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Protein

60S ribosome subunit biogenesis protein NIP7 homolog

Gene

NIP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.1 Publication

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosome subunit biogenesis protein NIP7 homolog
Alternative name(s):
KD93
Gene namesi
Name:NIP7
ORF Names:CGI-37, HSPC031, HSPC180, OK/SW-cl.76, OK/SW-cl.78
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:24328. NIP7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671264.

Polymorphism and mutation databases

BioMutaiNIP7.
DMDMi56404676.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18018060S ribosome subunit biogenesis protein NIP7 homologPRO_0000218773Add
BLAST

Proteomic databases

EPDiQ9Y221.
MaxQBiQ9Y221.
PaxDbiQ9Y221.
PeptideAtlasiQ9Y221.
PRIDEiQ9Y221.
TopDownProteomicsiQ9Y221-1. [Q9Y221-1]

2D gel databases

SWISS-2DPAGEQ9Y221.

PTM databases

iPTMnetiQ9Y221.
PhosphoSiteiQ9Y221.
SwissPalmiQ9Y221.

Expressioni

Tissue specificityi

Expressed in hematopoietic stem/progenitor cells.1 Publication

Gene expression databases

BgeeiENSG00000132603.
CleanExiHS_NIP7.
ExpressionAtlasiQ9Y221. baseline and differential.
GenevisibleiQ9Y221. HS.

Organism-specific databases

HPAiHPA040856.
HPA059850.

Interactioni

Subunit structurei

Monomer. Interacts with pre-ribosome complex. May bind to RNA (By similarity). Interacts with NOL8. May interact with SBDS. Interacts with FTSJ3.By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CRXO431863EBI-749003,EBI-748171
LZTS2Q9BRK43EBI-749003,EBI-741037
NECAB2H3BTW23EBI-749003,EBI-10172876

Protein-protein interaction databases

BioGridi119517. 32 interactions.
IntActiQ9Y221. 10 interactions.
MINTiMINT-1472771.
STRINGi9606.ENSP00000254940.

Structurei

Secondary structure

1
180
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 2015Combined sources
Helixi21 – 244Combined sources
Helixi25 – 284Combined sources
Beta strandi33 – 408Combined sources
Beta strandi43 – 486Combined sources
Helixi49 – 535Combined sources
Turni54 – 563Combined sources
Helixi60 – 667Combined sources
Beta strandi67 – 737Combined sources
Beta strandi79 – 813Combined sources
Helixi83 – 853Combined sources
Helixi86 – 894Combined sources
Helixi90 – 923Combined sources
Beta strandi96 – 994Combined sources
Helixi101 – 1077Combined sources
Turni108 – 1103Combined sources
Helixi115 – 1173Combined sources
Beta strandi118 – 1214Combined sources
Beta strandi130 – 1356Combined sources
Beta strandi140 – 1489Combined sources
Helixi150 – 1556Combined sources
Beta strandi160 – 1689Combined sources
Helixi169 – 1713Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SQWX-ray1.90A1-180[»]
1T5YX-ray2.50A1-180[»]
ProteinModelPortaliQ9Y221.
SMRiQ9Y221. Positions 1-176.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y221.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 17077PUAPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9292N-terminal domainAdd
BLAST
Regioni93 – 18088C-terminal domainAdd
BLAST

Sequence similaritiesi

Belongs to the NIP7 family.Curated
Contains 1 PUA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3492. Eukaryota.
COG1374. LUCA.
GeneTreeiENSGT00390000003591.
HOGENOMiHOG000168475.
HOVERGENiHBG052625.
InParanoidiQ9Y221.
KOiK07565.
OMAiYCFREHR.
OrthoDBiEOG091G0NVA.
PhylomeDBiQ9Y221.
TreeFamiTF300081.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiIPR002478. PUA.
IPR015947. PUA-like_domain.
IPR005155. Rbsml_synth_fac_NIP7-like.
IPR016686. Ribosomal_synth_fac_NIP7.
[Graphical view]
PfamiPF03657. UPF0113. 1 hit.
[Graphical view]
PIRSFiPIRSF017190. Rbsml_synth_fac_NIP7. 1 hit.
SMARTiSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiPS50890. PUA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y221-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPLTEEETR VMFEKIAKYI GENLQLLVDR PDGTYCFRLH NDRVYYVSEK
60 70 80 90 100
IMKLAANISG DKLVSLGTCF GKFTKTHKFR LHVTALDYLA PYAKYKVWIK
110 120 130 140 150
PGAEQSFLYG NHVLKSGLGR ITENTSQYQG VVVYSMADIP LGFGVAAKST
160 170 180
QDCRKVDPMA IVVFHQADIG EYVRHEETLT
Length:180
Mass (Da):20,463
Last modified:November 1, 1999 - v1
Checksum:iFC6CFB2250AA4FC9
GO
Isoform 2 (identifier: Q9Y221-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-141: Missing.

Show »
Length:133
Mass (Da):15,222
Checksum:i9C538A2DED755248
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti171 – 1711E → Q in a breast cancer sample; somatic mutation. 1 Publication
VAR_036488

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei95 – 14147Missing in isoform 2. 1 PublicationVSP_012094Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132971 mRNA. Translation: AAD27746.1.
AF085360 mRNA. Translation: AAD40195.1.
AF161528 mRNA. Translation: AAF29143.1.
AB062398 mRNA. Translation: BAB93485.1.
AB062479 mRNA. Translation: BAB93504.1.
AB112439 mRNA. Translation: BAD05056.1.
AK315355 mRNA. Translation: BAG37751.1.
CH471092 Genomic DNA. Translation: EAW83271.1.
BC015941 mRNA. Translation: AAH15941.1.
CCDSiCCDS10877.1. [Q9Y221-1]
CCDS56003.1. [Q9Y221-2]
RefSeqiNP_001186363.1. NM_001199434.1. [Q9Y221-2]
NP_057185.1. NM_016101.4. [Q9Y221-1]
UniGeneiHs.585728.

Genome annotation databases

EnsembliENST00000254940; ENSP00000254940; ENSG00000132603. [Q9Y221-1]
ENST00000254941; ENSP00000254941; ENSG00000132603. [Q9Y221-2]
GeneIDi51388.
KEGGihsa:51388.
UCSCiuc002exa.4. human. [Q9Y221-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132971 mRNA. Translation: AAD27746.1.
AF085360 mRNA. Translation: AAD40195.1.
AF161528 mRNA. Translation: AAF29143.1.
AB062398 mRNA. Translation: BAB93485.1.
AB062479 mRNA. Translation: BAB93504.1.
AB112439 mRNA. Translation: BAD05056.1.
AK315355 mRNA. Translation: BAG37751.1.
CH471092 Genomic DNA. Translation: EAW83271.1.
BC015941 mRNA. Translation: AAH15941.1.
CCDSiCCDS10877.1. [Q9Y221-1]
CCDS56003.1. [Q9Y221-2]
RefSeqiNP_001186363.1. NM_001199434.1. [Q9Y221-2]
NP_057185.1. NM_016101.4. [Q9Y221-1]
UniGeneiHs.585728.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SQWX-ray1.90A1-180[»]
1T5YX-ray2.50A1-180[»]
ProteinModelPortaliQ9Y221.
SMRiQ9Y221. Positions 1-176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119517. 32 interactions.
IntActiQ9Y221. 10 interactions.
MINTiMINT-1472771.
STRINGi9606.ENSP00000254940.

PTM databases

iPTMnetiQ9Y221.
PhosphoSiteiQ9Y221.
SwissPalmiQ9Y221.

Polymorphism and mutation databases

BioMutaiNIP7.
DMDMi56404676.

2D gel databases

SWISS-2DPAGEQ9Y221.

Proteomic databases

EPDiQ9Y221.
MaxQBiQ9Y221.
PaxDbiQ9Y221.
PeptideAtlasiQ9Y221.
PRIDEiQ9Y221.
TopDownProteomicsiQ9Y221-1. [Q9Y221-1]

Protocols and materials databases

DNASUi51388.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254940; ENSP00000254940; ENSG00000132603. [Q9Y221-1]
ENST00000254941; ENSP00000254941; ENSG00000132603. [Q9Y221-2]
GeneIDi51388.
KEGGihsa:51388.
UCSCiuc002exa.4. human. [Q9Y221-1]

Organism-specific databases

CTDi51388.
GeneCardsiNIP7.
HGNCiHGNC:24328. NIP7.
HPAiHPA040856.
HPA059850.
neXtProtiNX_Q9Y221.
PharmGKBiPA142671264.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3492. Eukaryota.
COG1374. LUCA.
GeneTreeiENSGT00390000003591.
HOGENOMiHOG000168475.
HOVERGENiHBG052625.
InParanoidiQ9Y221.
KOiK07565.
OMAiYCFREHR.
OrthoDBiEOG091G0NVA.
PhylomeDBiQ9Y221.
TreeFamiTF300081.

Miscellaneous databases

ChiTaRSiNIP7. human.
EvolutionaryTraceiQ9Y221.
GeneWikiiNIP7.
GenomeRNAii51388.
PROiQ9Y221.

Gene expression databases

BgeeiENSG00000132603.
CleanExiHS_NIP7.
ExpressionAtlasiQ9Y221. baseline and differential.
GenevisibleiQ9Y221. HS.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiIPR002478. PUA.
IPR015947. PUA-like_domain.
IPR005155. Rbsml_synth_fac_NIP7-like.
IPR016686. Ribosomal_synth_fac_NIP7.
[Graphical view]
PfamiPF03657. UPF0113. 1 hit.
[Graphical view]
PIRSFiPIRSF017190. Rbsml_synth_fac_NIP7. 1 hit.
SMARTiSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiPS50890. PUA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNIP7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y221
Secondary accession number(s): B2RD04, Q9NZZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.