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Protein

Solute carrier family 22 member 13

Gene

SLC22A13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • nicotinate transporter activity Source: UniProtKB
  • organic cation transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • nicotinate transport Source: UniProtKB
  • organic cation transport Source: UniProtKB
  • urate transport Source: UniProtKB
Complete GO annotation...

Protein family/group databases

TCDBi2.A.1.19.17. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 13
Alternative name(s):
Organic cation transporter-like 3
Short name:
ORCTL-3
Gene namesi
Name:SLC22A13
Synonyms:OCTL1, ORCTL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:8494. SLC22A13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST
Topological domaini42 – 13897ExtracellularSequence AnalysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence AnalysisAdd
BLAST
Topological domaini160 – 1678CytoplasmicSequence Analysis
Transmembranei168 – 18821HelicalSequence AnalysisAdd
BLAST
Topological domaini189 – 1957ExtracellularSequence Analysis
Transmembranei196 – 21621HelicalSequence AnalysisAdd
BLAST
Topological domaini217 – 2248CytoplasmicSequence Analysis
Transmembranei225 – 24521HelicalSequence AnalysisAdd
BLAST
Topological domaini246 – 2516ExtracellularSequence Analysis
Transmembranei252 – 27221HelicalSequence AnalysisAdd
BLAST
Topological domaini273 – 33260CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei333 – 35321HelicalSequence AnalysisAdd
BLAST
Topological domaini354 – 3541ExtracellularSequence Analysis
Transmembranei355 – 37521HelicalSequence AnalysisAdd
BLAST
Topological domaini376 – 39722CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei398 – 41821HelicalSequence AnalysisAdd
BLAST
Topological domaini419 – 4279ExtracellularSequence Analysis
Transmembranei428 – 44821HelicalSequence AnalysisAdd
BLAST
Topological domaini449 – 4524CytoplasmicSequence Analysis
Transmembranei453 – 47321HelicalSequence AnalysisAdd
BLAST
Topological domaini474 – 4785ExtracellularSequence Analysis
Transmembranei479 – 49921HelicalSequence AnalysisAdd
BLAST
Topological domaini500 – 55152CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32814.

Polymorphism and mutation databases

BioMutaiSLC22A13.
DMDMi91207263.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Solute carrier family 22 member 13PRO_0000230782Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y226.
PRIDEiQ9Y226.

PTM databases

PhosphoSiteiQ9Y226.

Expressioni

Tissue specificityi

Ubiquitous, expressed at low levels.1 Publication

Gene expression databases

BgeeiQ9Y226.
CleanExiHS_SLC22A13.
ExpressionAtlasiQ9Y226. baseline and differential.
GenevisibleiQ9Y226. HS.

Organism-specific databases

HPAiHPA035603.
HPA035962.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310241.

Structurei

3D structure databases

ProteinModelPortaliQ9Y226.
SMRiQ9Y226. Positions 136-504.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ9Y226.
KOiK08209.
OMAiMCIIIIF.
OrthoDBiEOG7C8GH9.
PhylomeDBiQ9Y226.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. Sub_transporter.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y226-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQFVQVLAE IGDFGRFQIQ LLILLCVLNF LSPFYFFAHV FMVLDEPHHC
60 70 80 90 100
AVAWVKNHTF NLSAAEQLVL SVPLDTAGHP EPCLMFRPPP ANASLQDILS
110 120 130 140 150
HRFNETQPCD MGWEYPENRL PSLKNEFNLV CDRKHLKDTT QSVFMAGLLV
160 170 180 190 200
GTLMFGPLCD RIGRKATILA QLLLFTLIGL ATAFVPSFEL YMALRFAVAT
210 220 230 240 250
AVAGLSFSNV TLLTEWVGPS WRTQAVVLAQ CNFSLGQMVL AGLAYGFRNW
260 270 280 290 300
RLLQITGTAP GLLLFFYFWA LPESARWLLT RGRMDEAIQL IQKAASVNRR
310 320 330 340 350
KLSPELMNQL VPEKTGPSGN ALDLFRHPQL RKVTLIIFCV WFVDSLGYYG
360 370 380 390 400
LSLQVGDFGL DVYLTQLIFG AVEVPARCSS IFMMQRFGRK WSQLGTLVLG
410 420 430 440 450
GLMCIIIIFI PADLPVVVTM LAVVGKMATA AAFTISYVYS AELFPTILRQ
460 470 480 490 500
TGMGLVGIFS RIGGILTPLV ILLGEYHAAL PMLIYGSLPI VAGLLCTLLP
510 520 530 540 550
ETHGQGLKDT LQDLELGPHP RSPKSVPSEK ETEAKGRTSS PGVAFVSSTY

F
Length:551
Mass (Da):60,862
Last modified:April 4, 2006 - v2
Checksum:i80D69A0D5DDDA447
GO
Isoform 2 (identifier: Q9Y226-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     451-551: TGMGLVGIFS...GVAFVSSTYF → AWGWWASSHGSGASSHHL

Show »
Length:468
Mass (Da):52,166
Checksum:iE7ACCFA1BDA54040
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti146 – 1461A → G (PubMed:10072596).Curated
Sequence conflicti146 – 1461A → G (PubMed:10231028).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431V → I.1 Publication
Corresponds to variant rs17853496 [ dbSNP | Ensembl ].
VAR_025787
Natural varianti443 – 4431L → F.1 Publication
Corresponds to variant rs17857080 [ dbSNP | Ensembl ].
VAR_025788

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei451 – 551101TGMGL…SSTYF → AWGWWASSHGSGASSHHL in isoform 2. 1 PublicationVSP_017830Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010438 mRNA. Translation: BAA76350.1.
AB026898 Genomic DNA. Translation: BAA77625.1.
AK315301 mRNA. Translation: BAG37706.1.
CH471055 Genomic DNA. Translation: EAW64527.1.
BC035973 mRNA. Translation: AAH35973.1.
CCDSiCCDS2676.1. [Q9Y226-1]
RefSeqiNP_004247.2. NM_004256.3. [Q9Y226-1]
UniGeneiHs.225941.

Genome annotation databases

EnsembliENST00000311856; ENSP00000310241; ENSG00000172940.
GeneIDi9390.
KEGGihsa:9390.
UCSCiuc003chz.3. human. [Q9Y226-1]
uc011ayn.1. human. [Q9Y226-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010438 mRNA. Translation: BAA76350.1.
AB026898 Genomic DNA. Translation: BAA77625.1.
AK315301 mRNA. Translation: BAG37706.1.
CH471055 Genomic DNA. Translation: EAW64527.1.
BC035973 mRNA. Translation: AAH35973.1.
CCDSiCCDS2676.1. [Q9Y226-1]
RefSeqiNP_004247.2. NM_004256.3. [Q9Y226-1]
UniGeneiHs.225941.

3D structure databases

ProteinModelPortaliQ9Y226.
SMRiQ9Y226. Positions 136-504.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000310241.

Protein family/group databases

TCDBi2.A.1.19.17. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteiQ9Y226.

Polymorphism and mutation databases

BioMutaiSLC22A13.
DMDMi91207263.

Proteomic databases

PaxDbiQ9Y226.
PRIDEiQ9Y226.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311856; ENSP00000310241; ENSG00000172940.
GeneIDi9390.
KEGGihsa:9390.
UCSCiuc003chz.3. human. [Q9Y226-1]
uc011ayn.1. human. [Q9Y226-2]

Organism-specific databases

CTDi9390.
GeneCardsiGC03P038307.
H-InvDBHIX0024264.
HGNCiHGNC:8494. SLC22A13.
HPAiHPA035603.
HPA035962.
MIMi604047. gene.
neXtProtiNX_Q9Y226.
PharmGKBiPA32814.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ9Y226.
KOiK08209.
OMAiMCIIIIF.
OrthoDBiEOG7C8GH9.
PhylomeDBiQ9Y226.
TreeFamiTF315847.

Miscellaneous databases

GenomeRNAii9390.
NextBioi35183.
PROiQ9Y226.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y226.
CleanExiHS_SLC22A13.
ExpressionAtlasiQ9Y226. baseline and differential.
GenevisibleiQ9Y226. HS.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. Sub_transporter.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters."
    Nishiwaki T., Daigo Y., Tamari M., Fujii Y., Nakamura Y.
    Cytogenet. Cell Genet. 83:251-255(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ILE-43 AND PHE-443.
    Tissue: Kidney.

Entry informationi

Entry nameiS22AD_HUMAN
AccessioniPrimary (citable) accession number: Q9Y226
Secondary accession number(s): B2RCV9, Q8IYG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: July 22, 2015
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.