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Q9Y228

- T3JAM_HUMAN

UniProt

Q9Y228 - T3JAM_HUMAN

Protein

TRAF3-interacting JNK-activating modulator

Gene

TRAF3IP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (21 Feb 2006)
      Previous versions | rss
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    Functioni

    May function as an adapter molecule that regulates TRAF3-mediated JNK activation.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TRAF3-interacting JNK-activating modulator
    Alternative name(s):
    TRAF3-interacting protein 3
    Gene namesi
    Name:TRAF3IP3
    Synonyms:T3JAM
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:30766. TRAF3IP3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670711.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 551551TRAF3-interacting JNK-activating modulatorPRO_0000072403Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki267 – 267Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiQ9Y228.
    PaxDbiQ9Y228.
    PRIDEiQ9Y228.

    PTM databases

    PhosphoSiteiQ9Y228.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y228.
    BgeeiQ9Y228.
    CleanExiHS_TRAF3IP3.
    GenevestigatoriQ9Y228.

    Organism-specific databases

    HPAiHPA040796.

    Interactioni

    Subunit structurei

    Binds to the isoleucine zipper of TRAF3 via its coiled-coil domain.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MOB4Q9Y3A32EBI-765817,EBI-713935
    SIKE1Q9BRV82EBI-765817,EBI-1773646
    STK24Q9Y6E02EBI-765817,EBI-740175
    STRIP1Q5VSL92EBI-765817,EBI-1773588
    STRNO438152EBI-765817,EBI-1046642
    STRN3Q130332EBI-765817,EBI-1053857

    Protein-protein interaction databases

    BioGridi123249. 19 interactions.
    IntActiQ9Y228. 30 interactions.
    MINTiMINT-6768551.
    STRINGi9606.ENSP00000010338.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y228.
    SMRiQ9Y228. Positions 466-515.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 526526CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini545 – 5517ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei527 – 54418Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili240 – 436197Sequence AnalysisAdd
    BLAST
    Coiled coili464 – 50643Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG81914.
    HOGENOMiHOG000070108.
    HOVERGENiHBG054704.
    InParanoidiQ9Y228.
    OMAiKCERRQE.
    OrthoDBiEOG7V1FQD.
    PhylomeDBiQ9Y228.
    TreeFamiTF334641.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y228-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MISPDPRPSP GLARWAESYE AKCERRQEIR ESRRCRPNVT TCRQVGKTLR    50
    IQQREQLQRA RLQQFFRRRN LELEEKGKAQ HPQAREQGPS RRPGQVTVLK 100
    EPLSCARRIS SPREQVTGTS SEVFPAQHPP PSGICRDLSD HLSSQAGGLP 150
    PQDTPIKKPP KHHRGTQTKA EGPTIKNDAS QQTNYGVAVL DKEIIQLSDY 200
    LKEALQRELV LKQKMVILQD LLSTLIQASD SSWKGQLNED KLKGKLRSLE 250
    NQLYTCTQKY SPWGMKKVLL EMEDQKNSYE QKAKESLQKV LEEKMNAEQQ 300
    LQSTQRSLAL AEQKCEEWRS QYEALKEDWR TLGTQHRELE SQLHVLQSKL 350
    QGADSRDLQM NQALRFLENE HQQLQAKIEC LQGDRDLCSL DTQDLQDQLK 400
    RSEAEKLTLV TRVQQLQGLL QNQSLQLQEQ EKLLTKKDQA LPVWSPKSFP 450
    NEVEPEGTGK EKDWDLRDQL QKKTLQLQAK EKECRELHSE LDNLSDEYLS 500
    CLRKLQHCRE ELNQSQQLPP RRQCGRWLPV LMVVIAAALA VFLANKDNLM 550
    I 551

    Note: No experimental confirmation available.

    Length:551
    Mass (Da):63,626
    Last modified:February 21, 2006 - v2
    Checksum:iEA2DFF45A8D6ED19
    GO
    Isoform 2 (identifier: Q9Y228-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         95-114: Missing.

    Show »
    Length:531
    Mass (Da):61,375
    Checksum:i3ABAB20EEB018E30
    GO
    Isoform 3 (identifier: Q9Y228-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         352-353: GA → IN
         354-551: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:353
    Mass (Da):40,674
    Checksum:i5405FE9F07EE18F7
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti373 – 3731Q → E.2 Publications
    Corresponds to variant rs669694 [ dbSNP | Ensembl ].
    VAR_024283
    Natural varianti529 – 5291P → S in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035664

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei95 – 11420Missing in isoform 2. 1 PublicationVSP_017271Add
    BLAST
    Alternative sequencei352 – 3532GA → IN in isoform 3. 1 PublicationVSP_017272
    Alternative sequencei354 – 551198Missing in isoform 3. 1 PublicationVSP_017273Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL049667 mRNA. Translation: CAB41242.1.
    AL022398 Genomic DNA. Translation: CAI95687.1.
    CH471100 Genomic DNA. Translation: EAW93444.1.
    BC110302 mRNA. Translation: AAI10303.1.
    BC130417 mRNA. Translation: AAI30418.1.
    BC144139 mRNA. Translation: AAI44140.1.
    CCDSiCCDS1490.2. [Q9Y228-1]
    RefSeqiNP_001274683.1. NM_001287754.1.
    NP_079504.2. NM_025228.3. [Q9Y228-1]
    UniGeneiHs.147434.

    Genome annotation databases

    EnsembliENST00000367024; ENSP00000355991; ENSG00000009790. [Q9Y228-1]
    ENST00000367025; ENSP00000355992; ENSG00000009790. [Q9Y228-1]
    ENST00000367026; ENSP00000355993; ENSG00000009790. [Q9Y228-2]
    ENST00000478359; ENSP00000417665; ENSG00000009790. [Q9Y228-3]
    GeneIDi80342.
    KEGGihsa:80342.
    UCSCiuc001hhm.2. human. [Q9Y228-3]
    uc001hhn.3. human. [Q9Y228-2]
    uc001hho.3. human. [Q9Y228-1]

    Polymorphism databases

    DMDMi88984949.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL049667 mRNA. Translation: CAB41242.1 .
    AL022398 Genomic DNA. Translation: CAI95687.1 .
    CH471100 Genomic DNA. Translation: EAW93444.1 .
    BC110302 mRNA. Translation: AAI10303.1 .
    BC130417 mRNA. Translation: AAI30418.1 .
    BC144139 mRNA. Translation: AAI44140.1 .
    CCDSi CCDS1490.2. [Q9Y228-1 ]
    RefSeqi NP_001274683.1. NM_001287754.1.
    NP_079504.2. NM_025228.3. [Q9Y228-1 ]
    UniGenei Hs.147434.

    3D structure databases

    ProteinModelPortali Q9Y228.
    SMRi Q9Y228. Positions 466-515.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123249. 19 interactions.
    IntActi Q9Y228. 30 interactions.
    MINTi MINT-6768551.
    STRINGi 9606.ENSP00000010338.

    PTM databases

    PhosphoSitei Q9Y228.

    Polymorphism databases

    DMDMi 88984949.

    Proteomic databases

    MaxQBi Q9Y228.
    PaxDbi Q9Y228.
    PRIDEi Q9Y228.

    Protocols and materials databases

    DNASUi 80342.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367024 ; ENSP00000355991 ; ENSG00000009790 . [Q9Y228-1 ]
    ENST00000367025 ; ENSP00000355992 ; ENSG00000009790 . [Q9Y228-1 ]
    ENST00000367026 ; ENSP00000355993 ; ENSG00000009790 . [Q9Y228-2 ]
    ENST00000478359 ; ENSP00000417665 ; ENSG00000009790 . [Q9Y228-3 ]
    GeneIDi 80342.
    KEGGi hsa:80342.
    UCSCi uc001hhm.2. human. [Q9Y228-3 ]
    uc001hhn.3. human. [Q9Y228-2 ]
    uc001hho.3. human. [Q9Y228-1 ]

    Organism-specific databases

    CTDi 80342.
    GeneCardsi GC01P209929.
    H-InvDB HIX0159943.
    HGNCi HGNC:30766. TRAF3IP3.
    HPAi HPA040796.
    MIMi 608255. gene.
    neXtProti NX_Q9Y228.
    PharmGKBi PA142670711.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG81914.
    HOGENOMi HOG000070108.
    HOVERGENi HBG054704.
    InParanoidi Q9Y228.
    OMAi KCERRQE.
    OrthoDBi EOG7V1FQD.
    PhylomeDBi Q9Y228.
    TreeFami TF334641.

    Miscellaneous databases

    ChiTaRSi TRAF3IP3. human.
    GeneWikii TRAF3IP3.
    GenomeRNAii 80342.
    NextBioi 70918.
    PROi Q9Y228.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y228.
    Bgeei Q9Y228.
    CleanExi HS_TRAF3IP3.
    Genevestigatori Q9Y228.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Rhodes S.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-373.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT GLU-373.
      Tissue: Blood and Brain.
    5. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."
      Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D.
      J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-267.
      Tissue: Lung adenocarcinoma.
    6. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-529.

    Entry informationi

    Entry nameiT3JAM_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y228
    Secondary accession number(s): A1L464
    , A6NIU9, Q2YDB5, Q4VY06, Q7Z706
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: February 21, 2006
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3