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Protein

Protein FAM50B

Gene

FAM50B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM50B
Alternative name(s):
Protein XAP-5-like
Gene namesi
Name:FAM50B
Synonyms:X5L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000145945.5
HGNCiHGNC:18789 FAM50B
MIMi614686 gene
neXtProtiNX_Q9Y247

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi26240
OpenTargetsiENSG00000145945
PharmGKBiPA134912073

Polymorphism and mutation databases

BioMutaiFAM50B
DMDMi48474710

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000682862 – 325Protein FAM50BAdd BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Y247
MaxQBiQ9Y247
PaxDbiQ9Y247
PeptideAtlasiQ9Y247
PRIDEiQ9Y247
ProteomicsDBi85644

PTM databases

iPTMnetiQ9Y247
PhosphoSitePlusiQ9Y247

Expressioni

Tissue specificityi

Widely expressed. Mostly abundant in testis and adult and fetal brain.

Inductioni

Imprinted. Promoter methylation of the maternal allele may restrict expression to the paternal allele in placenta.1 Publication

Gene expression databases

BgeeiENSG00000145945
CleanExiHS_FAM50B
ExpressionAtlasiQ9Y247 baseline and differential
GenevisibleiQ9Y247 HS

Organism-specific databases

HPAiHPA064111
HPA067817

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi117631, 16 interactors
IntActiQ9Y247, 42 interactors
MINTiQ9Y247
STRINGi9606.ENSP00000369625

Structurei

3D structure databases

ProteinModelPortaliQ9Y247
SMRiQ9Y247
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM50 family.Curated

Phylogenomic databases

eggNOGiKOG2894 Eukaryota
ENOG410XNXM LUCA
GeneTreeiENSGT00390000004735
HOGENOMiHOG000283611
HOVERGENiHBG000678
InParanoidiQ9Y247
KOiK13119
OMAiYKGTMRE
OrthoDBiEOG091G0KZY
PhylomeDBiQ9Y247
TreeFamiTF314738

Family and domain databases

InterProiView protein in InterPro
IPR007005 XAP5
PANTHERiPTHR12722 PTHR12722, 1 hit
PfamiView protein in Pfam
PF04921 XAP5, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQYKGTMRE AGRAMHLLKK RERQREQMEV LKQRIAEETI LKSQVDKRFS
60 70 80 90 100
AHYDAVEAEL KSSTVGLVTL NDMKARQEAL VRERERQLAK RQHLEEQRLQ
110 120 130 140 150
QERQREQEQR RERKRKISCL SFALDDLDDQ ADAAEARRAG NLGKNPDVDT
160 170 180 190 200
SFLPDRDREE EENRLREELR QEWEAQREKV KDEEMEVTFS YWDGSGHRRT
210 220 230 240 250
VRVRKGNTVQ QFLKKALQGL RKDFLELRSA GVEQLMFIKE DLILPHYHTF
260 270 280 290 300
YDFIIARARG KSGPLFSFDV HDDVRLLSDA TMEKDESHAG KVVLRSWYEK
310 320
NKHIFPASRW EAYDPEKKWD KYTIR
Length:325
Mass (Da):38,709
Last modified:November 1, 1999 - v1
Checksum:i9F0653C3D7236997
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18504 Genomic DNA Translation: CAB46273.1
Y18503 mRNA Translation: CAB46272.1
AL391422 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55142.1
BC001261 mRNA Translation: AAH01261.1
CCDSiCCDS4487.1
RefSeqiNP_036267.1, NM_012135.2
XP_016866218.1, XM_017010729.1
UniGeneiHs.140944

Genome annotation databases

EnsembliENST00000380272; ENSP00000369625; ENSG00000145945
ENST00000380274; ENSP00000369627; ENSG00000145945
GeneIDi26240
KEGGihsa:26240
UCSCiuc003mvu.4 human

Similar proteinsi

Entry informationi

Entry nameiFA50B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y247
Secondary accession number(s): Q5T2L6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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