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Protein

RING finger protein 24

Gene

RNF24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in TRPCs intracellular trafficking.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri78 – 119RING-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 24
Gene namesi
Name:RNF24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101236.16
HGNCiHGNC:13779 RNF24
MIMi612489 gene
neXtProtiNX_Q9Y225

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101236
PharmGKBiPA34428

Polymorphism and mutation databases

BioMutaiRNF24
DMDMi20139860

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000560631 – 148RING finger protein 24Add BLAST148

Proteomic databases

PaxDbiQ9Y225
PeptideAtlasiQ9Y225
PRIDEiQ9Y225

PTM databases

iPTMnetiQ9Y225
PhosphoSitePlusiQ9Y225

Expressioni

Gene expression databases

BgeeiENSG00000101236
CleanExiHS_RNF24
GenevisibleiQ9Y225 HS

Organism-specific databases

HPAiHPA011900

Interactioni

Subunit structurei

Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116402, 2 interactors
IntActiQ9Y225, 3 interactors
STRINGi9606.ENSP00000388550

Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi79 – 81Combined sources3
Beta strandi87 – 89Combined sources3
Beta strandi91 – 94Combined sources4
Turni95 – 97Combined sources3
Beta strandi98 – 101Combined sources4
Helixi102 – 111Combined sources10
Turni116 – 118Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EP4NMR-A68-128[»]
ProteinModelPortaliQ9Y225
SMRiQ9Y225
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y225

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri78 – 119RING-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG0800 Eukaryota
ENOG41121N2 LUCA
GeneTreeiENSGT00710000106755
HOGENOMiHOG000004806
HOVERGENiHBG058899
InParanoidiQ9Y225
OMAiMSSDFQH
OrthoDBiEOG091G0PFG
PhylomeDBiQ9Y225

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR011016 Znf_RING-CH
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SM00744 RINGv, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y225-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSDFPHYNF RMPNIGFQNL PLNIYIVVFG TAIFVFILSL LFCCYLIRLR
60 70 80 90 100
HQAHKEFYAY KQVILKEKVK ELNLHELCAV CLEDFKPRDE LGICPCKHAF
110 120 130 140
HRKCLIKWLE VRKVCPLCNM PVLQLAQLHS KQDRGPPQGP LPGAENIV
Length:148
Mass (Da):17,210
Last modified:November 1, 1999 - v1
Checksum:i66C240C3A5991EA5
GO
Isoform 2 (identifier: Q9Y225-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLNKSGESRYPALFPVLGGSSM

Show »
Length:169
Mass (Da):19,402
Checksum:i55CAC34EB8E662F7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45Y → S in CAB45279 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0410261M → MLNKSGESRYPALFPVLGGS SM in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096778 mRNA Translation: CAB46627.1
BT007406 mRNA Translation: AAP36074.1
AL031670 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10467.1
CH471133 Genomic DNA Translation: EAX10468.1
CH471133 Genomic DNA Translation: EAX10469.1
CH471133 Genomic DNA Translation: EAX10471.1
BC000213 mRNA Translation: AAH00213.1
BC039584 mRNA Translation: AAH39584.1
AL079313 mRNA Translation: CAB45279.1
CCDSiCCDS13074.1 [Q9Y225-1]
CCDS46577.1 [Q9Y225-2]
RefSeqiNP_001127809.1, NM_001134337.2 [Q9Y225-1]
NP_001127810.1, NM_001134338.2 [Q9Y225-2]
NP_001308678.1, NM_001321749.1 [Q9Y225-1]
NP_009150.1, NM_007219.4 [Q9Y225-1]
XP_011527447.1, XM_011529145.2 [Q9Y225-2]
XP_016883109.1, XM_017027620.1 [Q9Y225-2]
XP_016883110.1, XM_017027621.1 [Q9Y225-2]
UniGeneiHs.547576
Hs.589884

Genome annotation databases

EnsembliENST00000336095; ENSP00000336753; ENSG00000101236 [Q9Y225-1]
ENST00000358395; ENSP00000351166; ENSG00000101236 [Q9Y225-1]
ENST00000432261; ENSP00000388550; ENSG00000101236 [Q9Y225-2]
ENST00000545616; ENSP00000444711; ENSG00000101236 [Q9Y225-2]
GeneIDi11237
KEGGihsa:11237
UCSCiuc002wkh.4 human [Q9Y225-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRNF24_HUMAN
AccessioniPrimary (citable) accession number: Q9Y225
Secondary accession number(s): D3DVZ2, D3DVZ3, Q9UMH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 1, 1999
Last modified: April 25, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health