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Protein

Alpha-(1,3)-fucosyltransferase 9

Gene

FUT9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides.1 Publication

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • alpha-(1->3)-fucosyltransferase activity Source: UniProtKB
  • fucosyltransferase activity Source: ProtInc

GO - Biological processi

  • carbohydrate metabolic process Source: ProtInc
  • L-fucose catabolic process Source: UniProtKB
  • nervous system development Source: Ensembl
  • protein glycosylation Source: UniProtKB

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:HS10520-MONOMER
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT10 Glycosyltransferase Family 10

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 9 (EC:2.4.1.-)
Alternative name(s):
Fucosyltransferase 9
Fucosyltransferase IX
Short name:
Fuc-TIX
Short name:
FucT-IX
Galactoside 3-L-fucosyltransferase
Gene namesi
Name:FUT9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000172461.10
HGNCiHGNC:4020 FUT9
MIMi606865 gene
neXtProtiNX_Q9Y231

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini33 – 359LumenalSequence analysisAdd BLAST327

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10690
OpenTargetsiENSG00000172461
PharmGKBiPA28436

Chemistry databases

ChEMBLiCHEMBL4985

Polymorphism and mutation databases

BioMutaiFUT9
DMDMi311033382

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002211181 – 359Alpha-(1,3)-fucosyltransferase 9Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y231
PaxDbiQ9Y231
PeptideAtlasiQ9Y231
PRIDEiQ9Y231

PTM databases

iPTMnetiQ9Y231
PhosphoSitePlusiQ9Y231

Expressioni

Tissue specificityi

Strongly expressed in forebrain and stomach, lower expression in spleen and peripheral blood leukocytes, and no expression in small intestine, colon, liver, lung, kidney, adrenal cortex or uterus.1 Publication

Gene expression databases

BgeeiENSG00000172461
CleanExiHS_FUT9
GenevisibleiQ9Y231 HS

Organism-specific databases

HPAiHPA070923

Interactioni

Protein-protein interaction databases

BioGridi1159299 interactors.
IntActiQ9Y231 3 interactors.
STRINGi9606.ENSP00000302599

Chemistry databases

BindingDBiQ9Y231

Structurei

3D structure databases

ProteinModelPortaliQ9Y231
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2619 Eukaryota
ENOG410ZIMX LUCA
GeneTreeiENSGT00680000099679
HOGENOMiHOG000045583
HOVERGENiHBG000274
InParanoidiQ9Y231
KOiK03663
OMAiKGIFRPF
OrthoDBiEOG091G0846
PhylomeDBiQ9Y231
TreeFamiTF316348

Family and domain databases

Gene3Di3.40.50.116601 hit
InterProiView protein in InterPro
IPR031481 Glyco_tran_10_N
IPR001503 Glyco_trans_10
IPR038577 GT10-like_sf
PANTHERiPTHR11929 PTHR11929, 1 hit
PfamiView protein in Pfam
PF17039 Glyco_tran_10_N, 1 hit
PF00852 Glyco_transf_10, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTSKGILR PFLIVCIILG CFMACLLIYI KPTNSWIFSP MESASSVLKM
60 70 80 90 100
KNFFSTKTDY FNETTILVWV WPFGQTFDLT SCQAMFNIQG CHLTTDRSLY
110 120 130 140 150
NKSHAVLIHH RDISWDLTNL PQQARPPFQK WIWMNLESPT HTPQKSGIEH
160 170 180 190 200
LFNLTLTYRR DSDIQVPYGF LTVSTNPFVF EVPSKEKLVC WVVSNWNPEH
210 220 230 240 250
ARVKYYNELS KSIEIHTYGQ AFGEYVNDKN LIPTISTCKF YLSFENSIHK
260 270 280 290 300
DYITEKLYNA FLAGSVPVVL GPSRENYENY IPADSFIHVE DYNSPSELAK
310 320 330 340 350
YLKEVDKNNK LYLSYFNWRK DFTVNLPRFW ESHACLACDH VKRHQEYKSV

GNLEKWFWN
Length:359
Mass (Da):42,071
Last modified:November 2, 2010 - v2
Checksum:iD57CFCB039B644D9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024465237T → A3 PublicationsCorresponds to variant dbSNP:rs3811069Ensembl.1
Natural variantiVAR_030575358W → G. Corresponds to variant dbSNP:rs9986564Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023021 mRNA Translation: BAA81685.1
AJ238701 mRNA Translation: CAB41890.1
AL512406 Genomic DNA No translation available.
BC036101 mRNA Translation: AAH36101.1
CCDSiCCDS5033.1
RefSeqiNP_006572.2, NM_006581.3
XP_011533685.1, XM_011535383.2
XP_011533687.1, XM_011535385.2
XP_016865677.1, XM_017010188.1
XP_016865679.1, XM_017010190.1
UniGeneiHs.49117

Genome annotation databases

EnsembliENST00000302103; ENSP00000302599; ENSG00000172461
GeneIDi10690
KEGGihsa:10690
UCSCiuc003pop.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFUT9_HUMAN
AccessioniPrimary (citable) accession number: Q9Y231
Secondary accession number(s): Q5T0W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 2, 2010
Last modified: March 28, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome