Q9Y225 (RNF24_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RING finger protein 24

Gene names

Name:

RNF24

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in TRPCs intracellular trafficking. Ref.7
Subunit structure	Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7. Ref.7
Subcellular location	Golgi apparatus membrane; Single-pass membrane protein Ref.7.
Sequence similarities	Contains 1 RING-type zinc finger.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix Zinc-finger
Ligand	Metal-binding Zinc
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y225-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y225-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLNKSGESRYPALFPVLGGSSM

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 148

148

RING finger protein 24

PRO_0000056063

Regions

Transmembrane

24 – 44

21

Helical; Potential

Zinc finger

78 – 119

42

RING-type

Natural variations

Alternative sequence

1

1

M → MLNKSGESRYPALFPVLGGS SM in isoform 2.

VSP_041026

Experimental info

Sequence conflict

45

1

Y → S in CAB45279. Ref.6

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

148

Helix Strand Turn

Details...

Beta strand

79 – 81

3

Beta strand

87 – 89

3

Beta strand

91 – 94

4

Turn

95 – 97

3

Beta strand

98 – 101

4

Helix

102 – 111

10

Turn

116 – 118

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 66C240C3A5991EA5	FASTA	148	17,210
	10 20 30 40 50 60 MSSDFPHYNF RMPNIGFQNL PLNIYIVVFG TAIFVFILSL LFCCYLIRLR HQAHKEFYAY 70 80 90 100 110 120 KQVILKEKVK ELNLHELCAV CLEDFKPRDE LGICPCKHAF HRKCLIKWLE VRKVCPLCNM 130 140 PVLQLAQLHS KQDRGPPQGP LPGAENIV
	Isoform 2 [UniParc]. Checksum: 55CAC34EB8E662F7	FASTA	169	19,402
	10 20 30 40 50 60 MLNKSGESRY PALFPVLGGS SMSSDFPHYN FRMPNIGFQN LPLNIYIVVF GTAIFVFILS 70 80 90 100 110 120 LLFCCYLIRL RHQAHKEFYA YKQVILKEKV KELNLHELCA VCLEDFKPRD ELGICPCKHA 130 140 150 160 FHRKCLIKWL EVRKVCPLCN MPVLQLAQLH SKQDRGPPQG PLPGAENIV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Stavrides G.S., Huckle E.J., Deloukas P. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Blood and Kidney.
[6]	The European IMAGE consortium Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-148.
[7]	"RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC." Lussier M.P., Lepage P.K., Bousquet S.M., Boulay G. Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH TRPC1; TRPC3; TRPC4; TRPC5; TRPC6 AND TRPC7, SUBCELLULAR LOCATION.
[8]	"Solution structure of RING finger from human RING finger protein 24." RIKEN structural genomics initiative (RSGI) Submitted (FEB-2009) to the PDB data bank Cited for: STRUCTURE BY NMR OF 68-128 IN COMPLEX WITH ZINC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AL096778 mRNA. Translation: CAB46627.1.
BT007406 mRNA. Translation: AAP36074.1.
AL031670 Genomic DNA. Translation: CAB43182.1.
CH471133 Genomic DNA. Translation: EAX10467.1.
CH471133 Genomic DNA. Translation: EAX10468.1.
CH471133 Genomic DNA. Translation: EAX10469.1.
CH471133 Genomic DNA. Translation: EAX10471.1.
BC000213 mRNA. Translation: AAH00213.1.
BC039584 mRNA. Translation: AAH39584.1.
AL079313 mRNA. Translation: CAB45279.1.

IPI

IPI00797703.
IPI00910656.

RefSeq

NP_001127809.1. NM_001134337.1.
NP_001127810.1. NM_001134338.1.
NP_009150.1. NM_007219.3.

UniGene

Hs.589884.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2EP4	NMR	-	A	68-128	[»]

ProteinModelPortal

Q9Y225.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000388550.

PTM databases

PhosphoSite

Q9Y225.

Polymorphism databases

DMDM

20139860.

Proteomic databases

PaxDb

Q9Y225.

PRIDE

Q9Y225.

Protocols and materials databases

DNASU

11237.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000336095; ENSP00000336753; ENSG00000101236.
ENST00000358395; ENSP00000351166; ENSG00000101236.
ENST00000432261; ENSP00000388550; ENSG00000101236.
ENST00000545616; ENSP00000444711; ENSG00000101236.

GeneID

11237.

KEGG

hsa:11237.

UCSC

uc002wkh.2. human.
uc002wki.2. human.

Organism-specific databases

CTD

11237.

GeneCards

GC20M003912.

HGNC

HGNC:13779. RNF24.

HPA

HPA011900.

MIM

612489. gene.

neXtProt

NX_Q9Y225.

PharmGKB

PA34428.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG299260.

HOGENOM

HOG000004806.

HOVERGEN

HBG058899.

InParanoid

Q9Y225.

OMA

KQVIQKE.

OrthoDB

EOG4VX26J.

PhylomeDB

Q9Y225.

Gene expression databases

Bgee

Q9Y225.

CleanEx

HS_RNF24.

Genevestigator

Q9Y225.

GermOnline

ENSG00000101236. Homo sapiens.

Family and domain databases

Gene3D

3.30.40.10. 1 hit.

InterPro

IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]

Pfam

PF13639. zf-RING_2. 1 hit.
[Graphical view]

SMART

SM00184. RING. 1 hit.
[Graphical view]

PROSITE

PS00518. ZF_RING_1. False negative.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

RNF24. human.

EvolutionaryTrace

Q9Y225.

GenomeRNAi

11237.

NextBio

42770.

SOURCE

Search...

Entry information

Entry name

RNF24_HUMAN

Accession

Primary (citable) accession number: Q9Y225
Secondary accession number(s): D3DVZ2, D3DVZ3, Q9UMH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.