Q9Y1T2 (Q9Y1T2_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Adenomatous polyposis coli 2 EMBL AAD20985.2

Submitted name:
Adenomatous polyposis coli tumor suppressor homolog 2 EMBL AAF56249.1
Submitted name:
Epithelial adenomatous polyposis coli EMBL AAD40227.1

Gene names

Name:	Apc2 EMBL AAF56249.1 FlyBase FBgn0026598
Synonyms:	E-APC EMBL AAD40227.1
ORF Names:	CG6193 FlyBase FBgn0026598, Dmel_CG6193 EMBL AAF56249.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1067 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Traceable author statement. Source: FlyBase axon guidance Inferred from genetic interaction. Source: FlyBase cell-cell adhesion Inferred from genetic interaction. Source: FlyBase chitin-based embryonic cuticle biosynthetic process Inferred from mutant phenotype. Source: FlyBase chitin-based larval cuticle pattern formation Inferred from genetic interaction. Source: FlyBase cytokinesis Traceable author statement. Source: FlyBase establishment of mitotic spindle localization Traceable author statement. Source: FlyBase establishment or maintenance of microtubule cytoskeleton polarity Inferred from mutant phenotype. Source: FlyBase head involution Inferred from genetic interaction. Source: FlyBase imaginal disc pattern formation Inferred from genetic interaction. Source: FlyBase medulla oblongata development Inferred from genetic interaction. Source: FlyBase negative regulation of Wnt receptor signaling pathway Inferred from genetic interaction. Source: FlyBase negative regulation of transcription, DNA-dependent Traceable author statement. Source: FlyBase neuroblast proliferation Inferred from genetic interaction. Source: FlyBase oocyte localization involved in germarium-derived egg chamber formation Inferred from mutant phenotype. Source: FlyBase positive regulation of proteolysis Traceable author statement. Source: FlyBase pseudocleavage involved in syncytial blastoderm formation Inferred from mutant phenotype. Source: FlyBase syncytial nuclear migration Inferred from mutant phenotype. Source: FlyBase
Cellular component	adherens junction Traceable author statement. Source: FlyBase apical cortex Inferred from direct assay. Source: FlyBase apicolateral plasma membrane Traceable author statement. Source: FlyBase cleavage furrow Inferred from direct assay. Source: FlyBase dendrite Inferred from direct assay. Source: FlyBase neuronal cell body Inferred from direct assay. Source: FlyBase nucleus Traceable author statement. Source: FlyBase protein complex Inferred from physical interaction. Source: FlyBase
Molecular function	beta-catenin binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9Y1T2 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 20C8F5F6121888F8	FASTA	1,067	116,704
	10 20 30 40 50 60 MTLNESDATR LELTRNFLEL SRNPETCTAL RSSDCIQLLV QILHANDEGL STAKKYASQA 70 80 90 100 110 120 LHNIVHNNPE EKERQREVKM LRLLDQILDY CNFLHTQLQS GGEAIADDED RHPLAAMKLL 130 140 150 160 170 180 MKASFDEEHR QTMCELGALK AIPNLVHLDH AVHGPAAGRE QCNALRSYGL MALTNLTFGD 190 200 210 220 230 240 ENVHNKSYLC GQRQFMEVVI AQLNTAPDEL LQVLAGVLRN LSWRADKHMK TIFNELGTVT 250 260 270 280 290 300 SLARAAMQNK NENTLKAILS ALWNLSAHCS TNKAEFCAVD GALAFLVGML SYEGPSKTLK 310 320 330 340 350 360 IIENAGGILR NVSSHIAVCE PYRQILRRYN CLAILLQQLK SESLTVVSNS CGTLWNLSAR 370 380 390 400 410 420 CPEDQQYLID HNAIPLLRAL ISSKNSMIAE GSASALKNLV NFRATQELMP NGDGGSLPLD 430 440 450 460 470 480 KEAGHGGTLP RRFSSLRLSS NPTGSLKKVR PSTVSTTGFL NRKCESRESI YSGKSDSTKY 490 500 510 520 530 540 STKSEGAKNP FEIVTPTEEQ PIDYSMKYME HKPNSSKTFE IDLDQPTDFS ARYKERRSAQ 550 560 570 580 590 600 TAQPELKSET NEIRSKELQL TKSSSATELR NSPGLVAVSA AKQKIATETE TETAERPINY 610 620 630 640 650 660 CEEGTPGSFS RFDSLNSLTE KPEKCMPPKT PTKTAVLPVH VDGNTPQNID SALETPLMFS 670 680 690 700 710 720 RRSSMDSLVG DDETVACEDN GSVISEYSRM QSGVISPSEL PDSPTQSMPQ SPRRDRKVST 730 740 750 760 770 780 QNNLDTPEQK PSTVFEDKLN RFHVEHTPAA FSCATSLSNL SMMDDSNANA IRGQRGNDIN 790 800 810 820 830 840 GNGDAPRSYC TEDTTAVLSK APSNSDLSIL SIPNDLNANE AQPVPAPRAD VTGMDTRMPA 850 860 870 880 890 900 EDAISKMRCG GNALPSYLPV SDEMSKYYVE DSPCTFSVIS GLSHLTVGSA KAGPVLKLPM 910 920 930 940 950 960 RTAEEAQAPK LPPRRSAVQG DAEPRLPPKK SDSLSSLSMD SDDDCNLLSQ AIAAGSCRPQ 970 980 990 1000 1010 1020 PSGASTSSSL ANASTSTLCR ENGQSKKQVE HGDKPNYSSD DSLDDDDDDA RSKSLFEQCI 1030 1040 1050 1060 LSGMHKSNDA LESEGEPPGQ RQEISARDRF VSNQVRQIES MLAGRQH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor." van Es J.H., Kirkpatrick C., van de Wetering M., Molenaar M., Miles A., Kuipers J., Destree O., Peifer M., Clevers H. Curr. Biol. 9:105-108(1999) [PubMed: 10021369] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"A new Drosophila APC homolog concentrated in apical adhesion zones of epithelial cells." Yu X., Bienz M. Nat. Cell Biol. 0:0-0(1999) Cited for: NUCLEOTIDE SEQUENCE.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF091430 mRNA. Translation: AAD20985.2. AF113913 mRNA. Translation: AAD40227.1. AE014297 Genomic DNA. Translation: AAF56249.1.
RefSeq	NP_477430.1. NM_058082.2.
UniGene	Dm.3113.
3D structure databases
ProteinModelPortal	Q9Y1T2.
SMR	Q9Y1T2. Positions 9-406.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-763536.
STRING	Q9Y1T2.
Proteomic databases
PRIDE	Q9Y1T2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0084552; FBpp0083937; FBgn0026598.
GeneID	42871.
KEGG	dme:Dmel_CG6193.
NMPDR	fig|7227.3.peg.14382.
UCSC	CG6193-RA. d. melanogaster.
Organism-specific databases
CTD	10297.
FlyBase	FBgn0026598. Apc2.
Phylogenomic databases
GeneTree	EMGT00050000011467.
InParanoid	Q9Y1T2.
OMA	ASFDEEH.
PhylomeDB	Q9Y1T2.
Gene expression databases
ArrayExpress	Q9Y1T2.
Bgee	Q9Y1T2.
Family and domain databases
InterPro	IPR009240. APC_15aa_rpt. IPR009223. APC_Cys-rich_rpt. IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR000225. Armadillo. [Graphical view]
Gene3D	G3DSA:1.25.10.10. ARM-like. 1 hit.
KO	K02085.
Pfam	PF05972. APC_15aa. 2 hits. PF05923. APC_crr. 4 hits. PF00514. Arm. 2 hits. [Graphical view]
SMART	SM00185. ARM. 7 hits. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50176. ARM_REPEAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	831014.

Entry information

Entry name

Q9Y1T2_DROME

Accession

Primary (citable) accession number: Q9Y1T2

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	January 25, 2012
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)