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Q9Y225

- RNF24_HUMAN

UniProt

Q9Y225 - RNF24_HUMAN

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Protein
RING finger protein 24
Gene
RNF24
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in TRPCs intracellular trafficking.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri78 – 11942RING-type
Add
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 24
Gene namesi
Name:RNF24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:13779. RNF24.

Subcellular locationi

Golgi apparatus membrane; Single-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34428.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 148148RING finger protein 24
PRO_0000056063Add
BLAST

Proteomic databases

MaxQBiQ9Y225.
PaxDbiQ9Y225.
PRIDEiQ9Y225.

PTM databases

PhosphoSiteiQ9Y225.

Expressioni

Gene expression databases

BgeeiQ9Y225.
CleanExiHS_RNF24.
GenevestigatoriQ9Y225.

Organism-specific databases

HPAiHPA011900.

Interactioni

Subunit structurei

Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7.1 Publication

Protein-protein interaction databases

BioGridi116402. 3 interactions.
STRINGi9606.ENSP00000388550.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi79 – 813
Beta strandi87 – 893
Beta strandi91 – 944
Turni95 – 973
Beta strandi98 – 1014
Helixi102 – 11110
Turni116 – 1183

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EP4NMR-A68-128[»]
ProteinModelPortaliQ9Y225.
SMRiQ9Y225. Positions 68-139.

Miscellaneous databases

EvolutionaryTraceiQ9Y225.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiNOG299260.
HOGENOMiHOG000004806.
HOVERGENiHBG058899.
InParanoidiQ9Y225.
OMAiPHYSFRM.
OrthoDBiEOG7XDBHK.
PhylomeDBiQ9Y225.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y225-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSSDFPHYNF RMPNIGFQNL PLNIYIVVFG TAIFVFILSL LFCCYLIRLR    50
HQAHKEFYAY KQVILKEKVK ELNLHELCAV CLEDFKPRDE LGICPCKHAF 100
HRKCLIKWLE VRKVCPLCNM PVLQLAQLHS KQDRGPPQGP LPGAENIV 148
Length:148
Mass (Da):17,210
Last modified:November 1, 1999 - v1
Checksum:i66C240C3A5991EA5
GO
Isoform 2 (identifier: Q9Y225-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLNKSGESRYPALFPVLGGSSM

Show »
Length:169
Mass (Da):19,402
Checksum:i55CAC34EB8E662F7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MLNKSGESRYPALFPVLGGS SM in isoform 2.
VSP_041026

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451Y → S in CAB45279. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL096778 mRNA. Translation: CAB46627.1.
BT007406 mRNA. Translation: AAP36074.1.
AL031670 Genomic DNA. Translation: CAB43182.1.
CH471133 Genomic DNA. Translation: EAX10467.1.
CH471133 Genomic DNA. Translation: EAX10468.1.
CH471133 Genomic DNA. Translation: EAX10469.1.
CH471133 Genomic DNA. Translation: EAX10471.1.
BC000213 mRNA. Translation: AAH00213.1.
BC039584 mRNA. Translation: AAH39584.1.
AL079313 mRNA. Translation: CAB45279.1.
CCDSiCCDS13074.1. [Q9Y225-1]
CCDS46577.1. [Q9Y225-2]
RefSeqiNP_001127809.1. NM_001134337.1. [Q9Y225-1]
NP_001127810.1. NM_001134338.1. [Q9Y225-2]
NP_009150.1. NM_007219.3. [Q9Y225-1]
XP_006723599.1. XM_006723536.1. [Q9Y225-1]
UniGeneiHs.589884.

Genome annotation databases

EnsembliENST00000336095; ENSP00000336753; ENSG00000101236. [Q9Y225-1]
ENST00000358395; ENSP00000351166; ENSG00000101236. [Q9Y225-1]
ENST00000432261; ENSP00000388550; ENSG00000101236. [Q9Y225-2]
ENST00000545616; ENSP00000444711; ENSG00000101236. [Q9Y225-2]
GeneIDi11237.
KEGGihsa:11237.
UCSCiuc002wkh.2. human. [Q9Y225-1]
uc002wki.2. human. [Q9Y225-2]

Polymorphism databases

DMDMi20139860.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL096778 mRNA. Translation: CAB46627.1 .
BT007406 mRNA. Translation: AAP36074.1 .
AL031670 Genomic DNA. Translation: CAB43182.1 .
CH471133 Genomic DNA. Translation: EAX10467.1 .
CH471133 Genomic DNA. Translation: EAX10468.1 .
CH471133 Genomic DNA. Translation: EAX10469.1 .
CH471133 Genomic DNA. Translation: EAX10471.1 .
BC000213 mRNA. Translation: AAH00213.1 .
BC039584 mRNA. Translation: AAH39584.1 .
AL079313 mRNA. Translation: CAB45279.1 .
CCDSi CCDS13074.1. [Q9Y225-1 ]
CCDS46577.1. [Q9Y225-2 ]
RefSeqi NP_001127809.1. NM_001134337.1. [Q9Y225-1 ]
NP_001127810.1. NM_001134338.1. [Q9Y225-2 ]
NP_009150.1. NM_007219.3. [Q9Y225-1 ]
XP_006723599.1. XM_006723536.1. [Q9Y225-1 ]
UniGenei Hs.589884.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2EP4 NMR - A 68-128 [» ]
ProteinModelPortali Q9Y225.
SMRi Q9Y225. Positions 68-139.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116402. 3 interactions.
STRINGi 9606.ENSP00000388550.

PTM databases

PhosphoSitei Q9Y225.

Polymorphism databases

DMDMi 20139860.

Proteomic databases

MaxQBi Q9Y225.
PaxDbi Q9Y225.
PRIDEi Q9Y225.

Protocols and materials databases

DNASUi 11237.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336095 ; ENSP00000336753 ; ENSG00000101236 . [Q9Y225-1 ]
ENST00000358395 ; ENSP00000351166 ; ENSG00000101236 . [Q9Y225-1 ]
ENST00000432261 ; ENSP00000388550 ; ENSG00000101236 . [Q9Y225-2 ]
ENST00000545616 ; ENSP00000444711 ; ENSG00000101236 . [Q9Y225-2 ]
GeneIDi 11237.
KEGGi hsa:11237.
UCSCi uc002wkh.2. human. [Q9Y225-1 ]
uc002wki.2. human. [Q9Y225-2 ]

Organism-specific databases

CTDi 11237.
GeneCardsi GC20M003912.
HGNCi HGNC:13779. RNF24.
HPAi HPA011900.
MIMi 612489. gene.
neXtProti NX_Q9Y225.
PharmGKBi PA34428.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG299260.
HOGENOMi HOG000004806.
HOVERGENi HBG058899.
InParanoidi Q9Y225.
OMAi PHYSFRM.
OrthoDBi EOG7XDBHK.
PhylomeDBi Q9Y225.

Miscellaneous databases

ChiTaRSi RNF24. human.
EvolutionaryTracei Q9Y225.
GeneWikii RNF24.
GenomeRNAii 11237.
NextBioi 42770.
PROi Q9Y225.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y225.
CleanExi HS_RNF24.
Genevestigatori Q9Y225.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF13639. zf-RING_2. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
[Graphical view ]
PROSITEi PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Stavrides G.S., Huckle E.J., Deloukas P.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Blood and Kidney.
  6. The European IMAGE consortium
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-148.
  7. "RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC."
    Lussier M.P., Lepage P.K., Bousquet S.M., Boulay G.
    Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TRPC1; TRPC3; TRPC4; TRPC5; TRPC6 AND TRPC7, SUBCELLULAR LOCATION.
  8. "Solution structure of RING finger from human RING finger protein 24."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 68-128 IN COMPLEX WITH ZINC.

Entry informationi

Entry nameiRNF24_HUMAN
AccessioniPrimary (citable) accession number: Q9Y225
Secondary accession number(s): D3DVZ2, D3DVZ3, Q9UMH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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