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Protein

Alpha-(1,3)-fucosyltransferase 9

Gene

FUT9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides.1 Publication

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • alpha-(1->3)-fucosyltransferase activity Source: UniProtKB
  • fucosyltransferase activity Source: ProtInc

GO - Biological processi

  • carbohydrate metabolic process Source: ProtInc
  • L-fucose catabolic process Source: UniProtKB
  • nervous system development Source: Ensembl
  • protein glycosylation Source: UniProtKB

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:HS10520-MONOMER.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT10. Glycosyltransferase Family 10.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 9 (EC:2.4.1.-)
Alternative name(s):
Fucosyltransferase 9
Fucosyltransferase IX
Short name:
Fuc-TIX
Short name:
FucT-IX
Galactoside 3-L-fucosyltransferase
Gene namesi
Name:FUT9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4020. FUT9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini33 – 359LumenalSequence analysisAdd BLAST327

GO - Cellular componenti

  • Golgi apparatus Source: UniProtKB
  • Golgi cisterna membrane Source: UniProtKB-SubCell
  • Golgi membrane Source: GO_Central
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10690.
OpenTargetsiENSG00000172461.
PharmGKBiPA28436.

Chemistry databases

ChEMBLiCHEMBL4985.

Polymorphism and mutation databases

BioMutaiFUT9.
DMDMi311033382.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002211181 – 359Alpha-(1,3)-fucosyltransferase 9Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y231.
PeptideAtlasiQ9Y231.
PRIDEiQ9Y231.

PTM databases

iPTMnetiQ9Y231.
PhosphoSitePlusiQ9Y231.

Expressioni

Tissue specificityi

Strongly expressed in forebrain and stomach, lower expression in spleen and peripheral blood leukocytes, and no expression in small intestine, colon, liver, lung, kidney, adrenal cortex or uterus.1 Publication

Gene expression databases

BgeeiENSG00000172461.
CleanExiHS_FUT9.
GenevisibleiQ9Y231. HS.

Organism-specific databases

HPAiHPA070923.

Interactioni

Protein-protein interaction databases

BioGridi115929. 8 interactors.
IntActiQ9Y231. 3 interactors.
STRINGi9606.ENSP00000302599.

Chemistry databases

BindingDBiQ9Y231.

Structurei

3D structure databases

ProteinModelPortaliQ9Y231.
SMRiQ9Y231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2619. Eukaryota.
ENOG410ZIMX. LUCA.
GeneTreeiENSGT00680000099679.
HOGENOMiHOG000045583.
HOVERGENiHBG000274.
InParanoidiQ9Y231.
KOiK03663.
OMAiKGIFRPF.
OrthoDBiEOG091G0846.
PhylomeDBiQ9Y231.
TreeFamiTF316348.

Family and domain databases

InterProiView protein in InterPro
IPR031481. Glyco_tran_10_N.
IPR001503. Glyco_trans_10.
PANTHERiPTHR11929. PTHR11929. 1 hit.
PfamiView protein in Pfam
PF17039. Glyco_tran_10_N. 1 hit.
PF00852. Glyco_transf_10. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTSKGILR PFLIVCIILG CFMACLLIYI KPTNSWIFSP MESASSVLKM
60 70 80 90 100
KNFFSTKTDY FNETTILVWV WPFGQTFDLT SCQAMFNIQG CHLTTDRSLY
110 120 130 140 150
NKSHAVLIHH RDISWDLTNL PQQARPPFQK WIWMNLESPT HTPQKSGIEH
160 170 180 190 200
LFNLTLTYRR DSDIQVPYGF LTVSTNPFVF EVPSKEKLVC WVVSNWNPEH
210 220 230 240 250
ARVKYYNELS KSIEIHTYGQ AFGEYVNDKN LIPTISTCKF YLSFENSIHK
260 270 280 290 300
DYITEKLYNA FLAGSVPVVL GPSRENYENY IPADSFIHVE DYNSPSELAK
310 320 330 340 350
YLKEVDKNNK LYLSYFNWRK DFTVNLPRFW ESHACLACDH VKRHQEYKSV

GNLEKWFWN
Length:359
Mass (Da):42,071
Last modified:November 2, 2010 - v2
Checksum:iD57CFCB039B644D9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024465237T → A3 PublicationsCorresponds to variant dbSNP:rs3811069Ensembl.1
Natural variantiVAR_030575358W → G. Corresponds to variant dbSNP:rs9986564Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023021 mRNA. Translation: BAA81685.1.
AJ238701 mRNA. Translation: CAB41890.1.
AL512406 Genomic DNA. No translation available.
BC036101 mRNA. Translation: AAH36101.1.
CCDSiCCDS5033.1.
RefSeqiNP_006572.2. NM_006581.3.
XP_011533685.1. XM_011535383.2.
XP_011533687.1. XM_011535385.2.
XP_016865677.1. XM_017010188.1.
XP_016865679.1. XM_017010190.1.
UniGeneiHs.49117.

Genome annotation databases

EnsembliENST00000302103; ENSP00000302599; ENSG00000172461.
GeneIDi10690.
KEGGihsa:10690.
UCSCiuc003pop.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFUT9_HUMAN
AccessioniPrimary (citable) accession number: Q9Y231
Secondary accession number(s): Q5T0W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 2, 2010
Last modified: May 10, 2017
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families