Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

TRAF3-interacting JNK-activating modulator

Gene

TRAF3IP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as an adapter molecule that regulates TRAF3-mediated JNK activation.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
TRAF3-interacting JNK-activating modulator
Alternative name(s):
TRAF3-interacting protein 3
Gene namesi
Name:TRAF3IP3
Synonyms:T3JAM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000009790.14.
HGNCiHGNC:30766. TRAF3IP3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 526CytoplasmicSequence analysisAdd BLAST526
Transmembranei527 – 544Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST18
Topological domaini545 – 551ExtracellularSequence analysis7

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi80342.
OpenTargetsiENSG00000009790.
PharmGKBiPA142670711.

Polymorphism and mutation databases

BioMutaiTRAF3IP3.
DMDMi88984949.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724031 – 551TRAF3-interacting JNK-activating modulatorAdd BLAST551

Proteomic databases

EPDiQ9Y228.
PaxDbiQ9Y228.
PeptideAtlasiQ9Y228.
PRIDEiQ9Y228.

PTM databases

iPTMnetiQ9Y228.
PhosphoSitePlusiQ9Y228.
SwissPalmiQ9Y228.

Expressioni

Gene expression databases

BgeeiENSG00000009790.
CleanExiHS_TRAF3IP3.
ExpressionAtlasiQ9Y228. baseline and differential.
GenevisibleiQ9Y228. HS.

Organism-specific databases

HPAiHPA040796.

Interactioni

Subunit structurei

Binds to the isoleucine zipper of TRAF3 via its coiled-coil domain.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123249. 36 interactors.
IntActiQ9Y228. 57 interactors.
MINTiMINT-6768551.
STRINGi9606.ENSP00000355991.

Structurei

3D structure databases

ProteinModelPortaliQ9Y228.
SMRiQ9Y228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili240 – 436Sequence analysisAdd BLAST197
Coiled coili464 – 506Sequence analysisAdd BLAST43

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHX6. Eukaryota.
ENOG410ZX9A. LUCA.
GeneTreeiENSGT00530000063197.
HOGENOMiHOG000070108.
HOVERGENiHBG054704.
InParanoidiQ9Y228.
OMAiKCERRQE.
OrthoDBiEOG091G081W.
PhylomeDBiQ9Y228.
TreeFamiTF334641.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y228-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISPDPRPSP GLARWAESYE AKCERRQEIR ESRRCRPNVT TCRQVGKTLR
60 70 80 90 100
IQQREQLQRA RLQQFFRRRN LELEEKGKAQ HPQAREQGPS RRPGQVTVLK
110 120 130 140 150
EPLSCARRIS SPREQVTGTS SEVFPAQHPP PSGICRDLSD HLSSQAGGLP
160 170 180 190 200
PQDTPIKKPP KHHRGTQTKA EGPTIKNDAS QQTNYGVAVL DKEIIQLSDY
210 220 230 240 250
LKEALQRELV LKQKMVILQD LLSTLIQASD SSWKGQLNED KLKGKLRSLE
260 270 280 290 300
NQLYTCTQKY SPWGMKKVLL EMEDQKNSYE QKAKESLQKV LEEKMNAEQQ
310 320 330 340 350
LQSTQRSLAL AEQKCEEWRS QYEALKEDWR TLGTQHRELE SQLHVLQSKL
360 370 380 390 400
QGADSRDLQM NQALRFLENE HQQLQAKIEC LQGDRDLCSL DTQDLQDQLK
410 420 430 440 450
RSEAEKLTLV TRVQQLQGLL QNQSLQLQEQ EKLLTKKDQA LPVWSPKSFP
460 470 480 490 500
NEVEPEGTGK EKDWDLRDQL QKKTLQLQAK EKECRELHSE LDNLSDEYLS
510 520 530 540 550
CLRKLQHCRE ELNQSQQLPP RRQCGRWLPV LMVVIAAALA VFLANKDNLM

I
Note: No experimental confirmation available.
Length:551
Mass (Da):63,626
Last modified:February 21, 2006 - v2
Checksum:iEA2DFF45A8D6ED19
GO
Isoform 2 (identifier: Q9Y228-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-114: Missing.

Show »
Length:531
Mass (Da):61,375
Checksum:i3ABAB20EEB018E30
GO
Isoform 3 (identifier: Q9Y228-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     352-353: GA → IN
     354-551: Missing.

Note: No experimental confirmation available.
Show »
Length:353
Mass (Da):40,674
Checksum:i5405FE9F07EE18F7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024283373Q → E2 PublicationsCorresponds to variant dbSNP:rs669694Ensembl.1
Natural variantiVAR_035664529P → S in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01727195 – 114Missing in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_017272352 – 353GA → IN in isoform 3. 1 Publication2
Alternative sequenceiVSP_017273354 – 551Missing in isoform 3. 1 PublicationAdd BLAST198

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049667 mRNA. Translation: CAB41242.1.
AL022398 Genomic DNA. No translation available.
CH471100 Genomic DNA. Translation: EAW93444.1.
BC110302 mRNA. Translation: AAI10303.1.
BC130417 mRNA. Translation: AAI30418.1.
BC144139 mRNA. Translation: AAI44140.1.
CCDSiCCDS1490.2. [Q9Y228-1]
CCDS81422.1. [Q9Y228-2]
RefSeqiNP_001274683.1. NM_001287754.1.
NP_001307072.1. NM_001320143.1. [Q9Y228-1]
NP_001307073.1. NM_001320144.1. [Q9Y228-2]
NP_079504.2. NM_025228.3. [Q9Y228-1]
UniGeneiHs.147434.

Genome annotation databases

EnsembliENST00000367024; ENSP00000355991; ENSG00000009790. [Q9Y228-1]
ENST00000367025; ENSP00000355992; ENSG00000009790. [Q9Y228-1]
ENST00000367026; ENSP00000355993; ENSG00000009790. [Q9Y228-2]
ENST00000478359; ENSP00000417665; ENSG00000009790. [Q9Y228-3]
GeneIDi80342.
KEGGihsa:80342.
UCSCiuc001hhm.4. human. [Q9Y228-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiT3JAM_HUMAN
AccessioniPrimary (citable) accession number: Q9Y228
Secondary accession number(s): A1L464
, A6NIU9, Q2YDB5, Q4VY06, Q7Z706
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: February 21, 2006
Last modified: September 27, 2017
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot