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Q9Y231

- FUT9_HUMAN

UniProt

Q9Y231 - FUT9_HUMAN

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Protein

Alpha-(1,3)-fucosyltransferase 9

Gene

FUT9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides.1 Publication

Pathwayi

GO - Molecular functioni

  1. alpha-(1->3)-fucosyltransferase activity Source: UniProtKB
  2. fucosyltransferase activity Source: ProtInc

GO - Biological processi

  1. carbohydrate metabolic process Source: ProtInc
  2. fucosylation Source: GOC
  3. L-fucose catabolic process Source: UniProtKB
  4. nervous system development Source: Ensembl
  5. protein glycosylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:HS10520-MONOMER.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT10. Glycosyltransferase Family 10.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 9 (EC:2.4.1.-)
Alternative name(s):
Fucosyltransferase 9
Fucosyltransferase IX
Short name:
Fuc-TIX
Short name:
FucT-IX
Galactoside 3-L-fucosyltransferase
Gene namesi
Name:FUT9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:4020. FUT9.

Subcellular locationi

Golgi apparatusGolgi stack membrane By similarity; Single-pass type II membrane protein By similarity
Note: Membrane-bound form in trans cisternae of Golgi.By similarity

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28436.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Alpha-(1,3)-fucosyltransferase 9PRO_0000221118Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y231.
PRIDEiQ9Y231.

PTM databases

PhosphoSiteiQ9Y231.

Expressioni

Tissue specificityi

Strongly expressed in forebrain and stomach, lower expression in spleen and peripheral blood leukocytes, and no expression in small intestine, colon, liver, lung, kidney, adrenal cortex or uterus.1 Publication

Gene expression databases

BgeeiQ9Y231.
CleanExiHS_FUT9.
GenevestigatoriQ9Y231.

Interactioni

Protein-protein interaction databases

BioGridi115929. 6 interactions.
IntActiQ9Y231. 2 interactions.
STRINGi9606.ENSP00000302599.

Structurei

3D structure databases

ProteinModelPortaliQ9Y231.
SMRiQ9Y231. Positions 183-313.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini33 – 359327LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG19459.
GeneTreeiENSGT00680000099679.
HOGENOMiHOG000045583.
HOVERGENiHBG000274.
InParanoidiQ9Y231.
KOiK03663.
OMAiLIWVWPF.
OrthoDBiEOG7Z69C9.
PhylomeDBiQ9Y231.
TreeFamiTF316348.

Family and domain databases

InterProiIPR001503. Glyco_trans_10.
[Graphical view]
PANTHERiPTHR11929. PTHR11929. 1 hit.
PfamiPF00852. Glyco_transf_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y231-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSTSKGILR PFLIVCIILG CFMACLLIYI KPTNSWIFSP MESASSVLKM
60 70 80 90 100
KNFFSTKTDY FNETTILVWV WPFGQTFDLT SCQAMFNIQG CHLTTDRSLY
110 120 130 140 150
NKSHAVLIHH RDISWDLTNL PQQARPPFQK WIWMNLESPT HTPQKSGIEH
160 170 180 190 200
LFNLTLTYRR DSDIQVPYGF LTVSTNPFVF EVPSKEKLVC WVVSNWNPEH
210 220 230 240 250
ARVKYYNELS KSIEIHTYGQ AFGEYVNDKN LIPTISTCKF YLSFENSIHK
260 270 280 290 300
DYITEKLYNA FLAGSVPVVL GPSRENYENY IPADSFIHVE DYNSPSELAK
310 320 330 340 350
YLKEVDKNNK LYLSYFNWRK DFTVNLPRFW ESHACLACDH VKRHQEYKSV

GNLEKWFWN
Length:359
Mass (Da):42,071
Last modified:November 2, 2010 - v2
Checksum:iD57CFCB039B644D9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti237 – 2371T → A.3 Publications
Corresponds to variant rs3811069 [ dbSNP | Ensembl ].
VAR_024465
Natural varianti358 – 3581W → G.
Corresponds to variant rs9986564 [ dbSNP | Ensembl ].
VAR_030575

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023021 mRNA. Translation: BAA81685.1.
AJ238701 mRNA. Translation: CAB41890.1.
AL512406 Genomic DNA. Translation: CAI14863.1.
BC036101 mRNA. Translation: AAH36101.1.
CCDSiCCDS5033.1.
RefSeqiNP_006572.2. NM_006581.3.
UniGeneiHs.49117.

Genome annotation databases

EnsembliENST00000302103; ENSP00000302599; ENSG00000172461.
GeneIDi10690.
KEGGihsa:10690.
UCSCiuc003pop.4. human.

Polymorphism databases

DMDMi311033382.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Functional Glycomics Gateway - GTase

Fucosyltransferase 9

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023021 mRNA. Translation: BAA81685.1 .
AJ238701 mRNA. Translation: CAB41890.1 .
AL512406 Genomic DNA. Translation: CAI14863.1 .
BC036101 mRNA. Translation: AAH36101.1 .
CCDSi CCDS5033.1.
RefSeqi NP_006572.2. NM_006581.3.
UniGenei Hs.49117.

3D structure databases

ProteinModelPortali Q9Y231.
SMRi Q9Y231. Positions 183-313.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115929. 6 interactions.
IntActi Q9Y231. 2 interactions.
STRINGi 9606.ENSP00000302599.

Protein family/group databases

CAZyi GT10. Glycosyltransferase Family 10.

PTM databases

PhosphoSitei Q9Y231.

Polymorphism databases

DMDMi 311033382.

Proteomic databases

PaxDbi Q9Y231.
PRIDEi Q9Y231.

Protocols and materials databases

DNASUi 10690.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302103 ; ENSP00000302599 ; ENSG00000172461 .
GeneIDi 10690.
KEGGi hsa:10690.
UCSCi uc003pop.4. human.

Organism-specific databases

CTDi 10690.
GeneCardsi GC06P096463.
H-InvDB HIX0025005.
HGNCi HGNC:4020. FUT9.
MIMi 606865. gene.
neXtProti NX_Q9Y231.
PharmGKBi PA28436.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG19459.
GeneTreei ENSGT00680000099679.
HOGENOMi HOG000045583.
HOVERGENi HBG000274.
InParanoidi Q9Y231.
KOi K03663.
OMAi LIWVWPF.
OrthoDBi EOG7Z69C9.
PhylomeDBi Q9Y231.
TreeFami TF316348.

Enzyme and pathway databases

UniPathwayi UPA00378 .
BioCyci MetaCyc:HS10520-MONOMER.

Miscellaneous databases

ChiTaRSi FUT9. human.
GeneWikii FUT9.
GenomeRNAii 10690.
NextBioi 40631.
PROi Q9Y231.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y231.
CleanExi HS_FUT9.
Genevestigatori Q9Y231.

Family and domain databases

InterProi IPR001503. Glyco_trans_10.
[Graphical view ]
PANTHERi PTHR11929. PTHR11929. 1 hit.
Pfami PF00852. Glyco_transf_10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Alpha-1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX."
    Kaneko M., Kudo T., Iwasaki H., Ikehara Y., Nishihara S., Nakagawa S., Sasaki K., Shiina T., Inoko H., Saitou N., Narimatsu H.
    FEBS Lett. 452:237-242(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANT ALA-237.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-237.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-237.
    Tissue: Brain.

Entry informationi

Entry nameiFUT9_HUMAN
AccessioniPrimary (citable) accession number: Q9Y231
Secondary accession number(s): Q5T0W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3