Reviewed, UniProtKB/Swiss-Prot Q9Y241 (HIG1A_HUMAN)

Names and origin

Protein names

Recommended name:
    HIG1 domain family member 1A
Alternative name(s):
    Hypoxia-inducible gene 1 protein

Gene names

Name:	HIGD1A
Synonyms:	HIG1
ORF Names:	HSPC010

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	93 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Induction	By hypoxia. Ref.1
Sequence similarities	Contains 1 HIG1 domain.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Membrane
Domain	Transmembrane
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW protein complex Inferred from direct assay. Source: LIFEdb
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CASP4	P49662	1	EBI-1051940,EBI-1057327
PAK7	Q9P286	1	EBI-1051940,EBI-1051061
SNRPB	P14678	1	EBI-1051940,EBI-372458

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.6
	Chain	2 – 93	92	HIG1 domain family member 1A		PRO_0000215770
Regions
	Topological domain	2 – 25	24	Cytoplasmic Potential
	Transmembrane	26 – 46	21	Potential
	Topological domain	47 – 59	13	Extracellular Potential
	Transmembrane	60 – 80	21	Potential
	Topological domain	81 – 93	13	Cytoplasmic Potential
	Domain	11 – 81	71	HIG1
Amino acid modifications
	Modified residue	2	1	N-acetylserine Ref.6
Experimental info
	Sequence conflict	92	1	K → E Ref.3
	Sequence conflict	92	1	K → E Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q9Y241-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 9399D8D1D381B66B	FASTA	93	10,143
	10 20 30 40 50 60 MSTDTGVSLP SYEEDQGSKL IRKAKEAPFV PVGIAGFAAI VAYGLYKLKS RGNTKMSIHL 70 80 90 IHMRVAAQGF VVGAMTVGMG YSMYREFWAK PKP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment." Denko N.C., Schindler C., Koong A., Laderoute K., Green C., Giaccia A.J. Clin. Cancer Res. 6:480-487(2000) [PubMed: 10690527] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION. Tissue: Cervix carcinoma.
[2]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed: 11042152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[3]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow, Brain, Lung and Skin.
[6]	Bienvenut W.V., Waridel P., Quadroni M. Submitted (MAR-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-19 AND 26-47, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[7]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF145385 mRNA. Translation: AAD33954.1. AF077034 mRNA. Translation: AAD27767.1. AL110233 mRNA. Translation: CAB53686.1. CR457385 mRNA. Translation: CAG33666.1. BC000601 mRNA. Translation: AAH00601.1. BC009583 mRNA. Translation: AAH09583.1. BC009594 mRNA. Translation: AAH09594.1. BC070277 mRNA. Translation: AAH70277.1.
IPI	IPI00295621.
PIR	T14766.
RefSeq	NP_001093138.1. NP_001093139.1. NP_054775.2.
UniGene	Hs.593134 Hs.705661 Hs.7917
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y241. 9 interactions.
Proteomic databases
PRIDE	Q9Y241.
Genome annotation databases
Ensembl	ENSG00000181061. Homo sapiens. [Contig view]
GeneID	25994.
KEGG	hsa:25994.
UCSC	uc003cma.2. human.
Organism-specific databases
GeneCards	GC03M042801. GC03M042802. GC04P110814. GC12P051827.
H-InvDB	HIX0003212. HIX0037218.
HGNC	HGNC:29527. HIGD1A.
PharmGKB	PA142671681.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9Y241.
HOVERGEN	Q9Y241.
OMA	Q9Y241. NTKMSVH.
Gene expression databases
ArrayExpress	Q9Y241.
Bgee	Q9Y241.
CleanEx	HS_HIGD1A.
GermOnline	ENSG00000181061. Homo sapiens.
Family and domain databases
InterPro	IPR007667. HIG_1_N. [Graphical view]
Pfam	PF04588. HIG_1_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	47702.

Entry information

Entry name

HIG1A_HUMAN

Accession

Primary (citable) accession number: Q9Y241
Secondary accession number(s): Q9UFZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	November 1, 1999
Last modified:	July 7, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)