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Q9Y149 (MED15_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mediator of RNA polymerase II transcription subunit 15
Alternative name(s):
Mediator complex subunit 15
dARC105
Gene names
Name:MED15
Synonyms:Arc105
ORF Names:CG4184
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length749 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors By similarity. Required for activated transcription of the MtnA, MtnB and MtnD genes. Ref.4

Subunit structure

Component of the Mediator complex By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the Mediator complex subunit 15 family.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentmediator complex

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular functionRNA polymerase II transcription cofactor activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 749749Mediator of RNA polymerase II transcription subunit 15
PRO_0000304668

Regions

Compositional bias69 – 460392Gln-rich

Sequences

Sequence LengthMass (Da)Tools
Q9Y149 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 42375AEB7C13A1DF

FASTA74980,526
        10         20         30         40         50         60 
MTEDWQSQKF RQNVISKIHD LLPPNAQDQT KNAGVMENHI FRKSRTKDEY LGLVAKLFMH 

        70         80         90        100        110        120 
YKDMSRKSQQ QQQQQQQQGG PPPNAEMGGG QNMMQDPLNA LQNLASQGNR NPQMMPMGAG 

       130        140        150        160        170        180 
GGAPVPGGPG TASNLLQSLN QQRPGQQQMQ PMSNIRGQMP MGAGGAGAQQ MMQVQQMQQG 

       190        200        210        220        230        240 
GNAPGVMNVM GAGGGQNQGQ IVGNPGQQMG VGVGMPNQMV GPGPNSGPAV GGAGGPNAAP 

       250        260        270        280        290        300 
GAGGPGPNQM QGGPMNVNAM QQMPPMQQIQ QNQLGMGMNP MMRMGQGNGM GGPQGMPGQG 

       310        320        330        340        350        360 
MQGMPQGPHN VVGGPAGQQQ VGGAGLPPNA VQQGGMNPMG GMGVNMPPNL QQKPNMPMGQ 

       370        380        390        400        410        420 
AGQMFPGNRG GVGVGGQQPG QPFMRSSPSP ADAQQLQQQA QLQQMQQQQQ QLVVGNQTPT 

       430        440        450        460        470        480 
QQPPTPQMPT PNMIPSPALV PQSSPQMMQM QNSQRNIRQQ SPSASINTPG QVTGNSPFNP 

       490        500        510        520        530        540 
QEEALYREKY KQLTKYIEPL KRMLAKISND GTNVEKMTKM SKLLEILCNP TQRVPLETLL 

       550        560        570        580        590        600 
KCEKALEKMD LISYSGQQFG KSSNPLLEVI NTTLQSPVAN HTLYRTFRPT LELLFGTDIT 

       610        620        630        640        650        660 
APVPAKRPRV EEKSTSFEQE VPHVLQGEIA RLDTKFKVKL DTTSQINNKA IRLICCLDDK 

       670        680        690        700        710        720 
RLPSVPPVSV SVPEEYPWQA PDCSLAEQEY SATPFLQTVQ QALIARISKL PKNYSLSHLL 

       730        740 
DTWEMAVRQA CSPQSKPRAV CELSTLLGV

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[3]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Head.
[4]"Coactivator cross-talk specifies transcriptional output."
Marr M.T. II, Isogai Y., Wright K.J., Tjian R.
Genes Dev. 20:1458-1469(2006) [PubMed: 16751183] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE014134 Genomic DNA. Translation: AAF51490.1.
AF145620 mRNA. Translation: AAD38595.1.
RefSeqNP_608528.1. NM_134684.2.
UniGeneDm.3163.

3D structure databases

ProteinModelPortalQ9Y149.
SMRQ9Y149. Positions 1-71.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9Y149. 25 interactions.
MINTMINT-1559001.

Proteomic databases

PRIDEQ9Y149.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0078062; FBpp0077722; FBgn0027592.
GeneID33223.
KEGGdme:Dmel_CG4184.
NMPDRfig|7227.3.peg.105.

Organism-specific databases

CTD51586.
FlyBaseFBgn0027592. MED15.

Phylogenomic databases

eggNOGinNOG04274.
GeneTreeEMGT00050000001407.
InParanoidQ9Y149.
OMAHLLDTWE.
OrthoDBEOG4Z34W2.
PhylomeDBQ9Y149.

Gene expression databases

BgeeQ9Y149.

Family and domain databases

InterProIPR019087. Mediator_Med15_met.
[Graphical view]
KOK15157.
PfamPF09606. Med15. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio782520.

Entry information

Entry nameMED15_DROME
AccessionPrimary (citable) accession number: Q9Y149
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 1, 1999
Last modified: January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents