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Q9Y225 (RNF24_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RING finger protein 24
Gene names
Name:RNF24
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length148 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in TRPCs intracellular trafficking. Ref.7

Subunit structure

Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7. Ref.7

Subcellular location

Golgi apparatus membrane; Single-pass membrane protein Ref.7.

Sequence similarities

Contains 1 RING-type zinc finger.

Ontologies

Keywords
   Cellular componentGolgi apparatus
Membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
Zinc-finger
   LigandMetal-binding
Zinc
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentGolgi membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y225-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y225-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLNKSGESRYPALFPVLGGSSM

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 148148RING finger protein 24
PRO_0000056063

Regions

Transmembrane24 – 4421Helical; Potential
Zinc finger78 – 11942RING-type

Natural variations

Alternative sequence11M → MLNKSGESRYPALFPVLGGS SM in isoform 2.
VSP_041026

Experimental info

Sequence conflict451Y → S in CAB45279. Ref.6

Secondary structure

............ 148
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 66C240C3A5991EA5

FASTA14817,210
        10         20         30         40         50         60 
MSSDFPHYNF RMPNIGFQNL PLNIYIVVFG TAIFVFILSL LFCCYLIRLR HQAHKEFYAY 

        70         80         90        100        110        120 
KQVILKEKVK ELNLHELCAV CLEDFKPRDE LGICPCKHAF HRKCLIKWLE VRKVCPLCNM 

       130        140 
PVLQLAQLHS KQDRGPPQGP LPGAENIV 

« Hide

Isoform 2 [UniParc].

Checksum: 55CAC34EB8E662F7
Show »

FASTA16919,402

References

« Hide 'large scale' references
[1]Stavrides G.S., Huckle E.J., Deloukas P.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Blood and Kidney.
[6]The European IMAGE consortium
Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-148.
[7]"RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC."
Lussier M.P., Lepage P.K., Bousquet S.M., Boulay G.
Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH TRPC1; TRPC3; TRPC4; TRPC5; TRPC6 AND TRPC7, SUBCELLULAR LOCATION.
[8]"Solution structure of RING finger from human RING finger protein 24."
RIKEN structural genomics initiative (RSGI)
Submitted (FEB-2009) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 68-128 IN COMPLEX WITH ZINC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL096778 mRNA. Translation: CAB46627.1.
BT007406 mRNA. Translation: AAP36074.1.
AL031670 Genomic DNA. Translation: CAB43182.1.
CH471133 Genomic DNA. Translation: EAX10467.1.
CH471133 Genomic DNA. Translation: EAX10468.1.
CH471133 Genomic DNA. Translation: EAX10469.1.
CH471133 Genomic DNA. Translation: EAX10471.1.
BC000213 mRNA. Translation: AAH00213.1.
BC039584 mRNA. Translation: AAH39584.1.
AL079313 mRNA. Translation: CAB45279.1.
CCDSCCDS13074.1. [Q9Y225-1]
CCDS46577.1. [Q9Y225-2]
RefSeqNP_001127809.1. NM_001134337.1. [Q9Y225-1]
NP_001127810.1. NM_001134338.1. [Q9Y225-2]
NP_009150.1. NM_007219.3. [Q9Y225-1]
XP_006723599.1. XM_006723536.1. [Q9Y225-1]
UniGeneHs.589884.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2EP4NMR-A68-128[»]
ProteinModelPortalQ9Y225.
SMRQ9Y225. Positions 68-139.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116402. 3 interactions.
STRING9606.ENSP00000388550.

PTM databases

PhosphoSiteQ9Y225.

Polymorphism databases

DMDM20139860.

Proteomic databases

MaxQBQ9Y225.
PaxDbQ9Y225.
PRIDEQ9Y225.

Protocols and materials databases

DNASU11237.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000336095; ENSP00000336753; ENSG00000101236. [Q9Y225-1]
ENST00000358395; ENSP00000351166; ENSG00000101236. [Q9Y225-1]
ENST00000432261; ENSP00000388550; ENSG00000101236. [Q9Y225-2]
ENST00000545616; ENSP00000444711; ENSG00000101236. [Q9Y225-2]
GeneID11237.
KEGGhsa:11237.
UCSCuc002wkh.2. human. [Q9Y225-1]
uc002wki.2. human. [Q9Y225-2]

Organism-specific databases

CTD11237.
GeneCardsGC20M003912.
HGNCHGNC:13779. RNF24.
HPAHPA011900.
MIM612489. gene.
neXtProtNX_Q9Y225.
PharmGKBPA34428.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG299260.
HOGENOMHOG000004806.
HOVERGENHBG058899.
InParanoidQ9Y225.
OMAPHYSFRM.
OrthoDBEOG7XDBHK.
PhylomeDBQ9Y225.

Gene expression databases

BgeeQ9Y225.
CleanExHS_RNF24.
GenevestigatorQ9Y225.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTSM00184. RING. 1 hit.
[Graphical view]
PROSITEPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRNF24. human.
EvolutionaryTraceQ9Y225.
GeneWikiRNF24.
GenomeRNAi11237.
NextBio42770.
PROQ9Y225.
SOURCESearch...

Entry information

Entry nameRNF24_HUMAN
AccessionPrimary (citable) accession number: Q9Y225
Secondary accession number(s): D3DVZ2, D3DVZ3, Q9UMH1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM