Q9Y222 (DMTF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-D-binding Myb-like transcription factor 1
Short name=hDMTF1

Alternative name(s):
Cyclin-D-interacting Myb-like protein 1
Short name=hDMP1

Gene names

Name:	DMTF1
Synonyms:	DMP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	760 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest By similarity. Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' By similarity. Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1. Ref.2
Subunit structure	Interacts with the D-type cyclins CCND1, CCND2 and CCND3 By similarity. Interaction with D-type cyclins may modulate transcriptional activation by this protein By similarity.
Subcellular location	Nucleus Ref.8.
Tissue specificity	Expressed at relatively low levels in colonic mucosa, ovary, peripheral leukocytes, prostate and small intestine, and at higher levels in spleen, testis and thymus. Expressed in multiple regions of the brain and CNS including amygdala, caudate, corpus callosum, hippocampus, substantia nigra and subthalamic nucleus. Isoform 1 is the predominant isoform in monocytes, macrophages and neutrophils, isoform 2 is most strongly expressed in peripheral blood leukocytes and quiescent CD34 positive cells, and isoform 3 is expressed at low levels in all hematopoietic cell types. Expression is frequently reduced in non-small-cell lung carcinomas (NSCLC) due to hemizygous gene deletion, strongly suggesting that this locus is haploinsufficient for tumor suppression. Loss of this locus frequently occurs in tumors which retain wild-type CDKN2A/ARF and p53/TP53 loci. Hemizygous gene deletion has also been observed in leukemic blasts from patients with abnormalities of the long arm of chromosome 7. Ref.1 Ref.2 Ref.8
Developmental stage	Isoform 2 expression is down-regulated during myeloid differentiation, while the expression of isoform 1 and isoform 3 remain constant.
Post-translational modification	Phosphorylated by the cyclin-D2/CDK4, cyclin-D3/CDK4 and cyclin-D2/CDK6 complexes and to a lesser extent by the cyclin-D1/CDK4 complex By similarity.
Sequence similarities	Belongs to the DMTF1 family. Contains 1 HTH myb-type DNA-binding domain. Contains 2 Myb-like domains.
Sequence caution	The sequence BAD92467.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

Ontologies

Keywords
Biological process	Cell cycle Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Tumor suppressor
Domain	Repeat
Ligand	DNA-binding
Molecular function	Activator
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleus Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW chromatin binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y222-1)

Also known as: Alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y222-2)

Also known as: Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     238-273: LRIKHGNDWATIGAALGRSASSVKDRCRLMKDTCNT → QLWTPKKGHTFKLWLSKYCCPQLPNQSNGKKKNEE
     274-760: Missing.

Isoform 3 (identifier: Q9Y222-3)

Also known as: Gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     238-285: LRIKHGNDWA...WTEEEEKRLA → KKAIAACFFF...QSNGKKKNEE
     286-760: Missing.

Isoform 4 (identifier: Q9Y222-4)

The sequence of this isoform differs from the canonical sequence as follows:
     37-78: EADEIDSEDSIEPPHKRLCLSSEDDQSIDDSTPCISVVALPL → V
     238-285: LRIKHGNDWA...WTEEEEKRLA → KKAIAACFFF...QSNGKKKNEE
     286-760: Missing.

Isoform 5 (identifier: Q9Y222-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 760

760

Cyclin-D-binding Myb-like transcription factor 1

PRO_0000323729

Regions

Domain

225 – 263

39

Myb-like 1

Domain

268 – 333

66

HTH myb-type

Domain

339 – 388

50

Myb-like 2

DNA binding

306 – 329

24

H-T-H motif By similarity

Region

1 – 237

237

Interaction with CCND2 By similarity

Region

87 – 458

372

Required for DNA-binding By similarity

Region

87 – 170

84

Required for transcriptional activation By similarity

Region

176 – 760

585

Interaction with CCND1, CCND2 and CCND3 By similarity

Region

459 – 760

302

Required for transcriptional activation By similarity

Natural variations

Alternative sequence

1 – 88

88

Missing in isoform 5.

VSP_041063

Alternative sequence

37 – 78

42

EADEI…VALPL → V in isoform 4.

VSP_032089

Alternative sequence

238 – 285

48

LRIKH…EKRLA → KKAIAACFFFTHRQLWTPKK GHTFKLWLSKYCCPQLPNQS NGKKKNEE in isoform 3 and isoform 4.

VSP_032090

Alternative sequence

238 – 273

36

LRIKH…DTCNT → QLWTPKKGHTFKLWLSKYCC PQLPNQSNGKKKNEE in isoform 2.

VSP_032091

Alternative sequence

274 – 760

487

Missing in isoform 2.

VSP_032092

Alternative sequence

286 – 760

475

Missing in isoform 3 and isoform 4.

VSP_032093

Natural variant

479

1

V → I.
Corresponds to variant rs1558049 [ dbSNP | Ensembl ].

VAR_039577

Experimental info

Sequence conflict

345

1

I → T in BAG58937. Ref.3

Sequence conflict

616

1

I → V in AAH70064. Ref.7

Secondary structure

1

.

.

.

.

.

.

.

760

Helix Strand Turn

Details...

Helix

229 – 242

14

Helix

246 – 253

8

Helix

257 – 266

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Alpha) [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 57B3AE332F21A333	FASTA	760	84,471
	10 20 30 40 50 60 MSTVEEDSDT VTVETVNSVT LTQDTEGNLI LHCPQNEADE IDSEDSIEPP HKRLCLSSED 70 80 90 100 110 120 DQSIDDSTPC ISVVALPLSE NDQSFEVTMT ATTEVADDEV TEGTVTQIQI LQNEQLDEIS 130 140 150 160 170 180 PLGNEEVSAV SQAWFTTKED KDSLTNKGHK WKQGMWSKEE IDILMNNIER YLKARGIKDA 190 200 210 220 230 240 TEIIFEMSKD ERKDFYRTIA WGLNRPLFAV YRRVLRMYDD RNHVGKYTPE EIEKLKELRI 250 260 270 280 290 300 KHGNDWATIG AALGRSASSV KDRCRLMKDT CNTGKWTEEE EKRLAEVVHE LTSTEPGDIV 310 320 330 340 350 360 TQGVSWAAVA ERVGTRSEKQ CRSKWLNYLN WKQSGGTEWT KEDEINLILR IAELDVADEN 370 380 390 400 410 420 DINWDLLAEG WSSVRSPQWL RSKWWTIKRQ IANHKDVSFP VLIKGLKQLH ENQKNNPTLL 430 440 450 460 470 480 ENKSGSGVPN SNTNSSVQHV QIRVARLEDN TAISSSPMAA LQIPVQITHV SSADSPATVD 490 500 510 520 530 540 SETITLNSGT LQTFEILPSF HLQPTGTPGT YLLQTSSSQG LPLTLTASPT VTLTAAAPAS 550 560 570 580 590 600 PEQIIVHALS PEHLLNTSDN VTVQCHTPRV IIQTVATEDI TSSISQAELT VDSDIQSSDF 610 620 630 640 650 660 PEPPDALEAD TFPDEIHHPK MTVEPSFNDA HVSKFSDQNS TELMNSVMVR TEEEISDTDL 670 680 690 700 710 720 KQEESPSDLA SAYVTEGLES PTIEEQVDQT IDDETILIVP SPHGFIQASD VIDTESVLPL 730 740 750 760 TTLTDPILQH HQEESNIIGS SLGSPVSEDS KDVEDLVNCH
	Isoform 2 (Beta) [UniParc]. Checksum: 0D3F2715231DAED9	FASTA	272	31,227
	10 20 30 40 50 60 MSTVEEDSDT VTVETVNSVT LTQDTEGNLI LHCPQNEADE IDSEDSIEPP HKRLCLSSED 70 80 90 100 110 120 DQSIDDSTPC ISVVALPLSE NDQSFEVTMT ATTEVADDEV TEGTVTQIQI LQNEQLDEIS 130 140 150 160 170 180 PLGNEEVSAV SQAWFTTKED KDSLTNKGHK WKQGMWSKEE IDILMNNIER YLKARGIKDA 190 200 210 220 230 240 TEIIFEMSKD ERKDFYRTIA WGLNRPLFAV YRRVLRMYDD RNHVGKYTPE EIEKLKEQLW 250 260 270 TPKKGHTFKL WLSKYCCPQL PNQSNGKKKN EE
	Isoform 3 (Gamma) [UniParc]. Checksum: 0DBCC4F2345C48BF	FASTA	285	32,749
	10 20 30 40 50 60 MSTVEEDSDT VTVETVNSVT LTQDTEGNLI LHCPQNEADE IDSEDSIEPP HKRLCLSSED 70 80 90 100 110 120 DQSIDDSTPC ISVVALPLSE NDQSFEVTMT ATTEVADDEV TEGTVTQIQI LQNEQLDEIS 130 140 150 160 170 180 PLGNEEVSAV SQAWFTTKED KDSLTNKGHK WKQGMWSKEE IDILMNNIER YLKARGIKDA 190 200 210 220 230 240 TEIIFEMSKD ERKDFYRTIA WGLNRPLFAV YRRVLRMYDD RNHVGKYTPE EIEKLKEKKA 250 260 270 280 IAACFFFTHR QLWTPKKGHT FKLWLSKYCC PQLPNQSNGK KKNEE
	Isoform 4 [UniParc]. Checksum: 59F912F2CC8082E7	FASTA	244	28,296
	10 20 30 40 50 60 MSTVEEDSDT VTVETVNSVT LTQDTEGNLI LHCPQNVSEN DQSFEVTMTA TTEVADDEVT 70 80 90 100 110 120 EGTVTQIQIL QNEQLDEISP LGNEEVSAVS QAWFTTKEDK DSLTNKGHKW KQGMWSKEEI 130 140 150 160 170 180 DILMNNIERY LKARGIKDAT EIIFEMSKDE RKDFYRTIAW GLNRPLFAVY RRVLRMYDDR 190 200 210 220 230 240 NHVGKYTPEE IEKLKEKKAI AACFFFTHRQ LWTPKKGHTF KLWLSKYCCP QLPNQSNGKK KNEE
	Isoform 5 [UniParc]. Checksum: 818B4CFA4326350C	FASTA	672	74,878
	10 20 30 40 50 60 MTATTEVADD EVTEGTVTQI QILQNEQLDE ISPLGNEEVS AVSQAWFTTK EDKDSLTNKG 70 80 90 100 110 120 HKWKQGMWSK EEIDILMNNI ERYLKARGIK DATEIIFEMS KDERKDFYRT IAWGLNRPLF 130 140 150 160 170 180 AVYRRVLRMY DDRNHVGKYT PEEIEKLKEL RIKHGNDWAT IGAALGRSAS SVKDRCRLMK 190 200 210 220 230 240 DTCNTGKWTE EEEKRLAEVV HELTSTEPGD IVTQGVSWAA VAERVGTRSE KQCRSKWLNY 250 260 270 280 290 300 LNWKQSGGTE WTKEDEINLI LRIAELDVAD ENDINWDLLA EGWSSVRSPQ WLRSKWWTIK 310 320 330 340 350 360 RQIANHKDVS FPVLIKGLKQ LHENQKNNPT LLENKSGSGV PNSNTNSSVQ HVQIRVARLE 370 380 390 400 410 420 DNTAISSSPM AALQIPVQIT HVSSADSPAT VDSETITLNS GTLQTFEILP SFHLQPTGTP 430 440 450 460 470 480 GTYLLQTSSS QGLPLTLTAS PTVTLTAAAP ASPEQIIVHA LSPEHLLNTS DNVTVQCHTP 490 500 510 520 530 540 RVIIQTVATE DITSSISQAE LTVDSDIQSS DFPEPPDALE ADTFPDEIHH PKMTVEPSFN 550 560 570 580 590 600 DAHVSKFSDQ NSTELMNSVM VRTEEEISDT DLKQEESPSD LASAYVTEGL ESPTIEEQVD 610 620 630 640 650 660 QTIDDETILI VPSPHGFIQA SDVIDTESVL PLTTLTDPIL QHHQEESNII GSSLGSPVSE 670 DSKDVEDLVN CH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1)." Bodner S.M., Naeve C.W., Rakestraw K.M., Jones B.G., Valentine V.A., Valentine M.B., Luthardt F.W., Willman C.L., Raimondi S.C., Downing J.R., Roussel M.F., Sherr C.J., Look A.T. Gene 229:223-228(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"Alternative splicing of the human cyclin D-binding Myb-like protein (hDMP1) yields a truncated protein isoform that alters macrophage differentiation patterns." Tschan M.P., Fischer K.M., Fung V.S., Pirnia F., Borner M.M., Fey M.F., Tobler A., Torbett B.E. J. Biol. Chem. 278:42750-42760(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), FUNCTION, TISSUE SPECIFICITY. Tissue: Chronic myeloid leukemia cell.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 5). Tissue: Cerebellum, Placenta and Thalamus.
[4]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Brain.
[5]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Muscle, Placenta and Testis.
[8]	"Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer." Mallakin A., Sugiyama T., Taneja P., Matise L.A., Frazier D.P., Choudhary M., Hawkins G.A., D'Agostino R.B. Jr., Willingham M.C., Inoue K. Cancer Cell 12:381-394(2007) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF084530 mRNA. Translation: AAC33480.1.
AF202144 mRNA. Translation: AAG35613.1.
AF202145 mRNA. Translation: AAG35614.1.
AK296211 mRNA. Translation: BAG58937.1.
AK126664 mRNA. No translation available.
AK314622 mRNA. Translation: BAG37188.1.
AB209230 mRNA. Translation: BAD92467.1. Sequence problems.
AC005076 Genomic DNA. Translation: AAD43181.1.
CH471091 Genomic DNA. Translation: EAW76963.1.
BC007418 mRNA. Translation: AAH07418.2.
BC007447 mRNA. Translation: AAH07447.2.
BC029370 mRNA. Translation: AAH29370.1. Different termination.
BC070064 mRNA. Translation: AAH70064.1.

IPI

IPI00028123.
IPI00852885.
IPI00887567.
IPI00889129.
IPI01009399.

RefSeq

NP_001135798.1. NM_001142326.1.
NP_001135799.1. NM_001142327.1.
NP_066968.3. NM_021145.3.

UniGene

Hs.196129.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2LLK	NMR	-	A	220-274	[»]

ProteinModelPortal

Q9Y222.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9Y222. 2 interactions.

MINT

MINT-1196157.

STRING

9606.ENSP00000332171.

PTM databases

PhosphoSite

Q9Y222.

Polymorphism databases

DMDM

74762040.

Proteomic databases

PaxDb

Q9Y222.

PRIDE

Q9Y222.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000331242; ENSP00000332171; ENSG00000135164.
ENST00000394702; ENSP00000378192; ENSG00000135164.
ENST00000394703; ENSP00000378193; ENSG00000135164.
ENST00000411766; ENSP00000396570; ENSG00000135164.
ENST00000412139; ENSP00000407941; ENSG00000135164.
ENST00000425406; ENSP00000411908; ENSG00000135164.
ENST00000432937; ENSP00000412532; ENSG00000135164.
ENST00000447863; ENSP00000389774; ENSG00000135164.
ENST00000579677; ENSP00000464596; ENSG00000135164.
ENST00000584619; ENSP00000464092; ENSG00000135164.

GeneID

9988.

KEGG

hsa:9988.

UCSC

uc003uih.3. human.
uc003uim.1. human.

Organism-specific databases

CTD

9988.

GeneCards

GC07P086781.

H-InvDB

HIX0006815.

HGNC

HGNC:14603. DMTF1.

HPA

HPA023846.

MIM

608491. gene.

neXtProt

NX_Q9Y222.

PharmGKB

PA27389.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG288590.

HOVERGEN

HBG053416.

InParanoid

Q9Y222.

OMA

ELMNSVM.

OrthoDB

EOG4RJG0Z.

PhylomeDB

Q9Y222.

Gene expression databases

ArrayExpress

Q9Y222.

Bgee

Q9Y222.

CleanEx

HS_DMP1.
HS_DMTF1.

Genevestigator

Q9Y222.

Family and domain databases

Gene3D

1.10.10.60. 2 hits.

InterPro

IPR009057. Homeodomain-like.
IPR017877. Myb-like_dom.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
[Graphical view]

Pfam

PF00249. Myb_DNA-binding. 2 hits.
[Graphical view]

SMART

SM00717. SANT. 3 hits.
[Graphical view]

SUPFAM

SSF46689. Homeodomain_like. 2 hits.

PROSITE

PS51294. HTH_MYB. 1 hit.
PS50090. MYB_LIKE. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

DMTF1. human.

GenomeRNAi

9988.

NextBio

37719.

SOURCE

Search...

Entry information

Entry name

DMTF1_HUMAN

Accession

Primary (citable) accession number: Q9Y222
Secondary accession number(s): B2RBE1 , B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.