Q9Y238 (DLEC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deleted in lung and esophageal cancer protein 1

Alternative name(s):
Deleted in lung cancer protein 1
Short name=DLC-1

Gene names

Name:	DLEC1
Synonyms:	DLC1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1755 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May act as a tumor suppressor by inhibiting cell proliferation. Ref.1
Subcellular location	Cytoplasm Ref.1.
Tissue specificity	Expressed in all tissues examined. Expression is highest in prostate and testis. Ref.1
Involvement in disease	Note=DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of different cancers, including esophageal (ESCR), renal and lung cancers (LNCR). Defects in DLEC1 are a cause of lung cancer (LNCR) [MIM:211980]. A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. Note=DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of lung cancer. Defects in DLEC1 are a cause of esophageal cancer (ESCR) [MIM:133239]. A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. Note=DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of esophageal cancer.
Sequence caution	The sequence CAB70676.1 differs from that shown. Reason: Intron retention. The sequence CAB70884.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Tumor suppressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	negative regulation of cell proliferation Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: At least six differentially spliced products may exist.

Isoform 1 Ref.1 (identifier: Q9Y238-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 Ref.2 (identifier: Q9Y238-2)

The sequence of this isoform differs from the canonical sequence as follows:
     704-704: E → MARLRGGRIPAMPQPSPGQPAGTQWCFQGTVFALQ
     856-885: GPALIINVSALQFGLLRLGQKATNSIQIRN → PFSLVCSAWGRKPQTPSRSGTSASSQPHGA
     886-1755: Missing.

Note: No experimental confirmation available. Levels of this splice isoform may be increased in cancer cell lines and primary cancers.

Isoform 3 Ref.2 (identifier: Q9Y238-3)

Also known as: 1S3;

The sequence of this isoform differs from the canonical sequence as follows:
     1675-1755: QQEPAKAAVA...DERYMLPHQP → VVSCTSPRWW...GPHDMSSELT

Note: Levels of this splice isoform are increased in cancer cell lines and primary cancers.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1755	1755	Deleted in lung and esophageal cancer protein 1		PRO_0000079929
Natural variations
	Alternative sequence	704	1	E → MARLRGGRIPAMPQPSPGQP AGTQWCFQGTVFALQ in isoform 2. Ref.2		VSP_051847
	Alternative sequence	856 – 885	30	GPALI…IQIRN → PFSLVCSAWGRKPQTPSRSG TSASSQPHGA in isoform 2. Ref.2		VSP_051848
	Alternative sequence	886 – 1755	870	Missing in isoform 2. Ref.2		VSP_051849
	Alternative sequence	1675 – 1755	81	QQEPA…LPHQP → VVSCTSPRWWWKVCSVRSPA PCGSGAKAPMMRDTCCLTSP EAPPQPSAPGPSWRKNIAQG LGAALQHKDTDLGTWGPLGS SWNGRTPFHNGLSLGPHDMS SELT in isoform 3. Ref.2		VSP_051850
	Natural variant	79	1	L → R. Corresponds to variant rs7625806 [ dbSNP | Ensembl ].		VAR_056860
	Natural variant	192	1	S → F. Corresponds to variant rs34012183 [ dbSNP | Ensembl ].		VAR_056861
	Natural variant	351	1	P → R in a breast cancer sample; somatic mutation. Ref.4		VAR_035908
	Natural variant	1022	1	K → N. Corresponds to variant rs36012922 [ dbSNP | Ensembl ].		VAR_056862
	Natural variant	1150	1	N → D. Corresponds to variant rs9840172 [ dbSNP | Ensembl ].		VAR_056863
	Natural variant	1227	1	L → P. Corresponds to variant rs9810085 [ dbSNP | Ensembl ].		VAR_056864
Experimental info
	Sequence conflict	704	1	E → M in CAB70884. Ref.2
	Sequence conflict	1442	1	G → R in BAA77624. Ref.1
	Sequence conflict	1442	1	G → R in BAA77247. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: CD4BDB5EEF24DF98	FASTA	1,755	195,684
	10 20 30 40 50 60 METRSSKTRR SLASRTNECQ GTMWAPTSPP AGSSSPSQPT WKSSLYSSLA YSEAFHYSFA 70 80 90 100 110 120 ARPRRLTQLA LAQRPEPQLL RLRPSSLRTQ DISHLLTGVF RNLYSAEVIG DEVSASLIKA 130 140 150 160 170 180 RGSENERHEE FVDQLQQIRE LYKQRLDEFE MLERHITQAQ ARAIAENERV MSQAGVQDLE 190 200 210 220 230 240 SLVRLPPVKS VSRWCIDSEL LRKHHLISPE DYYTDTVPFH SAPKGISLPG CSKLTFSCEK 250 260 270 280 290 300 RSVQKKELNK KLEDSCRKKL AEFEDELDHT VDSLTWNLTP KAKERTREPL KKASQPRNKN 310 320 330 340 350 360 WMNHLRVPQR ELDRLLLARM ESRNHFLKNP RFFPPNTRYG GKSLVFPPKK PAPIGEFQST 370 380 390 400 410 420 EPEQSCADTP VFLAKPPIGF FTDYEIGPVY EMVIALQNTT TTSRYLRVLP PSTPYFALGL 430 440 450 460 470 480 GMFPGKGGMV APGMTCQYIV QFFPDCLGDF DDFILVETQS AHTLLIPLQA RRPPPVLTLS 490 500 510 520 530 540 PVLDCGYCLI GGVKMTRFIC KNVGFSVGRF CIMPKTSWPP LSFKAIATVG FVEQPPFGIL 550 560 570 580 590 600 PSVFELAPGH AILVEVLFSP KSLGKAEQTF IIMCDNCQIK ELVTIGIGQL IALDLIYISG 610 620 630 640 650 660 EKSQPDPGEL TDLTAQHFIR FEPENLRSTA RKQLIIRNAT HVELAFYWQI MKPNLQPLMP 670 680 690 700 710 720 GETFSMDSIK CYPDKETAFS IMPRKGVLSP HTDHEFILSF SPHELRDFHS VLQMVLEEVP 730 740 750 760 770 780 EPVSSEAESL GHSSYSVDDV IVLEIEVKGS VEPFQVLLEP YALIIPGENY IGINVKKAFK 790 800 810 820 830 840 MWNNSKSPIR YLWGKISDCH IIEVEPGTGV IEPSEVGDFE LNFTGGVPGP TSQDLLCEIE 850 860 870 880 890 900 DSPSPVVLHI EAVFKGPALI INVSALQFGL LRLGQKATNS IQIRNVSQLP ATWRMKESPV 910 920 930 940 950 960 SLQERPEDVS PFDIEPSSGQ LHSLGECRVD ITLEALHCQH LETVLELEVE NGAWSYLPVY 970 980 990 1000 1010 1020 AEVQKPHVYL QSSQVEVRNL YLGVPTKTTI TLINGTLLPT QFHWGKLLGH QAEFCMVTVS 1030 1040 1050 1060 1070 1080 PKHGLLGPSE ECQLKLELTA HTQEELTHLA LPCHVSGMKK PLVLGISGKP QGLQVAITIS 1090 1100 1110 1120 1130 1140 KESSDCSTEQ WPGHPKELRL DFGSAVPLRT RVTRQLILTN RSPIRTRFSL KFEYFGSPQN 1150 1160 1170 1180 1190 1200 SLSKKTSLPN MPPALLKTVR MQEHLAKREQ LDFMESMLSH GKGAAFFPHF SQGMLGPYQQ 1210 1220 1230 1240 1250 1260 LCIDITGCAN MWGEYWDNLI CTVGDLLPEV IPVHMAAVGC PISSLRTTSY TIDQAQKEPA 1270 1280 1290 1300 1310 1320 MRFGTQVSGG DTVTRTLRLN NSSPCDIRLD WETYVPEDKE DRLVELLVFY GPPFPLRDQA 1330 1340 1350 1360 1370 1380 GNELVCPDTP EGGCLLWSPG PSSSSEFSHE TDSSVEGSSS ASNRVAQKLI SVILQAHEGV 1390 1400 1410 1420 1430 1440 PSGHLYCISP KQVVVPAGGS STIYISFTPM VLSPEILHKV ECTGYALGFM SLDSKVEREI 1450 1460 1470 1480 1490 1500 PGKRHRLQDF AVGPLKLDLH SYVRPAQLSV ELDYGGSMEF QCQASDLIPE QPCSGVLSEL 1510 1520 1530 1540 1550 1560 VTTHHLKLTN TTEIPHYFRL MVSRPFSVSQ DGASQDHRAP GPGQKQECEE ETASADKQLV 1570 1580 1590 1600 1610 1620 LQAQENMLVN VSFSLSLELL SYQKLPADQT LPGVDIQQSA SGEREMVFTQ NLLLEYTNQT 1630 1640 1650 1660 1670 1680 TQVVPLRAVV AVPELQLSTS WVDFGTCFVS QQRVREVYLM NLSGCRSYWT MLMGQQEPAK 1690 1700 1710 1720 1730 1740 AAVAFRVSPN SGLLEARSAN APPTSIALQV FFTARSSELY ESTMVVEGVL GEKSCTLRLR 1750 GQGSYDERYM LPHQP
	Isoform 2 [UniParc]. Checksum: 4F420168922F4002	FASTA	919	102,903
	10 20 30 40 50 60 METRSSKTRR SLASRTNECQ GTMWAPTSPP AGSSSPSQPT WKSSLYSSLA YSEAFHYSFA 70 80 90 100 110 120 ARPRRLTQLA LAQRPEPQLL RLRPSSLRTQ DISHLLTGVF RNLYSAEVIG DEVSASLIKA 130 140 150 160 170 180 RGSENERHEE FVDQLQQIRE LYKQRLDEFE MLERHITQAQ ARAIAENERV MSQAGVQDLE 190 200 210 220 230 240 SLVRLPPVKS VSRWCIDSEL LRKHHLISPE DYYTDTVPFH SAPKGISLPG CSKLTFSCEK 250 260 270 280 290 300 RSVQKKELNK KLEDSCRKKL AEFEDELDHT VDSLTWNLTP KAKERTREPL KKASQPRNKN 310 320 330 340 350 360 WMNHLRVPQR ELDRLLLARM ESRNHFLKNP RFFPPNTRYG GKSLVFPPKK PAPIGEFQST 370 380 390 400 410 420 EPEQSCADTP VFLAKPPIGF FTDYEIGPVY EMVIALQNTT TTSRYLRVLP PSTPYFALGL 430 440 450 460 470 480 GMFPGKGGMV APGMTCQYIV QFFPDCLGDF DDFILVETQS AHTLLIPLQA RRPPPVLTLS 490 500 510 520 530 540 PVLDCGYCLI GGVKMTRFIC KNVGFSVGRF CIMPKTSWPP LSFKAIATVG FVEQPPFGIL 550 560 570 580 590 600 PSVFELAPGH AILVEVLFSP KSLGKAEQTF IIMCDNCQIK ELVTIGIGQL IALDLIYISG 610 620 630 640 650 660 EKSQPDPGEL TDLTAQHFIR FEPENLRSTA RKQLIIRNAT HVELAFYWQI MKPNLQPLMP 670 680 690 700 710 720 GETFSMDSIK CYPDKETAFS IMPRKGVLSP HTDHEFILSF SPHMARLRGG RIPAMPQPSP 730 740 750 760 770 780 GQPAGTQWCF QGTVFALQLR DFHSVLQMVL EEVPEPVSSE AESLGHSSYS VDDVIVLEIE 790 800 810 820 830 840 VKGSVEPFQV LLEPYALIIP GENYIGINVK KAFKMWNNSK SPIRYLWGKI SDCHIIEVEP 850 860 870 880 890 900 GTGVIEPSEV GDFELNFTGG VPGPTSQDLL CEIEDSPSPV VLHIEAVFKP FSLVCSAWGR 910 KPQTPSRSGT SASSQPHGA
	Isoform 3 (1S3) [UniParc]. Checksum: F210AE22AEF86E6B	FASTA	1,778	197,898
	10 20 30 40 50 60 METRSSKTRR SLASRTNECQ GTMWAPTSPP AGSSSPSQPT WKSSLYSSLA YSEAFHYSFA 70 80 90 100 110 120 ARPRRLTQLA LAQRPEPQLL RLRPSSLRTQ DISHLLTGVF RNLYSAEVIG DEVSASLIKA 130 140 150 160 170 180 RGSENERHEE FVDQLQQIRE LYKQRLDEFE MLERHITQAQ ARAIAENERV MSQAGVQDLE 190 200 210 220 230 240 SLVRLPPVKS VSRWCIDSEL LRKHHLISPE DYYTDTVPFH SAPKGISLPG CSKLTFSCEK 250 260 270 280 290 300 RSVQKKELNK KLEDSCRKKL AEFEDELDHT VDSLTWNLTP KAKERTREPL KKASQPRNKN 310 320 330 340 350 360 WMNHLRVPQR ELDRLLLARM ESRNHFLKNP RFFPPNTRYG GKSLVFPPKK PAPIGEFQST 370 380 390 400 410 420 EPEQSCADTP VFLAKPPIGF FTDYEIGPVY EMVIALQNTT TTSRYLRVLP PSTPYFALGL 430 440 450 460 470 480 GMFPGKGGMV APGMTCQYIV QFFPDCLGDF DDFILVETQS AHTLLIPLQA RRPPPVLTLS 490 500 510 520 530 540 PVLDCGYCLI GGVKMTRFIC KNVGFSVGRF CIMPKTSWPP LSFKAIATVG FVEQPPFGIL 550 560 570 580 590 600 PSVFELAPGH AILVEVLFSP KSLGKAEQTF IIMCDNCQIK ELVTIGIGQL IALDLIYISG 610 620 630 640 650 660 EKSQPDPGEL TDLTAQHFIR FEPENLRSTA RKQLIIRNAT HVELAFYWQI MKPNLQPLMP 670 680 690 700 710 720 GETFSMDSIK CYPDKETAFS IMPRKGVLSP HTDHEFILSF SPHELRDFHS VLQMVLEEVP 730 740 750 760 770 780 EPVSSEAESL GHSSYSVDDV IVLEIEVKGS VEPFQVLLEP YALIIPGENY IGINVKKAFK 790 800 810 820 830 840 MWNNSKSPIR YLWGKISDCH IIEVEPGTGV IEPSEVGDFE LNFTGGVPGP TSQDLLCEIE 850 860 870 880 890 900 DSPSPVVLHI EAVFKGPALI INVSALQFGL LRLGQKATNS IQIRNVSQLP ATWRMKESPV 910 920 930 940 950 960 SLQERPEDVS PFDIEPSSGQ LHSLGECRVD ITLEALHCQH LETVLELEVE NGAWSYLPVY 970 980 990 1000 1010 1020 AEVQKPHVYL QSSQVEVRNL YLGVPTKTTI TLINGTLLPT QFHWGKLLGH QAEFCMVTVS 1030 1040 1050 1060 1070 1080 PKHGLLGPSE ECQLKLELTA HTQEELTHLA LPCHVSGMKK PLVLGISGKP QGLQVAITIS 1090 1100 1110 1120 1130 1140 KESSDCSTEQ WPGHPKELRL DFGSAVPLRT RVTRQLILTN RSPIRTRFSL KFEYFGSPQN 1150 1160 1170 1180 1190 1200 SLSKKTSLPN MPPALLKTVR MQEHLAKREQ LDFMESMLSH GKGAAFFPHF SQGMLGPYQQ 1210 1220 1230 1240 1250 1260 LCIDITGCAN MWGEYWDNLI CTVGDLLPEV IPVHMAAVGC PISSLRTTSY TIDQAQKEPA 1270 1280 1290 1300 1310 1320 MRFGTQVSGG DTVTRTLRLN NSSPCDIRLD WETYVPEDKE DRLVELLVFY GPPFPLRDQA 1330 1340 1350 1360 1370 1380 GNELVCPDTP EGGCLLWSPG PSSSSEFSHE TDSSVEGSSS ASNRVAQKLI SVILQAHEGV 1390 1400 1410 1420 1430 1440 PSGHLYCISP KQVVVPAGGS STIYISFTPM VLSPEILHKV ECTGYALGFM SLDSKVEREI 1450 1460 1470 1480 1490 1500 PGKRHRLQDF AVGPLKLDLH SYVRPAQLSV ELDYGGSMEF QCQASDLIPE QPCSGVLSEL 1510 1520 1530 1540 1550 1560 VTTHHLKLTN TTEIPHYFRL MVSRPFSVSQ DGASQDHRAP GPGQKQECEE ETASADKQLV 1570 1580 1590 1600 1610 1620 LQAQENMLVN VSFSLSLELL SYQKLPADQT LPGVDIQQSA SGEREMVFTQ NLLLEYTNQT 1630 1640 1650 1660 1670 1680 TQVVPLRAVV AVPELQLSTS WVDFGTCFVS QQRVREVYLM NLSGCRSYWT MLMGVVSCTS 1690 1700 1710 1720 1730 1740 PRWWWKVCSV RSPAPCGSGA KAPMMRDTCC LTSPEAPPQP SAPGPSWRKN IAQGLGAALQ 1750 1760 1770 HKDTDLGTWG PLGSSWNGRT PFHNGLSLGP HDMSSELT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3." Daigo Y., Nishiwaki T., Kawasoe T., Tamari M., Tsuchiya E., Nakamura Y. Cancer Res. 59:1966-1972(1999) [PubMed: 10213508] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, PUTATIVE FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INVOLVEMENT IN LUNG CANCER; ESOPHAGEAL CANCER AND RENAL CANCER.
[2]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 595-1755 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1417-1755 (ISOFORM 3). Tissue: Testis.
[4]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-351.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB026898 Genomic DNA. Translation: BAA77624.1. AB020522 mRNA. Translation: BAA77247.1. AC144536 Genomic DNA. No translation available. AP006309 Genomic DNA. No translation available. AL137706 Transcribed RNA. Translation: CAB70884.2. Different initiation. AL137282 mRNA. Translation: CAB70676.1. Sequence problems.
IPI	IPI00164104. IPI00178066. IPI00377259.
PIR	T46351. T46406.
RefSeq	NP_031361.2. NM_007335.2. NP_031363.2. NM_007337.2.
UniGene	Hs.714499.
3D structure databases
ProteinModelPortal	Q9Y238.
SMR	Q9Y238. Positions 751-857.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9Y238.
Polymorphism databases
DMDM	296434480.
Proteomic databases
PRIDE	Q9Y238.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000308059; ENSP00000308597; ENSG00000008226.
GeneID	9940.
KEGG	hsa:9940.
UCSC	uc003cho.1. human. uc003chp.1. human.
Organism-specific databases
CTD	9940.
GeneCards	GC03P038080.
H-InvDB	HIX0003176.
HGNC	HGNC:2899. DLEC1.
HPA	HPA019077. HPA020455.
MIM	133239. phenotype. 211980. phenotype. 604050. gene.
neXtProt	NX_Q9Y238.
Orphanet	70482. Esophageal carcinoma.
PharmGKB	PA27353.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000006098.
HOVERGEN	HBG081444.
OMA	NNSSPCD.
OrthoDB	EOG4NCMBV.
Gene expression databases
ArrayExpress	Q9Y238.
Bgee	Q9Y238.
CleanEx	HS_DLC1. HS_DLEC1.
Genevestigator	Q9Y238.
GermOnline	ENSG00000008226. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	37502.
SOURCE	Search...

Entry information

Entry name

DLEC1_HUMAN

Accession

Primary (citable) accession number: Q9Y238
Secondary accession number(s): Q9NSW0, Q9NTG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	May 18, 2010
Last modified:	January 25, 2012
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.