M.R., Camargo M.E.R., Kobarg J.
      J. Biol. Chem. 281:9869-9881(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TLK2.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiLZTS1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y250
    Secondary accession number(s): D3DSQ6
    , Q9Y5V7, Q9Y5V8, Q9Y5V9, Q9Y5W0, Q9Y5W1, Q9Y5W2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 110 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Defects in LZTS1 are found in many types of tumors.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3