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Q9Y210

- TRPC6_HUMAN

UniProt

Q9Y210 - TRPC6_HUMAN

Protein

Short transient receptor potential channel 6

Gene

TRPC6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.

    GO - Molecular functioni

    1. inositol 1,4,5 trisphosphate binding Source: BHF-UCL
    2. protein binding Source: IntAct
    3. store-operated calcium channel activity Source: Ensembl

    GO - Biological processi

    1. aging Source: Ensembl
    2. axon guidance Source: Reactome
    3. blood coagulation Source: Reactome
    4. calcium ion transmembrane transport Source: Reactome
    5. cation transport Source: ProtInc
    6. cellular response to hydrogen peroxide Source: Ensembl
    7. cellular response to hypoxia Source: Ensembl
    8. ion transmembrane transport Source: Reactome
    9. platelet activation Source: Reactome
    10. positive regulation of calcium ion transport Source: MGI
    11. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    12. positive regulation of ion transmembrane transporter activity Source: MGI
    13. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Calcium channel, Ion channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_162. Elevation of cytosolic Ca2+ levels.
    REACT_169333. TRP channels.
    REACT_2202. Effects of PIP2 hydrolysis.
    REACT_22228. Role of second messengers in netrin-1 signaling.

    Protein family/group databases

    TCDBi1.A.4.1.5. the transient receptor potential ca(2+) channel (trp-cc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Short transient receptor potential channel 6
    Short name:
    TrpC6
    Alternative name(s):
    Transient receptor protein 6
    Short name:
    TRP-6
    Gene namesi
    Name:TRPC6
    Synonyms:TRP6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:12338. TRPC6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: MGI
    3. slit diaphragm Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Focal segmental glomerulosclerosis 2 (FSGS2) [MIM:603965]: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.3 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti112 – 1121P → Q in FSGS2. 1 Publication
    VAR_026730
    Natural varianti143 – 1431N → S in FSGS2. 1 Publication
    Corresponds to variant rs121434391 [ dbSNP | Ensembl ].
    VAR_026731
    Natural varianti218 – 2181H → L in FSGS2. 1 Publication
    VAR_067248
    Natural varianti270 – 2701S → T in FSGS2. 1 Publication
    VAR_026732
    Natural varianti895 – 8951R → C in FSGS2. 1 Publication
    VAR_026733
    Natural varianti897 – 8971E → K in FSGS2. 1 Publication
    VAR_026734

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi125 – 1251N → A: No effect on RNF24-binding; when associated with A-127; A-128 and A-130. 1 Publication
    Mutagenesisi127 – 1271N → A: No effect on RNF24-binding; when associated with A-125; A-128 and A-130. 1 Publication
    Mutagenesisi128 – 1281C → A: No effect on RNF24-binding; when associated with A-125; A-127 and A-130. 1 Publication
    Mutagenesisi130 – 1301D → A: No effect on RNF24-binding; when associated with A-125; A-127 and A-128. 1 Publication
    Mutagenesisi561 – 5611N → Q: Constitutively activates channel. 1 Publication

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi603965. phenotype.
    Orphaneti93213. Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis.
    PharmGKBiPA37011.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 931931Short transient receptor potential channel 6PRO_0000215322Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi473 – 4731N-linked (GlcNAc...)1 Publication
    Glycosylationi561 – 5611N-linked (GlcNAc...)1 Publication
    Modified residuei815 – 8151Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated by FYN, leading to an increase of TRPC6 channel activity.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ9Y210.
    PRIDEiQ9Y210.

    PTM databases

    PhosphoSiteiQ9Y210.

    Expressioni

    Tissue specificityi

    Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.1 Publication

    Gene expression databases

    ArrayExpressiQ9Y210.
    BgeeiQ9Y210.
    CleanExiHS_TRPC6.
    GenevestigatoriQ9Y210.

    Organism-specific databases

    HPAiHPA045098.

    Interactioni

    Subunit structurei

    Interacts with MX1 and RNF24.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MX1P205914EBI-929362,EBI-929476

    Protein-protein interaction databases

    BioGridi113076. 12 interactions.
    IntActiQ9Y210. 2 interactions.
    STRINGi9606.ENSP00000340913.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y210.
    SMRiQ9Y210. Positions 48-254.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 438438CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini460 – 48728ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini509 – 52113CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini543 – 59250ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini614 – 63623CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini658 – 70649ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini728 – 931204CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei439 – 45921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei488 – 50821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei522 – 54221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei593 – 61321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei637 – 65721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei707 – 72721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati97 – 12630ANK 1Add
    BLAST
    Repeati132 – 16130ANK 2Add
    BLAST
    Repeati163 – 18927ANK 3Add
    BLAST
    Repeati218 – 24730ANK 4Add
    BLAST

    Sequence similaritiesi

    Contains 4 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG254238.
    HOGENOMiHOG000020590.
    HOVERGENiHBG068337.
    InParanoidiQ9Y210.
    KOiK04969.
    OMAiNRGPAYM.
    OrthoDBiEOG77HDD1.
    PhylomeDBiQ9Y210.
    TreeFamiTF313147.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR013555. TRP_dom.
    IPR005462. TRPC6_channel.
    IPR002153. TRPC_channel.
    [Graphical view]
    PANTHERiPTHR10117. PTHR10117. 1 hit.
    PTHR10117:SF7. PTHR10117:SF7. 1 hit.
    PfamiPF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF08344. TRP_2. 1 hit.
    [Graphical view]
    PRINTSiPR01097. TRNSRECEPTRP.
    PR01647. TRPCHANNEL6.
    SMARTiSM00248. ANK. 3 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    TIGRFAMsiTIGR00870. trp. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 2 hits.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y210-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSQSPAFGPR RGSSPRGAAG AAARRNESQD YLLMDSELGE DGCPQAPLPC    50
    YGYYPCFRGS DNRLAHRRQT VLREKGRRLA NRGPAYMFSD RSTSLSIEEE 100
    RFLDAAEYGN IPVVRKMLEE CHSLNVNCVD YMGQNALQLA VANEHLEITE 150
    LLLKKENLSR VGDALLLAIS KGYVRIVEAI LSHPAFAEGK RLATSPSQSE 200
    LQQDDFYAYD EDGTRFSHDV TPIILAAHCQ EYEIVHTLLR KGARIERPHD 250
    YFCKCNDCNQ KQKHDSFSHS RSRINAYKGL ASPAYLSLSS EDPVMTALEL 300
    SNELAVLANI EKEFKNDYKK LSMQCKDFVV GLLDLCRNTE EVEAILNGDV 350
    ETLQSGDHGR PNLSRLKLAI KYEVKKFVAH PNCQQQLLSI WYENLSGLRQ 400
    QTMAVKFLVV LAVAIGLPFL ALIYWFAPCS KMGKIMRGPF MKFVAHAASF 450
    TIFLGLLVMN AADRFEGTKL LPNETSTDNA KQLFRMKTSC FSWMEMLIIS 500
    WVIGMIWAEC KEIWTQGPKE YLFELWNMLD FGMLAIFAAS FIARFMAFWH 550
    ASKAQSIIDA NDTLKDLTKV TLGDNVKYYN LARIKWDPSD PQIISEGLYA 600
    IAVVLSFSRI AYILPANESF GPLQISLGRT VKDIFKFMVI FIMVFVAFMI 650
    GMFNLYSYYI GAKQNEAFTT VEESFKTLFW AIFGLSEVKS VVINYNHKFI 700
    ENIGYVLYGV YNVTMVIVLL NMLIAMINSS FQEIEDDADV EWKFARAKLW 750
    FSYFEEGRTL PVPFNLVPSP KSLFYLLLKL KKWISELFQG HKKGFQEDAE 800
    MNKINEEKKL GILGSHEDLS KLSLDKKQVG HNKQPSIRSS EDFHLNSFNN 850
    PPRQYQKIMK RLIKRYVLQA QIDKESDEVN EGELKEIKQD ISSLRYELLE 900
    EKSQNTEDLA ELIRELGEKL SMEPNQEETN R 931
    Length:931
    Mass (Da):106,326
    Last modified:November 1, 1999 - v1
    Checksum:i7C955C2B0389AC47
    GO
    Isoform 2 (identifier: Q9Y210-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         316-431: Missing.

    Show »
    Length:815
    Mass (Da):93,187
    Checksum:i2E78B50F956CBF0D
    GO
    Isoform 3 (identifier: Q9Y210-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         377-431: Missing.

    Show »
    Length:876
    Mass (Da):100,106
    Checksum:i8A1F52196619E147
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti336 – 3361C → R in CAC01686. (PubMed:10816590)Curated
    Sequence conflicti585 – 5851K → R in CAC06090. 1 PublicationCurated
    Sequence conflicti613 – 6131I → T in CAC01686. (PubMed:10816590)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti112 – 1121P → Q in FSGS2. 1 Publication
    VAR_026730
    Natural varianti125 – 1251N → S Found in two siblings with early-onset steroid-resistant nephrotic syndrome. 1 Publication
    VAR_067247
    Natural varianti143 – 1431N → S in FSGS2. 1 Publication
    Corresponds to variant rs121434391 [ dbSNP | Ensembl ].
    VAR_026731
    Natural varianti157 – 1571N → T.
    Corresponds to variant rs35857503 [ dbSNP | Ensembl ].
    VAR_038419
    Natural varianti218 – 2181H → L in FSGS2. 1 Publication
    VAR_067248
    Natural varianti270 – 2701S → T in FSGS2. 1 Publication
    VAR_026732
    Natural varianti404 – 4041A → V.
    Corresponds to variant rs36111323 [ dbSNP | Ensembl ].
    VAR_061861
    Natural varianti895 – 8951R → C in FSGS2. 1 Publication
    VAR_026733
    Natural varianti895 – 8951R → L in a patient with collapsing glomerulosclerosis. 1 Publication
    VAR_067249
    Natural varianti897 – 8971E → K in FSGS2. 1 Publication
    VAR_026734

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei316 – 431116Missing in isoform 2. 1 PublicationVSP_006572Add
    BLAST
    Alternative sequencei377 – 43155Missing in isoform 3. 1 PublicationVSP_006573Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF080394 mRNA. Translation: AAC63289.2.
    AJ006276 mRNA. Translation: CAA06943.1.
    AJ271066 mRNA. Translation: CAC01684.1.
    AJ271067 mRNA. Translation: CAC01685.1.
    AJ271068 mRNA. Translation: CAC01686.1.
    BC093658 mRNA. Translation: AAH93658.1.
    BC093660 mRNA. Translation: AAH93660.1.
    AJ007018 mRNA. Translation: CAC06090.1.
    CCDSiCCDS8311.1. [Q9Y210-1]
    RefSeqiNP_004612.2. NM_004621.5. [Q9Y210-1]
    UniGeneiHs.159003.

    Genome annotation databases

    EnsembliENST00000344327; ENSP00000340913; ENSG00000137672. [Q9Y210-1]
    ENST00000348423; ENSP00000343672; ENSG00000137672. [Q9Y210-2]
    ENST00000360497; ENSP00000353687; ENSG00000137672. [Q9Y210-3]
    GeneIDi7225.
    KEGGihsa:7225.
    UCSCiuc001pgk.4. human. [Q9Y210-1]
    uc009ywy.3. human. [Q9Y210-2]
    uc009ywz.1. human. [Q9Y210-3]

    Polymorphism databases

    DMDMi6686048.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF080394 mRNA. Translation: AAC63289.2 .
    AJ006276 mRNA. Translation: CAA06943.1 .
    AJ271066 mRNA. Translation: CAC01684.1 .
    AJ271067 mRNA. Translation: CAC01685.1 .
    AJ271068 mRNA. Translation: CAC01686.1 .
    BC093658 mRNA. Translation: AAH93658.1 .
    BC093660 mRNA. Translation: AAH93660.1 .
    AJ007018 mRNA. Translation: CAC06090.1 .
    CCDSi CCDS8311.1. [Q9Y210-1 ]
    RefSeqi NP_004612.2. NM_004621.5. [Q9Y210-1 ]
    UniGenei Hs.159003.

    3D structure databases

    ProteinModelPortali Q9Y210.
    SMRi Q9Y210. Positions 48-254.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113076. 12 interactions.
    IntActi Q9Y210. 2 interactions.
    STRINGi 9606.ENSP00000340913.

    Chemistry

    ChEMBLi CHEMBL2417347.
    GuidetoPHARMACOLOGYi 491.

    Protein family/group databases

    TCDBi 1.A.4.1.5. the transient receptor potential ca(2+) channel (trp-cc) family.

    PTM databases

    PhosphoSitei Q9Y210.

    Polymorphism databases

    DMDMi 6686048.

    Proteomic databases

    PaxDbi Q9Y210.
    PRIDEi Q9Y210.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344327 ; ENSP00000340913 ; ENSG00000137672 . [Q9Y210-1 ]
    ENST00000348423 ; ENSP00000343672 ; ENSG00000137672 . [Q9Y210-2 ]
    ENST00000360497 ; ENSP00000353687 ; ENSG00000137672 . [Q9Y210-3 ]
    GeneIDi 7225.
    KEGGi hsa:7225.
    UCSCi uc001pgk.4. human. [Q9Y210-1 ]
    uc009ywy.3. human. [Q9Y210-2 ]
    uc009ywz.1. human. [Q9Y210-3 ]

    Organism-specific databases

    CTDi 7225.
    GeneCardsi GC11M101322.
    HGNCi HGNC:12338. TRPC6.
    HPAi HPA045098.
    MIMi 603652. gene.
    603965. phenotype.
    neXtProti NX_Q9Y210.
    Orphaneti 93213. Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis.
    PharmGKBi PA37011.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG254238.
    HOGENOMi HOG000020590.
    HOVERGENi HBG068337.
    InParanoidi Q9Y210.
    KOi K04969.
    OMAi NRGPAYM.
    OrthoDBi EOG77HDD1.
    PhylomeDBi Q9Y210.
    TreeFami TF313147.

    Enzyme and pathway databases

    Reactomei REACT_162. Elevation of cytosolic Ca2+ levels.
    REACT_169333. TRP channels.
    REACT_2202. Effects of PIP2 hydrolysis.
    REACT_22228. Role of second messengers in netrin-1 signaling.

    Miscellaneous databases

    ChiTaRSi TRPC6. human.
    GeneWikii TRPC6.
    GenomeRNAii 7225.
    NextBioi 28295.
    PROi Q9Y210.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y210.
    Bgeei Q9Y210.
    CleanExi HS_TRPC6.
    Genevestigatori Q9Y210.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR013555. TRP_dom.
    IPR005462. TRPC6_channel.
    IPR002153. TRPC_channel.
    [Graphical view ]
    PANTHERi PTHR10117. PTHR10117. 1 hit.
    PTHR10117:SF7. PTHR10117:SF7. 1 hit.
    Pfami PF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF08344. TRP_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01097. TRNSRECEPTRP.
    PR01647. TRPCHANNEL6.
    SMARTi SM00248. ANK. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    TIGRFAMsi TIGR00870. trp. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 2 hits.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol."
      Hofmann T., Obukhov A.G., Schaefer M., Harteneck C., Gudermann T., Schultz G.
      Nature 397:259-263(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta and Testis.
    2. "Identification and assignment of the human transient receptor potential channel 6 gene TRPC6 to chromosome 11q21-22."
      D'Esposito M., Strazzullo M., Cuccurese M., Spalluto C., Rocchi M., D'Urso M., Ciccodicola A.
      Cytogenet. Cell Genet. 83:46-47(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Teratocarcinoma.
    3. "TRP4 (CCE1) protein is part of native calcium release-activated Ca2+-like channels in adrenal cells."
      Philipp S., Trost C., Warnat J., Rautmann J., Himmerkus N., Schroth G., Kretz O., Nastainczyk W., Cavalie A., Hoth M., Flockerzi V.
      J. Biol. Chem. 275:23965-23972(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Placenta.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "The capacitative calcium entry cation channel Trp6 is expressed in the muscularis externa of the guinea pig ileum and in a human jejunum smooth muscle cell line."
      Fenech C.J., Prestwich S.A., Zholos A.V., Bolton T.B.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 487-643.
    6. "N-linked protein glycosylation is a major determinant for basal TRPC3 and TRPC6 channel activity."
      Dietrich A., Mederos y Schnitzler M., Emmel J., Kalwa H., Hofmann T., Gudermann T.
      J. Biol. Chem. 278:47842-47852(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-473 AND ASN-561, MUTAGENESIS OF ASN-561.
    7. "MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC."
      Lussier M.P., Cayouette S., Lepage P.K., Bernier C.L., Francoeur N., St-Hilaire M., Pinard M., Boulay G.
      J. Biol. Chem. 280:19393-19400(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MX1.
    8. "RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC."
      Lussier M.P., Lepage P.K., Bousquet S.M., Boulay G.
      Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RNF24, MUTAGENESIS OF ASN-125; ASN-127; CYS-128 AND ASP-130.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-815, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    10. Cited for: VARIANTS FSGS2 SER-143; THR-270; CYS-895 AND LYS-897, TISSUE SPECIFICITY.
    11. Cited for: VARIANT FSGS2 GLN-112.
    12. Cited for: VARIANT FSGS2 LEU-218, VARIANTS SER-125 AND LEU-895.

    Entry informationi

    Entry nameiTRPC6_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y210
    Secondary accession number(s): Q52M59
    , Q9HCW3, Q9NQA8, Q9NQA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 140 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

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