Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y225

- RNF24_HUMAN

UniProt

Q9Y225 - RNF24_HUMAN

Protein

RING finger protein 24

Gene

RNF24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May play a role in TRPCs intracellular trafficking.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri78 – 11942RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RING finger protein 24
    Gene namesi
    Name:RNF24
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:13779. RNF24.

    Subcellular locationi

    Golgi apparatus membrane 1 Publication; Single-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34428.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 148148RING finger protein 24PRO_0000056063Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y225.
    PaxDbiQ9Y225.
    PRIDEiQ9Y225.

    PTM databases

    PhosphoSiteiQ9Y225.

    Expressioni

    Gene expression databases

    BgeeiQ9Y225.
    CleanExiHS_RNF24.
    GenevestigatoriQ9Y225.

    Organism-specific databases

    HPAiHPA011900.

    Interactioni

    Subunit structurei

    Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7.2 Publications

    Protein-protein interaction databases

    BioGridi116402. 3 interactions.
    STRINGi9606.ENSP00000388550.

    Structurei

    Secondary structure

    1
    148
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi79 – 813
    Beta strandi87 – 893
    Beta strandi91 – 944
    Turni95 – 973
    Beta strandi98 – 1014
    Helixi102 – 11110
    Turni116 – 1183

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2EP4NMR-A68-128[»]
    ProteinModelPortaliQ9Y225.
    SMRiQ9Y225. Positions 68-139.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y225.

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri78 – 11942RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Transmembrane, Transmembrane helix, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG299260.
    HOGENOMiHOG000004806.
    HOVERGENiHBG058899.
    InParanoidiQ9Y225.
    OMAiPHYSFRM.
    OrthoDBiEOG7XDBHK.
    PhylomeDBiQ9Y225.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF13639. zf-RING_2. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]
    PROSITEiPS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y225-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSDFPHYNF RMPNIGFQNL PLNIYIVVFG TAIFVFILSL LFCCYLIRLR    50
    HQAHKEFYAY KQVILKEKVK ELNLHELCAV CLEDFKPRDE LGICPCKHAF 100
    HRKCLIKWLE VRKVCPLCNM PVLQLAQLHS KQDRGPPQGP LPGAENIV 148
    Length:148
    Mass (Da):17,210
    Last modified:November 1, 1999 - v1
    Checksum:i66C240C3A5991EA5
    GO
    Isoform 2 (identifier: Q9Y225-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MLNKSGESRYPALFPVLGGSSM

    Show »
    Length:169
    Mass (Da):19,402
    Checksum:i55CAC34EB8E662F7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti45 – 451Y → S in CAB45279. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MLNKSGESRYPALFPVLGGS SM in isoform 2. CuratedVSP_041026

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL096778 mRNA. Translation: CAB46627.1.
    BT007406 mRNA. Translation: AAP36074.1.
    AL031670 Genomic DNA. Translation: CAB43182.1.
    CH471133 Genomic DNA. Translation: EAX10467.1.
    CH471133 Genomic DNA. Translation: EAX10468.1.
    CH471133 Genomic DNA. Translation: EAX10469.1.
    CH471133 Genomic DNA. Translation: EAX10471.1.
    BC000213 mRNA. Translation: AAH00213.1.
    BC039584 mRNA. Translation: AAH39584.1.
    AL079313 mRNA. Translation: CAB45279.1.
    CCDSiCCDS13074.1. [Q9Y225-1]
    CCDS46577.1. [Q9Y225-2]
    RefSeqiNP_001127809.1. NM_001134337.1. [Q9Y225-1]
    NP_001127810.1. NM_001134338.1. [Q9Y225-2]
    NP_009150.1. NM_007219.3. [Q9Y225-1]
    XP_006723599.1. XM_006723536.1. [Q9Y225-1]
    UniGeneiHs.589884.

    Genome annotation databases

    EnsembliENST00000336095; ENSP00000336753; ENSG00000101236. [Q9Y225-1]
    ENST00000358395; ENSP00000351166; ENSG00000101236. [Q9Y225-1]
    ENST00000432261; ENSP00000388550; ENSG00000101236. [Q9Y225-2]
    ENST00000545616; ENSP00000444711; ENSG00000101236. [Q9Y225-2]
    GeneIDi11237.
    KEGGihsa:11237.
    UCSCiuc002wkh.2. human. [Q9Y225-1]
    uc002wki.2. human. [Q9Y225-2]

    Polymorphism databases

    DMDMi20139860.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL096778 mRNA. Translation: CAB46627.1 .
    BT007406 mRNA. Translation: AAP36074.1 .
    AL031670 Genomic DNA. Translation: CAB43182.1 .
    CH471133 Genomic DNA. Translation: EAX10467.1 .
    CH471133 Genomic DNA. Translation: EAX10468.1 .
    CH471133 Genomic DNA. Translation: EAX10469.1 .
    CH471133 Genomic DNA. Translation: EAX10471.1 .
    BC000213 mRNA. Translation: AAH00213.1 .
    BC039584 mRNA. Translation: AAH39584.1 .
    AL079313 mRNA. Translation: CAB45279.1 .
    CCDSi CCDS13074.1. [Q9Y225-1 ]
    CCDS46577.1. [Q9Y225-2 ]
    RefSeqi NP_001127809.1. NM_001134337.1. [Q9Y225-1 ]
    NP_001127810.1. NM_001134338.1. [Q9Y225-2 ]
    NP_009150.1. NM_007219.3. [Q9Y225-1 ]
    XP_006723599.1. XM_006723536.1. [Q9Y225-1 ]
    UniGenei Hs.589884.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2EP4 NMR - A 68-128 [» ]
    ProteinModelPortali Q9Y225.
    SMRi Q9Y225. Positions 68-139.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116402. 3 interactions.
    STRINGi 9606.ENSP00000388550.

    PTM databases

    PhosphoSitei Q9Y225.

    Polymorphism databases

    DMDMi 20139860.

    Proteomic databases

    MaxQBi Q9Y225.
    PaxDbi Q9Y225.
    PRIDEi Q9Y225.

    Protocols and materials databases

    DNASUi 11237.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336095 ; ENSP00000336753 ; ENSG00000101236 . [Q9Y225-1 ]
    ENST00000358395 ; ENSP00000351166 ; ENSG00000101236 . [Q9Y225-1 ]
    ENST00000432261 ; ENSP00000388550 ; ENSG00000101236 . [Q9Y225-2 ]
    ENST00000545616 ; ENSP00000444711 ; ENSG00000101236 . [Q9Y225-2 ]
    GeneIDi 11237.
    KEGGi hsa:11237.
    UCSCi uc002wkh.2. human. [Q9Y225-1 ]
    uc002wki.2. human. [Q9Y225-2 ]

    Organism-specific databases

    CTDi 11237.
    GeneCardsi GC20M003912.
    HGNCi HGNC:13779. RNF24.
    HPAi HPA011900.
    MIMi 612489. gene.
    neXtProti NX_Q9Y225.
    PharmGKBi PA34428.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG299260.
    HOGENOMi HOG000004806.
    HOVERGENi HBG058899.
    InParanoidi Q9Y225.
    OMAi PHYSFRM.
    OrthoDBi EOG7XDBHK.
    PhylomeDBi Q9Y225.

    Miscellaneous databases

    ChiTaRSi RNF24. human.
    EvolutionaryTracei Q9Y225.
    GeneWikii RNF24.
    GenomeRNAii 11237.
    NextBioi 42770.
    PROi Q9Y225.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y225.
    CleanExi HS_RNF24.
    Genevestigatori Q9Y225.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF13639. zf-RING_2. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    PROSITEi PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Stavrides G.S., Huckle E.J., Deloukas P.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Blood and Kidney.
    6. The European IMAGE consortium
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-148.
    7. "RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC."
      Lussier M.P., Lepage P.K., Bousquet S.M., Boulay G.
      Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TRPC1; TRPC3; TRPC4; TRPC5; TRPC6 AND TRPC7, SUBCELLULAR LOCATION.
    8. "Solution structure of RING finger from human RING finger protein 24."
      RIKEN structural genomics initiative (RSGI)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 68-128 IN COMPLEX WITH ZINC.

    Entry informationi

    Entry nameiRNF24_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y225
    Secondary accession number(s): D3DVZ2, D3DVZ3, Q9UMH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3