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Q9Y219

- JAG2_HUMAN

UniProt

Q9Y219 - JAG2_HUMAN

Protein

Protein jagged-2

Gene

JAG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 151 (01 Oct 2014)
      Sequence version 3 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development By similarity.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. growth factor activity Source: UniProtKB
    3. Notch binding Source: UniProtKB
    4. protein binding Source: IntAct

    GO - Biological processi

    1. auditory receptor cell fate commitment Source: UniProtKB
    2. cell cycle Source: UniProtKB
    3. cell differentiation Source: UniProtKB
    4. epithelial cell apoptotic process involved in palatal shelf morphogenesis Source: Ensembl
    5. gamma-delta T cell differentiation Source: Ensembl
    6. in utero embryonic development Source: Ensembl
    7. morphogenesis of embryonic epithelium Source: Ensembl
    8. Notch receptor processing Source: Reactome
    9. Notch signaling pathway Source: UniProtKB
    10. odontogenesis of dentin-containing tooth Source: Ensembl
    11. regulation of cell adhesion Source: Ensembl
    12. regulation of cell migration Source: UniProtKB
    13. regulation of cell proliferation Source: UniProtKB
    14. respiratory system process Source: Ensembl
    15. skeletal system development Source: Ensembl
    16. spermatogenesis Source: UniProtKB
    17. T cell differentiation Source: UniProtKB
    18. thymic T cell selection Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Notch signaling pathway

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
    REACT_118636. Signaling by NOTCH4.
    REACT_118862. Signaling by NOTCH3.
    REACT_160089. Constitutive Signaling by NOTCH1 HD Domain Mutants.
    REACT_160106. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
    REACT_160205. NOTCH2 Activation and Transmission of Signal to the Nucleus.
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    SignaLinkiQ9Y219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein jagged-2
    Short name:
    Jagged2
    Short name:
    hJ2
    Gene namesi
    Name:JAG2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:6189. JAG2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29987.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 12381215Protein jagged-2PRO_0000007629Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi198 ↔ 207By similarity
    Disulfide bondi211 ↔ 223By similarity
    Disulfide bondi231 ↔ 240By similarity
    Disulfide bondi245 ↔ 256By similarity
    Disulfide bondi249 ↔ 262By similarity
    Disulfide bondi264 ↔ 273By similarity
    Disulfide bondi276 ↔ 287By similarity
    Disulfide bondi282 ↔ 293By similarity
    Disulfide bondi295 ↔ 304By similarity
    Disulfide bondi311 ↔ 323By similarity
    Disulfide bondi317 ↔ 333By similarity
    Disulfide bondi335 ↔ 344By similarity
    Disulfide bondi351 ↔ 362By similarity
    Disulfide bondi356 ↔ 371By similarity
    Disulfide bondi373 ↔ 382By similarity
    Disulfide bondi389 ↔ 400By similarity
    Disulfide bondi394 ↔ 409By similarity
    Disulfide bondi411 ↔ 420By similarity
    Disulfide bondi427 ↔ 438By similarity
    Disulfide bondi432 ↔ 447By similarity
    Disulfide bondi449 ↔ 458By similarity
    Disulfide bondi465 ↔ 475By similarity
    Disulfide bondi469 ↔ 484By similarity
    Disulfide bondi486 ↔ 495By similarity
    Disulfide bondi502 ↔ 513By similarity
    Disulfide bondi507 ↔ 522By similarity
    Disulfide bondi524 ↔ 533By similarity
    Disulfide bondi540 ↔ 551By similarity
    Disulfide bondi545 ↔ 560By similarity
    Disulfide bondi562 ↔ 571By similarity
    Glycosylationi570 – 5701N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi589 ↔ 612Sequence Analysis
    Disulfide bondi606 ↔ 622Sequence Analysis
    Glycosylationi619 – 6191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi624 ↔ 633By similarity
    Disulfide bondi640 ↔ 651By similarity
    Disulfide bondi645 ↔ 660By similarity
    Disulfide bondi662 ↔ 671By similarity
    Disulfide bondi678 ↔ 689By similarity
    Disulfide bondi683 ↔ 698By similarity
    Disulfide bondi700 ↔ 709By similarity
    Disulfide bondi716 ↔ 727By similarity
    Disulfide bondi721 ↔ 736By similarity
    Disulfide bondi738 ↔ 747By similarity
    Glycosylationi752 – 7521N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi755 ↔ 766By similarity
    Disulfide bondi760 ↔ 775By similarity
    Disulfide bondi777 ↔ 786By similarity
    Disulfide bondi793 ↔ 804By similarity
    Disulfide bondi798 ↔ 813By similarity
    Disulfide bondi815 ↔ 824By similarity
    Disulfide bondi831 ↔ 842By similarity
    Disulfide bondi836 ↔ 851By similarity
    Disulfide bondi853 ↔ 862By similarity
    Glycosylationi1058 – 10581N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9Y219.
    PaxDbiQ9Y219.
    PRIDEiQ9Y219.

    PTM databases

    PhosphoSiteiQ9Y219.

    Miscellaneous databases

    PMAP-CutDBQ9Y219.

    Expressioni

    Tissue specificityi

    Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney.

    Gene expression databases

    BgeeiQ9Y219.
    CleanExiHS_JAG2.
    GenevestigatoriQ9Y219.

    Organism-specific databases

    HPAiCAB025481.
    HPA030636.
    HPA050567.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GFI1BQ5VTD92EBI-946223,EBI-946212

    Protein-protein interaction databases

    BioGridi109918. 8 interactions.
    IntActiQ9Y219. 7 interactions.
    MINTiMINT-2822882.
    STRINGi9606.ENSP00000328169.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y219.
    SMRiQ9Y219. Positions 28-904, 942-971.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 10801054ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1102 – 1238137CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1081 – 110121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini196 – 24045DSLPROSITE-ProRule annotationAdd
    BLAST
    Domaini241 – 27434EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini275 – 30531EGF-like 2; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Domaini307 – 34539EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini347 – 38337EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini385 – 42137EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini423 – 45937EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini461 – 49636EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini498 – 53437EGF-like 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini536 – 57237EGF-like 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini574 – 63461EGF-like 10; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Domaini636 – 67237EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini674 – 71037EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini712 – 74837EGF-like 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini751 – 78737EGF-like 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini789 – 82537EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini827 – 86337EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini870 – 94475VWFCPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DSL domain.PROSITE-ProRule annotation
    Contains 16 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000113124.
    HOVERGENiHBG031645.
    InParanoidiQ9Y219.
    KOiK06052.
    OMAiECDTYVR.
    OrthoDBiEOG7BKCSS.
    PhylomeDBiQ9Y219.
    TreeFamiTF351835.

    Family and domain databases

    InterProiIPR001774. DSL.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR026219. Jagged/Serrate.
    IPR011651. Notch_ligand_N.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF01414. DSL. 1 hit.
    PF00008. EGF. 9 hits.
    PF07645. EGF_CA. 1 hit.
    PF12661. hEGF. 2 hits.
    PF07657. MNNL. 1 hit.
    [Graphical view]
    PRINTSiPR02059. JAGGEDFAMILY.
    SMARTiSM00051. DSL. 1 hit.
    SM00181. EGF. 6 hits.
    SM00179. EGF_CA. 9 hits.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 2 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
    PS51051. DSL. 1 hit.
    PS00022. EGF_1. 16 hits.
    PS01186. EGF_2. 12 hits.
    PS50026. EGF_3. 15 hits.
    PS01187. EGF_CA. 8 hits.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: Q9Y219-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRAQGRGRLP RRLLLLLALW VQAARPMGYF ELQLSALRNV NGELLSGACC     50
    DGDGRTTRAG GCGHDECDTY VRVCLKEYQA KVTPTGPCSY GHGATPVLGG 100
    NSFYLPPAGA AGDRARARAR AGGDQDPGLV VIPFQFAWPR SFTLIVEAWD 150
    WDNDTTPNEE LLIERVSHAG MINPEDRWKS LHFSGHVAHL ELQIRVRCDE 200
    NYYSATCNKF CRPRNDFFGH YTCDQYGNKA CMDGWMGKEC KEAVCKQGCN 250
    LLHGGCTVPG ECRCSYGWQG RFCDECVPYP GCVHGSCVEP WQCNCETNWG 300
    GLLCDKDLNY CGSHHPCTNG GTCINAEPDQ YRCTCPDGYS GRNCEKAEHA 350
    CTSNPCANGG SCHEVPSGFE CHCPSGWSGP TCALDIDECA SNPCAAGGTC 400
    VDQVDGFECI CPEQWVGATC QLDANECEGK PCLNAFSCKN LIGGYYCDCI 450
    PGWKGINCHI NVNDCRGQCQ HGGTCKDLVN GYQCVCPRGF GGRHCELERD 500
    ECASSPCHSG GLCEDLADGF HCHCPQGFSG PLCEVDVDLC EPSPCRNGAR 550
    CYNLEGDYYC ACPDDFGGKN CSVPREPCPG GACRVIDGCG SDAGPGMPGT 600
    AASGVCGPHG RCVSQPGGNF SCICDSGFTG TYCHENIDDC LGQPCRNGGT 650
    CIDEVDAFRC FCPSGWEGEL CDTNPNDCLP DPCHSRGRCY DLVNDFYCAC 700
    DDGWKGKTCH SREFQCDAYT CSNGGTCYDS GDTFRCACPP GWKGSTCAVA 750
    KNSSCLPNPC VNGGTCVGSG ASFSCICRDG WEGRTCTHNT NDCNPLPCYN 800
    GGICVDGVNW FRCECAPGFA GPDCRINIDE CQSSPCAYGA TCVDEINGYR 850
    CSCPPGRAGP RCQEVIGFGR SCWSRGTPFP HGSSWVEDCN SCRCLDGRRD 900
    CSKVWCGWKP CLLAGQPEAL SAQCPLGQRC LEKAPGQCLR PPCEAWGECG 950
    AEEPPSTPCL PRSGHLDNNC ARLTLHFNRD HVPQGTTVGA ICSGIRSLPA 1000
    TRAVARDRLL VLLCDRASSG ASAVEVAVSF SPARDLPDSS LIQGAAHAIV 1050
    AAITQRGNSS LLLAVTEVKV ETVVTGGSST GLLVPVLCGA FSVLWLACVV 1100
    LCVWWTRKRR KERERSRLPR EESANNQWAP LNPIRNPIER PGGHKDVLYQ 1150
    CKNFTPPPRR ADEALPGPAG HAAVREDEED EDLGRGEEDS LEAEKFLSHK 1200
    FTKDPGRSPG RPAHWASGPK VDNRAVRSIN EARYAGKE 1238
    Length:1,238
    Mass (Da):133,367
    Last modified:October 17, 2006 - v3
    Checksum:i23B4FCD7D2891EF7
    GO
    Isoform Short (identifier: Q9Y219-2) [UniParc]FASTAAdd to Basket

    Also known as: HJAG2.del-E6

    The sequence of this isoform differs from the canonical sequence as follows:
         424-461: Missing.

    Show »
    Length:1,200
    Mass (Da):129,235
    Checksum:iC74AA0EE201D5FA7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 125RLPRR → AFPPA in AAB71189. (PubMed:9315665)Curated
    Sequence conflicti119 – 1191A → P in AAB71189. (PubMed:9315665)Curated
    Sequence conflicti129 – 1291L → F in AAB71189. (PubMed:9315665)Curated
    Sequence conflicti384 – 3841L → SA in CAA74706. (PubMed:9486542)Curated
    Sequence conflicti424 – 4263ANE → VND in AAB71189. (PubMed:9315665)Curated
    Sequence conflicti1235 – 12351A → V in AAB61285. (PubMed:10079256)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti501 – 5011E → K.3 Publications
    Corresponds to variant rs1057744 [ dbSNP | Ensembl ].
    VAR_028113
    Natural varianti538 – 5381D → N.
    Corresponds to variant rs9972231 [ dbSNP | Ensembl ].
    VAR_048986

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei424 – 46138Missing in isoform Short. 1 PublicationVSP_001395Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF020201 mRNA. Translation: AAB71189.1.
    AF003521 mRNA. Translation: AAB61285.1.
    AF029778 mRNA. Translation: AAB84215.1.
    AF029779 mRNA. Translation: AAB84216.1.
    AF111170 Genomic DNA. Translation: AAD15562.1.
    Y14330 mRNA. Translation: CAA74706.1.
    CCDSiCCDS9998.1. [Q9Y219-1]
    CCDS9999.1. [Q9Y219-2]
    RefSeqiNP_002217.3. NM_002226.4. [Q9Y219-1]
    NP_660142.1. NM_145159.2. [Q9Y219-2]
    UniGeneiHs.433445.

    Genome annotation databases

    EnsembliENST00000331782; ENSP00000328169; ENSG00000184916. [Q9Y219-1]
    ENST00000347004; ENSP00000328566; ENSG00000184916. [Q9Y219-2]
    GeneIDi3714.
    KEGGihsa:3714.
    UCSCiuc001yqf.4. human. [Q9Y219-1]
    uc001yqh.4. human. [Q9Y219-2]

    Polymorphism databases

    DMDMi116242598.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF020201 mRNA. Translation: AAB71189.1 .
    AF003521 mRNA. Translation: AAB61285.1 .
    AF029778 mRNA. Translation: AAB84215.1 .
    AF029779 mRNA. Translation: AAB84216.1 .
    AF111170 Genomic DNA. Translation: AAD15562.1 .
    Y14330 mRNA. Translation: CAA74706.1 .
    CCDSi CCDS9998.1. [Q9Y219-1 ]
    CCDS9999.1. [Q9Y219-2 ]
    RefSeqi NP_002217.3. NM_002226.4. [Q9Y219-1 ]
    NP_660142.1. NM_145159.2. [Q9Y219-2 ]
    UniGenei Hs.433445.

    3D structure databases

    ProteinModelPortali Q9Y219.
    SMRi Q9Y219. Positions 28-904, 942-971.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109918. 8 interactions.
    IntActi Q9Y219. 7 interactions.
    MINTi MINT-2822882.
    STRINGi 9606.ENSP00000328169.

    PTM databases

    PhosphoSitei Q9Y219.

    Polymorphism databases

    DMDMi 116242598.

    Proteomic databases

    MaxQBi Q9Y219.
    PaxDbi Q9Y219.
    PRIDEi Q9Y219.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000331782 ; ENSP00000328169 ; ENSG00000184916 . [Q9Y219-1 ]
    ENST00000347004 ; ENSP00000328566 ; ENSG00000184916 . [Q9Y219-2 ]
    GeneIDi 3714.
    KEGGi hsa:3714.
    UCSCi uc001yqf.4. human. [Q9Y219-1 ]
    uc001yqh.4. human. [Q9Y219-2 ]

    Organism-specific databases

    CTDi 3714.
    GeneCardsi GC14M105607.
    H-InvDB HIX0037647.
    HGNCi HGNC:6189. JAG2.
    HPAi CAB025481.
    HPA030636.
    HPA050567.
    MIMi 602570. gene.
    neXtProti NX_Q9Y219.
    PharmGKBi PA29987.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000113124.
    HOVERGENi HBG031645.
    InParanoidi Q9Y219.
    KOi K06052.
    OMAi ECDTYVR.
    OrthoDBi EOG7BKCSS.
    PhylomeDBi Q9Y219.
    TreeFami TF351835.

    Enzyme and pathway databases

    Reactomei REACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
    REACT_118636. Signaling by NOTCH4.
    REACT_118862. Signaling by NOTCH3.
    REACT_160089. Constitutive Signaling by NOTCH1 HD Domain Mutants.
    REACT_160106. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
    REACT_160205. NOTCH2 Activation and Transmission of Signal to the Nucleus.
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    SignaLinki Q9Y219.

    Miscellaneous databases

    GeneWikii JAG2.
    GenomeRNAii 3714.
    NextBioi 14557.
    PMAP-CutDB Q9Y219.
    PROi Q9Y219.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y219.
    CleanExi HS_JAG2.
    Genevestigatori Q9Y219.

    Family and domain databases

    InterProi IPR001774. DSL.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR026219. Jagged/Serrate.
    IPR011651. Notch_ligand_N.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF01414. DSL. 1 hit.
    PF00008. EGF. 9 hits.
    PF07645. EGF_CA. 1 hit.
    PF12661. hEGF. 2 hits.
    PF07657. MNNL. 1 hit.
    [Graphical view ]
    PRINTSi PR02059. JAGGEDFAMILY.
    SMARTi SM00051. DSL. 1 hit.
    SM00181. EGF. 6 hits.
    SM00179. EGF_CA. 9 hits.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 2 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 10 hits.
    PS51051. DSL. 1 hit.
    PS00022. EGF_1. 16 hits.
    PS01186. EGF_2. 12 hits.
    PS50026. EGF_3. 15 hits.
    PS01187. EGF_CA. 8 hits.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor."
      Luo B., Aster J.C., Hasserjian R.P., Kuo F., Sklar J.
      Mol. Cell. Biol. 17:6057-6067(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), VARIANT LYS-501.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), VARIANT LYS-501.
      Tissue: Fetal brain.
    3. "Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene."
      Deng Y., Madan A., Banta A.B., Friedman C., Trask B.J., Hood L., Li L.
      Genomics 63:133-138(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS LONG AND SHORT), VARIANT LYS-501.
      Tissue: Bone marrow.
    4. "JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions."
      Valsecchi C., Ghezzi C., Ballabio A., Rugarli E.I.
      Mech. Dev. 69:203-207(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-1238 (ISOFORM LONG).
      Tissue: Heart.

    Entry informationi

    Entry nameiJAG2_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y219
    Secondary accession number(s): Q9UE17
    , Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 151 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

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