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Q9Y226

- S22AD_HUMAN

UniProt

Q9Y226 - S22AD_HUMAN

Protein

Solute carrier family 22 member 13

Gene

SLC22A13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (04 Apr 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. nicotinate transporter activity Source: UniProt
    2. organic cation transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. nicotinate transport Source: UniProt
    2. organic cation transport Source: UniProtKB
    3. urate transport Source: UniProt

    Protein family/group databases

    TCDBi2.A.1.19.17. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 22 member 13
    Alternative name(s):
    Organic cation transporter-like 3
    Short name:
    ORCTL-3
    Gene namesi
    Name:SLC22A13
    Synonyms:OCTL1, ORCTL3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:8494. SLC22A13.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProt
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32814.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 551551Solute carrier family 22 member 13PRO_0000230782Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9Y226.
    PRIDEiQ9Y226.

    PTM databases

    PhosphoSiteiQ9Y226.

    Expressioni

    Tissue specificityi

    Ubiquitous, expressed at low levels.1 Publication

    Gene expression databases

    ArrayExpressiQ9Y226.
    BgeeiQ9Y226.
    CleanExiHS_SLC22A13.
    GenevestigatoriQ9Y226.

    Organism-specific databases

    HPAiHPA035603.
    HPA035962.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000310241.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y226.
    SMRiQ9Y226. Positions 136-504.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini42 – 13897ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini160 – 1678CytoplasmicSequence Analysis
    Topological domaini189 – 1957ExtracellularSequence Analysis
    Topological domaini217 – 2248CytoplasmicSequence Analysis
    Topological domaini246 – 2516ExtracellularSequence Analysis
    Topological domaini273 – 33260CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini354 – 3541ExtracellularSequence Analysis
    Topological domaini376 – 39722CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini419 – 4279ExtracellularSequence Analysis
    Topological domaini449 – 4524CytoplasmicSequence Analysis
    Topological domaini474 – 4785ExtracellularSequence Analysis
    Topological domaini500 – 55152CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei196 – 21621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei252 – 27221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei333 – 35321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei355 – 37521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei398 – 41821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei428 – 44821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei453 – 47321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei479 – 49921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000234569.
    HOVERGENiHBG108433.
    InParanoidiQ9Y226.
    KOiK08209.
    OMAiWTIGFIA.
    OrthoDBiEOG7C8GH9.
    PhylomeDBiQ9Y226.
    TreeFamiTF315847.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 2 hits.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y226-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQFVQVLAE IGDFGRFQIQ LLILLCVLNF LSPFYFFAHV FMVLDEPHHC    50
    AVAWVKNHTF NLSAAEQLVL SVPLDTAGHP EPCLMFRPPP ANASLQDILS 100
    HRFNETQPCD MGWEYPENRL PSLKNEFNLV CDRKHLKDTT QSVFMAGLLV 150
    GTLMFGPLCD RIGRKATILA QLLLFTLIGL ATAFVPSFEL YMALRFAVAT 200
    AVAGLSFSNV TLLTEWVGPS WRTQAVVLAQ CNFSLGQMVL AGLAYGFRNW 250
    RLLQITGTAP GLLLFFYFWA LPESARWLLT RGRMDEAIQL IQKAASVNRR 300
    KLSPELMNQL VPEKTGPSGN ALDLFRHPQL RKVTLIIFCV WFVDSLGYYG 350
    LSLQVGDFGL DVYLTQLIFG AVEVPARCSS IFMMQRFGRK WSQLGTLVLG 400
    GLMCIIIIFI PADLPVVVTM LAVVGKMATA AAFTISYVYS AELFPTILRQ 450
    TGMGLVGIFS RIGGILTPLV ILLGEYHAAL PMLIYGSLPI VAGLLCTLLP 500
    ETHGQGLKDT LQDLELGPHP RSPKSVPSEK ETEAKGRTSS PGVAFVSSTY 550
    F 551
    Length:551
    Mass (Da):60,862
    Last modified:April 4, 2006 - v2
    Checksum:i80D69A0D5DDDA447
    GO
    Isoform 2 (identifier: Q9Y226-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         451-551: TGMGLVGIFS...GVAFVSSTYF → AWGWWASSHGSGASSHHL

    Show »
    Length:468
    Mass (Da):52,166
    Checksum:iE7ACCFA1BDA54040
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti146 – 1461A → G(PubMed:10072596)Curated
    Sequence conflicti146 – 1461A → G(PubMed:10231028)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti43 – 431V → I.1 Publication
    Corresponds to variant rs17853496 [ dbSNP | Ensembl ].
    VAR_025787
    Natural varianti443 – 4431L → F.1 Publication
    Corresponds to variant rs17857080 [ dbSNP | Ensembl ].
    VAR_025788

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei451 – 551101TGMGL…SSTYF → AWGWWASSHGSGASSHHL in isoform 2. 1 PublicationVSP_017830Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010438 mRNA. Translation: BAA76350.1.
    AB026898 Genomic DNA. Translation: BAA77625.1.
    AK315301 mRNA. Translation: BAG37706.1.
    CH471055 Genomic DNA. Translation: EAW64527.1.
    BC035973 mRNA. Translation: AAH35973.1.
    CCDSiCCDS2676.1. [Q9Y226-1]
    RefSeqiNP_004247.2. NM_004256.3. [Q9Y226-1]
    UniGeneiHs.225941.

    Genome annotation databases

    EnsembliENST00000311856; ENSP00000310241; ENSG00000172940. [Q9Y226-1]
    GeneIDi9390.
    KEGGihsa:9390.
    UCSCiuc003chz.3. human. [Q9Y226-1]
    uc011ayn.1. human. [Q9Y226-2]

    Polymorphism databases

    DMDMi91207263.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010438 mRNA. Translation: BAA76350.1 .
    AB026898 Genomic DNA. Translation: BAA77625.1 .
    AK315301 mRNA. Translation: BAG37706.1 .
    CH471055 Genomic DNA. Translation: EAW64527.1 .
    BC035973 mRNA. Translation: AAH35973.1 .
    CCDSi CCDS2676.1. [Q9Y226-1 ]
    RefSeqi NP_004247.2. NM_004256.3. [Q9Y226-1 ]
    UniGenei Hs.225941.

    3D structure databases

    ProteinModelPortali Q9Y226.
    SMRi Q9Y226. Positions 136-504.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000310241.

    Protein family/group databases

    TCDBi 2.A.1.19.17. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei Q9Y226.

    Polymorphism databases

    DMDMi 91207263.

    Proteomic databases

    PaxDbi Q9Y226.
    PRIDEi Q9Y226.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311856 ; ENSP00000310241 ; ENSG00000172940 . [Q9Y226-1 ]
    GeneIDi 9390.
    KEGGi hsa:9390.
    UCSCi uc003chz.3. human. [Q9Y226-1 ]
    uc011ayn.1. human. [Q9Y226-2 ]

    Organism-specific databases

    CTDi 9390.
    GeneCardsi GC03P038307.
    H-InvDB HIX0024264.
    HGNCi HGNC:8494. SLC22A13.
    HPAi HPA035603.
    HPA035962.
    MIMi 604047. gene.
    neXtProti NX_Q9Y226.
    PharmGKBi PA32814.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000234569.
    HOVERGENi HBG108433.
    InParanoidi Q9Y226.
    KOi K08209.
    OMAi WTIGFIA.
    OrthoDBi EOG7C8GH9.
    PhylomeDBi Q9Y226.
    TreeFami TF315847.

    Miscellaneous databases

    GenomeRNAii 9390.
    NextBioi 35183.
    PROi Q9Y226.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y226.
    Bgeei Q9Y226.
    CleanExi HS_SLC22A13.
    Genevestigatori Q9Y226.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 2 hits.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters."
      Nishiwaki T., Daigo Y., Tamari M., Fujii Y., Nakamura Y.
      Cytogenet. Cell Genet. 83:251-255(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ILE-43 AND PHE-443.
      Tissue: Kidney.

    Entry informationi

    Entry nameiS22AD_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y226
    Secondary accession number(s): B2RCV9, Q8IYG1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: April 4, 2006
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3