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Protein

Transcription factor 19

Gene

TCF19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri296 – 33944PHD-typeAdd
BLAST

GO - Molecular functioni

  • transcription factor activity, sequence-specific DNA binding Source: ProtInc
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cell proliferation Source: ProtInc
  • regulation of transcription from RNA polymerase II promoter Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 19
Short name:
TCF-19
Alternative name(s):
Transcription factor SC1
Gene namesi
Name:TCF19
Synonyms:SC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:11629. TCF19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36384.

Polymorphism and mutation databases

BioMutaiTCF19.
DMDMi126302606.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Transcription factor 19PRO_0000059327Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei78 – 781PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y242.
PaxDbiQ9Y242.
PeptideAtlasiQ9Y242.
PRIDEiQ9Y242.

PTM databases

iPTMnetiQ9Y242.
PhosphoSiteiQ9Y242.

Expressioni

Developmental stagei

Growth regulated.

Gene expression databases

BgeeiQ9Y242.
ExpressionAtlasiQ9Y242. baseline and differential.
GenevisibleiQ9Y242. HS.

Interactioni

Protein-protein interaction databases

BioGridi112801. 13 interactions.
IntActiQ9Y242. 2 interactions.
MINTiMINT-8247619.
STRINGi9606.ENSP00000365431.

Structurei

3D structure databases

ProteinModelPortaliQ9Y242.
SMRiQ9Y242. Positions 292-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 8858FHAPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi187 – 300114Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 FHA domain.PROSITE-ProRule annotation
Contains 1 PHD-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri296 – 33944PHD-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IXZZ. Eukaryota.
ENOG4111J5W. LUCA.
GeneTreeiENSGT00390000015391.
HOVERGENiHBG054343.
InParanoidiQ9Y242.
OMAiLESCTHF.
OrthoDBiEOG7CG70W.
PhylomeDBiQ9Y242.
TreeFamiTF334697.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y242-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPCFQLLRI GGGRGGDLYT FHPPAGAGCT YRLGHRADLC DVALRPQQEP
60 70 80 90 100
GLISGIHAEL HAEPRGDDWR VSLEDHSSQG TLVNNVRLPR GHRLELSDGD
110 120 130 140 150
LLTFGPEGPP GTSPSEFYFM FQQVRVKPQD FAAITIPRSR GEARVGAGFR
160 170 180 190 200
PMLPSQGAPQ RPLSTFSPAP KATLILNSIG SLSKLRPQPL TFSPSWGGPK
210 220 230 240 250
SLPVPAPPGE MGTTPSAPPQ RNRRKSVHRV LAELDDESEP PENPPPVLME
260 270 280 290 300
PRKKLRVDKA PLTPTGNRRG RPRKYPVSAP MAPPAVGGGE PCAAPCCCLP
310 320 330 340
QEETVAWVQC DGCDVWFHVA CVGCSIQAAR EADFRCPGCR AGIQT
Length:345
Mass (Da):37,184
Last modified:February 20, 2007 - v2
Checksum:iB5730936A842B83A
GO

Sequence cautioni

The sequence AAB60363.1 differs from that shown. Reason: Frameshift at positions 288, 290 and 291. Curated
The sequence AAB60363.1 differs from that shown. Reason: Frameshift at position 288. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271A → V in AAB60363 (Ref. 3) Curated
Sequence conflicti123 – 1231Q → N in AAB19475 (PubMed:1868030).Curated
Sequence conflicti193 – 1931S → T in AAB19475 (PubMed:1868030).Curated
Sequence conflicti268 – 2681R → A in AAB60363 (Ref. 3) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti109 – 1091P → S.1 Publication
Corresponds to variant rs7750641 [ dbSNP | Ensembl ].
VAR_051604
Natural varianti211 – 2111M → V.8 Publications
Corresponds to variant rs2073721 [ dbSNP | Ensembl ].
VAR_017741
Natural varianti241 – 2411P → L.3 Publications
Corresponds to variant rs2073724 [ dbSNP | Ensembl ].
VAR_017742

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S53374 mRNA. Translation: AAB19475.2. Frameshift.
AB029516 Genomic DNA. Translation: BAA82324.1.
AB029517 Genomic DNA. Translation: BAA82325.1.
AB029518 Genomic DNA. Translation: BAA82326.1.
AB029519 Genomic DNA. Translation: BAA82327.1.
U25826 Genomic DNA. Translation: AAB60363.1. Frameshift.
BA000025 Genomic DNA. Translation: BAB63312.1.
AB088113 Genomic DNA. Translation: BAC54945.1.
AB103619 Genomic DNA. Translation: BAF31280.1.
AB202105 Genomic DNA. Translation: BAE78629.1.
BT007247 mRNA. Translation: AAP35911.1.
AL662833 Genomic DNA. Translation: CAI17406.1.
AL662844 Genomic DNA. Translation: CAI18329.1.
AL773544 Genomic DNA. Translation: CAI18484.1.
BX088580 Genomic DNA. Translation: CAI18707.1.
CR759815 Genomic DNA. Translation: CAQ07091.1.
CR388229, CR753819 Genomic DNA. Translation: CAQ09228.1.
CR753819, CR388229 Genomic DNA. Translation: CAQ10603.1.
CR847794 Genomic DNA. Translation: CAQ10779.1.
CH471081 Genomic DNA. Translation: EAX03363.1.
BC002493 mRNA. Translation: AAH02493.1.
BC033086 mRNA. Translation: AAH33086.1.
BC044632 mRNA. Translation: AAH44632.1.
CCDSiCCDS43446.1.
PIRiA61188.
RefSeqiNP_001070979.1. NM_001077511.1.
NP_001305837.1. NM_001318908.1.
NP_009040.2. NM_007109.2.
XP_005249391.1. XM_005249334.2.
XP_005275075.1. XM_005275018.1.
XP_005275077.1. XM_005275020.1.
XP_005275212.1. XM_005275155.1.
XP_005275214.1. XM_005275157.1.
XP_005275344.1. XM_005275287.1.
XP_005275346.1. XM_005275289.1.
XP_005275506.1. XM_005275449.2.
XP_005275507.1. XM_005275450.1.
XP_005275645.1. XM_005275588.1.
XP_011513131.1. XM_011514829.1.
XP_011545982.1. XM_011547680.1.
XP_011546202.1. XM_011547900.1.
XP_011546380.1. XM_011548078.1.
XP_011546763.1. XM_011548461.1.
UniGeneiHs.584807.

Genome annotation databases

EnsembliENST00000376255; ENSP00000365431; ENSG00000137310.
ENST00000376257; ENSP00000365433; ENSG00000137310.
GeneIDi6941.
KEGGihsa:6941.
UCSCiuc003nss.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S53374 mRNA. Translation: AAB19475.2. Frameshift.
AB029516 Genomic DNA. Translation: BAA82324.1.
AB029517 Genomic DNA. Translation: BAA82325.1.
AB029518 Genomic DNA. Translation: BAA82326.1.
AB029519 Genomic DNA. Translation: BAA82327.1.
U25826 Genomic DNA. Translation: AAB60363.1. Frameshift.
BA000025 Genomic DNA. Translation: BAB63312.1.
AB088113 Genomic DNA. Translation: BAC54945.1.
AB103619 Genomic DNA. Translation: BAF31280.1.
AB202105 Genomic DNA. Translation: BAE78629.1.
BT007247 mRNA. Translation: AAP35911.1.
AL662833 Genomic DNA. Translation: CAI17406.1.
AL662844 Genomic DNA. Translation: CAI18329.1.
AL773544 Genomic DNA. Translation: CAI18484.1.
BX088580 Genomic DNA. Translation: CAI18707.1.
CR759815 Genomic DNA. Translation: CAQ07091.1.
CR388229, CR753819 Genomic DNA. Translation: CAQ09228.1.
CR753819, CR388229 Genomic DNA. Translation: CAQ10603.1.
CR847794 Genomic DNA. Translation: CAQ10779.1.
CH471081 Genomic DNA. Translation: EAX03363.1.
BC002493 mRNA. Translation: AAH02493.1.
BC033086 mRNA. Translation: AAH33086.1.
BC044632 mRNA. Translation: AAH44632.1.
CCDSiCCDS43446.1.
PIRiA61188.
RefSeqiNP_001070979.1. NM_001077511.1.
NP_001305837.1. NM_001318908.1.
NP_009040.2. NM_007109.2.
XP_005249391.1. XM_005249334.2.
XP_005275075.1. XM_005275018.1.
XP_005275077.1. XM_005275020.1.
XP_005275212.1. XM_005275155.1.
XP_005275214.1. XM_005275157.1.
XP_005275344.1. XM_005275287.1.
XP_005275346.1. XM_005275289.1.
XP_005275506.1. XM_005275449.2.
XP_005275507.1. XM_005275450.1.
XP_005275645.1. XM_005275588.1.
XP_011513131.1. XM_011514829.1.
XP_011545982.1. XM_011547680.1.
XP_011546202.1. XM_011547900.1.
XP_011546380.1. XM_011548078.1.
XP_011546763.1. XM_011548461.1.
UniGeneiHs.584807.

3D structure databases

ProteinModelPortaliQ9Y242.
SMRiQ9Y242. Positions 292-339.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112801. 13 interactions.
IntActiQ9Y242. 2 interactions.
MINTiMINT-8247619.
STRINGi9606.ENSP00000365431.

PTM databases

iPTMnetiQ9Y242.
PhosphoSiteiQ9Y242.

Polymorphism and mutation databases

BioMutaiTCF19.
DMDMi126302606.

Proteomic databases

MaxQBiQ9Y242.
PaxDbiQ9Y242.
PeptideAtlasiQ9Y242.
PRIDEiQ9Y242.

Protocols and materials databases

DNASUi6941.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376255; ENSP00000365431; ENSG00000137310.
ENST00000376257; ENSP00000365433; ENSG00000137310.
GeneIDi6941.
KEGGihsa:6941.
UCSCiuc003nss.4. human.

Organism-specific databases

CTDi6941.
GeneCardsiTCF19.
H-InvDBHIX0005713.
HGNCiHGNC:11629. TCF19.
MIMi600912. gene.
neXtProtiNX_Q9Y242.
PharmGKBiPA36384.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXZZ. Eukaryota.
ENOG4111J5W. LUCA.
GeneTreeiENSGT00390000015391.
HOVERGENiHBG054343.
InParanoidiQ9Y242.
OMAiLESCTHF.
OrthoDBiEOG7CG70W.
PhylomeDBiQ9Y242.
TreeFamiTF334697.

Miscellaneous databases

GeneWikiiTCF19.
GenomeRNAii6941.
PROiQ9Y242.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y242.
ExpressionAtlasiQ9Y242. baseline and differential.
GenevisibleiQ9Y242. HS.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor."
    Ku D.H., Chang C.D., Koniecki J., Cannizzaro L.A., Boghosian-Sell L., Alder H., Baserga R.
    Cell Growth Differ. 2:179-186(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-211.
    Tissue: Blood.
  2. "Genetic polymorphisms in the cell growth regulated gene, SC1 telomeric of the HLA-C gene and lack of association of psoriasis vulgaris."
    Teraoka Y., Naruse T.K., Oka A., Matsuzawa Y., Shiina T., Iizuka M., Iwashita K., Ozawa A., Inoko H.
    Tissue Antigens 55:206-211(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-211 AND LEU-241.
  3. "Molecular mapping by transposon-based nested deletion sequencing: the SC1 gene maps near the HLA-C locus."
    Krishnan R.
    Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-211.
    Tissue: Blood.
  4. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-211.
  5. "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity."
    Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.
    , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S.
    Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-211.
  6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-211 AND LEU-241.
  7. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS SER-109 AND VAL-211.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-211 AND LEU-241.
    Tissue: Brain, Colon and Skin.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.

Entry informationi

Entry nameiTCF19_HUMAN
AccessioniPrimary (citable) accession number: Q9Y242
Secondary accession number(s): A6NCT8
, B0UY11, Q0EFA8, Q13176, Q15967, Q5SQ89, Q5STD6, Q5STF5, Q9BUM2, Q9UBH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 20, 2007
Last modified: July 6, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.