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Q9Y219

- JAG2_HUMAN

UniProt

Q9Y219 - JAG2_HUMAN

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Protein

Protein jagged-2

Gene

JAG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. growth factor activity Source: UniProtKB
  3. Notch binding Source: UniProtKB

GO - Biological processi

  1. auditory receptor cell fate commitment Source: UniProtKB
  2. cell cycle Source: UniProtKB
  3. cell differentiation Source: UniProtKB
  4. epithelial cell apoptotic process involved in palatal shelf morphogenesis Source: Ensembl
  5. gamma-delta T cell differentiation Source: Ensembl
  6. in utero embryonic development Source: Ensembl
  7. morphogenesis of embryonic epithelium Source: Ensembl
  8. Notch receptor processing Source: Reactome
  9. Notch signaling pathway Source: UniProtKB
  10. odontogenesis of dentin-containing tooth Source: Ensembl
  11. regulation of cell adhesion Source: Ensembl
  12. regulation of cell migration Source: UniProtKB
  13. regulation of cell proliferation Source: UniProtKB
  14. respiratory system process Source: Ensembl
  15. skeletal system development Source: Ensembl
  16. spermatogenesis Source: UniProtKB
  17. T cell differentiation Source: UniProtKB
  18. thymic T cell selection Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Notch signaling pathway

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_118636. Signaling by NOTCH4.
REACT_118862. Signaling by NOTCH3.
REACT_160089. Constitutive Signaling by NOTCH1 HD Domain Mutants.
REACT_160106. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
REACT_160205. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
SignaLinkiQ9Y219.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein jagged-2
Short name:
Jagged2
Short name:
hJ2
Gene namesi
Name:JAG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:6189. JAG2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 10801054ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1081 – 110121HelicalSequence AnalysisAdd
BLAST
Topological domaini1102 – 1238137CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29987.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 12381215Protein jagged-2PRO_0000007629Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi198 ↔ 207By similarity
Disulfide bondi211 ↔ 223By similarity
Disulfide bondi231 ↔ 240By similarity
Disulfide bondi245 ↔ 256By similarity
Disulfide bondi249 ↔ 262By similarity
Disulfide bondi264 ↔ 273By similarity
Disulfide bondi276 ↔ 287By similarity
Disulfide bondi282 ↔ 293By similarity
Disulfide bondi295 ↔ 304By similarity
Disulfide bondi311 ↔ 323By similarity
Disulfide bondi317 ↔ 333By similarity
Disulfide bondi335 ↔ 344By similarity
Disulfide bondi351 ↔ 362By similarity
Disulfide bondi356 ↔ 371By similarity
Disulfide bondi373 ↔ 382By similarity
Disulfide bondi389 ↔ 400By similarity
Disulfide bondi394 ↔ 409By similarity
Disulfide bondi411 ↔ 420By similarity
Disulfide bondi427 ↔ 438By similarity
Disulfide bondi432 ↔ 447By similarity
Disulfide bondi449 ↔ 458By similarity
Disulfide bondi465 ↔ 475By similarity
Disulfide bondi469 ↔ 484By similarity
Disulfide bondi486 ↔ 495By similarity
Disulfide bondi502 ↔ 513By similarity
Disulfide bondi507 ↔ 522By similarity
Disulfide bondi524 ↔ 533By similarity
Disulfide bondi540 ↔ 551By similarity
Disulfide bondi545 ↔ 560By similarity
Disulfide bondi562 ↔ 571By similarity
Glycosylationi570 – 5701N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi589 ↔ 612Sequence Analysis
Disulfide bondi606 ↔ 622Sequence Analysis
Glycosylationi619 – 6191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi624 ↔ 633By similarity
Disulfide bondi640 ↔ 651By similarity
Disulfide bondi645 ↔ 660By similarity
Disulfide bondi662 ↔ 671By similarity
Disulfide bondi678 ↔ 689By similarity
Disulfide bondi683 ↔ 698By similarity
Disulfide bondi700 ↔ 709By similarity
Disulfide bondi716 ↔ 727By similarity
Disulfide bondi721 ↔ 736By similarity
Disulfide bondi738 ↔ 747By similarity
Glycosylationi752 – 7521N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi755 ↔ 766By similarity
Disulfide bondi760 ↔ 775By similarity
Disulfide bondi777 ↔ 786By similarity
Disulfide bondi793 ↔ 804By similarity
Disulfide bondi798 ↔ 813By similarity
Disulfide bondi815 ↔ 824By similarity
Disulfide bondi831 ↔ 842By similarity
Disulfide bondi836 ↔ 851By similarity
Disulfide bondi853 ↔ 862By similarity
Glycosylationi1058 – 10581N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9Y219.
PaxDbiQ9Y219.
PRIDEiQ9Y219.

PTM databases

PhosphoSiteiQ9Y219.

Miscellaneous databases

PMAP-CutDBQ9Y219.

Expressioni

Tissue specificityi

Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney.

Gene expression databases

BgeeiQ9Y219.
CleanExiHS_JAG2.
GenevestigatoriQ9Y219.

Organism-specific databases

HPAiCAB025481.
HPA030636.
HPA050567.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GFI1BQ5VTD92EBI-946223,EBI-946212

Protein-protein interaction databases

BioGridi109918. 10 interactions.
IntActiQ9Y219. 7 interactions.
MINTiMINT-2822882.
STRINGi9606.ENSP00000328169.

Structurei

3D structure databases

ProteinModelPortaliQ9Y219.
SMRiQ9Y219. Positions 28-904.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini196 – 24045DSLPROSITE-ProRule annotationAdd
BLAST
Domaini241 – 27434EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini275 – 30531EGF-like 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Domaini307 – 34539EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini347 – 38337EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini385 – 42137EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini423 – 45937EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini461 – 49636EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini498 – 53437EGF-like 8PROSITE-ProRule annotationAdd
BLAST
Domaini536 – 57237EGF-like 9PROSITE-ProRule annotationAdd
BLAST
Domaini574 – 63461EGF-like 10; atypicalPROSITE-ProRule annotationAdd
BLAST
Domaini636 – 67237EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini674 – 71037EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini712 – 74837EGF-like 13PROSITE-ProRule annotationAdd
BLAST
Domaini751 – 78737EGF-like 14PROSITE-ProRule annotationAdd
BLAST
Domaini789 – 82537EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini827 – 86337EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini870 – 94475VWFCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DSL domain.PROSITE-ProRule annotation
Contains 16 EGF-like domains.PROSITE-ProRule annotation
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00760000118786.
HOGENOMiHOG000113124.
HOVERGENiHBG031645.
InParanoidiQ9Y219.
KOiK06052.
OMAiECDTYVR.
OrthoDBiEOG7BKCSS.
PhylomeDBiQ9Y219.
TreeFamiTF351835.

Family and domain databases

InterProiIPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_C.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 9 hits.
PF07645. EGF_CA. 1 hit.
PF12661. hEGF. 2 hits.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 9 hits.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 12 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 8 hits.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: Q9Y219-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRAQGRGRLP RRLLLLLALW VQAARPMGYF ELQLSALRNV NGELLSGACC
60 70 80 90 100
DGDGRTTRAG GCGHDECDTY VRVCLKEYQA KVTPTGPCSY GHGATPVLGG
110 120 130 140 150
NSFYLPPAGA AGDRARARAR AGGDQDPGLV VIPFQFAWPR SFTLIVEAWD
160 170 180 190 200
WDNDTTPNEE LLIERVSHAG MINPEDRWKS LHFSGHVAHL ELQIRVRCDE
210 220 230 240 250
NYYSATCNKF CRPRNDFFGH YTCDQYGNKA CMDGWMGKEC KEAVCKQGCN
260 270 280 290 300
LLHGGCTVPG ECRCSYGWQG RFCDECVPYP GCVHGSCVEP WQCNCETNWG
310 320 330 340 350
GLLCDKDLNY CGSHHPCTNG GTCINAEPDQ YRCTCPDGYS GRNCEKAEHA
360 370 380 390 400
CTSNPCANGG SCHEVPSGFE CHCPSGWSGP TCALDIDECA SNPCAAGGTC
410 420 430 440 450
VDQVDGFECI CPEQWVGATC QLDANECEGK PCLNAFSCKN LIGGYYCDCI
460 470 480 490 500
PGWKGINCHI NVNDCRGQCQ HGGTCKDLVN GYQCVCPRGF GGRHCELERD
510 520 530 540 550
ECASSPCHSG GLCEDLADGF HCHCPQGFSG PLCEVDVDLC EPSPCRNGAR
560 570 580 590 600
CYNLEGDYYC ACPDDFGGKN CSVPREPCPG GACRVIDGCG SDAGPGMPGT
610 620 630 640 650
AASGVCGPHG RCVSQPGGNF SCICDSGFTG TYCHENIDDC LGQPCRNGGT
660 670 680 690 700
CIDEVDAFRC FCPSGWEGEL CDTNPNDCLP DPCHSRGRCY DLVNDFYCAC
710 720 730 740 750
DDGWKGKTCH SREFQCDAYT CSNGGTCYDS GDTFRCACPP GWKGSTCAVA
760 770 780 790 800
KNSSCLPNPC VNGGTCVGSG ASFSCICRDG WEGRTCTHNT NDCNPLPCYN
810 820 830 840 850
GGICVDGVNW FRCECAPGFA GPDCRINIDE CQSSPCAYGA TCVDEINGYR
860 870 880 890 900
CSCPPGRAGP RCQEVIGFGR SCWSRGTPFP HGSSWVEDCN SCRCLDGRRD
910 920 930 940 950
CSKVWCGWKP CLLAGQPEAL SAQCPLGQRC LEKAPGQCLR PPCEAWGECG
960 970 980 990 1000
AEEPPSTPCL PRSGHLDNNC ARLTLHFNRD HVPQGTTVGA ICSGIRSLPA
1010 1020 1030 1040 1050
TRAVARDRLL VLLCDRASSG ASAVEVAVSF SPARDLPDSS LIQGAAHAIV
1060 1070 1080 1090 1100
AAITQRGNSS LLLAVTEVKV ETVVTGGSST GLLVPVLCGA FSVLWLACVV
1110 1120 1130 1140 1150
LCVWWTRKRR KERERSRLPR EESANNQWAP LNPIRNPIER PGGHKDVLYQ
1160 1170 1180 1190 1200
CKNFTPPPRR ADEALPGPAG HAAVREDEED EDLGRGEEDS LEAEKFLSHK
1210 1220 1230
FTKDPGRSPG RPAHWASGPK VDNRAVRSIN EARYAGKE
Length:1,238
Mass (Da):133,367
Last modified:October 17, 2006 - v3
Checksum:i23B4FCD7D2891EF7
GO
Isoform Short (identifier: Q9Y219-2) [UniParc]FASTAAdd to Basket

Also known as: HJAG2.del-E6

The sequence of this isoform differs from the canonical sequence as follows:
     424-461: Missing.

Show »
Length:1,200
Mass (Da):129,235
Checksum:iC74AA0EE201D5FA7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 125RLPRR → AFPPA in AAB71189. (PubMed:9315665)Curated
Sequence conflicti119 – 1191A → P in AAB71189. (PubMed:9315665)Curated
Sequence conflicti129 – 1291L → F in AAB71189. (PubMed:9315665)Curated
Sequence conflicti384 – 3841L → SA in CAA74706. (PubMed:9486542)Curated
Sequence conflicti424 – 4263ANE → VND in AAB71189. (PubMed:9315665)Curated
Sequence conflicti1235 – 12351A → V in AAB61285. (PubMed:10079256)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti501 – 5011E → K.3 Publications
Corresponds to variant rs1057744 [ dbSNP | Ensembl ].
VAR_028113
Natural varianti538 – 5381D → N.
Corresponds to variant rs9972231 [ dbSNP | Ensembl ].
VAR_048986

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei424 – 46138Missing in isoform Short. 1 PublicationVSP_001395Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020201 mRNA. Translation: AAB71189.1.
AF003521 mRNA. Translation: AAB61285.1.
AF029778 mRNA. Translation: AAB84215.1.
AF029779 mRNA. Translation: AAB84216.1.
AF111170 Genomic DNA. Translation: AAD15562.1.
Y14330 mRNA. Translation: CAA74706.1.
CCDSiCCDS9998.1. [Q9Y219-1]
CCDS9999.1. [Q9Y219-2]
RefSeqiNP_002217.3. NM_002226.4. [Q9Y219-1]
NP_660142.1. NM_145159.2. [Q9Y219-2]
UniGeneiHs.433445.

Genome annotation databases

EnsembliENST00000331782; ENSP00000328169; ENSG00000184916. [Q9Y219-1]
ENST00000347004; ENSP00000328566; ENSG00000184916. [Q9Y219-2]
GeneIDi3714.
KEGGihsa:3714.
UCSCiuc001yqf.4. human. [Q9Y219-1]
uc001yqh.4. human. [Q9Y219-2]

Polymorphism databases

DMDMi116242598.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020201 mRNA. Translation: AAB71189.1 .
AF003521 mRNA. Translation: AAB61285.1 .
AF029778 mRNA. Translation: AAB84215.1 .
AF029779 mRNA. Translation: AAB84216.1 .
AF111170 Genomic DNA. Translation: AAD15562.1 .
Y14330 mRNA. Translation: CAA74706.1 .
CCDSi CCDS9998.1. [Q9Y219-1 ]
CCDS9999.1. [Q9Y219-2 ]
RefSeqi NP_002217.3. NM_002226.4. [Q9Y219-1 ]
NP_660142.1. NM_145159.2. [Q9Y219-2 ]
UniGenei Hs.433445.

3D structure databases

ProteinModelPortali Q9Y219.
SMRi Q9Y219. Positions 28-904.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109918. 10 interactions.
IntActi Q9Y219. 7 interactions.
MINTi MINT-2822882.
STRINGi 9606.ENSP00000328169.

PTM databases

PhosphoSitei Q9Y219.

Polymorphism databases

DMDMi 116242598.

Proteomic databases

MaxQBi Q9Y219.
PaxDbi Q9Y219.
PRIDEi Q9Y219.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000331782 ; ENSP00000328169 ; ENSG00000184916 . [Q9Y219-1 ]
ENST00000347004 ; ENSP00000328566 ; ENSG00000184916 . [Q9Y219-2 ]
GeneIDi 3714.
KEGGi hsa:3714.
UCSCi uc001yqf.4. human. [Q9Y219-1 ]
uc001yqh.4. human. [Q9Y219-2 ]

Organism-specific databases

CTDi 3714.
GeneCardsi GC14M105607.
H-InvDB HIX0037647.
HGNCi HGNC:6189. JAG2.
HPAi CAB025481.
HPA030636.
HPA050567.
MIMi 602570. gene.
neXtProti NX_Q9Y219.
PharmGKBi PA29987.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00760000118786.
HOGENOMi HOG000113124.
HOVERGENi HBG031645.
InParanoidi Q9Y219.
KOi K06052.
OMAi ECDTYVR.
OrthoDBi EOG7BKCSS.
PhylomeDBi Q9Y219.
TreeFami TF351835.

Enzyme and pathway databases

Reactomei REACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_118636. Signaling by NOTCH4.
REACT_118862. Signaling by NOTCH3.
REACT_160089. Constitutive Signaling by NOTCH1 HD Domain Mutants.
REACT_160106. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
REACT_160205. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
SignaLinki Q9Y219.

Miscellaneous databases

ChiTaRSi JAG2. human.
GeneWikii JAG2.
GenomeRNAii 3714.
NextBioi 14557.
PMAP-CutDB Q9Y219.
PROi Q9Y219.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y219.
CleanExi HS_JAG2.
Genevestigatori Q9Y219.

Family and domain databases

InterProi IPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF01414. DSL. 1 hit.
PF00008. EGF. 9 hits.
PF07645. EGF_CA. 1 hit.
PF12661. hEGF. 2 hits.
PF07657. MNNL. 1 hit.
[Graphical view ]
PRINTSi PR02059. JAGGEDFAMILY.
SMARTi SM00051. DSL. 1 hit.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 9 hits.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 2 hits.
PROSITEi PS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 12 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 8 hits.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor."
    Luo B., Aster J.C., Hasserjian R.P., Kuo F., Sklar J.
    Mol. Cell. Biol. 17:6057-6067(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), VARIANT LYS-501.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), VARIANT LYS-501.
    Tissue: Fetal brain.
  3. "Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene."
    Deng Y., Madan A., Banta A.B., Friedman C., Trask B.J., Hood L., Li L.
    Genomics 63:133-138(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS LONG AND SHORT), VARIANT LYS-501.
    Tissue: Bone marrow.
  4. "JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions."
    Valsecchi C., Ghezzi C., Ballabio A., Rugarli E.I.
    Mech. Dev. 69:203-207(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-1238 (ISOFORM LONG).
    Tissue: Heart.

Entry informationi

Entry nameiJAG2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y219
Secondary accession number(s): Q9UE17
, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 17, 2006
Last modified: November 26, 2014
This is version 153 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3