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Protein
Submitted name:

L.2.35Df

Gene

Mtr4

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: InterPro
  • ATP-dependent RNA helicase activity Source: FlyBase
  • RNA binding Source: InterPro

GO - Biological processi

  • defense response to virus Source: FlyBase
  • maturation of 5.8S rRNA Source: GO_Central
  • mRNA splicing, via spliceosome Source: FlyBase
  • RNA catabolic process Source: GO_Central

Keywordsi

Molecular functionHelicaseImported, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-DME-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
L.2.35DfImported
Submitted name:
Mtr4 helicaseImported (EC:3.6.1.3Imported)
Gene namesi
Name:Mtr4Imported
Synonyms:BcDNA:GH07290Imported, BG:DS09217.2Imported, br44Imported, Dmel\CG4152Imported, dMtr4Imported, L(2)35DfImported, l(2)35DfImported, l(2)br44Imported, l(2)k14422Imported, l(2)k14423Imported, l.2.35DfImported, lethal(2)35DfImported
ORF Names:CG4152Imported, Dmel_CG4152Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0001986. Mtr4.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: FlyBase

Expressioni

Gene expression databases

BgeeiFBgn0001986.

Interactioni

Protein-protein interaction databases

IntActiQ9Y134. 2 interactors.
MINTiMINT-942655.
STRINGi7227.FBpp0080319.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini160 – 316Helicase ATP-bindingInterPro annotationAdd BLAST157
Domaini389 – 593Helicase C-terminalInterPro annotationAdd BLAST205

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili838 – 865Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0948. Eukaryota.
COG4581. LUCA.
GeneTreeiENSGT00820000127042.
KOiK12598.
OMAiNMLYRGS.
OrthoDBiEOG091G01TA.

Family and domain databases

InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR025696. rRNA_proc-arch_dom.
IPR016438. Ski2.
IPR012961. Ski2_C.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF08148. DSHCT. 1 hit.
PF00271. Helicase_C. 1 hit.
PF13234. rRNA_proc-arch. 1 hit.
PIRSFiPIRSF005198. Antiviral_helicase_SKI2. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM01142. DSHCT. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIEELFDCF DEVTPSVPPP ALNQEEKPSG SSASKKGNKR QADGTTASKE
60 70 80 90 100
ATSSKGAEGD DKGDVTEEPT KRLKQEASTV AVDDDNNADD EPTRTLDIDD
110 120 130 140 150
SATLEALRTR IVTHLLDAPK SCTHEVAAHP DQEYIPLKPF SGVPAKEYPF
160 170 180 190 200
VLDPFQRQAI LCIDNSQSVL VSAHTSAGKT VVAEYAIAKS LAAKQRVIYT
210 220 230 240 250
TPIKALSNQK FREFTDEFKD VGLVTGDVTI NPSASCLIMT TEILRNMLYR
260 270 280 290 300
GSEIMREVGW VVFDEIHYMR DKERGVVWEE TLILLPDNVR YVFLSATIPN
310 320 330 340 350
ARQFAEWVCH LHKQPCHVVY TDYRPTPLQH YIFPAGGDGI HLIVDEKGQF
360 370 380 390 400
KEDNFTTAMA VLANAGEAGK GDQKGRHGGI KGTNAGQTNI FKIVKMIMER
410 420 430 440 450
NFAPVIIFSF SKKDCEIYAM QMAKLDFNTP DEKKLVDEVF NNAMDVLTEE
460 470 480 490 500
DRRLPQVENV LPLLRRGIGI HHGGLLPILK ETIEILFGEG LIKALFATET
510 520 530 540 550
FAMGLNMPAR TVLFTAPRKF DGKKFRWISS GEYIQMAGRA GRRGLDDKGI
560 570 580 590 600
VILMIDEKVS PAVGRDIVQG KADPINSAFH LTYNMVLNLL RVEEINPEYM
610 620 630 640 650
LERSFYQFQN QAALPGLHDQ VEQKTLELNK LTIKDEHNIA SYHHIRSQLD
660 670 680 690 700
QHGKQFRQWI TKPQYLLPFL QPGRLVKVAA GSQEYDWGIV LNFKKQDQSR
710 720 730 740 750
KNPLKAEPSV TIDVLLHVSE AAAKTGDTEP CKPNERGCME VVPVAHTLIT
760 770 780 790 800
QISSIRVYFP NDLRSADNRR AVLKTIQEAK KRFPLGPPVL NPIDDMNIKD
810 820 830 840 850
REFRDIVNTI SQFEKRLEEH PLHKSPELER IHRRYQDKVT LQKQLQDLKA
860 870 880 890 900
ELKAARSLLQ MDELKHRKRV LRRMGYCKPG DVIEFKGRVA CELSSADELL
910 920 930 940 950
MTEMIFNGVF NDLTAPQAVA LLSCFVCDEK SSESVKSATE LSGPLRSMQD
960 970 980 990 1000
LARRIAKVST ECKLDLDADT YVDKFKPFLM DVVLAWCKGS SFLAVCKMTD
1010 1020 1030 1040 1050
IFEGSIIRCM RRLEELLRQM CQASKTIGNT DLENKFSEGI RLLKRDIVFA

ASLYL
Length:1,055
Mass (Da):118,925
Last modified:November 1, 1999 - v1
Checksum:iF6D797BA076F708D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145638 mRNA. Translation: AAD38613.1.
AE014134 Genomic DNA. Translation: AAF53481.1.
RefSeqiNP_524929.1. NM_080190.3.
UniGeneiDm.1748.

Genome annotation databases

EnsemblMetazoaiFBtr0080760; FBpp0080319; FBgn0001986.
GeneIDi48782.
KEGGidme:Dmel_CG4152.
UCSCiCG4152-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ9Y134_DROME
AccessioniPrimary (citable) accession number: Q9Y134
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: August 30, 2017
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported