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Q9Y226 (S22AD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 22 member 13
Alternative name(s):
Organic cation transporter-like 3
Short name=ORCTL-3
Gene names
Name:SLC22A13
Synonyms:ORCTL3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Ubiquitous, expressed at low levels. Ref.1

Sequence similarities

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral to plasma membrane

Non-traceable author statement Ref.1. Source: UniProtKB

   Molecular_functionorganic cation transmembrane transporter activity

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y226-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y226-2)

The sequence of this isoform differs from the canonical sequence as follows:
     451-551: TGMGLVGIFS...GVAFVSSTYF → AWGWWASSHGSGASSHHL

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 551551Solute carrier family 22 member 13
PRO_0000230782

Regions

Topological domain1 – 2020Cytoplasmic Potential
Transmembrane21 – 4121Helical; Potential
Topological domain42 – 13897Extracellular Potential
Transmembrane139 – 15921Helical; Potential
Topological domain160 – 1678Cytoplasmic Potential
Transmembrane168 – 18821Helical; Potential
Topological domain189 – 1957Extracellular Potential
Transmembrane196 – 21621Helical; Potential
Topological domain217 – 2248Cytoplasmic Potential
Transmembrane225 – 24521Helical; Potential
Topological domain246 – 2516Extracellular Potential
Transmembrane252 – 27221Helical; Potential
Topological domain273 – 33260Cytoplasmic Potential
Transmembrane333 – 35321Helical; Potential
Topological domain3541Extracellular Potential
Transmembrane355 – 37521Helical; Potential
Topological domain376 – 39722Cytoplasmic Potential
Transmembrane398 – 41821Helical; Potential
Topological domain419 – 4279Extracellular Potential
Transmembrane428 – 44821Helical; Potential
Topological domain449 – 4524Cytoplasmic Potential
Transmembrane453 – 47321Helical; Potential
Topological domain474 – 4785Extracellular Potential
Transmembrane479 – 49921Helical; Potential
Topological domain500 – 55152Cytoplasmic Potential

Amino acid modifications

Glycosylation571N-linked (GlcNAc...) Potential
Glycosylation611N-linked (GlcNAc...) Potential
Glycosylation921N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence451 – 551101TGMGL…SSTYF → AWGWWASSHGSGASSHHL in isoform 2.
VSP_017830
Natural variant431V → I. Ref.5
Corresponds to variant rs17853496 [ dbSNP | Ensembl ].
VAR_025787
Natural variant4431L → F. Ref.5
Corresponds to variant rs17857080 [ dbSNP | Ensembl ].
VAR_025788

Experimental info

Sequence conflict1461A → G Ref.1
Sequence conflict1461A → G Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 4, 2006. Version 2.
Checksum: 80D69A0D5DDDA447

FASTA55160,862
        10         20         30         40         50         60 
MAQFVQVLAE IGDFGRFQIQ LLILLCVLNF LSPFYFFAHV FMVLDEPHHC AVAWVKNHTF 

        70         80         90        100        110        120 
NLSAAEQLVL SVPLDTAGHP EPCLMFRPPP ANASLQDILS HRFNETQPCD MGWEYPENRL 

       130        140        150        160        170        180 
PSLKNEFNLV CDRKHLKDTT QSVFMAGLLV GTLMFGPLCD RIGRKATILA QLLLFTLIGL 

       190        200        210        220        230        240 
ATAFVPSFEL YMALRFAVAT AVAGLSFSNV TLLTEWVGPS WRTQAVVLAQ CNFSLGQMVL 

       250        260        270        280        290        300 
AGLAYGFRNW RLLQITGTAP GLLLFFYFWA LPESARWLLT RGRMDEAIQL IQKAASVNRR 

       310        320        330        340        350        360 
KLSPELMNQL VPEKTGPSGN ALDLFRHPQL RKVTLIIFCV WFVDSLGYYG LSLQVGDFGL 

       370        380        390        400        410        420 
DVYLTQLIFG AVEVPARCSS IFMMQRFGRK WSQLGTLVLG GLMCIIIIFI PADLPVVVTM 

       430        440        450        460        470        480 
LAVVGKMATA AAFTISYVYS AELFPTILRQ TGMGLVGIFS RIGGILTPLV ILLGEYHAAL 

       490        500        510        520        530        540 
PMLIYGSLPI VAGLLCTLLP ETHGQGLKDT LQDLELGPHP RSPKSVPSEK ETEAKGRTSS 

       550 
PGVAFVSSTY F

« Hide

Isoform 2 [UniParc].

Checksum: E7ACCFA1BDA54040
Show »

FASTA46852,166

References

« Hide 'large scale' references
[1]"Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters."
Nishiwaki T., Daigo Y., Tamari M., Fujii Y., Nakamura Y.
Cytogenet. Cell Genet. 83:251-255(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3."
Daigo Y., Isomura M., Nishiwaki T., Tamari M., Ishikawa S., Kai M., Takeuchi K., Yamane Y., Hayashi R., Minami M., Fujino M.A., Hojo Y., Uchiyama I., Takagi T., Nakamura Y.
DNA Res. 6:37-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Kidney.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ILE-43 AND PHE-443.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB010438 mRNA. Translation: BAA76350.1.
AB026898 Genomic DNA. Translation: BAA77625.1.
AK315301 mRNA. Translation: BAG37706.1.
CH471055 Genomic DNA. Translation: EAW64527.1.
BC035973 mRNA. Translation: AAH35973.1.
IPIIPI00219845.
IPI00735389.
RefSeqNP_004247.2. NM_004256.3.
UniGeneHs.225941.

3D structure databases

ProteinModelPortalQ9Y226.
ModBaseSearch...

Protein-protein interaction databases

STRING9606.ENSP00000310241.

Protein family/group databases

TCDB2.A.1.19.17. major facilitator superfamily (MFS).

PTM databases

PhosphoSiteQ9Y226.

Polymorphism databases

DMDM91207263.

Proteomic databases

PaxDbQ9Y226.
PRIDEQ9Y226.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000311856; ENSP00000310241; ENSG00000172940.
GeneID9390.
KEGGhsa:9390.
UCSCuc003chz.3. human.
uc011ayn.1. human.

Organism-specific databases

CTD9390.
GeneCardsGC03P038307.
H-InvDBHIX0024264.
HGNCHGNC:8494. SLC22A13.
HPAHPA035603.
MIM604047. gene.
neXtProtNX_Q9Y226.
PharmGKBPA32814.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0477.
HOGENOMHOG000234569.
HOVERGENHBG108433.
InParanoidQ9Y226.
KOK08209.
OMAVMRFLIG.
OrthoDBEOG43TZVK.
PhylomeDBQ9Y226.

Gene expression databases

ArrayExpressQ9Y226.
BgeeQ9Y226.
CleanExHS_SLC22A13.
GenevestigatorQ9Y226.
GermOnlineENSG00000172940. Homo sapiens.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi9390.
NextBio35183.
SOURCESearch...

Entry information

Entry nameS22AD_HUMAN
AccessionPrimary (citable) accession number: Q9Y226
Secondary accession number(s): B2RCV9, Q8IYG1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: April 3, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents