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Protein

Leucine zipper putative tumor suppressor 1

Gene

LZTS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor.3 Publications

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • negative regulation of macroautophagy Source: BHF-UCL
  • regulation of dendrite morphogenesis Source: Ensembl
  • regulation of transcription, DNA-templated Source: GOC
  • transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine zipper putative tumor suppressor 1
Alternative name(s):
F37/esophageal cancer-related gene-coding leucine-zipper motif
Fez1
Gene namesi
Name:LZTS1
Synonyms:FEZ1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:13861. LZTS1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Esophageal cancer (ESCR)1 Publication

The disease may be caused by mutations affecting the gene represented in this entry.

Disease descriptionA malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.

See also OMIM:133239

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

MIMi133239. phenotype.
PharmGKBiPA30507.

Polymorphism and mutation databases

BioMutaiLZTS1.
DMDMi46396556.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 596595Leucine zipper putative tumor suppressor 1PRO_0000182971Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Post-translational modificationi

Phorphorylated on serine residues. Hyperphosphorylated by the cAMP-dependent kinase PKA during cell-cycle progression.

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiQ9Y250.
PaxDbiQ9Y250.
PRIDEiQ9Y250.

PTM databases

PhosphoSiteiQ9Y250.

Expressioni

Tissue specificityi

Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas. Not detectable in primary tumors from breast and prostate and in many cancer cell lines.1 Publication

Gene expression databases

BgeeiQ9Y250.
CleanExiHS_FEZ1.
HS_LZTS1.
GenevisibleiQ9Y250. HS.

Organism-specific databases

HPAiHPA006294.
HPA022046.

Interactioni

Subunit structurei

Binds EEF1G, TLK2 and CDK1.

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC25CP303072EBI-1216080,EBI-974439

Protein-protein interaction databases

BioGridi116348. 3 interactions.
IntActiQ9Y250. 1 interaction.
STRINGi9606.ENSP00000265801.

Structurei

3D structure databases

ProteinModelPortaliQ9Y250.
SMRiQ9Y250. Positions 261-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili256 – 374119Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the LZTS family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG137465.
GeneTreeiENSGT00510000046769.
HOVERGENiHBG052381.
InParanoidiQ9Y250.
OMAiGFQHERL.
OrthoDBiEOG7F7W8K.
PhylomeDBiQ9Y250.
TreeFamiTF331420.

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y250-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSVSSLISG HSFHSKHCRA SQYKLRKSSH LKKLNRYSDG LLRFGFSQDS
60 70 80 90 100
GHGKSSSKMG KSEDFFYIKV SQKARGSHHP DYTALSSGDL GGQAGVDFDP
110 120 130 140 150
STPPKLMPFS NQLEMGSEKG AVRPTAFKPV LPRSGAILHS SPESASHQLH
160 170 180 190 200
PAPPDKPKEQ ELKPGLCSGA LSDSGRNSMS SLPTHSTSSS YQLDPLVTPV
210 220 230 240 250
GPTSRFGGSA HNITQGIVLQ DSNMMSLKAL SFSDGGSKLG HSNKADKGPS
260 270 280 290 300
CVRSPISTDE CSIQELEQKL LEREGALQKL QRSFEEKELA SSLAYEERPR
310 320 330 340 350
RCRDELEGPE PKGGNKLKQA SQKSQRAQQV LHLQVLQLQQ EKRQLRQELE
360 370 380 390 400
SLMKEQDLLE TKLRSYEREK TSFGPALEET QWEVCQKSGE ISLLKQQLKE
410 420 430 440 450
SQTEVNAKAS EILGLKAQLK DTRGKLEGLE LRTQDLEGAL RTKGLELEVC
460 470 480 490 500
ENELQRKKNE AELLREKVNL LEQELQELRA QAALARDMGP PTFPEDVPAL
510 520 530 540 550
QRELERLRAE LREERQGHDQ MSSGFQHERL VWKEEKEKVI QYQKQLQQSY
560 570 580 590
VAMYQRNQRL EKALQQLARG DSAGEPLEVD LEGADIPYED IIATEI
Length:596
Mass (Da):66,613
Last modified:January 23, 2007 - v3
Checksum:i8ED96C707BA27659
GO
Isoform 2 (identifier: Q9Y250-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     505-527: Missing.

Show »
Length:573
Mass (Da):63,834
Checksum:i6360669E73603939
GO
Isoform 3 (identifier: Q9Y250-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     471-503: Missing.

Show »
Length:563
Mass (Da):62,911
Checksum:iE6EF5D260E41380C
GO
Isoform 4 (identifier: Q9Y250-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     468-526: Missing.

Show »
Length:537
Mass (Da):59,829
Checksum:iCE0F771B1629051B
GO
Isoform 5 (identifier: Q9Y250-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     454-545: Missing.

Show »
Length:504
Mass (Da):55,611
Checksum:i6665CACB72272BC0
GO
Isoform 6 (identifier: Q9Y250-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-571: Missing.

Show »
Length:210
Mass (Da):22,529
Checksum:iF6937560E3EB349C
GO
Isoform 7 (identifier: Q9Y250-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-76: SSSKMGKSEDFFYIKVSQKARG → AMTRCPRASSMSGSCGRRRRRR
     77-596: Missing.

Show »
Length:76
Mass (Da):8,571
Checksum:i9968B6605A104F27
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291S → P Found in an esophageal cancer sample; esophageal squamous cell carcinoma; somatic mutation. 1 Publication
Corresponds to variant rs28937897 [ dbSNP | Ensembl ].
VAR_018274
Natural varianti50 – 501S → F.
Corresponds to variant rs34620053 [ dbSNP | Ensembl ].
VAR_053490
Natural varianti119 – 1191K → E Found in an esophageal cancer sample; esophageal squamous cell carcinoma; somatic mutation. 1 Publication
VAR_018275
Natural varianti475 – 4751L → V.
Corresponds to variant rs723874 [ dbSNP | Ensembl ].
VAR_018276

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei55 – 7622SSSKM…QKARG → AMTRCPRASSMSGSCGRRRR RR in isoform 7. 1 PublicationVSP_009940Add
BLAST
Alternative sequencei77 – 596520Missing in isoform 7. 1 PublicationVSP_009941Add
BLAST
Alternative sequencei186 – 571386Missing in isoform 6. 1 PublicationVSP_009942Add
BLAST
Alternative sequencei454 – 54592Missing in isoform 5. 1 PublicationVSP_009943Add
BLAST
Alternative sequencei468 – 52659Missing in isoform 4. 1 PublicationVSP_009944Add
BLAST
Alternative sequencei471 – 50333Missing in isoform 3. 1 PublicationVSP_009945Add
BLAST
Alternative sequencei505 – 52723Missing in isoform 2. 1 PublicationVSP_009946Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123652 mRNA. Translation: AAD23833.1.
AF123653 Genomic DNA. Translation: AAD23834.1.
AF123654 mRNA. Translation: AAD23835.1.
AF123655 mRNA. Translation: AAD23836.1.
AF123656 mRNA. Translation: AAD23837.1.
AF123657 mRNA. Translation: AAD23838.1.
AF123658 mRNA. Translation: AAD23839.1.
AF123659 mRNA. Translation: AAD23840.1.
CH471080 Genomic DNA. Translation: EAW63753.1.
CH471080 Genomic DNA. Translation: EAW63755.1.
BC075006 mRNA. Translation: AAH75006.1.
BC075007 mRNA. Translation: AAH75007.1.
CCDSiCCDS6015.1. [Q9Y250-1]
RefSeqiNP_066300.1. NM_021020.3. [Q9Y250-1]
XP_005273451.1. XM_005273394.3. [Q9Y250-1]
UniGeneiHs.521432.

Genome annotation databases

EnsembliENST00000265801; ENSP00000265801; ENSG00000061337. [Q9Y250-1]
ENST00000381569; ENSP00000370981; ENSG00000061337. [Q9Y250-1]
ENST00000522290; ENSP00000429263; ENSG00000061337. [Q9Y250-4]
ENST00000616228; ENSP00000479534; ENSG00000061337. [Q9Y250-7]
GeneIDi11178.
KEGGihsa:11178.
UCSCiuc003wzr.3. human. [Q9Y250-1]
uc010ltg.2. human. [Q9Y250-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123652 mRNA. Translation: AAD23833.1.
AF123653 Genomic DNA. Translation: AAD23834.1.
AF123654 mRNA. Translation: AAD23835.1.
AF123655 mRNA. Translation: AAD23836.1.
AF123656 mRNA. Translation: AAD23837.1.
AF123657 mRNA. Translation: AAD23838.1.
AF123658 mRNA. Translation: AAD23839.1.
AF123659 mRNA. Translation: AAD23840.1.
CH471080 Genomic DNA. Translation: EAW63753.1.
CH471080 Genomic DNA. Translation: EAW63755.1.
BC075006 mRNA. Translation: AAH75006.1.
BC075007 mRNA. Translation: AAH75007.1.
CCDSiCCDS6015.1. [Q9Y250-1]
RefSeqiNP_066300.1. NM_021020.3. [Q9Y250-1]
XP_005273451.1. XM_005273394.3. [Q9Y250-1]
UniGeneiHs.521432.

3D structure databases

ProteinModelPortaliQ9Y250.
SMRiQ9Y250. Positions 261-288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116348. 3 interactions.
IntActiQ9Y250. 1 interaction.
STRINGi9606.ENSP00000265801.

PTM databases

PhosphoSiteiQ9Y250.

Polymorphism and mutation databases

BioMutaiLZTS1.
DMDMi46396556.

Proteomic databases

MaxQBiQ9Y250.
PaxDbiQ9Y250.
PRIDEiQ9Y250.

Protocols and materials databases

DNASUi11178.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265801; ENSP00000265801; ENSG00000061337. [Q9Y250-1]
ENST00000381569; ENSP00000370981; ENSG00000061337. [Q9Y250-1]
ENST00000522290; ENSP00000429263; ENSG00000061337. [Q9Y250-4]
ENST00000616228; ENSP00000479534; ENSG00000061337. [Q9Y250-7]
GeneIDi11178.
KEGGihsa:11178.
UCSCiuc003wzr.3. human. [Q9Y250-1]
uc010ltg.2. human. [Q9Y250-4]

Organism-specific databases

CTDi11178.
GeneCardsiGC08M020147.
HGNCiHGNC:13861. LZTS1.
HPAiHPA006294.
HPA022046.
MIMi133239. phenotype.
606551. gene.
neXtProtiNX_Q9Y250.
PharmGKBiPA30507.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG137465.
GeneTreeiENSGT00510000046769.
HOVERGENiHBG052381.
InParanoidiQ9Y250.
OMAiGFQHERL.
OrthoDBiEOG7F7W8K.
PhylomeDBiQ9Y250.
TreeFamiTF331420.

Miscellaneous databases

GeneWikiiLZTS1.
GenomeRNAii11178.
NextBioi42535.
PROiQ9Y250.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y250.
CleanExiHS_FEZ1.
HS_LZTS1.
GenevisibleiQ9Y250. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors."
    Ishii H., Baffa R., Numata S., Murakumo Y., Rattan S., Inoue H., Mori M., Fidanza V., Alder H., Croce C.M.
    Proc. Natl. Acad. Sci. U.S.A. 96:3928-3933(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6 AND 7), INVOLVEMENT IN ESCR, VARIANTS PRO-29 AND GLU-119, FUNCTION, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  4. "Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22."
    Cabeza-Arvelaiz Y., Sepulveda J.L., Lebovitz R.M., Thompson T.C., Chinault A.C.
    Oncogene 20:4169-4179(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ALTERNATIVE SPLICING.
  5. Cited for: FUNCTION, PHOSPHORYLATION, SUBCELLULAR LOCATION, INTERACTION WITH EEF1G AND CDK1.
  6. "FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region."
    Assmann E.M., Alborghetti M.R., Camargo M.E.R., Kobarg J.
    J. Biol. Chem. 281:9869-9881(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TLK2.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiLZTS1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y250
Secondary accession number(s): D3DSQ6
, Q9Y5V7, Q9Y5V8, Q9Y5V9, Q9Y5W0, Q9Y5W1, Q9Y5W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Defects in LZTS1 are found in many types of tumors.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.