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Protein

Probable glutamine--tRNA ligase

Gene

Aats-gln

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei499ATPBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • glutamine-tRNA ligase activity Source: FlyBase
  • RNA binding Source: GO_Central

GO - Biological processi

  • dendrite morphogenesis Source: FlyBase
  • glutaminyl-tRNA aminoacylation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutamine--tRNA ligase (EC:6.1.1.18)
Alternative name(s):
Glutaminyl-tRNA synthetase
Short name:
GlnRS
Gene namesi
ORF Names:CG10506
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0027090. Aats-gln.

Subcellular locationi

GO - Cellular componenti

  • aminoacyl-tRNA synthetase multienzyme complex Source: FlyBase
  • cytoplasm Source: FlyBase
  • cytosol Source: GO_Central
  • microtubule associated complex Source: FlyBase
  • mitochondrion Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001958631 – 778Probable glutamine--tRNA ligaseAdd BLAST778

Proteomic databases

PaxDbiQ9Y105.
PRIDEiQ9Y105.

Expressioni

Gene expression databases

BgeeiFBgn0027090.
GenevisibleiQ9Y105. DM.

Interactioni

Protein-protein interaction databases

BioGridi69882. 8 interactors.
DIPiDIP-18324N.
IntActiQ9Y105. 4 interactors.
MINTiMINT-307310.
STRINGi7227.FBpp0084240.

Structurei

3D structure databases

ProteinModelPortaliQ9Y105.
SMRiQ9Y105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi273 – 283"HIGH" regionAdd BLAST11
Motifi496 – 500"KMSKS" region5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1148. Eukaryota.
COG0008. LUCA.
GeneTreeiENSGT00550000074972.
InParanoidiQ9Y105.
KOiK01886.
OMAiKFQALGM.
OrthoDBiEOG091G026F.
PhylomeDBiQ9Y105.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR007638. Gln-tRNA-synth_Ib_RNA-bd_2.
IPR007639. Gln-tRNA-synth_Ib_RNA-bd_N.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
PF04558. tRNA_synt_1c_R1. 1 hit.
PF04557. tRNA_synt_1c_R2. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGDDLIAKF QALGMSEQKA KETLKNANVT KNLQLSLAAA GSATLSDGTG
60 70 80 90 100
MLIYHMATKL KPQTADHLPL LVRYIVEHKL DNTQRVDAAL EYLLKCGQSL
110 120 130 140 150
NANIDLQALE KECGVGVVVT PEQIERTVQA KIKASYKEAL LEQRYHFNSF
160 170 180 190 200
KILQDVRGEL KWADAKSVKA AIDVEIFDLL GPKTEADLKP QTKANDKPKA
210 220 230 240 250
AKPKAEVTPA AQTAEAASDG ATTISELMKT KVHFHAPGEN FKADGYVVTE
260 270 280 290 300
HTERLLKEHL ARTGGKVHTR FPPEPNGILH IGHAKAININ FGYAAAHDGV
310 320 330 340 350
CYLRYDDTNP EKEEEKFFLA IKEMVEWLGY KPFKITYSSD NFQQLYEWAV
360 370 380 390 400
VLINKGLAYV CHQKAEELKG FNPKPSPWRE RPIEESLRLF EDMKRGKIDE
410 420 430 440 450
GAATLRMKVT LEEGKMDPVA YRIKFISHHR TGSDWCIYPT YDYTHCLCDS
460 470 480 490 500
LEDITHSLCT KEFQSRRSSY YWLCNALGIY CPVQWEYGRL NMNYALVSKR
510 520 530 540 550
KIAKLITEQI VHDWDDPRLF TLTALRRRGF PAEAINNFCA QMGVTGAQIA
560 570 580 590 600
VDPAMLEAAV RDVLNVTAPR RLVVLEPLKV TIKNFPHAAP VQLEVPDFPQ
610 620 630 640 650
NPQQGTHKIT LDKVIYIEQG DFKLEPEKGY RRLAPKQSVG LRHAGLVISV
660 670 680 690 700
DEIVKDPATG QVVELICTSQ PAEQAEKPKA FVQWVSQPIQ LEVRLYEQLF
710 720 730 740 750
KHKNPEDPNE VPGGFLSDIS EQSMSVVVAF ADRALNQAKV YDKFQFERIG
760 770
FFSVDPDTSA NHLVFNRTVG LKEDAGKK
Length:778
Mass (Da):87,508
Last modified:November 1, 1999 - v1
Checksum:i748509EC93E5E43A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56434.2.
AF145668 mRNA. Translation: AAD38643.1.
RefSeqiNP_524841.1. NM_080102.5.
UniGeneiDm.1790.

Genome annotation databases

EnsemblMetazoaiFBtr0084866; FBpp0084240; FBgn0027090.
GeneIDi45786.
KEGGidme:Dmel_CG10506.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF56434.2.
AF145668 mRNA. Translation: AAD38643.1.
RefSeqiNP_524841.1. NM_080102.5.
UniGeneiDm.1790.

3D structure databases

ProteinModelPortaliQ9Y105.
SMRiQ9Y105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi69882. 8 interactors.
DIPiDIP-18324N.
IntActiQ9Y105. 4 interactors.
MINTiMINT-307310.
STRINGi7227.FBpp0084240.

Proteomic databases

PaxDbiQ9Y105.
PRIDEiQ9Y105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0084866; FBpp0084240; FBgn0027090.
GeneIDi45786.
KEGGidme:Dmel_CG10506.

Organism-specific databases

CTDi45786.
FlyBaseiFBgn0027090. Aats-gln.

Phylogenomic databases

eggNOGiKOG1148. Eukaryota.
COG0008. LUCA.
GeneTreeiENSGT00550000074972.
InParanoidiQ9Y105.
KOiK01886.
OMAiKFQALGM.
OrthoDBiEOG091G026F.
PhylomeDBiQ9Y105.

Miscellaneous databases

GenomeRNAii45786.
PROiQ9Y105.

Gene expression databases

BgeeiFBgn0027090.
GenevisibleiQ9Y105. DM.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR007638. Gln-tRNA-synth_Ib_RNA-bd_2.
IPR007639. Gln-tRNA-synth_Ib_RNA-bd_N.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
PF04558. tRNA_synt_1c_R1. 1 hit.
PF04557. tRNA_synt_1c_R2. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYQ_DROME
AccessioniPrimary (citable) accession number: Q9Y105
Secondary accession number(s): Q9VBU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.