Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S ribosome subunit biogenesis protein NIP7 homolog

Gene

NIP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.1 Publication

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosome subunit biogenesis protein NIP7 homolog
Alternative name(s):
KD93
Gene namesi
Name:NIP7
ORF Names:CGI-37, HSPC031, HSPC180, OK/SW-cl.76, OK/SW-cl.78
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:24328. NIP7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132603.
PharmGKBiPA142671264.

Polymorphism and mutation databases

BioMutaiNIP7.
DMDMi56404676.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002187731 – 18060S ribosome subunit biogenesis protein NIP7 homologAdd BLAST180

Proteomic databases

EPDiQ9Y221.
PaxDbiQ9Y221.
PeptideAtlasiQ9Y221.
PRIDEiQ9Y221.
TopDownProteomicsiQ9Y221-1. [Q9Y221-1]

2D gel databases

SWISS-2DPAGEQ9Y221.

PTM databases

iPTMnetiQ9Y221.
PhosphoSitePlusiQ9Y221.
SwissPalmiQ9Y221.

Expressioni

Tissue specificityi

Expressed in hematopoietic stem/progenitor cells.1 Publication

Gene expression databases

BgeeiENSG00000132603.
CleanExiHS_NIP7.
ExpressionAtlasiQ9Y221. baseline and differential.
GenevisibleiQ9Y221. HS.

Organism-specific databases

HPAiHPA040856.
HPA059850.

Interactioni

Subunit structurei

Monomer. Interacts with pre-ribosome complex. May bind to RNA (By similarity). Interacts with NOL8. May interact with SBDS. Interacts with FTSJ3.By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CRXO431863EBI-749003,EBI-748171
LZTS2Q9BRK43EBI-749003,EBI-741037
NECAB2H3BTW23EBI-749003,EBI-10172876

Protein-protein interaction databases

BioGridi119517. 32 interactors.
IntActiQ9Y221. 10 interactors.
MINTiMINT-1472771.
STRINGi9606.ENSP00000254940.

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 20Combined sources15
Helixi21 – 24Combined sources4
Helixi25 – 28Combined sources4
Beta strandi33 – 40Combined sources8
Beta strandi43 – 48Combined sources6
Helixi49 – 53Combined sources5
Turni54 – 56Combined sources3
Helixi60 – 66Combined sources7
Beta strandi67 – 73Combined sources7
Beta strandi79 – 81Combined sources3
Helixi83 – 85Combined sources3
Helixi86 – 89Combined sources4
Helixi90 – 92Combined sources3
Beta strandi96 – 99Combined sources4
Helixi101 – 107Combined sources7
Turni108 – 110Combined sources3
Helixi115 – 117Combined sources3
Beta strandi118 – 121Combined sources4
Beta strandi130 – 135Combined sources6
Beta strandi140 – 148Combined sources9
Helixi150 – 155Combined sources6
Beta strandi160 – 168Combined sources9
Helixi169 – 171Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SQWX-ray1.90A1-180[»]
1T5YX-ray2.50A1-180[»]
ProteinModelPortaliQ9Y221.
SMRiQ9Y221.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y221.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 170PUAPROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 92N-terminal domainAdd BLAST92
Regioni93 – 180C-terminal domainAdd BLAST88

Sequence similaritiesi

Belongs to the NIP7 family.Curated
Contains 1 PUA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3492. Eukaryota.
COG1374. LUCA.
GeneTreeiENSGT00390000003591.
HOGENOMiHOG000168475.
HOVERGENiHBG052625.
InParanoidiQ9Y221.
KOiK07565.
OMAiYCFREHR.
OrthoDBiEOG091G0NVA.
PhylomeDBiQ9Y221.
TreeFamiTF300081.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiIPR002478. PUA.
IPR015947. PUA-like_domain.
IPR005155. Rbsml_synth_fac_NIP7-like.
IPR016686. Ribosomal_synth_fac_NIP7.
[Graphical view]
PfamiPF03657. UPF0113. 1 hit.
[Graphical view]
PIRSFiPIRSF017190. Rbsml_synth_fac_NIP7. 1 hit.
SMARTiSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiPS50890. PUA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y221-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPLTEEETR VMFEKIAKYI GENLQLLVDR PDGTYCFRLH NDRVYYVSEK
60 70 80 90 100
IMKLAANISG DKLVSLGTCF GKFTKTHKFR LHVTALDYLA PYAKYKVWIK
110 120 130 140 150
PGAEQSFLYG NHVLKSGLGR ITENTSQYQG VVVYSMADIP LGFGVAAKST
160 170 180
QDCRKVDPMA IVVFHQADIG EYVRHEETLT
Length:180
Mass (Da):20,463
Last modified:November 1, 1999 - v1
Checksum:iFC6CFB2250AA4FC9
GO
Isoform 2 (identifier: Q9Y221-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-141: Missing.

Show »
Length:133
Mass (Da):15,222
Checksum:i9C538A2DED755248
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036488171E → Q in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01209495 – 141Missing in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132971 mRNA. Translation: AAD27746.1.
AF085360 mRNA. Translation: AAD40195.1.
AF161528 mRNA. Translation: AAF29143.1.
AB062398 mRNA. Translation: BAB93485.1.
AB062479 mRNA. Translation: BAB93504.1.
AB112439 mRNA. Translation: BAD05056.1.
AK315355 mRNA. Translation: BAG37751.1.
CH471092 Genomic DNA. Translation: EAW83271.1.
BC015941 mRNA. Translation: AAH15941.1.
CCDSiCCDS10877.1. [Q9Y221-1]
CCDS56003.1. [Q9Y221-2]
RefSeqiNP_001186363.1. NM_001199434.1. [Q9Y221-2]
NP_057185.1. NM_016101.4. [Q9Y221-1]
UniGeneiHs.585728.

Genome annotation databases

EnsembliENST00000254940; ENSP00000254940; ENSG00000132603. [Q9Y221-1]
ENST00000254941; ENSP00000254941; ENSG00000132603. [Q9Y221-2]
GeneIDi51388.
KEGGihsa:51388.
UCSCiuc002exa.4. human. [Q9Y221-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132971 mRNA. Translation: AAD27746.1.
AF085360 mRNA. Translation: AAD40195.1.
AF161528 mRNA. Translation: AAF29143.1.
AB062398 mRNA. Translation: BAB93485.1.
AB062479 mRNA. Translation: BAB93504.1.
AB112439 mRNA. Translation: BAD05056.1.
AK315355 mRNA. Translation: BAG37751.1.
CH471092 Genomic DNA. Translation: EAW83271.1.
BC015941 mRNA. Translation: AAH15941.1.
CCDSiCCDS10877.1. [Q9Y221-1]
CCDS56003.1. [Q9Y221-2]
RefSeqiNP_001186363.1. NM_001199434.1. [Q9Y221-2]
NP_057185.1. NM_016101.4. [Q9Y221-1]
UniGeneiHs.585728.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SQWX-ray1.90A1-180[»]
1T5YX-ray2.50A1-180[»]
ProteinModelPortaliQ9Y221.
SMRiQ9Y221.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119517. 32 interactors.
IntActiQ9Y221. 10 interactors.
MINTiMINT-1472771.
STRINGi9606.ENSP00000254940.

PTM databases

iPTMnetiQ9Y221.
PhosphoSitePlusiQ9Y221.
SwissPalmiQ9Y221.

Polymorphism and mutation databases

BioMutaiNIP7.
DMDMi56404676.

2D gel databases

SWISS-2DPAGEQ9Y221.

Proteomic databases

EPDiQ9Y221.
PaxDbiQ9Y221.
PeptideAtlasiQ9Y221.
PRIDEiQ9Y221.
TopDownProteomicsiQ9Y221-1. [Q9Y221-1]

Protocols and materials databases

DNASUi51388.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254940; ENSP00000254940; ENSG00000132603. [Q9Y221-1]
ENST00000254941; ENSP00000254941; ENSG00000132603. [Q9Y221-2]
GeneIDi51388.
KEGGihsa:51388.
UCSCiuc002exa.4. human. [Q9Y221-1]

Organism-specific databases

CTDi51388.
GeneCardsiNIP7.
HGNCiHGNC:24328. NIP7.
HPAiHPA040856.
HPA059850.
neXtProtiNX_Q9Y221.
OpenTargetsiENSG00000132603.
PharmGKBiPA142671264.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3492. Eukaryota.
COG1374. LUCA.
GeneTreeiENSGT00390000003591.
HOGENOMiHOG000168475.
HOVERGENiHBG052625.
InParanoidiQ9Y221.
KOiK07565.
OMAiYCFREHR.
OrthoDBiEOG091G0NVA.
PhylomeDBiQ9Y221.
TreeFamiTF300081.

Miscellaneous databases

ChiTaRSiNIP7. human.
EvolutionaryTraceiQ9Y221.
GeneWikiiNIP7.
GenomeRNAii51388.
PROiQ9Y221.

Gene expression databases

BgeeiENSG00000132603.
CleanExiHS_NIP7.
ExpressionAtlasiQ9Y221. baseline and differential.
GenevisibleiQ9Y221. HS.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiIPR002478. PUA.
IPR015947. PUA-like_domain.
IPR005155. Rbsml_synth_fac_NIP7-like.
IPR016686. Ribosomal_synth_fac_NIP7.
[Graphical view]
PfamiPF03657. UPF0113. 1 hit.
[Graphical view]
PIRSFiPIRSF017190. Rbsml_synth_fac_NIP7. 1 hit.
SMARTiSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiPS50890. PUA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNIP7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y221
Secondary accession number(s): B2RD04, Q9NZZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.