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Q9Y219 (JAG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 149. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein jagged-2

Short name=Jagged2
Short name=hJ2
Gene names
Name:JAG2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1238 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney.

Sequence similarities

Contains 1 DSL domain.

Contains 16 EGF-like domains.

Contains 1 VWFC domain.

Ontologies

Keywords
   Biological processNotch signaling pathway
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainEGF-like domain
Repeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
   Molecular functionDevelopmental protein
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNotch receptor processing

Traceable author statement. Source: Reactome

Notch signaling pathway

Non-traceable author statement PubMed 11056013. Source: UniProtKB

T cell differentiation

Inferred from direct assay PubMed 10383933. Source: UniProtKB

auditory receptor cell fate commitment

Inferred from sequence or structural similarity PubMed 10080181. Source: UniProtKB

cell cycle

Non-traceable author statement PubMed 11549580. Source: UniProtKB

cell differentiation

Inferred from direct assay PubMed 11549580PubMed 11700865. Source: UniProtKB

epithelial cell apoptotic process involved in palatal shelf morphogenesis

Inferred from electronic annotation. Source: Ensembl

gamma-delta T cell differentiation

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

morphogenesis of embryonic epithelium

Inferred from electronic annotation. Source: Ensembl

odontogenesis of dentin-containing tooth

Inferred from electronic annotation. Source: Ensembl

regulation of cell adhesion

Inferred from electronic annotation. Source: Ensembl

regulation of cell migration

Non-traceable author statement PubMed 11549580. Source: UniProtKB

regulation of cell proliferation

Inferred from direct assay PubMed 10383933PubMed 11549580. Source: UniProtKB

respiratory system process

Inferred from electronic annotation. Source: Ensembl

skeletal system development

Inferred from electronic annotation. Source: Ensembl

spermatogenesis

Inferred from expression pattern PubMed 11700865. Source: UniProtKB

thymic T cell selection

Inferred from direct assay PubMed 10383933. Source: UniProtKB

   Cellular_componentintegral component of plasma membrane

Inferred from sequence or structural similarity PubMed 10910909. Source: UniProtKB

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionNotch binding

Inferred from physical interaction Ref.1. Source: UniProtKB

calcium ion binding

Inferred from electronic annotation. Source: InterPro

growth factor activity

Inferred from direct assay PubMed 10383933. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 16713569. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

GFI1BQ5VTD92EBI-946223,EBI-946212

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: Q9Y219-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: Q9Y219-2)

Also known as: HJAG2.del-E6;

The sequence of this isoform differs from the canonical sequence as follows:
     424-461: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 12381215Protein jagged-2
PRO_0000007629

Regions

Topological domain27 – 10801054Extracellular Potential
Transmembrane1081 – 110121Helical; Potential
Topological domain1102 – 1238137Cytoplasmic Potential
Domain196 – 24045DSL
Domain241 – 27434EGF-like 1
Domain275 – 30531EGF-like 2; atypical
Domain307 – 34539EGF-like 3
Domain347 – 38337EGF-like 4
Domain385 – 42137EGF-like 5; calcium-binding Potential
Domain423 – 45937EGF-like 6; calcium-binding Potential
Domain461 – 49636EGF-like 7; calcium-binding Potential
Domain498 – 53437EGF-like 8
Domain536 – 57237EGF-like 9
Domain574 – 63461EGF-like 10; atypical
Domain636 – 67237EGF-like 11; calcium-binding Potential
Domain674 – 71037EGF-like 12; calcium-binding Potential
Domain712 – 74837EGF-like 13
Domain751 – 78737EGF-like 14
Domain789 – 82537EGF-like 15; calcium-binding Potential
Domain827 – 86337EGF-like 16; calcium-binding Potential
Domain870 – 94475VWFC

Amino acid modifications

Glycosylation1531N-linked (GlcNAc...) Potential
Glycosylation5701N-linked (GlcNAc...) Potential
Glycosylation6191N-linked (GlcNAc...) Potential
Glycosylation7521N-linked (GlcNAc...) Potential
Glycosylation10581N-linked (GlcNAc...) Potential
Disulfide bond198 ↔ 207 By similarity
Disulfide bond211 ↔ 223 By similarity
Disulfide bond231 ↔ 240 By similarity
Disulfide bond245 ↔ 256 By similarity
Disulfide bond249 ↔ 262 By similarity
Disulfide bond264 ↔ 273 By similarity
Disulfide bond276 ↔ 287 By similarity
Disulfide bond282 ↔ 293 By similarity
Disulfide bond295 ↔ 304 By similarity
Disulfide bond311 ↔ 323 By similarity
Disulfide bond317 ↔ 333 By similarity
Disulfide bond335 ↔ 344 By similarity
Disulfide bond351 ↔ 362 By similarity
Disulfide bond356 ↔ 371 By similarity
Disulfide bond373 ↔ 382 By similarity
Disulfide bond389 ↔ 400 By similarity
Disulfide bond394 ↔ 409 By similarity
Disulfide bond411 ↔ 420 By similarity
Disulfide bond427 ↔ 438 By similarity
Disulfide bond432 ↔ 447 By similarity
Disulfide bond449 ↔ 458 By similarity
Disulfide bond465 ↔ 475 By similarity
Disulfide bond469 ↔ 484 By similarity
Disulfide bond486 ↔ 495 By similarity
Disulfide bond502 ↔ 513 By similarity
Disulfide bond507 ↔ 522 By similarity
Disulfide bond524 ↔ 533 By similarity
Disulfide bond540 ↔ 551 By similarity
Disulfide bond545 ↔ 560 By similarity
Disulfide bond562 ↔ 571 By similarity
Disulfide bond589 ↔ 612 Potential
Disulfide bond606 ↔ 622 Potential
Disulfide bond624 ↔ 633 By similarity
Disulfide bond640 ↔ 651 By similarity
Disulfide bond645 ↔ 660 By similarity
Disulfide bond662 ↔ 671 By similarity
Disulfide bond678 ↔ 689 By similarity
Disulfide bond683 ↔ 698 By similarity
Disulfide bond700 ↔ 709 By similarity
Disulfide bond716 ↔ 727 By similarity
Disulfide bond721 ↔ 736 By similarity
Disulfide bond738 ↔ 747 By similarity
Disulfide bond755 ↔ 766 By similarity
Disulfide bond760 ↔ 775 By similarity
Disulfide bond777 ↔ 786 By similarity
Disulfide bond793 ↔ 804 By similarity
Disulfide bond798 ↔ 813 By similarity
Disulfide bond815 ↔ 824 By similarity
Disulfide bond831 ↔ 842 By similarity
Disulfide bond836 ↔ 851 By similarity
Disulfide bond853 ↔ 862 By similarity

Natural variations

Alternative sequence424 – 46138Missing in isoform Short.
VSP_001395
Natural variant5011E → K. Ref.1 Ref.2 Ref.3
Corresponds to variant rs1057744 [ dbSNP | Ensembl ].
VAR_028113
Natural variant5381D → N.
Corresponds to variant rs9972231 [ dbSNP | Ensembl ].
VAR_048986

Experimental info

Sequence conflict8 – 125RLPRR → AFPPA in AAB71189. Ref.1
Sequence conflict1191A → P in AAB71189. Ref.1
Sequence conflict1291L → F in AAB71189. Ref.1
Sequence conflict3841L → SA in CAA74706. Ref.4
Sequence conflict424 – 4263ANE → VND in AAB71189. Ref.1
Sequence conflict12351A → V in AAB61285. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified October 17, 2006. Version 3.
Checksum: 23B4FCD7D2891EF7

FASTA1,238133,367
        10         20         30         40         50         60 
MRAQGRGRLP RRLLLLLALW VQAARPMGYF ELQLSALRNV NGELLSGACC DGDGRTTRAG 

        70         80         90        100        110        120 
GCGHDECDTY VRVCLKEYQA KVTPTGPCSY GHGATPVLGG NSFYLPPAGA AGDRARARAR 

       130        140        150        160        170        180 
AGGDQDPGLV VIPFQFAWPR SFTLIVEAWD WDNDTTPNEE LLIERVSHAG MINPEDRWKS 

       190        200        210        220        230        240 
LHFSGHVAHL ELQIRVRCDE NYYSATCNKF CRPRNDFFGH YTCDQYGNKA CMDGWMGKEC 

       250        260        270        280        290        300 
KEAVCKQGCN LLHGGCTVPG ECRCSYGWQG RFCDECVPYP GCVHGSCVEP WQCNCETNWG 

       310        320        330        340        350        360 
GLLCDKDLNY CGSHHPCTNG GTCINAEPDQ YRCTCPDGYS GRNCEKAEHA CTSNPCANGG 

       370        380        390        400        410        420 
SCHEVPSGFE CHCPSGWSGP TCALDIDECA SNPCAAGGTC VDQVDGFECI CPEQWVGATC 

       430        440        450        460        470        480 
QLDANECEGK PCLNAFSCKN LIGGYYCDCI PGWKGINCHI NVNDCRGQCQ HGGTCKDLVN 

       490        500        510        520        530        540 
GYQCVCPRGF GGRHCELERD ECASSPCHSG GLCEDLADGF HCHCPQGFSG PLCEVDVDLC 

       550        560        570        580        590        600 
EPSPCRNGAR CYNLEGDYYC ACPDDFGGKN CSVPREPCPG GACRVIDGCG SDAGPGMPGT 

       610        620        630        640        650        660 
AASGVCGPHG RCVSQPGGNF SCICDSGFTG TYCHENIDDC LGQPCRNGGT CIDEVDAFRC 

       670        680        690        700        710        720 
FCPSGWEGEL CDTNPNDCLP DPCHSRGRCY DLVNDFYCAC DDGWKGKTCH SREFQCDAYT 

       730        740        750        760        770        780 
CSNGGTCYDS GDTFRCACPP GWKGSTCAVA KNSSCLPNPC VNGGTCVGSG ASFSCICRDG 

       790        800        810        820        830        840 
WEGRTCTHNT NDCNPLPCYN GGICVDGVNW FRCECAPGFA GPDCRINIDE CQSSPCAYGA 

       850        860        870        880        890        900 
TCVDEINGYR CSCPPGRAGP RCQEVIGFGR SCWSRGTPFP HGSSWVEDCN SCRCLDGRRD 

       910        920        930        940        950        960 
CSKVWCGWKP CLLAGQPEAL SAQCPLGQRC LEKAPGQCLR PPCEAWGECG AEEPPSTPCL 

       970        980        990       1000       1010       1020 
PRSGHLDNNC ARLTLHFNRD HVPQGTTVGA ICSGIRSLPA TRAVARDRLL VLLCDRASSG 

      1030       1040       1050       1060       1070       1080 
ASAVEVAVSF SPARDLPDSS LIQGAAHAIV AAITQRGNSS LLLAVTEVKV ETVVTGGSST 

      1090       1100       1110       1120       1130       1140 
GLLVPVLCGA FSVLWLACVV LCVWWTRKRR KERERSRLPR EESANNQWAP LNPIRNPIER 

      1150       1160       1170       1180       1190       1200 
PGGHKDVLYQ CKNFTPPPRR ADEALPGPAG HAAVREDEED EDLGRGEEDS LEAEKFLSHK 

      1210       1220       1230 
FTKDPGRSPG RPAHWASGPK VDNRAVRSIN EARYAGKE 

« Hide

Isoform Short (HJAG2.del-E6) [UniParc].

Checksum: C74AA0EE201D5FA7
Show »

FASTA1,200129,235

References

[1]"Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor."
Luo B., Aster J.C., Hasserjian R.P., Kuo F., Sklar J.
Mol. Cell. Biol. 17:6057-6067(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), VARIANT LYS-501.
[2]"Human ligands of the Notch receptor."
Gray G.E., Mann R.S., Mitsiadis E., Henrique D., Carcangiu M.-L., Banks A., Leiman J., Ward D., Ish-Horowitz D., Artavanis-Tsakonas S.
Am. J. Pathol. 154:785-794(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), VARIANT LYS-501.
Tissue: Fetal brain.
[3]"Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene."
Deng Y., Madan A., Banta A.B., Friedman C., Trask B.J., Hood L., Li L.
Genomics 63:133-138(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS LONG AND SHORT), VARIANT LYS-501.
Tissue: Bone marrow.
[4]"JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions."
Valsecchi C., Ghezzi C., Ballabio A., Rugarli E.I.
Mech. Dev. 69:203-207(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-1238 (ISOFORM LONG).
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF020201 mRNA. Translation: AAB71189.1.
AF003521 mRNA. Translation: AAB61285.1.
AF029778 mRNA. Translation: AAB84215.1.
AF029779 mRNA. Translation: AAB84216.1.
AF111170 Genomic DNA. Translation: AAD15562.1.
Y14330 mRNA. Translation: CAA74706.1.
CCDSCCDS9998.1. [Q9Y219-1]
CCDS9999.1. [Q9Y219-2]
RefSeqNP_002217.3. NM_002226.4. [Q9Y219-1]
NP_660142.1. NM_145159.2. [Q9Y219-2]
UniGeneHs.433445.

3D structure databases

ProteinModelPortalQ9Y219.
SMRQ9Y219. Positions 28-904, 942-971.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109918. 8 interactions.
IntActQ9Y219. 7 interactions.
MINTMINT-2822882.
STRING9606.ENSP00000328169.

PTM databases

PhosphoSiteQ9Y219.

Polymorphism databases

DMDM116242598.

Proteomic databases

MaxQBQ9Y219.
PaxDbQ9Y219.
PRIDEQ9Y219.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000331782; ENSP00000328169; ENSG00000184916. [Q9Y219-1]
ENST00000347004; ENSP00000328566; ENSG00000184916. [Q9Y219-2]
GeneID3714.
KEGGhsa:3714.
UCSCuc001yqf.4. human. [Q9Y219-1]
uc001yqh.4. human. [Q9Y219-2]

Organism-specific databases

CTD3714.
GeneCardsGC14M105607.
H-InvDBHIX0037647.
HGNCHGNC:6189. JAG2.
HPACAB025481.
HPA030636.
HPA050567.
MIM602570. gene.
neXtProtNX_Q9Y219.
PharmGKBPA29987.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000113124.
HOVERGENHBG031645.
InParanoidQ9Y219.
KOK06052.
OMAECDTYVR.
OrthoDBEOG7BKCSS.
PhylomeDBQ9Y219.
TreeFamTF351835.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_2001. Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor.
SignaLinkQ9Y219.

Gene expression databases

BgeeQ9Y219.
CleanExHS_JAG2.
GenevestigatorQ9Y219.

Family and domain databases

InterProIPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_C.
[Graphical view]
PfamPF01414. DSL. 1 hit.
PF00008. EGF. 9 hits.
PF07645. EGF_CA. 1 hit.
PF12661. hEGF. 2 hits.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSPR02059. JAGGEDFAMILY.
SMARTSM00051. DSL. 1 hit.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 9 hits.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 2 hits.
PROSITEPS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 16 hits.
PS01186. EGF_2. 12 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 8 hits.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiJAG2.
GenomeRNAi3714.
NextBio14557.
PMAP-CutDBQ9Y219.
PROQ9Y219.
SOURCESearch...

Entry information

Entry nameJAG2_HUMAN
AccessionPrimary (citable) accession number: Q9Y219
Secondary accession number(s): Q9UE17 expand/collapse secondary AC list , Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 149 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM