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Q9Y228 (T3JAM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
TRAF3-interacting JNK-activating modulator
Alternative name(s):
TRAF3-interacting protein 3
Gene names
Name:TRAF3IP3
Synonyms:T3JAM
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function as an adapter molecule that regulates TRAF3-mediated JNK activation By similarity.

Subunit structure

Binds to the isoleucine zipper of TRAF3 via its coiled-coil domain By similarity.

Subcellular location

Membrane; Single-pass type IV membrane protein Potential.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Transmembrane
Transmembrane helix
   PTMIsopeptide bond
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y228-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q9Y228-2)

The sequence of this isoform differs from the canonical sequence as follows:
     95-114: Missing.
Isoform 3 (identifier: Q9Y228-3)

The sequence of this isoform differs from the canonical sequence as follows:
     352-353: GA → IN
     354-551: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 551551TRAF3-interacting JNK-activating modulator
PRO_0000072403

Regions

Topological domain1 – 526526Cytoplasmic Potential
Transmembrane527 – 54418Helical; Anchor for type IV membrane protein; Potential
Topological domain545 – 5517Extracellular Potential
Coiled coil240 – 436197 Potential
Coiled coil464 – 50643 Potential

Amino acid modifications

Cross-link267Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.5

Natural variations

Alternative sequence95 – 11420Missing in isoform 2.
VSP_017271
Alternative sequence352 – 3532GA → IN in isoform 3.
VSP_017272
Alternative sequence354 – 551198Missing in isoform 3.
VSP_017273
Natural variant3731Q → E. Ref.3 Ref.4
Corresponds to variant rs669694 [ dbSNP | Ensembl ].
VAR_024283
Natural variant5291P → S in a colorectal cancer sample; somatic mutation. Ref.6
VAR_035664

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 21, 2006. Version 2.
Checksum: EA2DFF45A8D6ED19

FASTA55163,626
        10         20         30         40         50         60 
MISPDPRPSP GLARWAESYE AKCERRQEIR ESRRCRPNVT TCRQVGKTLR IQQREQLQRA 

        70         80         90        100        110        120 
RLQQFFRRRN LELEEKGKAQ HPQAREQGPS RRPGQVTVLK EPLSCARRIS SPREQVTGTS 

       130        140        150        160        170        180 
SEVFPAQHPP PSGICRDLSD HLSSQAGGLP PQDTPIKKPP KHHRGTQTKA EGPTIKNDAS 

       190        200        210        220        230        240 
QQTNYGVAVL DKEIIQLSDY LKEALQRELV LKQKMVILQD LLSTLIQASD SSWKGQLNED 

       250        260        270        280        290        300 
KLKGKLRSLE NQLYTCTQKY SPWGMKKVLL EMEDQKNSYE QKAKESLQKV LEEKMNAEQQ 

       310        320        330        340        350        360 
LQSTQRSLAL AEQKCEEWRS QYEALKEDWR TLGTQHRELE SQLHVLQSKL QGADSRDLQM 

       370        380        390        400        410        420 
NQALRFLENE HQQLQAKIEC LQGDRDLCSL DTQDLQDQLK RSEAEKLTLV TRVQQLQGLL 

       430        440        450        460        470        480 
QNQSLQLQEQ EKLLTKKDQA LPVWSPKSFP NEVEPEGTGK EKDWDLRDQL QKKTLQLQAK 

       490        500        510        520        530        540 
EKECRELHSE LDNLSDEYLS CLRKLQHCRE ELNQSQQLPP RRQCGRWLPV LMVVIAAALA 

       550 
VFLANKDNLM I 

« Hide

Isoform 2 [UniParc].

Checksum: 3ABAB20EEB018E30
Show »

FASTA53161,375
Isoform 3 [UniParc].

Checksum: 5405FE9F07EE18F7
Show »

FASTA35340,674

References

[1]Rhodes S.
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1).
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-373.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT GLU-373.
Tissue: Blood and Brain.
[5]"The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."
Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D.
J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-267.
Tissue: Lung adenocarcinoma.
[6]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-529.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL049667 mRNA. Translation: CAB41242.1.
AL022398 Genomic DNA. Translation: CAI95687.1.
CH471100 Genomic DNA. Translation: EAW93444.1.
BC110302 mRNA. Translation: AAI10303.1.
BC130417 mRNA. Translation: AAI30418.1.
BC144139 mRNA. Translation: AAI44140.1.
RefSeqNP_001274683.1. NM_001287754.1.
NP_079504.2. NM_025228.3.
UniGeneHs.147434.

3D structure databases

ProteinModelPortalQ9Y228.
SMRQ9Y228. Positions 466-515.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123249. 19 interactions.
IntActQ9Y228. 29 interactions.
MINTMINT-6768551.
STRING9606.ENSP00000010338.

PTM databases

PhosphoSiteQ9Y228.

Polymorphism databases

DMDM88984949.

Proteomic databases

PaxDbQ9Y228.
PRIDEQ9Y228.

Protocols and materials databases

DNASU80342.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000010338; ENSP00000010338; ENSG00000009790. [Q9Y228-2]
ENST00000367024; ENSP00000355991; ENSG00000009790. [Q9Y228-1]
ENST00000367025; ENSP00000355992; ENSG00000009790. [Q9Y228-1]
ENST00000367026; ENSP00000355993; ENSG00000009790. [Q9Y228-2]
ENST00000478359; ENSP00000417665; ENSG00000009790. [Q9Y228-3]
GeneID80342.
KEGGhsa:80342.
UCSCuc001hhm.2. human. [Q9Y228-3]
uc001hhn.3. human. [Q9Y228-2]
uc001hho.3. human. [Q9Y228-1]

Organism-specific databases

CTD80342.
GeneCardsGC01P209929.
H-InvDBHIX0159943.
HGNCHGNC:30766. TRAF3IP3.
HPAHPA040796.
MIM608255. gene.
neXtProtNX_Q9Y228.
PharmGKBPA142670711.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG81914.
HOGENOMHOG000070108.
HOVERGENHBG054704.
InParanoidQ9Y228.
OMAKCERRQE.
OrthoDBEOG7V1FQD.
PhylomeDBQ9Y228.
TreeFamTF334641.

Gene expression databases

ArrayExpressQ9Y228.
BgeeQ9Y228.
CleanExHS_TRAF3IP3.
GenevestigatorQ9Y228.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSTRAF3IP3. human.
GeneWikiTRAF3IP3.
GenomeRNAi80342.
NextBio70918.
PROQ9Y228.
SOURCESearch...

Entry information

Entry nameT3JAM_HUMAN
AccessionPrimary (citable) accession number: Q9Y228
Secondary accession number(s): A1L464 expand/collapse secondary AC list , A6NIU9, Q2YDB5, Q4VY06, Q7Z706
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: February 21, 2006
Last modified: April 16, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM