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Q9Y210

- TRPC6_HUMAN

UniProt

Q9Y210 - TRPC6_HUMAN

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Protein

Short transient receptor potential channel 6

Gene
TRPC6, TRP6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.

GO - Molecular functioni

  1. inositol 1,4,5 trisphosphate binding Source: BHF-UCL
  2. protein binding Source: IntAct
  3. store-operated calcium channel activity Source: Ensembl

GO - Biological processi

  1. aging Source: Ensembl
  2. axon guidance Source: Reactome
  3. blood coagulation Source: Reactome
  4. calcium ion transmembrane transport Source: Reactome
  5. cation transport Source: ProtInc
  6. cellular response to hydrogen peroxide Source: Ensembl
  7. cellular response to hypoxia Source: Ensembl
  8. ion transmembrane transport Source: Reactome
  9. platelet activation Source: Reactome
  10. positive regulation of calcium ion transport Source: MGI
  11. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  12. positive regulation of ion transmembrane transporter activity Source: MGI
  13. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_162. Elevation of cytosolic Ca2+ levels.
REACT_169333. TRP channels.
REACT_2202. Effects of PIP2 hydrolysis.
REACT_22228. Role of second messengers in netrin-1 signaling.

Protein family/group databases

TCDBi1.A.4.1.5. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 6
Short name:
TrpC6
Alternative name(s):
Transient receptor protein 6
Short name:
TRP-6
Gene namesi
Name:TRPC6
Synonyms:TRP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:12338. TRPC6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 438438Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei439 – 45921Helical; Reviewed predictionAdd
BLAST
Topological domaini460 – 48728Extracellular Reviewed predictionAdd
BLAST
Transmembranei488 – 50821Helical; Reviewed predictionAdd
BLAST
Topological domaini509 – 52113Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei522 – 54221Helical; Reviewed predictionAdd
BLAST
Topological domaini543 – 59250Extracellular Reviewed predictionAdd
BLAST
Transmembranei593 – 61321Helical; Reviewed predictionAdd
BLAST
Topological domaini614 – 63623Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei637 – 65721Helical; Reviewed predictionAdd
BLAST
Topological domaini658 – 70649Extracellular Reviewed predictionAdd
BLAST
Transmembranei707 – 72721Helical; Reviewed predictionAdd
BLAST
Topological domaini728 – 931204Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
  3. slit diaphragm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Focal segmental glomerulosclerosis 2 (FSGS2) [MIM:603965]: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
Note: The disease is caused by mutations affecting the gene represented in this entry.3 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti112 – 1121P → Q in FSGS2. 1 Publication
VAR_026730
Natural varianti143 – 1431N → S in FSGS2. 1 Publication
Corresponds to variant rs121434391 [ dbSNP | Ensembl ].
VAR_026731
Natural varianti218 – 2181H → L in FSGS2. 1 Publication
VAR_067248
Natural varianti270 – 2701S → T in FSGS2. 1 Publication
VAR_026732
Natural varianti895 – 8951R → C in FSGS2. 1 Publication
VAR_026733
Natural varianti897 – 8971E → K in FSGS2. 1 Publication
VAR_026734

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi125 – 1251N → A: No effect on RNF24-binding; when associated with A-127; A-128 and A-130. 1 Publication
Mutagenesisi127 – 1271N → A: No effect on RNF24-binding; when associated with A-125; A-128 and A-130. 1 Publication
Mutagenesisi128 – 1281C → A: No effect on RNF24-binding; when associated with A-125; A-127 and A-130. 1 Publication
Mutagenesisi130 – 1301D → A: No effect on RNF24-binding; when associated with A-125; A-127 and A-128. 1 Publication
Mutagenesisi561 – 5611N → Q: Constitutively activates channel. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi603965. phenotype.
Orphaneti93213. Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis.
PharmGKBiPA37011.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 931931Short transient receptor potential channel 6PRO_0000215322Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi473 – 4731N-linked (GlcNAc...)1 Publication
Glycosylationi561 – 5611N-linked (GlcNAc...)1 Publication
Modified residuei815 – 8151Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated by FYN, leading to an increase of TRPC6 channel activity By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9Y210.
PRIDEiQ9Y210.

PTM databases

PhosphoSiteiQ9Y210.

Expressioni

Tissue specificityi

Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.1 Publication

Gene expression databases

ArrayExpressiQ9Y210.
BgeeiQ9Y210.
CleanExiHS_TRPC6.
GenevestigatoriQ9Y210.

Organism-specific databases

HPAiHPA045098.

Interactioni

Subunit structurei

Interacts with MX1 and RNF24.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MX1P205914EBI-929362,EBI-929476

Protein-protein interaction databases

BioGridi113076. 12 interactions.
IntActiQ9Y210. 2 interactions.
STRINGi9606.ENSP00000340913.

Structurei

3D structure databases

ProteinModelPortaliQ9Y210.
SMRiQ9Y210. Positions 48-254.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati97 – 12630ANK 1Add
BLAST
Repeati132 – 16130ANK 2Add
BLAST
Repeati163 – 18927ANK 3Add
BLAST
Repeati218 – 24730ANK 4Add
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG254238.
HOGENOMiHOG000020590.
HOVERGENiHBG068337.
InParanoidiQ9Y210.
KOiK04969.
OMAiNRGPAYM.
OrthoDBiEOG77HDD1.
PhylomeDBiQ9Y210.
TreeFamiTF313147.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005462. TRPC6_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF7. PTHR10117:SF7. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01647. TRPCHANNEL6.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y210-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSQSPAFGPR RGSSPRGAAG AAARRNESQD YLLMDSELGE DGCPQAPLPC    50
YGYYPCFRGS DNRLAHRRQT VLREKGRRLA NRGPAYMFSD RSTSLSIEEE 100
RFLDAAEYGN IPVVRKMLEE CHSLNVNCVD YMGQNALQLA VANEHLEITE 150
LLLKKENLSR VGDALLLAIS KGYVRIVEAI LSHPAFAEGK RLATSPSQSE 200
LQQDDFYAYD EDGTRFSHDV TPIILAAHCQ EYEIVHTLLR KGARIERPHD 250
YFCKCNDCNQ KQKHDSFSHS RSRINAYKGL ASPAYLSLSS EDPVMTALEL 300
SNELAVLANI EKEFKNDYKK LSMQCKDFVV GLLDLCRNTE EVEAILNGDV 350
ETLQSGDHGR PNLSRLKLAI KYEVKKFVAH PNCQQQLLSI WYENLSGLRQ 400
QTMAVKFLVV LAVAIGLPFL ALIYWFAPCS KMGKIMRGPF MKFVAHAASF 450
TIFLGLLVMN AADRFEGTKL LPNETSTDNA KQLFRMKTSC FSWMEMLIIS 500
WVIGMIWAEC KEIWTQGPKE YLFELWNMLD FGMLAIFAAS FIARFMAFWH 550
ASKAQSIIDA NDTLKDLTKV TLGDNVKYYN LARIKWDPSD PQIISEGLYA 600
IAVVLSFSRI AYILPANESF GPLQISLGRT VKDIFKFMVI FIMVFVAFMI 650
GMFNLYSYYI GAKQNEAFTT VEESFKTLFW AIFGLSEVKS VVINYNHKFI 700
ENIGYVLYGV YNVTMVIVLL NMLIAMINSS FQEIEDDADV EWKFARAKLW 750
FSYFEEGRTL PVPFNLVPSP KSLFYLLLKL KKWISELFQG HKKGFQEDAE 800
MNKINEEKKL GILGSHEDLS KLSLDKKQVG HNKQPSIRSS EDFHLNSFNN 850
PPRQYQKIMK RLIKRYVLQA QIDKESDEVN EGELKEIKQD ISSLRYELLE 900
EKSQNTEDLA ELIRELGEKL SMEPNQEETN R 931
Length:931
Mass (Da):106,326
Last modified:November 1, 1999 - v1
Checksum:i7C955C2B0389AC47
GO
Isoform 2 (identifier: Q9Y210-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     316-431: Missing.

Show »
Length:815
Mass (Da):93,187
Checksum:i2E78B50F956CBF0D
GO
Isoform 3 (identifier: Q9Y210-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     377-431: Missing.

Show »
Length:876
Mass (Da):100,106
Checksum:i8A1F52196619E147
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti112 – 1121P → Q in FSGS2. 1 Publication
VAR_026730
Natural varianti125 – 1251N → S Found in two siblings with early-onset steroid-resistant nephrotic syndrome. 1 Publication
VAR_067247
Natural varianti143 – 1431N → S in FSGS2. 1 Publication
Corresponds to variant rs121434391 [ dbSNP | Ensembl ].
VAR_026731
Natural varianti157 – 1571N → T.
Corresponds to variant rs35857503 [ dbSNP | Ensembl ].
VAR_038419
Natural varianti218 – 2181H → L in FSGS2. 1 Publication
VAR_067248
Natural varianti270 – 2701S → T in FSGS2. 1 Publication
VAR_026732
Natural varianti404 – 4041A → V.
Corresponds to variant rs36111323 [ dbSNP | Ensembl ].
VAR_061861
Natural varianti895 – 8951R → C in FSGS2. 1 Publication
VAR_026733
Natural varianti895 – 8951R → L in a patient with collapsing glomerulosclerosis. 1 Publication
VAR_067249
Natural varianti897 – 8971E → K in FSGS2. 1 Publication
VAR_026734

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei316 – 431116Missing in isoform 2. VSP_006572Add
BLAST
Alternative sequencei377 – 43155Missing in isoform 3. VSP_006573Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti336 – 3361C → R in CAC01686. 1 Publication
Sequence conflicti585 – 5851K → R in CAC06090. 1 Publication
Sequence conflicti613 – 6131I → T in CAC01686. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF080394 mRNA. Translation: AAC63289.2.
AJ006276 mRNA. Translation: CAA06943.1.
AJ271066 mRNA. Translation: CAC01684.1.
AJ271067 mRNA. Translation: CAC01685.1.
AJ271068 mRNA. Translation: CAC01686.1.
BC093658 mRNA. Translation: AAH93658.1.
BC093660 mRNA. Translation: AAH93660.1.
AJ007018 mRNA. Translation: CAC06090.1.
CCDSiCCDS8311.1. [Q9Y210-1]
RefSeqiNP_004612.2. NM_004621.5. [Q9Y210-1]
UniGeneiHs.159003.

Genome annotation databases

EnsembliENST00000344327; ENSP00000340913; ENSG00000137672. [Q9Y210-1]
ENST00000348423; ENSP00000343672; ENSG00000137672. [Q9Y210-2]
ENST00000360497; ENSP00000353687; ENSG00000137672. [Q9Y210-3]
GeneIDi7225.
KEGGihsa:7225.
UCSCiuc001pgk.4. human. [Q9Y210-1]
uc009ywy.3. human. [Q9Y210-2]
uc009ywz.1. human. [Q9Y210-3]

Polymorphism databases

DMDMi6686048.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF080394 mRNA. Translation: AAC63289.2 .
AJ006276 mRNA. Translation: CAA06943.1 .
AJ271066 mRNA. Translation: CAC01684.1 .
AJ271067 mRNA. Translation: CAC01685.1 .
AJ271068 mRNA. Translation: CAC01686.1 .
BC093658 mRNA. Translation: AAH93658.1 .
BC093660 mRNA. Translation: AAH93660.1 .
AJ007018 mRNA. Translation: CAC06090.1 .
CCDSi CCDS8311.1. [Q9Y210-1 ]
RefSeqi NP_004612.2. NM_004621.5. [Q9Y210-1 ]
UniGenei Hs.159003.

3D structure databases

ProteinModelPortali Q9Y210.
SMRi Q9Y210. Positions 48-254.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113076. 12 interactions.
IntActi Q9Y210. 2 interactions.
STRINGi 9606.ENSP00000340913.

Chemistry

ChEMBLi CHEMBL2417347.
GuidetoPHARMACOLOGYi 491.

Protein family/group databases

TCDBi 1.A.4.1.5. the transient receptor potential ca(2+) channel (trp-cc) family.

PTM databases

PhosphoSitei Q9Y210.

Polymorphism databases

DMDMi 6686048.

Proteomic databases

PaxDbi Q9Y210.
PRIDEi Q9Y210.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344327 ; ENSP00000340913 ; ENSG00000137672 . [Q9Y210-1 ]
ENST00000348423 ; ENSP00000343672 ; ENSG00000137672 . [Q9Y210-2 ]
ENST00000360497 ; ENSP00000353687 ; ENSG00000137672 . [Q9Y210-3 ]
GeneIDi 7225.
KEGGi hsa:7225.
UCSCi uc001pgk.4. human. [Q9Y210-1 ]
uc009ywy.3. human. [Q9Y210-2 ]
uc009ywz.1. human. [Q9Y210-3 ]

Organism-specific databases

CTDi 7225.
GeneCardsi GC11M101322.
HGNCi HGNC:12338. TRPC6.
HPAi HPA045098.
MIMi 603652. gene.
603965. phenotype.
neXtProti NX_Q9Y210.
Orphaneti 93213. Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis.
PharmGKBi PA37011.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG254238.
HOGENOMi HOG000020590.
HOVERGENi HBG068337.
InParanoidi Q9Y210.
KOi K04969.
OMAi NRGPAYM.
OrthoDBi EOG77HDD1.
PhylomeDBi Q9Y210.
TreeFami TF313147.

Enzyme and pathway databases

Reactomei REACT_162. Elevation of cytosolic Ca2+ levels.
REACT_169333. TRP channels.
REACT_2202. Effects of PIP2 hydrolysis.
REACT_22228. Role of second messengers in netrin-1 signaling.

Miscellaneous databases

ChiTaRSi TRPC6. human.
GeneWikii TRPC6.
GenomeRNAii 7225.
NextBioi 28295.
PROi Q9Y210.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y210.
Bgeei Q9Y210.
CleanExi HS_TRPC6.
Genevestigatori Q9Y210.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005462. TRPC6_channel.
IPR002153. TRPC_channel.
[Graphical view ]
PANTHERi PTHR10117. PTHR10117. 1 hit.
PTHR10117:SF7. PTHR10117:SF7. 1 hit.
Pfami PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view ]
PRINTSi PR01097. TRNSRECEPTRP.
PR01647. TRPCHANNEL6.
SMARTi SM00248. ANK. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
TIGRFAMsi TIGR00870. trp. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol."
    Hofmann T., Obukhov A.G., Schaefer M., Harteneck C., Gudermann T., Schultz G.
    Nature 397:259-263(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta and Testis.
  2. "Identification and assignment of the human transient receptor potential channel 6 gene TRPC6 to chromosome 11q21-22."
    D'Esposito M., Strazzullo M., Cuccurese M., Spalluto C., Rocchi M., D'Urso M., Ciccodicola A.
    Cytogenet. Cell Genet. 83:46-47(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Teratocarcinoma.
  3. "TRP4 (CCE1) protein is part of native calcium release-activated Ca2+-like channels in adrenal cells."
    Philipp S., Trost C., Warnat J., Rautmann J., Himmerkus N., Schroth G., Kretz O., Nastainczyk W., Cavalie A., Hoth M., Flockerzi V.
    J. Biol. Chem. 275:23965-23972(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Placenta.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "The capacitative calcium entry cation channel Trp6 is expressed in the muscularis externa of the guinea pig ileum and in a human jejunum smooth muscle cell line."
    Fenech C.J., Prestwich S.A., Zholos A.V., Bolton T.B.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 487-643.
  6. "N-linked protein glycosylation is a major determinant for basal TRPC3 and TRPC6 channel activity."
    Dietrich A., Mederos y Schnitzler M., Emmel J., Kalwa H., Hofmann T., Gudermann T.
    J. Biol. Chem. 278:47842-47852(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-473 AND ASN-561, MUTAGENESIS OF ASN-561.
  7. "MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC."
    Lussier M.P., Cayouette S., Lepage P.K., Bernier C.L., Francoeur N., St-Hilaire M., Pinard M., Boulay G.
    J. Biol. Chem. 280:19393-19400(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MX1.
  8. "RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC."
    Lussier M.P., Lepage P.K., Bousquet S.M., Boulay G.
    Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RNF24, MUTAGENESIS OF ASN-125; ASN-127; CYS-128 AND ASP-130.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-815, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  10. Cited for: VARIANTS FSGS2 SER-143; THR-270; CYS-895 AND LYS-897, TISSUE SPECIFICITY.
  11. Cited for: VARIANT FSGS2 GLN-112.
  12. Cited for: VARIANT FSGS2 LEU-218, VARIANTS SER-125 AND LEU-895.

Entry informationi

Entry nameiTRPC6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y210
Secondary accession number(s): Q52M59
, Q9HCW3, Q9NQA8, Q9NQA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi