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Protein

C-type lectin domain family 11 member A

Gene

CLEC11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts (PubMed:27976999). Important for repair and maintenance of adult bone (By similarity).By similarity1 Publication

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB
  • growth factor activity Source: UniProtKB

GO - Biological processi

  • ossification Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: UniProtKB

Keywordsi

Molecular functionGrowth factor
Biological processOsteogenesis
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 11 member A
Alternative name(s):
C-type lectin superfamily member 3
Lymphocyte secreted C-type lectin
Osteolectin1 Publication
Stem cell growth factor
p47
Gene namesi
Name:CLEC11A
Synonyms:CLECSF3, LSLCL, SCGF
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000105472.12
HGNCiHGNC:10576 CLEC11A
MIMi604713 gene
neXtProtiNX_Q9Y240

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6320
OpenTargetsiENSG00000105472
PharmGKBiPA34996

Polymorphism and mutation databases

BioMutaiCLEC11A
DMDMi34223087

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000001746822 – 323C-type lectin domain family 11 member AAdd BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi204 ↔ 319PROSITE-ProRule annotation
Disulfide bondi296 ↔ 311PROSITE-ProRule annotation

Post-translational modificationi

O-glycosylated. Probably sulfated on the O-glycans.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9Y240
MaxQBiQ9Y240
PaxDbiQ9Y240
PeptideAtlasiQ9Y240
PRIDEiQ9Y240

PTM databases

iPTMnetiQ9Y240
PhosphoSitePlusiQ9Y240

Expressioni

Tissue specificityi

Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen, thymus, appendix and fetal liver.4 Publications

Developmental stagei

In the bone marrow, expression is limited to immature neutrophils. Expression was not detected in circulating mature neutrophils.1 Publication

Gene expression databases

BgeeiENSG00000105472
CleanExiHS_CLEC11A
ExpressionAtlasiQ9Y240 baseline and differential
GenevisibleiQ9Y240 HS

Organism-specific databases

HPAiHPA042690

Interactioni

GO - Molecular functioni

  • growth factor activity Source: UniProtKB

Protein-protein interaction databases

BioGridi112226, 36 interactors
IntActiQ9Y240, 3 interactors
STRINGi9606.ENSP00000250340

Structurei

3D structure databases

ProteinModelPortaliQ9Y240
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini183 – 320C-type lectinPROSITE-ProRule annotationAdd BLAST138

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi61 – 63Cell attachment siteSequence analysis3

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00610000086061
HOGENOMiHOG000273889
HOVERGENiHBG052365
InParanoidiQ9Y240
KOiK17521
OMAiYNWPVWL
OrthoDBiEOG091G0D5T
PhylomeDBiQ9Y240
TreeFamiTF330481

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y240-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAAWLLGAL VVPQLLGFGH GARGAEREWE GGWGGAQEEE REREALMLKH
60 70 80 90 100
LQEALGLPAG RGDENPAGTV EGKEDWEMEE DQGEEEEEEA TPTPSSGPSP
110 120 130 140 150
SPTPEDIVTY ILGRLAGLDA GLHQLHVRLH ALDTRVVELT QGLRQLRNAA
160 170 180 190 200
GDTRDAVQAL QEAQGRAERE HGRLEGCLKG LRLGHKCFLL SRDFEAQAAA
210 220 230 240 250
QARCTARGGS LAQPADRQQM EALTRYLRAA LAPYNWPVWL GVHDRRAEGL
260 270 280 290 300
YLFENGQRVS FFAWHRSPRP ELGAQPSASP HPLSPDQPNG GTLENCVAQA
310 320
SDDGSWWDHD CQRRLYYVCE FPF
Length:323
Mass (Da):35,695
Last modified:November 1, 1999 - v1
Checksum:iD13604CDAF087427
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050116104P → R. Corresponds to variant dbSNP:rs2303688Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020044 mRNA Translation: AAC39569.1
AB009244 mRNA Translation: BAA32404.1
AF087658 Genomic DNA Translation: AAD26533.1
AK314141 mRNA Translation: BAG36831.1
CH471135 Genomic DNA Translation: EAW71896.1
BC005810 mRNA Translation: AAH05810.1
CCDSiCCDS12800.1
RefSeqiNP_002966.1, NM_002975.2
UniGeneiHs.512680

Genome annotation databases

EnsembliENST00000250340; ENSP00000250340; ENSG00000105472
GeneIDi6320
KEGGihsa:6320
UCSCiuc002psy.4 human

Keywords - Coding sequence diversityi

Polymorphism

Entry informationi

Entry nameiCLC11_HUMAN
AccessioniPrimary (citable) accession number: Q9Y240
Secondary accession number(s): B2RAD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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