Q9Y210 (TRPC6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Short transient receptor potential channel 6
Short name=TrpC6

Alternative name(s):
Transient receptor protein 6
Short name=TRP-6

Gene names

Name:	TRPC6
Synonyms:	TRP6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	931 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
Subunit structure	Interacts with MX1 and RNF24. Ref.6 Ref.7
Subcellular location	Membrane; Multi-pass membrane protein Probable.
Tissue specificity	Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. Ref.9
Post-translational modification	Phosphorylated by FYN, leading to an increase of TRPC6 channel activity By similarity.
Involvement in disease	Focal segmental glomerulosclerosis 2 (FSGS2) [MIM:603965]: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.10 Ref.11
Sequence similarities	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. [View classification] Contains 4 ANK repeats.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation
Domain	ANK repeat Repeat Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Traceable author statement. Source: Reactome cation transport Traceable author statement Ref.1. Source: ProtInc elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara platelet activation Traceable author statement. Source: Reactome positive regulation of calcium ion transport Inferred from direct assay PubMed 10998353. Source: MGI positive regulation of ion transmembrane transporter activity Inferred from direct assay PubMed 10998353. Source: MGI
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay PubMed 10998353. Source: MGI slit diaphragm Inferred from electronic annotation. Source: Compara
Molecular_function	inositol 1,4,5 trisphosphate binding Inferred from direct assay PubMed 14505576. Source: BHF-UCL store-operated calcium channel activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MX1	P20591	4	EBI-929362,EBI-929476

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y210-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y210-2)

The sequence of this isoform differs from the canonical sequence as follows:
     316-431: Missing.

Isoform 3 (identifier: Q9Y210-3)

The sequence of this isoform differs from the canonical sequence as follows:
     377-431: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 931	931	Short transient receptor potential channel 6		PRO_0000215322
Regions
	Topological domain	1 – 438	438	Cytoplasmic Potential
	Transmembrane	439 – 459	21	Helical; Potential
	Topological domain	460 – 487	28	Extracellular Potential
	Transmembrane	488 – 508	21	Helical; Potential
	Topological domain	509 – 521	13	Cytoplasmic Potential
	Transmembrane	522 – 542	21	Helical; Potential
	Topological domain	543 – 592	50	Extracellular Potential
	Transmembrane	593 – 613	21	Helical; Potential
	Topological domain	614 – 636	23	Cytoplasmic Potential
	Transmembrane	637 – 657	21	Helical; Potential
	Topological domain	658 – 706	49	Extracellular Potential
	Transmembrane	707 – 727	21	Helical; Potential
	Topological domain	728 – 931	204	Cytoplasmic Potential
	Repeat	97 – 126	30	ANK 1
	Repeat	132 – 161	30	ANK 2
	Repeat	163 – 189	27	ANK 3
	Repeat	218 – 247	30	ANK 4
Amino acid modifications
	Modified residue	815	1	Phosphoserine Ref.8
	Glycosylation	473	1	N-linked (GlcNAc...) Potential
	Glycosylation	561	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	316 – 431	116	Missing in isoform 2.		VSP_006572
	Alternative sequence	377 – 431	55	Missing in isoform 3.		VSP_006573
	Natural variant	112	1	P → Q in FSGS2. Ref.10		VAR_026730
	Natural variant	125	1	N → S Found in two siblings with early-onset steroid-resistant nephrotic syndrome. Ref.11		VAR_067247
	Natural variant	143	1	N → S in FSGS2. Ref.9		VAR_026731
	Natural variant	157	1	N → T. Corresponds to variant rs35857503 [ dbSNP | Ensembl ].		VAR_038419
	Natural variant	218	1	H → L in FSGS2. Ref.11		VAR_067248
	Natural variant	270	1	S → T in FSGS2. Ref.9		VAR_026732
	Natural variant	404	1	A → V. Corresponds to variant rs36111323 [ dbSNP | Ensembl ].		VAR_061861
	Natural variant	895	1	R → C in FSGS2. Ref.9		VAR_026733
	Natural variant	895	1	R → L in a patient with collapsing glomerulosclerosis. Ref.11		VAR_067249
	Natural variant	897	1	E → K in FSGS2. Ref.9		VAR_026734
Experimental info
	Mutagenesis	125	1	N → A: No effect on RNF24-binding; when associated with A-127; A-128 and A-130. Ref.7
	Mutagenesis	127	1	N → A: No effect on RNF24-binding; when associated with A-125; A-128 and A-130. Ref.7
	Mutagenesis	128	1	C → A: No effect on RNF24-binding; when associated with A-125; A-127 and A-130. Ref.7
	Mutagenesis	130	1	D → A: No effect on RNF24-binding; when associated with A-125; A-127 and A-128. Ref.7
	Sequence conflict	336	1	C → R in CAC01686. Ref.3
	Sequence conflict	585	1	K → R in CAC06090. Ref.5
	Sequence conflict	613	1	I → T in CAC01686. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 7C955C2B0389AC47	FASTA	931	106,326
	10 20 30 40 50 60 MSQSPAFGPR RGSSPRGAAG AAARRNESQD YLLMDSELGE DGCPQAPLPC YGYYPCFRGS 70 80 90 100 110 120 DNRLAHRRQT VLREKGRRLA NRGPAYMFSD RSTSLSIEEE RFLDAAEYGN IPVVRKMLEE 130 140 150 160 170 180 CHSLNVNCVD YMGQNALQLA VANEHLEITE LLLKKENLSR VGDALLLAIS KGYVRIVEAI 190 200 210 220 230 240 LSHPAFAEGK RLATSPSQSE LQQDDFYAYD EDGTRFSHDV TPIILAAHCQ EYEIVHTLLR 250 260 270 280 290 300 KGARIERPHD YFCKCNDCNQ KQKHDSFSHS RSRINAYKGL ASPAYLSLSS EDPVMTALEL 310 320 330 340 350 360 SNELAVLANI EKEFKNDYKK LSMQCKDFVV GLLDLCRNTE EVEAILNGDV ETLQSGDHGR 370 380 390 400 410 420 PNLSRLKLAI KYEVKKFVAH PNCQQQLLSI WYENLSGLRQ QTMAVKFLVV LAVAIGLPFL 430 440 450 460 470 480 ALIYWFAPCS KMGKIMRGPF MKFVAHAASF TIFLGLLVMN AADRFEGTKL LPNETSTDNA 490 500 510 520 530 540 KQLFRMKTSC FSWMEMLIIS WVIGMIWAEC KEIWTQGPKE YLFELWNMLD FGMLAIFAAS 550 560 570 580 590 600 FIARFMAFWH ASKAQSIIDA NDTLKDLTKV TLGDNVKYYN LARIKWDPSD PQIISEGLYA 610 620 630 640 650 660 IAVVLSFSRI AYILPANESF GPLQISLGRT VKDIFKFMVI FIMVFVAFMI GMFNLYSYYI 670 680 690 700 710 720 GAKQNEAFTT VEESFKTLFW AIFGLSEVKS VVINYNHKFI ENIGYVLYGV YNVTMVIVLL 730 740 750 760 770 780 NMLIAMINSS FQEIEDDADV EWKFARAKLW FSYFEEGRTL PVPFNLVPSP KSLFYLLLKL 790 800 810 820 830 840 KKWISELFQG HKKGFQEDAE MNKINEEKKL GILGSHEDLS KLSLDKKQVG HNKQPSIRSS 850 860 870 880 890 900 EDFHLNSFNN PPRQYQKIMK RLIKRYVLQA QIDKESDEVN EGELKEIKQD ISSLRYELLE 910 920 930 EKSQNTEDLA ELIRELGEKL SMEPNQEETN R
	Isoform 2 [UniParc]. Checksum: 2E78B50F956CBF0D	FASTA	815	93,187
	10 20 30 40 50 60 MSQSPAFGPR RGSSPRGAAG AAARRNESQD YLLMDSELGE DGCPQAPLPC YGYYPCFRGS 70 80 90 100 110 120 DNRLAHRRQT VLREKGRRLA NRGPAYMFSD RSTSLSIEEE RFLDAAEYGN IPVVRKMLEE 130 140 150 160 170 180 CHSLNVNCVD YMGQNALQLA VANEHLEITE LLLKKENLSR VGDALLLAIS KGYVRIVEAI 190 200 210 220 230 240 LSHPAFAEGK RLATSPSQSE LQQDDFYAYD EDGTRFSHDV TPIILAAHCQ EYEIVHTLLR 250 260 270 280 290 300 KGARIERPHD YFCKCNDCNQ KQKHDSFSHS RSRINAYKGL ASPAYLSLSS EDPVMTALEL 310 320 330 340 350 360 SNELAVLANI EKEFKMGKIM RGPFMKFVAH AASFTIFLGL LVMNAADRFE GTKLLPNETS 370 380 390 400 410 420 TDNAKQLFRM KTSCFSWMEM LIISWVIGMI WAECKEIWTQ GPKEYLFELW NMLDFGMLAI 430 440 450 460 470 480 FAASFIARFM AFWHASKAQS IIDANDTLKD LTKVTLGDNV KYYNLARIKW DPSDPQIISE 490 500 510 520 530 540 GLYAIAVVLS FSRIAYILPA NESFGPLQIS LGRTVKDIFK FMVIFIMVFV AFMIGMFNLY 550 560 570 580 590 600 SYYIGAKQNE AFTTVEESFK TLFWAIFGLS EVKSVVINYN HKFIENIGYV LYGVYNVTMV 610 620 630 640 650 660 IVLLNMLIAM INSSFQEIED DADVEWKFAR AKLWFSYFEE GRTLPVPFNL VPSPKSLFYL 670 680 690 700 710 720 LLKLKKWISE LFQGHKKGFQ EDAEMNKINE EKKLGILGSH EDLSKLSLDK KQVGHNKQPS 730 740 750 760 770 780 IRSSEDFHLN SFNNPPRQYQ KIMKRLIKRY VLQAQIDKES DEVNEGELKE IKQDISSLRY 790 800 810 ELLEEKSQNT EDLAELIREL GEKLSMEPNQ EETNR
	Isoform 3 [UniParc]. Checksum: 8A1F52196619E147	FASTA	876	100,106
	10 20 30 40 50 60 MSQSPAFGPR RGSSPRGAAG AAARRNESQD YLLMDSELGE DGCPQAPLPC YGYYPCFRGS 70 80 90 100 110 120 DNRLAHRRQT VLREKGRRLA NRGPAYMFSD RSTSLSIEEE RFLDAAEYGN IPVVRKMLEE 130 140 150 160 170 180 CHSLNVNCVD YMGQNALQLA VANEHLEITE LLLKKENLSR VGDALLLAIS KGYVRIVEAI 190 200 210 220 230 240 LSHPAFAEGK RLATSPSQSE LQQDDFYAYD EDGTRFSHDV TPIILAAHCQ EYEIVHTLLR 250 260 270 280 290 300 KGARIERPHD YFCKCNDCNQ KQKHDSFSHS RSRINAYKGL ASPAYLSLSS EDPVMTALEL 310 320 330 340 350 360 SNELAVLANI EKEFKNDYKK LSMQCKDFVV GLLDLCRNTE EVEAILNGDV ETLQSGDHGR 370 380 390 400 410 420 PNLSRLKLAI KYEVKKMGKI MRGPFMKFVA HAASFTIFLG LLVMNAADRF EGTKLLPNET 430 440 450 460 470 480 STDNAKQLFR MKTSCFSWME MLIISWVIGM IWAECKEIWT QGPKEYLFEL WNMLDFGMLA 490 500 510 520 530 540 IFAASFIARF MAFWHASKAQ SIIDANDTLK DLTKVTLGDN VKYYNLARIK WDPSDPQIIS 550 560 570 580 590 600 EGLYAIAVVL SFSRIAYILP ANESFGPLQI SLGRTVKDIF KFMVIFIMVF VAFMIGMFNL 610 620 630 640 650 660 YSYYIGAKQN EAFTTVEESF KTLFWAIFGL SEVKSVVINY NHKFIENIGY VLYGVYNVTM 670 680 690 700 710 720 VIVLLNMLIA MINSSFQEIE DDADVEWKFA RAKLWFSYFE EGRTLPVPFN LVPSPKSLFY 730 740 750 760 770 780 LLLKLKKWIS ELFQGHKKGF QEDAEMNKIN EEKKLGILGS HEDLSKLSLD KKQVGHNKQP 790 800 810 820 830 840 SIRSSEDFHL NSFNNPPRQY QKIMKRLIKR YVLQAQIDKE SDEVNEGELK EIKQDISSLR 850 860 870 YELLEEKSQN TEDLAELIRE LGEKLSMEPN QEETNR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol." Hofmann T., Obukhov A.G., Schaefer M., Harteneck C., Gudermann T., Schultz G. Nature 397:259-263(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Placenta and Testis.
[2]	"Identification and assignment of the human transient receptor potential channel 6 gene TRPC6 to chromosome 11q21-22." D'Esposito M., Strazzullo M., Cuccurese M., Spalluto C., Rocchi M., D'Urso M., Ciccodicola A. Cytogenet. Cell Genet. 83:46-47(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Teratocarcinoma.
[3]	"TRP4 (CCE1) protein is part of native calcium release-activated Ca2+-like channels in adrenal cells." Philipp S., Trost C., Warnat J., Rautmann J., Himmerkus N., Schroth G., Kretz O., Nastainczyk W., Cavalie A., Hoth M., Flockerzi V. J. Biol. Chem. 275:23965-23972(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Placenta.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]	"The capacitative calcium entry cation channel Trp6 is expressed in the muscularis externa of the guinea pig ileum and in a human jejunum smooth muscle cell line." Fenech C.J., Prestwich S.A., Zholos A.V., Bolton T.B. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 487-643.
[6]	"MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC." Lussier M.P., Cayouette S., Lepage P.K., Bernier C.L., Francoeur N., St-Hilaire M., Pinard M., Boulay G. J. Biol. Chem. 280:19393-19400(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MX1.
[7]	"RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC." Lussier M.P., Lepage P.K., Bousquet S.M., Boulay G. Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RNF24, MUTAGENESIS OF ASN-125; ASN-127; CYS-128 AND ASP-130.
[8]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-815, MASS SPECTROMETRY. Tissue: Platelet.
[9]	"TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function." Reiser J., Polu K.R., Moller C.C., Kenlan P., Altintas M.M., Wei C., Faul C., Herbert S., Villegas I., Avila-Casado C., McGee M., Sugimoto H., Brown D., Kalluri R., Mundel P., Smith P.L., Clapham D.E., Pollak M.R. Nat. Genet. 37:739-744(2005) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS FSGS2 SER-143; THR-270; CYS-895 AND LYS-897, TISSUE SPECIFICITY.
[10]	"A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis." Winn M.P., Conlon P.J., Lynn K.L., Farrington M.K., Creazzo T., Hawkins A.F., Daskalakis N., Kwan S.Y., Ebersviller S., Burchette J.L., Pericak-Vance M.A., Howell D.N., Vance J.M., Rosenberg P.B. Science 308:1801-1804(2005) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT FSGS2 GLN-112.
[11]	"TRPC6 mutations in children with steroid-resistant nephrotic syndrome and atypical phenotype." Gigante M., Caridi G., Montemurno E., Soccio M., d'Apolito M., Cerullo G., Aucella F., Schirinzi A., Emma F., Massella L., Messina G., De Palo T., Ranieri E., Ghiggeri G.M., Gesualdo L. Clin. J. Am. Soc. Nephrol. 6:1626-1634(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT FSGS2 LEU-218, VARIANTS SER-125 AND LEU-895.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF080394 mRNA. Translation: AAC63289.2. AJ006276 mRNA. Translation: CAA06943.1. AJ271066 mRNA. Translation: CAC01684.1. AJ271067 mRNA. Translation: CAC01685.1. AJ271068 mRNA. Translation: CAC01686.1. BC093658 mRNA. Translation: AAH93658.1. BC093660 mRNA. Translation: AAH93660.1. AJ007018 mRNA. Translation: CAC06090.1.
IPI	IPI00031683. IPI00220552. IPI00220553.
RefSeq	NP_004612.2. NM_004621.5.
UniGene	Hs.159003.
3D structure databases
ProteinModelPortal	Q9Y210.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y210. 2 interactions.
STRING	9606.ENSP00000340913.
Protein family/group databases
TCDB	1.A.4.1.5. transient receptor potential Ca2+ channel (TRP-CC) family.
PTM databases
PhosphoSite	Q9Y210.
Polymorphism databases
DMDM	6686048.
Proteomic databases
PaxDb	Q9Y210.
PRIDE	Q9Y210.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000344327; ENSP00000340913; ENSG00000137672. ENST00000348423; ENSP00000343672; ENSG00000137672. ENST00000360497; ENSP00000353687; ENSG00000137672.
GeneID	7225.
KEGG	hsa:7225.
UCSC	uc001pgk.4. human. uc009ywy.3. human. uc009ywz.1. human.
Organism-specific databases
CTD	7225.
GeneCards	GC11M101322.
HGNC	HGNC:12338. TRPC6.
HPA	HPA045098.
MIM	603652. gene. 603965. phenotype.
neXtProt	NX_Q9Y210.
Orphanet	93213. Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis.
PharmGKB	PA37011.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG254238.
HOGENOM	HOG000020590.
HOVERGEN	HBG068337.
InParanoid	Q9Y210.
KO	K04969.
OMA	NRGPAYM.
OrthoDB	EOG4V436Z.
PhylomeDB	Q9Y210.
Enzyme and pathway databases
Pathway_Interaction_DB	endothelinpathway. Endothelins. epopathway. EPO signaling pathway.
Reactome	REACT_111045. Developmental Biology. REACT_111102. Signal Transduction. REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	Q9Y210.
Bgee	Q9Y210.
CleanEx	HS_TRPC6.
Genevestigator	Q9Y210.
GermOnline	ENSG00000137672. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR005821. Ion_trans_dom. IPR004729. TRP_channel. IPR013555. TRP_dom. IPR005462. TRPC6_channel. IPR002153. TRPC_channel. [Graphical view]
PANTHER	PTHR10117. PTHR10117. 1 hit. PTHR10117:SF7. PTHR10117:SF7. 1 hit.
Pfam	PF12796. Ank_2. 1 hit. PF00520. Ion_trans. 1 hit. PF08344. TRP_2. 1 hit. [Graphical view]
PRINTS	PR01097. TRNSRECEPTRP. PR01647. TRPCHANNEL6.
SMART	SM00248. ANK. 3 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
TIGRFAMs	TIGR00870. trp. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 2 hits. PS50088. ANK_REPEAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TRPC6. human.
GenomeRNAi	7225.
NextBio	28295.
SOURCE	Search...

Entry information

Entry name

TRPC6_HUMAN

Accession

Primary (citable) accession number: Q9Y210
Secondary accession number(s): Q52M59 , Q9HCW3, Q9NQA8, Q9NQA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 124 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.