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Protein

Solute carrier family 22 member 13

Gene

SLC22A13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • nicotinate transporter activity Source: UniProtKB
  • organic cation transmembrane transporter activity Source: UniProtKB
  • substrate-specific transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • nicotinate transport Source: UniProtKB
  • organic cation transport Source: UniProtKB
  • urate transport Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172940-MONOMER.

Protein family/group databases

TCDBi2.A.1.19.17. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 13
Alternative name(s):
Organic cation transporter-like 3
Short name:
ORCTL-3
Gene namesi
Name:SLC22A13
Synonyms:OCTL1, ORCTL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:8494. SLC22A13.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Topological domaini42 – 138ExtracellularSequence analysisAdd BLAST97
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 167CytoplasmicSequence analysis8
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 195ExtracellularSequence analysis7
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 224CytoplasmicSequence analysis8
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 251ExtracellularSequence analysis6
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Topological domaini273 – 332CytoplasmicSequence analysisAdd BLAST60
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Topological domaini354ExtracellularSequence analysis1
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 397CytoplasmicSequence analysisAdd BLAST22
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 427ExtracellularSequence analysis9
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Topological domaini449 – 452CytoplasmicSequence analysis4
Transmembranei453 – 473HelicalSequence analysisAdd BLAST21
Topological domaini474 – 478ExtracellularSequence analysis5
Transmembranei479 – 499HelicalSequence analysisAdd BLAST21
Topological domaini500 – 551CytoplasmicSequence analysisAdd BLAST52

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9390.
OpenTargetsiENSG00000172940.
PharmGKBiPA32814.

Polymorphism and mutation databases

BioMutaiSLC22A13.
DMDMi91207263.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002307821 – 551Solute carrier family 22 member 13Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...)Sequence analysis1
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Glycosylationi92N-linked (GlcNAc...)Sequence analysis1
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y226.
PeptideAtlasiQ9Y226.
PRIDEiQ9Y226.

PTM databases

iPTMnetiQ9Y226.
PhosphoSitePlusiQ9Y226.

Expressioni

Tissue specificityi

Ubiquitous, expressed at low levels.1 Publication

Gene expression databases

BgeeiENSG00000172940.
CleanExiHS_SLC22A13.
ExpressionAtlasiQ9Y226. baseline and differential.
GenevisibleiQ9Y226. HS.

Organism-specific databases

HPAiHPA035603.
HPA035962.

Interactioni

Protein-protein interaction databases

BioGridi114790. 3 interactors.
STRINGi9606.ENSP00000310241.

Structurei

3D structure databases

ProteinModelPortaliQ9Y226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRIC. Eukaryota.
ENOG410YUFN. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ9Y226.
KOiK08209.
OMAiMCIIIIF.
OrthoDBiEOG091G05AC.
PhylomeDBiQ9Y226.
TreeFamiTF315847.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y226-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQFVQVLAE IGDFGRFQIQ LLILLCVLNF LSPFYFFAHV FMVLDEPHHC
60 70 80 90 100
AVAWVKNHTF NLSAAEQLVL SVPLDTAGHP EPCLMFRPPP ANASLQDILS
110 120 130 140 150
HRFNETQPCD MGWEYPENRL PSLKNEFNLV CDRKHLKDTT QSVFMAGLLV
160 170 180 190 200
GTLMFGPLCD RIGRKATILA QLLLFTLIGL ATAFVPSFEL YMALRFAVAT
210 220 230 240 250
AVAGLSFSNV TLLTEWVGPS WRTQAVVLAQ CNFSLGQMVL AGLAYGFRNW
260 270 280 290 300
RLLQITGTAP GLLLFFYFWA LPESARWLLT RGRMDEAIQL IQKAASVNRR
310 320 330 340 350
KLSPELMNQL VPEKTGPSGN ALDLFRHPQL RKVTLIIFCV WFVDSLGYYG
360 370 380 390 400
LSLQVGDFGL DVYLTQLIFG AVEVPARCSS IFMMQRFGRK WSQLGTLVLG
410 420 430 440 450
GLMCIIIIFI PADLPVVVTM LAVVGKMATA AAFTISYVYS AELFPTILRQ
460 470 480 490 500
TGMGLVGIFS RIGGILTPLV ILLGEYHAAL PMLIYGSLPI VAGLLCTLLP
510 520 530 540 550
ETHGQGLKDT LQDLELGPHP RSPKSVPSEK ETEAKGRTSS PGVAFVSSTY

F
Length:551
Mass (Da):60,862
Last modified:April 4, 2006 - v2
Checksum:i80D69A0D5DDDA447
GO
Isoform 2 (identifier: Q9Y226-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     451-551: TGMGLVGIFS...GVAFVSSTYF → AWGWWASSHGSGASSHHL

Show »
Length:468
Mass (Da):52,166
Checksum:iE7ACCFA1BDA54040
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146A → G (PubMed:10072596).Curated1
Sequence conflicti146A → G (PubMed:10231028).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02578743V → I.1 PublicationCorresponds to variant rs17853496dbSNPEnsembl.1
Natural variantiVAR_025788443L → F.1 PublicationCorresponds to variant rs17857080dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017830451 – 551TGMGL…SSTYF → AWGWWASSHGSGASSHHL in isoform 2. 1 PublicationAdd BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010438 mRNA. Translation: BAA76350.1.
AB026898 Genomic DNA. Translation: BAA77625.1.
AK315301 mRNA. Translation: BAG37706.1.
CH471055 Genomic DNA. Translation: EAW64527.1.
BC035973 mRNA. Translation: AAH35973.1.
CCDSiCCDS2676.1. [Q9Y226-1]
RefSeqiNP_004247.2. NM_004256.3. [Q9Y226-1]
UniGeneiHs.225941.

Genome annotation databases

EnsembliENST00000311856; ENSP00000310241; ENSG00000172940. [Q9Y226-1]
GeneIDi9390.
KEGGihsa:9390.
UCSCiuc003chz.4. human. [Q9Y226-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010438 mRNA. Translation: BAA76350.1.
AB026898 Genomic DNA. Translation: BAA77625.1.
AK315301 mRNA. Translation: BAG37706.1.
CH471055 Genomic DNA. Translation: EAW64527.1.
BC035973 mRNA. Translation: AAH35973.1.
CCDSiCCDS2676.1. [Q9Y226-1]
RefSeqiNP_004247.2. NM_004256.3. [Q9Y226-1]
UniGeneiHs.225941.

3D structure databases

ProteinModelPortaliQ9Y226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114790. 3 interactors.
STRINGi9606.ENSP00000310241.

Protein family/group databases

TCDBi2.A.1.19.17. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ9Y226.
PhosphoSitePlusiQ9Y226.

Polymorphism and mutation databases

BioMutaiSLC22A13.
DMDMi91207263.

Proteomic databases

PaxDbiQ9Y226.
PeptideAtlasiQ9Y226.
PRIDEiQ9Y226.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311856; ENSP00000310241; ENSG00000172940. [Q9Y226-1]
GeneIDi9390.
KEGGihsa:9390.
UCSCiuc003chz.4. human. [Q9Y226-1]

Organism-specific databases

CTDi9390.
DisGeNETi9390.
GeneCardsiSLC22A13.
H-InvDBHIX0024264.
HGNCiHGNC:8494. SLC22A13.
HPAiHPA035603.
HPA035962.
MIMi604047. gene.
neXtProtiNX_Q9Y226.
OpenTargetsiENSG00000172940.
PharmGKBiPA32814.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRIC. Eukaryota.
ENOG410YUFN. LUCA.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ9Y226.
KOiK08209.
OMAiMCIIIIF.
OrthoDBiEOG091G05AC.
PhylomeDBiQ9Y226.
TreeFamiTF315847.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172940-MONOMER.

Miscellaneous databases

GenomeRNAii9390.
PROiQ9Y226.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172940.
CleanExiHS_SLC22A13.
ExpressionAtlasiQ9Y226. baseline and differential.
GenevisibleiQ9Y226. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS22AD_HUMAN
AccessioniPrimary (citable) accession number: Q9Y226
Secondary accession number(s): B2RCV9, Q8IYG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: November 30, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.