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Q9Y217

- MTMR6_HUMAN

UniProt

Q9Y217 - MTMR6_HUMAN

Protein

Myotubularin-related protein 6

Gene

MTMR6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei336 – 3361Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei382 – 3821SubstrateBy similarity

    GO - Molecular functioni

    1. calcium-activated potassium channel activity Source: UniProtKB
    2. protein serine/threonine phosphatase activity Source: UniProtKB
    3. protein tyrosine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. peptidyl-tyrosine dephosphorylation Source: GOC
    2. phosphatidylinositol biosynthetic process Source: Reactome
    3. phospholipid metabolic process Source: Reactome
    4. potassium ion transmembrane transport Source: GOC
    5. protein dephosphorylation Source: UniProtKB
    6. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    ReactomeiREACT_121025. Synthesis of PIPs at the plasma membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myotubularin-related protein 6 (EC:3.1.3.-)
    Gene namesi
    Name:MTMR6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:7453. MTMR6.

    Subcellular locationi

    Nucleus envelope 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: LIFEdb
    2. cytosol Source: Reactome
    3. nuclear envelope Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31256.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 621621Myotubularin-related protein 6PRO_0000094939Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei108 – 1081PhosphotyrosineBy similarity
    Modified residuei561 – 5611Phosphoserine1 Publication
    Modified residuei589 – 5891Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y217.
    PaxDbiQ9Y217.
    PRIDEiQ9Y217.

    PTM databases

    PhosphoSiteiQ9Y217.

    Expressioni

    Tissue specificityi

    Expressed in CD4+ T-cells.1 Publication

    Gene expression databases

    ArrayExpressiQ9Y217.
    BgeeiQ9Y217.
    CleanExiHS_MTMR6.
    GenevestigatoriQ9Y217.

    Organism-specific databases

    HPAiHPA034778.

    Interactioni

    Subunit structurei

    Interacts with ALKBH4, KCNN4, MTMR7, MTMR8 and MTMR9.4 Publications

    Protein-protein interaction databases

    BioGridi114558. 5 interactions.
    IntActiQ9Y217. 3 interactions.
    MINTiMINT-2822863.
    STRINGi9606.ENSP00000371221.

    Structurei

    Secondary structure

    1
    621
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 117
    Beta strandi26 – 316
    Beta strandi33 – 4311
    Beta strandi45 – 495
    Helixi50 – 523
    Beta strandi53 – 586
    Beta strandi65 – 728
    Beta strandi77 – 837
    Helixi85 – 9814
    Helixi108 – 1103
    Helixi119 – 1257
    Helixi130 – 1367
    Beta strandi140 – 1478
    Helixi148 – 1503
    Beta strandi157 – 1593
    Beta strandi161 – 1699
    Helixi171 – 18010
    Helixi182 – 1843
    Beta strandi188 – 1925
    Turni194 – 1963
    Beta strandi199 – 2024
    Helixi215 – 22713
    Beta strandi234 – 2385
    Turni258 – 2603
    Beta strandi264 – 2685
    Helixi274 – 28815
    Helixi295 – 30410
    Helixi307 – 32620
    Beta strandi332 – 3343
    Turni336 – 3383
    Beta strandi339 – 3413
    Helixi342 – 35413
    Helixi357 – 3593
    Helixi361 – 37111
    Turni372 – 3765
    Helixi379 – 3835
    Beta strandi385 – 3873
    Helixi390 – 3923
    Helixi396 – 41015
    Turni412 – 4143
    Helixi419 – 42911
    Turni430 – 4323
    Beta strandi439 – 4413
    Helixi442 – 4476
    Helixi450 – 4534
    Helixi458 – 4614
    Helixi465 – 4684
    Beta strandi488 – 4914
    Helixi496 – 5027

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YF0X-ray2.65A1-505[»]
    ProteinModelPortaliQ9Y217.
    SMRiQ9Y217. Positions 4-505.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini124 – 499376Myotubularin phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni248 – 2514Substrate bindingBy similarity
    Regioni273 – 2742Substrate bindingBy similarity
    Regioni336 – 3427Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG322789.
    HOVERGENiHBG000220.
    InParanoidiQ9Y217.
    KOiK18083.
    OMAiVFNIIMN.
    OrthoDBiEOG71RXJC.
    PhylomeDBiQ9Y217.
    TreeFamiTF315197.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR010569. Myotubularin-like_Pase_dom.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PfamiPF06602. Myotub-related. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y217-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEHIRTTKVE QVKLLDRFST SNKSLTGTLY LTATHLLFID SHQKETWILH    50
    HHIASVEKLA LTTSGCPLVI QCKNFRTVHF IVPRERDCHD IYNSLLQLSK 100
    QAKYEDLYAF SYNPKQNDSE RLQGWQLIDL AEEYKRMGVP NSHWQLSDAN 150
    RDYKICETYP RELYVPRIAS KPIIVGSSKF RSKGRFPVLS YYHQDKEAAI 200
    CRCSQPLSGF SARCLEDEHL LQAISKANPV NRYMYVMDTR PKLNAMANRA 250
    AGKGYENEDN YSNIRFQFVG IENIHVMRSS LQKLLEVNGT KGLSVNDFYS 300
    GLESSGWLRH IKAVMDAAIF LAKAITVENA SVLVHCSDGW DRTSQVCSLG 350
    SLLLDSYYRT IKGFMVLIEK DWISFGHKFS ERCGQLDGDP KEVSPVFTQF 400
    LECVWHLTEQ FPQAFEFSEA FLLQIHEHIH SCQFGNFLGN CQKEREELKL 450
    KEKTYSLWPF LLEDQKKYLN PLYSSESHRF TVLEPNTVSF NFKFWRNMYH 500
    QFDRTLHPRQ SVFNIIMNMN EQNKQLEKDI KDLESKIKQR KNKQTDGILT 550
    KELLHSVHPE SPNLKTSLCF KEQTLLPVND ALRTIEGSSP ADNRYSEYAE 600
    EFSKSEPAVV SLEYGVARMT C 621
    Length:621
    Mass (Da):71,968
    Last modified:January 11, 2011 - v3
    Checksum:i1F34608F99DCEA39
    GO
    Isoform 2 (identifier: Q9Y217-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         536-548: KIKQRKNKQTDGI → LTSYSSFKIIVGQ
         549-621: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:548
    Mass (Da):63,743
    Checksum:i161703C7D46CBD88
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti89 – 891H → R in CAD89918. (PubMed:17974005)Curated
    Sequence conflicti114 – 1141P → S in BAG37162. (PubMed:14702039)Curated
    Sequence conflicti125 – 1251W → R in CAD89918. (PubMed:17974005)Curated
    Sequence conflicti333 – 3331L → S in AAL01037. 1 PublicationCurated
    Sequence conflicti333 – 3331L → S in AAC78841. (PubMed:9736772)Curated
    Sequence conflicti368 – 3681I → T in BAG37162. (PubMed:14702039)Curated
    Sequence conflicti430 – 4301H → D in BAG52676. (PubMed:14702039)Curated
    Sequence conflicti442 – 4421Q → P in AAL01037. 1 PublicationCurated
    Sequence conflicti442 – 4421Q → P in AAC78841. (PubMed:9736772)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti131 – 1311A → T.
    Corresponds to variant rs34885345 [ dbSNP | Ensembl ].
    VAR_057143
    Natural varianti319 – 3191I → V.5 Publications
    Corresponds to variant rs7995033 [ dbSNP | Ensembl ].
    VAR_024583

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei536 – 54813KIKQR…QTDGI → LTSYSSFKIIVGQ in isoform 2. 1 PublicationVSP_036614Add
    BLAST
    Alternative sequencei549 – 62173Missing in isoform 2. 1 PublicationVSP_036615Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF406619 mRNA. Translation: AAL01037.1.
    AK093237 mRNA. Translation: BAG52676.1.
    AK314587 mRNA. Translation: BAG37162.1.
    AL832017 mRNA. Translation: CAD89918.1.
    AL590787 Genomic DNA. Translation: CAI39897.1.
    BC040012 mRNA. Translation: AAH40012.1.
    AF072928 mRNA. Translation: AAC78841.1.
    CCDSiCCDS9313.1. [Q9Y217-1]
    RefSeqiNP_004676.3. NM_004685.3. [Q9Y217-1]
    UniGeneiHs.643702.

    Genome annotation databases

    EnsembliENST00000381801; ENSP00000371221; ENSG00000139505. [Q9Y217-1]
    GeneIDi9107.
    KEGGihsa:9107.
    UCSCiuc001uqe.1. human. [Q9Y217-2]
    uc001uqf.4. human. [Q9Y217-1]

    Polymorphism databases

    DMDMi317373414.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF406619 mRNA. Translation: AAL01037.1 .
    AK093237 mRNA. Translation: BAG52676.1 .
    AK314587 mRNA. Translation: BAG37162.1 .
    AL832017 mRNA. Translation: CAD89918.1 .
    AL590787 Genomic DNA. Translation: CAI39897.1 .
    BC040012 mRNA. Translation: AAH40012.1 .
    AF072928 mRNA. Translation: AAC78841.1 .
    CCDSi CCDS9313.1. [Q9Y217-1 ]
    RefSeqi NP_004676.3. NM_004685.3. [Q9Y217-1 ]
    UniGenei Hs.643702.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YF0 X-ray 2.65 A 1-505 [» ]
    ProteinModelPortali Q9Y217.
    SMRi Q9Y217. Positions 4-505.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114558. 5 interactions.
    IntActi Q9Y217. 3 interactions.
    MINTi MINT-2822863.
    STRINGi 9606.ENSP00000371221.

    PTM databases

    PhosphoSitei Q9Y217.

    Polymorphism databases

    DMDMi 317373414.

    Proteomic databases

    MaxQBi Q9Y217.
    PaxDbi Q9Y217.
    PRIDEi Q9Y217.

    Protocols and materials databases

    DNASUi 9107.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381801 ; ENSP00000371221 ; ENSG00000139505 . [Q9Y217-1 ]
    GeneIDi 9107.
    KEGGi hsa:9107.
    UCSCi uc001uqe.1. human. [Q9Y217-2 ]
    uc001uqf.4. human. [Q9Y217-1 ]

    Organism-specific databases

    CTDi 9107.
    GeneCardsi GC13M025820.
    H-InvDB HIX0011183.
    HIX0171878.
    HGNCi HGNC:7453. MTMR6.
    HPAi HPA034778.
    MIMi 603561. gene.
    neXtProti NX_Q9Y217.
    PharmGKBi PA31256.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG322789.
    HOVERGENi HBG000220.
    InParanoidi Q9Y217.
    KOi K18083.
    OMAi VFNIIMN.
    OrthoDBi EOG71RXJC.
    PhylomeDBi Q9Y217.
    TreeFami TF315197.

    Enzyme and pathway databases

    Reactomei REACT_121025. Synthesis of PIPs at the plasma membrane.

    Miscellaneous databases

    GeneWikii MTMR6.
    GenomeRNAii 9107.
    NextBioi 34137.
    PROi Q9Y217.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y217.
    Bgeei Q9Y217.
    CleanExi HS_MTMR6.
    Genevestigatori Q9Y217.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR010569. Myotubularin-like_Pase_dom.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    Pfami PF06602. Myotub-related. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9."
      Mochizuki Y., Majerus P.W.
      Proc. Natl. Acad. Sci. U.S.A. 100:9768-9773(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH MTMR9.
    2. Hong W.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-319.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-319.
      Tissue: Testis and Trachea.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-319.
      Tissue: Skeletal muscle.
    5. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-319.
      Tissue: Eye.
    7. "Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human."
      Laporte J., Blondeau F., Buj-Bello A., Tentler D., Kretz C., Dahl N., Mandel J.-L.
      Hum. Mol. Genet. 7:1703-1712(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 157-621 (ISOFORM 1), VARIANT VAL-319.
    8. "The phosphatidylinositol 3-phosphate phosphatase myotubularin-related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1."
      Srivastava S., Li Z., Lin L., Liu G., Ko K., Coetzee W.A., Skolnik E.Y.
      Mol. Cell. Biol. 25:3630-3638(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH KCNN4.
    9. "Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions."
      Lorenzo O., Urbe S., Clague M.J.
      J. Cell Sci. 119:2953-2959(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH MTMR7; MTMR8 AND MTMR9.
    10. "Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells."
      Srivastava S., Ko K., Choudhury P., Li Z., Johnson A.K., Nadkarni V., Unutmaz D., Coetzee W.A., Skolnik E.Y.
      Mol. Cell. Biol. 26:5595-5602(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-561 AND SER-589, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Human ALKBH4 interacts with proteins associated with transcription."
      Bjornstad L.G., Meza T.J., Otterlei M., Olafsrud S.M., Meza-Zepeda L.A., Falnes P.O.
      PLoS ONE 7:E49045-E49045(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ALKBH4.

    Entry informationi

    Entry nameiMTMR6_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y217
    Secondary accession number(s): B2RBB5
    , B3KSB4, Q5JRG6, Q86TB7, Q86YH4, Q96P80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 133 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

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