Reviewed, UniProtKB/Swiss-Prot Q9Y240 (CLC11_HUMAN)

Names and origin

Protein names

Recommended name:
    C-type lectin domain family 11 member A
Alternative name(s):
    Stem cell growth factor
    Lymphocyte secreted C-type lectin
    p47
    C-type lectin superfamily member 3

Gene names

Name:	CLEC11A
Synonyms:	CLECSF3, LSLCL, SCGF

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation. Ref.7
Subcellular location	Cytoplasm. Secreted Ref.8.
Tissue specificity	Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen, thymus, appendix and fetal liver. Ref.7 Ref.8 Ref.1 Ref.2
Developmental stage	In the bone marrow, expression is limited to immature neutrophils. Expression was not detected in circulating mature neutrophils. Ref.8
Post-translational modification	O-glycosylated. Probably sulfated on the O-glycans. Ref.1
Sequence similarities	Contains 1 C-type lectin domain.

Ontologies

Keywords
Cellular component	Cytoplasm Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Ligand	Lectin
Molecular function	Growth factor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	positive regulation of cell proliferation Ref.7 Inferred from direct assay. Source: UniProtKB
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Ref.1 Inferred from direct assay. Source: UniProtKB
Molecular function	growth factor activity Ref.7 Inferred from direct assay. Source: UniProtKB sugar binding Ref.2 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Ref.1
	Chain	22 – 323	302	C-type lectin domain family 11 member A Ref.1		PRO_0000017468
Regions
	Domain	183 – 320	138	C-type lectin
	Motif	61 – 63	3	Cell attachment site Potential
Amino acid modifications
	Disulfide bond	204 ↔ 319		By similarity
	Disulfide bond	296 ↔ 311		By similarity
Natural variations
	Natural variant	104	1	P → R: dbSNP rs2303688.		VAR_050116

Sequences

	Sequence		Length	Mass (Da)
	Q9Y240-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: D13604CDAF087427	FASTA	323	35,695
	10 20 30 40 50 60 MQAAWLLGAL VVPQLLGFGH GARGAEREWE GGWGGAQEEE REREALMLKH LQEALGLPAG 70 80 90 100 110 120 RGDENPAGTV EGKEDWEMEE DQGEEEEEEA TPTPSSGPSP SPTPEDIVTY ILGRLAGLDA 130 140 150 160 170 180 GLHQLHVRLH ALDTRVVELT QGLRQLRNAA GDTRDAVQAL QEAQGRAERE HGRLEGCLKG 190 200 210 220 230 240 LRLGHKCFLL SRDFEAQAAA QARCTARGGS LAQPADRQQM EALTRYLRAA LAPYNWPVWL 250 260 270 280 290 300 GVHDRRAEGL YLFENGQRVS FFAWHRSPRP ELGAQPSASP HPLSPDQPNG GTLENCVAQA 310 320 SDDGSWWDHD CQRRLYYVCE FPF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a new secreted sulfated mucin-like protein with a C-type lectin domain that is expressed in lymphoblastic cells." Bannwarth S., Giordanengo V., Lesimple J., Lefebvre J.-C. J. Biol. Chem. 273:1911-1916(1998) [PubMed: 9442024] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-39; 229-243 AND 314-323, TISSUE SPECIFICITY, GLYCOSYLATION. Tissue: Bone marrow.
[2]	"Isolation and characterization of a cDNA for human, mouse, and rat full-length stem cell growth factor, a new member of C-type lectin superfamily." Mio H., Kagami N., Yokokawa S., Kawai H., Nakagawa S., Takeuchi K., Sekine S., Hiraoka A. Biochem. Biophys. Res. Commun. 249:124-130(1998) [PubMed: 9705843] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Bone marrow.
[3]	"Cloning, mapping, and genomic organization of the LSLCL gene, encoding a new lymphocytic secreted mucin-like protein with a C-type lectin domain: a new model of exon shuffling." Bannwarth S., Giordanengo V., Grosgeorge J., Turc-Carel C., Lefebvre J.-C. Genomics 57:316-317(1999) [PubMed: 10198175] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[7]	"Stem cell growth factor: in situ hybridization analysis on the gene expression, molecular characterization and in vitro proliferative activity of a recombinant preparation on primitive hematopoietic progenitor cells." Hiraoka A., Yano K., Kagami N., Takeshige K., Mio H., Anazawa H., Sugimoto S. Hematol. J. 2:307-315(2001) [PubMed: 11920266] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[8]	"Expression of LSLCL, a new C-type lectin, is closely restricted, in bone marrow, to immature neutrophils." Perrin C., Bayle J., Bannwarth S., Michiels J.-F., Heudier P., Lefebvre J.-C., Giordanengo V. C. R. Acad. Sci. III, Sci. Vie 324:1125-1132(2001) [PubMed: 11803813] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Web resources

Functional Glycomics Gateway - Glycan Binding

Stem cell growth factor

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF020044 mRNA. Translation: AAC39569.1. AB009244 mRNA. Translation: BAA32404.1. AF087658 Genomic DNA. Translation: AAD26533.1. AK314141 mRNA. Translation: BAG36831.1. CH471135 Genomic DNA. Translation: EAW71896.1. BC005810 mRNA. Translation: AAH05810.1.
IPI	IPI00033466.
RefSeq	NP_002966.1.
UniGene	Hs.512680
3D structure databases
SMR	Q9Y240. Positions 134-322.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9Y240.
Proteomic databases
PRIDE	Q9Y240.
Genome annotation databases
Ensembl	ENST00000250340; ENSP00000250340; ENSG00000105472; Homo sapiens. [Genome view]
GeneID	6320.
KEGG	hsa:6320.
UCSC	uc002psy.1. human.
Organism-specific databases
CTD	6320.
GeneCards	GC19P055919.
H-InvDB	HIX0015365.
HGNC	HGNC:10576. CLEC11A.
MIM	604713. gene.
PharmGKB	PA34996.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG713748.
HOVERGEN	Q9Y240.
InParanoid	Q9Y240.
OMA	GCLKGLR.
OrthoDB	EOG96T5N3.
PhylomeDB	Q9Y240.
Gene expression databases
ArrayExpress	Q9Y240.
Bgee	Q9Y240.
CleanEx	HS_CLEC11A.
Genevestigator	Q9Y240.
GermOnline	ENSG00000105472. Homo sapiens.
Family and domain databases
InterPro	IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. IPR018378. C-type_lectin_CS. IPR016187. C-type_lectin_fold. [Graphical view]
Gene3D	G3DSA:3.10.100.10. C-type_lectin-like. 1 hit.
Pfam	PF00059. Lectin_C. 1 hit. [Graphical view]
SMART	SM00034. CLECT. 1 hit. [Graphical view]
PROSITE	PS00615. C_TYPE_LECTIN_1. 1 hit. PS50041. C_TYPE_LECTIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	24524.
SOURCE	Search...

Entry information

Entry name

CLC11_HUMAN

Accession

Primary (citable) accession number: Q9Y240
Secondary accession number(s): B2RAD4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	November 1, 1999
Last modified:	January 19, 2010
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.