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Q9Y231 (FUT9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-(1,3)-fucosyltransferase 9

EC=2.4.1.-
Alternative name(s):
Fucosyltransferase 9
Fucosyltransferase IX
Short name=Fuc-TIX
Short name=FucT-IX
Galactoside 3-L-fucosyltransferase
Gene names
Name:FUT9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides. Ref.1

Pathway

Protein modification; protein glycosylation.

Subcellular location

Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein By similarity. Note: Membrane-bound form in trans cisternae of Golgi By similarity.

Tissue specificity

Strongly expressed in forebrain and stomach, lower expression in spleen and peripheral blood leukocytes, and no expression in small intestine, colon, liver, lung, kidney, adrenal cortex or uterus. Ref.1

Sequence similarities

Belongs to the glycosyltransferase 10 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Alpha-(1,3)-fucosyltransferase 9
PRO_0000221118

Regions

Topological domain1 – 1111Cytoplasmic Potential
Transmembrane12 – 3221Helical; Signal-anchor for type II membrane protein; Potential
Topological domain33 – 359327Lumenal Potential

Amino acid modifications

Glycosylation621N-linked (GlcNAc...) Potential
Glycosylation1011N-linked (GlcNAc...) Potential
Glycosylation1531N-linked (GlcNAc...) Potential

Natural variations

Natural variant2371T → A. Ref.1 Ref.2 Ref.4
Corresponds to variant rs3811069 [ dbSNP | Ensembl ].
VAR_024465
Natural variant3581W → G.
Corresponds to variant rs9986564 [ dbSNP | Ensembl ].
VAR_030575

Sequences

Sequence LengthMass (Da)Tools
Q9Y231 [UniParc].

Last modified November 2, 2010. Version 2.
Checksum: D57CFCB039B644D9

FASTA35942,071
        10         20         30         40         50         60 
MTSTSKGILR PFLIVCIILG CFMACLLIYI KPTNSWIFSP MESASSVLKM KNFFSTKTDY 

        70         80         90        100        110        120 
FNETTILVWV WPFGQTFDLT SCQAMFNIQG CHLTTDRSLY NKSHAVLIHH RDISWDLTNL 

       130        140        150        160        170        180 
PQQARPPFQK WIWMNLESPT HTPQKSGIEH LFNLTLTYRR DSDIQVPYGF LTVSTNPFVF 

       190        200        210        220        230        240 
EVPSKEKLVC WVVSNWNPEH ARVKYYNELS KSIEIHTYGQ AFGEYVNDKN LIPTISTCKF 

       250        260        270        280        290        300 
YLSFENSIHK DYITEKLYNA FLAGSVPVVL GPSRENYENY IPADSFIHVE DYNSPSELAK 

       310        320        330        340        350 
YLKEVDKNNK LYLSYFNWRK DFTVNLPRFW ESHACLACDH VKRHQEYKSV GNLEKWFWN 

« Hide

References

« Hide 'large scale' references
[1]"Alpha-1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX."
Kaneko M., Kudo T., Iwasaki H., Ikehara Y., Nishihara S., Nakagawa S., Sasaki K., Shiina T., Inoko H., Saitou N., Narimatsu H.
FEBS Lett. 452:237-242(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANT ALA-237.
Tissue: Brain.
[2]"FUT4 and FUT9 genes are expressed early in human embryogenesis."
Cailleau-Thomas A., Coullin P., Candelier J.J., Balanzino L., Oriol R., Mollicone R., Mennesson B.
Glycobiology 10:789-802(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-237.
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-237.
Tissue: Brain.
+Additional computationally mapped references.

Web resources

GGDB

GlycoGene database

Functional Glycomics Gateway - GTase

Fucosyltransferase 9

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB023021 mRNA. Translation: BAA81685.1.
AJ238701 mRNA. Translation: CAB41890.1.
AL512406 Genomic DNA. Translation: CAI14863.1.
BC036101 mRNA. Translation: AAH36101.1.
CCDSCCDS5033.1.
RefSeqNP_006572.2. NM_006581.3.
UniGeneHs.49117.

3D structure databases

ProteinModelPortalQ9Y231.
SMRQ9Y231. Positions 183-313.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115929. 1 interaction.
IntActQ9Y231. 2 interactions.
STRING9606.ENSP00000302599.

Protein family/group databases

CAZyGT10. Glycosyltransferase Family 10.

PTM databases

PhosphoSiteQ9Y231.

Polymorphism databases

DMDM311033382.

Proteomic databases

PaxDbQ9Y231.
PRIDEQ9Y231.

Protocols and materials databases

DNASU10690.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302103; ENSP00000302599; ENSG00000172461.
GeneID10690.
KEGGhsa:10690.
UCSCuc003pop.4. human.

Organism-specific databases

CTD10690.
GeneCardsGC06P096463.
H-InvDBHIX0025005.
HGNCHGNC:4020. FUT9.
MIM606865. gene.
neXtProtNX_Q9Y231.
PharmGKBPA28436.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG19459.
HOGENOMHOG000045583.
HOVERGENHBG000274.
InParanoidQ9Y231.
KOK03663.
OMALIWVWPF.
OrthoDBEOG7Z69C9.
PhylomeDBQ9Y231.
TreeFamTF316348.

Enzyme and pathway databases

BioCycMetaCyc:HS10520-MONOMER.
UniPathwayUPA00378.

Gene expression databases

BgeeQ9Y231.
CleanExHS_FUT9.
GenevestigatorQ9Y231.

Family and domain databases

InterProIPR001503. Glyco_trans_10.
[Graphical view]
PANTHERPTHR11929. PTHR11929. 1 hit.
PfamPF00852. Glyco_transf_10. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFUT9. human.
GeneWikiFUT9.
GenomeRNAi10690.
NextBio40631.
PROQ9Y231.
SOURCESearch...

Entry information

Entry nameFUT9_HUMAN
AccessionPrimary (citable) accession number: Q9Y231
Secondary accession number(s): Q5T0W4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM