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Protein

Short transient receptor potential channel 6

Gene

TRPC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.

GO - Molecular functioni

  1. inositol 1,4,5 trisphosphate binding Source: BHF-UCL
  2. store-operated calcium channel activity Source: GO_Central

GO - Biological processi

  1. aging Source: Ensembl
  2. axon guidance Source: Reactome
  3. blood coagulation Source: Reactome
  4. calcium ion transmembrane transport Source: GO_Central
  5. cation transport Source: ProtInc
  6. cellular response to hydrogen peroxide Source: Ensembl
  7. cellular response to hypoxia Source: Ensembl
  8. cytosolic calcium ion homeostasis Source: GO_Central
  9. ion transmembrane transport Source: Reactome
  10. manganese ion transport Source: GO_Central
  11. platelet activation Source: Reactome
  12. positive regulation of calcium ion transport Source: MGI
  13. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  14. positive regulation of ion transmembrane transporter activity Source: MGI
  15. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_162. Elevation of cytosolic Ca2+ levels.
REACT_169333. TRP channels.
REACT_2202. Effects of PIP2 hydrolysis.
REACT_22228. Role of second messengers in netrin-1 signaling.

Protein family/group databases

TCDBi1.A.4.1.5. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 6
Short name:
TrpC6
Alternative name(s):
Transient receptor protein 6
Short name:
TRP-6
Gene namesi
Name:TRPC6
Synonyms:TRP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:12338. TRPC6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 438438CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei439 – 45921HelicalSequence AnalysisAdd
BLAST
Topological domaini460 – 48728ExtracellularSequence AnalysisAdd
BLAST
Transmembranei488 – 50821HelicalSequence AnalysisAdd
BLAST
Topological domaini509 – 52113CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei522 – 54221HelicalSequence AnalysisAdd
BLAST
Topological domaini543 – 59250ExtracellularSequence AnalysisAdd
BLAST
Transmembranei593 – 61321HelicalSequence AnalysisAdd
BLAST
Topological domaini614 – 63623CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei637 – 65721HelicalSequence AnalysisAdd
BLAST
Topological domaini658 – 70649ExtracellularSequence AnalysisAdd
BLAST
Transmembranei707 – 72721HelicalSequence AnalysisAdd
BLAST
Topological domaini728 – 931204CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. integral component of plasma membrane Source: GO_Central
  3. membrane Source: UniProtKB
  4. plasma membrane Source: MGI
  5. slit diaphragm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Focal segmental glomerulosclerosis 2 (FSGS2)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.

See also OMIM:603965
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti112 – 1121P → Q in FSGS2. 1 Publication
VAR_026730
Natural varianti143 – 1431N → S in FSGS2. 1 Publication
Corresponds to variant rs121434391 [ dbSNP | Ensembl ].
VAR_026731
Natural varianti218 – 2181H → L in FSGS2. 1 Publication
VAR_067248
Natural varianti270 – 2701S → T in FSGS2. 1 Publication
VAR_026732
Natural varianti895 – 8951R → C in FSGS2. 1 Publication
VAR_026733
Natural varianti897 – 8971E → K in FSGS2. 1 Publication
VAR_026734

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi125 – 1251N → A: No effect on RNF24-binding; when associated with A-127; A-128 and A-130. 1 Publication
Mutagenesisi127 – 1271N → A: No effect on RNF24-binding; when associated with A-125; A-128 and A-130. 1 Publication
Mutagenesisi128 – 1281C → A: No effect on RNF24-binding; when associated with A-125; A-127 and A-130. 1 Publication
Mutagenesisi130 – 1301D → A: No effect on RNF24-binding; when associated with A-125; A-127 and A-128. 1 Publication
Mutagenesisi561 – 5611N → Q: Constitutively activates channel. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi603965. phenotype.
Orphaneti93213. Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis.
PharmGKBiPA37011.

Polymorphism and mutation databases

BioMutaiTRPC6.
DMDMi6686048.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 931931Short transient receptor potential channel 6PRO_0000215322Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi473 – 4731N-linked (GlcNAc...)1 Publication
Glycosylationi561 – 5611N-linked (GlcNAc...)1 Publication
Modified residuei815 – 8151Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated by FYN, leading to an increase of TRPC6 channel activity.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9Y210.
PRIDEiQ9Y210.

PTM databases

PhosphoSiteiQ9Y210.

Expressioni

Tissue specificityi

Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.1 Publication

Gene expression databases

BgeeiQ9Y210.
CleanExiHS_TRPC6.
ExpressionAtlasiQ9Y210. baseline and differential.
GenevestigatoriQ9Y210.

Organism-specific databases

HPAiHPA045098.

Interactioni

Subunit structurei

Interacts with MX1 and RNF24.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MX1P205914EBI-929362,EBI-929476

Protein-protein interaction databases

BioGridi113076. 12 interactions.
IntActiQ9Y210. 2 interactions.
STRINGi9606.ENSP00000340913.

Structurei

3D structure databases

ProteinModelPortaliQ9Y210.
SMRiQ9Y210. Positions 100-254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati97 – 12630ANK 1Add
BLAST
Repeati132 – 16130ANK 2Add
BLAST
Repeati163 – 18927ANK 3Add
BLAST
Repeati218 – 24730ANK 4Add
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG254238.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000020590.
HOVERGENiHBG068337.
InParanoidiQ9Y210.
KOiK04969.
OMAiCSECNQK.
OrthoDBiEOG77HDD1.
PhylomeDBiQ9Y210.
TreeFamiTF313147.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005462. TRPC6_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF7. PTHR10117:SF7. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01647. TRPCHANNEL6.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y210-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQSPAFGPR RGSSPRGAAG AAARRNESQD YLLMDSELGE DGCPQAPLPC
60 70 80 90 100
YGYYPCFRGS DNRLAHRRQT VLREKGRRLA NRGPAYMFSD RSTSLSIEEE
110 120 130 140 150
RFLDAAEYGN IPVVRKMLEE CHSLNVNCVD YMGQNALQLA VANEHLEITE
160 170 180 190 200
LLLKKENLSR VGDALLLAIS KGYVRIVEAI LSHPAFAEGK RLATSPSQSE
210 220 230 240 250
LQQDDFYAYD EDGTRFSHDV TPIILAAHCQ EYEIVHTLLR KGARIERPHD
260 270 280 290 300
YFCKCNDCNQ KQKHDSFSHS RSRINAYKGL ASPAYLSLSS EDPVMTALEL
310 320 330 340 350
SNELAVLANI EKEFKNDYKK LSMQCKDFVV GLLDLCRNTE EVEAILNGDV
360 370 380 390 400
ETLQSGDHGR PNLSRLKLAI KYEVKKFVAH PNCQQQLLSI WYENLSGLRQ
410 420 430 440 450
QTMAVKFLVV LAVAIGLPFL ALIYWFAPCS KMGKIMRGPF MKFVAHAASF
460 470 480 490 500
TIFLGLLVMN AADRFEGTKL LPNETSTDNA KQLFRMKTSC FSWMEMLIIS
510 520 530 540 550
WVIGMIWAEC KEIWTQGPKE YLFELWNMLD FGMLAIFAAS FIARFMAFWH
560 570 580 590 600
ASKAQSIIDA NDTLKDLTKV TLGDNVKYYN LARIKWDPSD PQIISEGLYA
610 620 630 640 650
IAVVLSFSRI AYILPANESF GPLQISLGRT VKDIFKFMVI FIMVFVAFMI
660 670 680 690 700
GMFNLYSYYI GAKQNEAFTT VEESFKTLFW AIFGLSEVKS VVINYNHKFI
710 720 730 740 750
ENIGYVLYGV YNVTMVIVLL NMLIAMINSS FQEIEDDADV EWKFARAKLW
760 770 780 790 800
FSYFEEGRTL PVPFNLVPSP KSLFYLLLKL KKWISELFQG HKKGFQEDAE
810 820 830 840 850
MNKINEEKKL GILGSHEDLS KLSLDKKQVG HNKQPSIRSS EDFHLNSFNN
860 870 880 890 900
PPRQYQKIMK RLIKRYVLQA QIDKESDEVN EGELKEIKQD ISSLRYELLE
910 920 930
EKSQNTEDLA ELIRELGEKL SMEPNQEETN R
Length:931
Mass (Da):106,326
Last modified:November 1, 1999 - v1
Checksum:i7C955C2B0389AC47
GO
Isoform 2 (identifier: Q9Y210-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     316-431: Missing.

Show »
Length:815
Mass (Da):93,187
Checksum:i2E78B50F956CBF0D
GO
Isoform 3 (identifier: Q9Y210-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     377-431: Missing.

Show »
Length:876
Mass (Da):100,106
Checksum:i8A1F52196619E147
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti336 – 3361C → R in CAC01686 (PubMed:10816590).Curated
Sequence conflicti585 – 5851K → R in CAC06090 (Ref. 5) Curated
Sequence conflicti613 – 6131I → T in CAC01686 (PubMed:10816590).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti112 – 1121P → Q in FSGS2. 1 Publication
VAR_026730
Natural varianti125 – 1251N → S Found in two siblings with early-onset steroid-resistant nephrotic syndrome. 1 Publication
VAR_067247
Natural varianti143 – 1431N → S in FSGS2. 1 Publication
Corresponds to variant rs121434391 [ dbSNP | Ensembl ].
VAR_026731
Natural varianti157 – 1571N → T.
Corresponds to variant rs35857503 [ dbSNP | Ensembl ].
VAR_038419
Natural varianti218 – 2181H → L in FSGS2. 1 Publication
VAR_067248
Natural varianti270 – 2701S → T in FSGS2. 1 Publication
VAR_026732
Natural varianti404 – 4041A → V.
Corresponds to variant rs36111323 [ dbSNP | Ensembl ].
VAR_061861
Natural varianti895 – 8951R → C in FSGS2. 1 Publication
VAR_026733
Natural varianti895 – 8951R → L in a patient with collapsing glomerulosclerosis. 1 Publication
VAR_067249
Natural varianti897 – 8971E → K in FSGS2. 1 Publication
VAR_026734

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei316 – 431116Missing in isoform 2. 1 PublicationVSP_006572Add
BLAST
Alternative sequencei377 – 43155Missing in isoform 3. 1 PublicationVSP_006573Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080394 mRNA. Translation: AAC63289.2.
AJ006276 mRNA. Translation: CAA06943.1.
AJ271066 mRNA. Translation: CAC01684.1.
AJ271067 mRNA. Translation: CAC01685.1.
AJ271068 mRNA. Translation: CAC01686.1.
BC093658 mRNA. Translation: AAH93658.1.
BC093660 mRNA. Translation: AAH93660.1.
AJ007018 mRNA. Translation: CAC06090.1.
CCDSiCCDS8311.1. [Q9Y210-1]
RefSeqiNP_004612.2. NM_004621.5. [Q9Y210-1]
UniGeneiHs.159003.

Genome annotation databases

EnsembliENST00000344327; ENSP00000340913; ENSG00000137672. [Q9Y210-1]
ENST00000348423; ENSP00000343672; ENSG00000137672. [Q9Y210-2]
ENST00000360497; ENSP00000353687; ENSG00000137672. [Q9Y210-3]
GeneIDi7225.
KEGGihsa:7225.
UCSCiuc001pgk.4. human. [Q9Y210-1]
uc009ywy.3. human. [Q9Y210-2]
uc009ywz.1. human. [Q9Y210-3]

Polymorphism and mutation databases

BioMutaiTRPC6.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080394 mRNA. Translation: AAC63289.2.
AJ006276 mRNA. Translation: CAA06943.1.
AJ271066 mRNA. Translation: CAC01684.1.
AJ271067 mRNA. Translation: CAC01685.1.
AJ271068 mRNA. Translation: CAC01686.1.
BC093658 mRNA. Translation: AAH93658.1.
BC093660 mRNA. Translation: AAH93660.1.
AJ007018 mRNA. Translation: CAC06090.1.
CCDSiCCDS8311.1. [Q9Y210-1]
RefSeqiNP_004612.2. NM_004621.5. [Q9Y210-1]
UniGeneiHs.159003.

3D structure databases

ProteinModelPortaliQ9Y210.
SMRiQ9Y210. Positions 100-254.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113076. 12 interactions.
IntActiQ9Y210. 2 interactions.
STRINGi9606.ENSP00000340913.

Chemistry

BindingDBiQ9Y210.
ChEMBLiCHEMBL2417347.
GuidetoPHARMACOLOGYi491.

Protein family/group databases

TCDBi1.A.4.1.5. the transient receptor potential ca(2+) channel (trp-cc) family.

PTM databases

PhosphoSiteiQ9Y210.

Polymorphism and mutation databases

BioMutaiTRPC6.
DMDMi6686048.

Proteomic databases

PaxDbiQ9Y210.
PRIDEiQ9Y210.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344327; ENSP00000340913; ENSG00000137672. [Q9Y210-1]
ENST00000348423; ENSP00000343672; ENSG00000137672. [Q9Y210-2]
ENST00000360497; ENSP00000353687; ENSG00000137672. [Q9Y210-3]
GeneIDi7225.
KEGGihsa:7225.
UCSCiuc001pgk.4. human. [Q9Y210-1]
uc009ywy.3. human. [Q9Y210-2]
uc009ywz.1. human. [Q9Y210-3]

Organism-specific databases

CTDi7225.
GeneCardsiGC11M101322.
HGNCiHGNC:12338. TRPC6.
HPAiHPA045098.
MIMi603652. gene.
603965. phenotype.
neXtProtiNX_Q9Y210.
Orphaneti93213. Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis.
PharmGKBiPA37011.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG254238.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000020590.
HOVERGENiHBG068337.
InParanoidiQ9Y210.
KOiK04969.
OMAiCSECNQK.
OrthoDBiEOG77HDD1.
PhylomeDBiQ9Y210.
TreeFamiTF313147.

Enzyme and pathway databases

ReactomeiREACT_162. Elevation of cytosolic Ca2+ levels.
REACT_169333. TRP channels.
REACT_2202. Effects of PIP2 hydrolysis.
REACT_22228. Role of second messengers in netrin-1 signaling.

Miscellaneous databases

ChiTaRSiTRPC6. human.
GeneWikiiTRPC6.
GenomeRNAii7225.
NextBioi28295.
PROiQ9Y210.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y210.
CleanExiHS_TRPC6.
ExpressionAtlasiQ9Y210. baseline and differential.
GenevestigatoriQ9Y210.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005462. TRPC6_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF7. PTHR10117:SF7. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01647. TRPCHANNEL6.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol."
    Hofmann T., Obukhov A.G., Schaefer M., Harteneck C., Gudermann T., Schultz G.
    Nature 397:259-263(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta and Testis.
  2. "Identification and assignment of the human transient receptor potential channel 6 gene TRPC6 to chromosome 11q21-22."
    D'Esposito M., Strazzullo M., Cuccurese M., Spalluto C., Rocchi M., D'Urso M., Ciccodicola A.
    Cytogenet. Cell Genet. 83:46-47(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Teratocarcinoma.
  3. "TRP4 (CCE1) protein is part of native calcium release-activated Ca2+-like channels in adrenal cells."
    Philipp S., Trost C., Warnat J., Rautmann J., Himmerkus N., Schroth G., Kretz O., Nastainczyk W., Cavalie A., Hoth M., Flockerzi V.
    J. Biol. Chem. 275:23965-23972(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Placenta.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "The capacitative calcium entry cation channel Trp6 is expressed in the muscularis externa of the guinea pig ileum and in a human jejunum smooth muscle cell line."
    Fenech C.J., Prestwich S.A., Zholos A.V., Bolton T.B.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 487-643.
  6. "N-linked protein glycosylation is a major determinant for basal TRPC3 and TRPC6 channel activity."
    Dietrich A., Mederos y Schnitzler M., Emmel J., Kalwa H., Hofmann T., Gudermann T.
    J. Biol. Chem. 278:47842-47852(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-473 AND ASN-561, MUTAGENESIS OF ASN-561.
  7. "MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC."
    Lussier M.P., Cayouette S., Lepage P.K., Bernier C.L., Francoeur N., St-Hilaire M., Pinard M., Boulay G.
    J. Biol. Chem. 280:19393-19400(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MX1.
  8. "RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC."
    Lussier M.P., Lepage P.K., Bousquet S.M., Boulay G.
    Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RNF24, MUTAGENESIS OF ASN-125; ASN-127; CYS-128 AND ASP-130.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-815, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  10. Cited for: VARIANTS FSGS2 SER-143; THR-270; CYS-895 AND LYS-897, TISSUE SPECIFICITY.
  11. Cited for: VARIANT FSGS2 GLN-112.
  12. Cited for: VARIANT FSGS2 LEU-218, VARIANTS SER-125 AND LEU-895.

Entry informationi

Entry nameiTRPC6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y210
Secondary accession number(s): Q52M59
, Q9HCW3, Q9NQA8, Q9NQA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: April 29, 2015
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.