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Protein

TRAF3-interacting JNK-activating modulator

Gene

TRAF3IP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as an adapter molecule that regulates TRAF3-mediated JNK activation.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
TRAF3-interacting JNK-activating modulator
Alternative name(s):
TRAF3-interacting protein 3
Gene namesi
Name:TRAF3IP3
Synonyms:T3JAM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:30766. TRAF3IP3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 526526CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei527 – 54418Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST
Topological domaini545 – 5517ExtracellularSequence Analysis

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670711.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551TRAF3-interacting JNK-activating modulatorPRO_0000072403Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki267 – 267Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ9Y228.
PaxDbiQ9Y228.
PRIDEiQ9Y228.

PTM databases

PhosphoSiteiQ9Y228.

Expressioni

Gene expression databases

BgeeiQ9Y228.
CleanExiHS_TRAF3IP3.
ExpressionAtlasiQ9Y228. baseline and differential.
GenevestigatoriQ9Y228.

Organism-specific databases

HPAiHPA040796.

Interactioni

Subunit structurei

Binds to the isoleucine zipper of TRAF3 via its coiled-coil domain.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MOB4Q9Y3A32EBI-765817,EBI-713935
SIKE1Q9BRV82EBI-765817,EBI-1773646
STK24Q9Y6E02EBI-765817,EBI-740175
STRIP1Q5VSL92EBI-765817,EBI-1773588
STRNO438152EBI-765817,EBI-1046642
STRN3Q130332EBI-765817,EBI-1053857

Protein-protein interaction databases

BioGridi123249. 31 interactions.
IntActiQ9Y228. 30 interactions.
MINTiMINT-6768551.
STRINGi9606.ENSP00000010338.

Structurei

3D structure databases

ProteinModelPortaliQ9Y228.
SMRiQ9Y228. Positions 466-515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili240 – 436197Sequence AnalysisAdd
BLAST
Coiled coili464 – 50643Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG81914.
GeneTreeiENSGT00530000063197.
HOGENOMiHOG000070108.
HOVERGENiHBG054704.
InParanoidiQ9Y228.
OMAiKCERRQE.
OrthoDBiEOG7V1FQD.
PhylomeDBiQ9Y228.
TreeFamiTF334641.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y228-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISPDPRPSP GLARWAESYE AKCERRQEIR ESRRCRPNVT TCRQVGKTLR
60 70 80 90 100
IQQREQLQRA RLQQFFRRRN LELEEKGKAQ HPQAREQGPS RRPGQVTVLK
110 120 130 140 150
EPLSCARRIS SPREQVTGTS SEVFPAQHPP PSGICRDLSD HLSSQAGGLP
160 170 180 190 200
PQDTPIKKPP KHHRGTQTKA EGPTIKNDAS QQTNYGVAVL DKEIIQLSDY
210 220 230 240 250
LKEALQRELV LKQKMVILQD LLSTLIQASD SSWKGQLNED KLKGKLRSLE
260 270 280 290 300
NQLYTCTQKY SPWGMKKVLL EMEDQKNSYE QKAKESLQKV LEEKMNAEQQ
310 320 330 340 350
LQSTQRSLAL AEQKCEEWRS QYEALKEDWR TLGTQHRELE SQLHVLQSKL
360 370 380 390 400
QGADSRDLQM NQALRFLENE HQQLQAKIEC LQGDRDLCSL DTQDLQDQLK
410 420 430 440 450
RSEAEKLTLV TRVQQLQGLL QNQSLQLQEQ EKLLTKKDQA LPVWSPKSFP
460 470 480 490 500
NEVEPEGTGK EKDWDLRDQL QKKTLQLQAK EKECRELHSE LDNLSDEYLS
510 520 530 540 550
CLRKLQHCRE ELNQSQQLPP RRQCGRWLPV LMVVIAAALA VFLANKDNLM

I

Note: No experimental confirmation available.

Length:551
Mass (Da):63,626
Last modified:February 21, 2006 - v2
Checksum:iEA2DFF45A8D6ED19
GO
Isoform 2 (identifier: Q9Y228-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-114: Missing.

Show »
Length:531
Mass (Da):61,375
Checksum:i3ABAB20EEB018E30
GO
Isoform 3 (identifier: Q9Y228-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     352-353: GA → IN
     354-551: Missing.

Note: No experimental confirmation available.

Show »
Length:353
Mass (Da):40,674
Checksum:i5405FE9F07EE18F7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti373 – 3731Q → E.2 Publications
Corresponds to variant rs669694 [ dbSNP | Ensembl ].
VAR_024283
Natural varianti529 – 5291P → S in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035664

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei95 – 11420Missing in isoform 2. 1 PublicationVSP_017271Add
BLAST
Alternative sequencei352 – 3532GA → IN in isoform 3. 1 PublicationVSP_017272
Alternative sequencei354 – 551198Missing in isoform 3. 1 PublicationVSP_017273Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049667 mRNA. Translation: CAB41242.1.
AL022398 Genomic DNA. Translation: CAI95687.1.
CH471100 Genomic DNA. Translation: EAW93444.1.
BC110302 mRNA. Translation: AAI10303.1.
BC130417 mRNA. Translation: AAI30418.1.
BC144139 mRNA. Translation: AAI44140.1.
CCDSiCCDS1490.2. [Q9Y228-1]
RefSeqiNP_001274683.1. NM_001287754.1.
NP_079504.2. NM_025228.3. [Q9Y228-1]
UniGeneiHs.147434.

Genome annotation databases

EnsembliENST00000367024; ENSP00000355991; ENSG00000009790. [Q9Y228-1]
ENST00000367025; ENSP00000355992; ENSG00000009790. [Q9Y228-1]
ENST00000367026; ENSP00000355993; ENSG00000009790. [Q9Y228-2]
ENST00000478359; ENSP00000417665; ENSG00000009790. [Q9Y228-3]
GeneIDi80342.
KEGGihsa:80342.
UCSCiuc001hhm.2. human. [Q9Y228-3]
uc001hhn.3. human. [Q9Y228-2]
uc001hho.3. human. [Q9Y228-1]

Polymorphism databases

DMDMi88984949.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049667 mRNA. Translation: CAB41242.1.
AL022398 Genomic DNA. Translation: CAI95687.1.
CH471100 Genomic DNA. Translation: EAW93444.1.
BC110302 mRNA. Translation: AAI10303.1.
BC130417 mRNA. Translation: AAI30418.1.
BC144139 mRNA. Translation: AAI44140.1.
CCDSiCCDS1490.2. [Q9Y228-1]
RefSeqiNP_001274683.1. NM_001287754.1.
NP_079504.2. NM_025228.3. [Q9Y228-1]
UniGeneiHs.147434.

3D structure databases

ProteinModelPortaliQ9Y228.
SMRiQ9Y228. Positions 466-515.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123249. 31 interactions.
IntActiQ9Y228. 30 interactions.
MINTiMINT-6768551.
STRINGi9606.ENSP00000010338.

PTM databases

PhosphoSiteiQ9Y228.

Polymorphism databases

DMDMi88984949.

Proteomic databases

MaxQBiQ9Y228.
PaxDbiQ9Y228.
PRIDEiQ9Y228.

Protocols and materials databases

DNASUi80342.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367024; ENSP00000355991; ENSG00000009790. [Q9Y228-1]
ENST00000367025; ENSP00000355992; ENSG00000009790. [Q9Y228-1]
ENST00000367026; ENSP00000355993; ENSG00000009790. [Q9Y228-2]
ENST00000478359; ENSP00000417665; ENSG00000009790. [Q9Y228-3]
GeneIDi80342.
KEGGihsa:80342.
UCSCiuc001hhm.2. human. [Q9Y228-3]
uc001hhn.3. human. [Q9Y228-2]
uc001hho.3. human. [Q9Y228-1]

Organism-specific databases

CTDi80342.
GeneCardsiGC01P209929.
H-InvDBHIX0159943.
HGNCiHGNC:30766. TRAF3IP3.
HPAiHPA040796.
MIMi608255. gene.
neXtProtiNX_Q9Y228.
PharmGKBiPA142670711.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG81914.
GeneTreeiENSGT00530000063197.
HOGENOMiHOG000070108.
HOVERGENiHBG054704.
InParanoidiQ9Y228.
OMAiKCERRQE.
OrthoDBiEOG7V1FQD.
PhylomeDBiQ9Y228.
TreeFamiTF334641.

Miscellaneous databases

ChiTaRSiTRAF3IP3. human.
GeneWikiiTRAF3IP3.
GenomeRNAii80342.
NextBioi70918.
PROiQ9Y228.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y228.
CleanExiHS_TRAF3IP3.
ExpressionAtlasiQ9Y228. baseline and differential.
GenevestigatoriQ9Y228.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. Rhodes S.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-373.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT GLU-373.
    Tissue: Blood and Brain.
  5. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."
    Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D.
    J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-267.
    Tissue: Lung adenocarcinoma.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-529.

Entry informationi

Entry nameiT3JAM_HUMAN
AccessioniPrimary (citable) accession number: Q9Y228
Secondary accession number(s): A1L464
, A6NIU9, Q2YDB5, Q4VY06, Q7Z706
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: February 21, 2006
Last modified: February 4, 2015
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.