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Q9Y231

- FUT9_HUMAN

UniProt

Q9Y231 - FUT9_HUMAN

Protein

Alpha-(1,3)-fucosyltransferase 9

Gene

FUT9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides.1 Publication

    Pathwayi

    GO - Molecular functioni

    1. alpha-(1->3)-fucosyltransferase activity Source: UniProtKB
    2. fucosyltransferase activity Source: ProtInc

    GO - Biological processi

    1. carbohydrate metabolic process Source: ProtInc
    2. fucosylation Source: GOC
    3. L-fucose catabolic process Source: UniProtKB
    4. nervous system development Source: Ensembl
    5. protein glycosylation Source: UniProtKB

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciMetaCyc:HS10520-MONOMER.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT10. Glycosyltransferase Family 10.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 9 (EC:2.4.1.-)
    Alternative name(s):
    Fucosyltransferase 9
    Fucosyltransferase IX
    Short name:
    Fuc-TIX
    Short name:
    FucT-IX
    Galactoside 3-L-fucosyltransferase
    Gene namesi
    Name:FUT9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4020. FUT9.

    Subcellular locationi

    Golgi apparatusGolgi stack membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Membrane-bound form in trans cisternae of Golgi.By similarity

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB
    2. Golgi cisterna membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28436.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Alpha-(1,3)-fucosyltransferase 9PRO_0000221118Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9Y231.
    PRIDEiQ9Y231.

    PTM databases

    PhosphoSiteiQ9Y231.

    Expressioni

    Tissue specificityi

    Strongly expressed in forebrain and stomach, lower expression in spleen and peripheral blood leukocytes, and no expression in small intestine, colon, liver, lung, kidney, adrenal cortex or uterus.1 Publication

    Gene expression databases

    BgeeiQ9Y231.
    CleanExiHS_FUT9.
    GenevestigatoriQ9Y231.

    Interactioni

    Protein-protein interaction databases

    BioGridi115929. 1 interaction.
    IntActiQ9Y231. 2 interactions.
    STRINGi9606.ENSP00000302599.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y231.
    SMRiQ9Y231. Positions 183-313.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini33 – 359327LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 10 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG19459.
    HOGENOMiHOG000045583.
    HOVERGENiHBG000274.
    InParanoidiQ9Y231.
    KOiK03663.
    OMAiLIWVWPF.
    OrthoDBiEOG7Z69C9.
    PhylomeDBiQ9Y231.
    TreeFamiTF316348.

    Family and domain databases

    InterProiIPR001503. Glyco_trans_10.
    [Graphical view]
    PANTHERiPTHR11929. PTHR11929. 1 hit.
    PfamiPF00852. Glyco_transf_10. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y231-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSTSKGILR PFLIVCIILG CFMACLLIYI KPTNSWIFSP MESASSVLKM    50
    KNFFSTKTDY FNETTILVWV WPFGQTFDLT SCQAMFNIQG CHLTTDRSLY 100
    NKSHAVLIHH RDISWDLTNL PQQARPPFQK WIWMNLESPT HTPQKSGIEH 150
    LFNLTLTYRR DSDIQVPYGF LTVSTNPFVF EVPSKEKLVC WVVSNWNPEH 200
    ARVKYYNELS KSIEIHTYGQ AFGEYVNDKN LIPTISTCKF YLSFENSIHK 250
    DYITEKLYNA FLAGSVPVVL GPSRENYENY IPADSFIHVE DYNSPSELAK 300
    YLKEVDKNNK LYLSYFNWRK DFTVNLPRFW ESHACLACDH VKRHQEYKSV 350
    GNLEKWFWN 359
    Length:359
    Mass (Da):42,071
    Last modified:November 2, 2010 - v2
    Checksum:iD57CFCB039B644D9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti237 – 2371T → A.3 Publications
    Corresponds to variant rs3811069 [ dbSNP | Ensembl ].
    VAR_024465
    Natural varianti358 – 3581W → G.
    Corresponds to variant rs9986564 [ dbSNP | Ensembl ].
    VAR_030575

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023021 mRNA. Translation: BAA81685.1.
    AJ238701 mRNA. Translation: CAB41890.1.
    AL512406 Genomic DNA. Translation: CAI14863.1.
    BC036101 mRNA. Translation: AAH36101.1.
    CCDSiCCDS5033.1.
    RefSeqiNP_006572.2. NM_006581.3.
    UniGeneiHs.49117.

    Genome annotation databases

    EnsembliENST00000302103; ENSP00000302599; ENSG00000172461.
    GeneIDi10690.
    KEGGihsa:10690.
    UCSCiuc003pop.4. human.

    Polymorphism databases

    DMDMi311033382.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    GGDB

    GlycoGene database

    Functional Glycomics Gateway - GTase

    Fucosyltransferase 9

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023021 mRNA. Translation: BAA81685.1 .
    AJ238701 mRNA. Translation: CAB41890.1 .
    AL512406 Genomic DNA. Translation: CAI14863.1 .
    BC036101 mRNA. Translation: AAH36101.1 .
    CCDSi CCDS5033.1.
    RefSeqi NP_006572.2. NM_006581.3.
    UniGenei Hs.49117.

    3D structure databases

    ProteinModelPortali Q9Y231.
    SMRi Q9Y231. Positions 183-313.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115929. 1 interaction.
    IntActi Q9Y231. 2 interactions.
    STRINGi 9606.ENSP00000302599.

    Protein family/group databases

    CAZyi GT10. Glycosyltransferase Family 10.

    PTM databases

    PhosphoSitei Q9Y231.

    Polymorphism databases

    DMDMi 311033382.

    Proteomic databases

    PaxDbi Q9Y231.
    PRIDEi Q9Y231.

    Protocols and materials databases

    DNASUi 10690.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302103 ; ENSP00000302599 ; ENSG00000172461 .
    GeneIDi 10690.
    KEGGi hsa:10690.
    UCSCi uc003pop.4. human.

    Organism-specific databases

    CTDi 10690.
    GeneCardsi GC06P096463.
    H-InvDB HIX0025005.
    HGNCi HGNC:4020. FUT9.
    MIMi 606865. gene.
    neXtProti NX_Q9Y231.
    PharmGKBi PA28436.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG19459.
    HOGENOMi HOG000045583.
    HOVERGENi HBG000274.
    InParanoidi Q9Y231.
    KOi K03663.
    OMAi LIWVWPF.
    OrthoDBi EOG7Z69C9.
    PhylomeDBi Q9Y231.
    TreeFami TF316348.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    BioCyci MetaCyc:HS10520-MONOMER.

    Miscellaneous databases

    ChiTaRSi FUT9. human.
    GeneWikii FUT9.
    GenomeRNAii 10690.
    NextBioi 40631.
    PROi Q9Y231.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y231.
    CleanExi HS_FUT9.
    Genevestigatori Q9Y231.

    Family and domain databases

    InterProi IPR001503. Glyco_trans_10.
    [Graphical view ]
    PANTHERi PTHR11929. PTHR11929. 1 hit.
    Pfami PF00852. Glyco_transf_10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Alpha-1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX."
      Kaneko M., Kudo T., Iwasaki H., Ikehara Y., Nishihara S., Nakagawa S., Sasaki K., Shiina T., Inoko H., Saitou N., Narimatsu H.
      FEBS Lett. 452:237-242(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANT ALA-237.
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-237.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-237.
      Tissue: Brain.

    Entry informationi

    Entry nameiFUT9_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y231
    Secondary accession number(s): Q5T0W4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 9, 2004
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3