Unreviewed, UniProtKB/TrEMBL Q9Y0S9 (Q9Y0S9_DROME)

Names and origin

Protein names

Submitted name:
    Abelson interacting protein, isoform A EMBL AAF55021.1
Submitted name:
    Abelson interacting protein, isoform B EMBL ABW08669.1
    Abl tyrosine kinase-interacting protein EMBL AAD38382.1
    LD37010p EMBL AAK93301.1

Gene names

Name:	Abi EMBL AAF55021.1 FlyBase FBgn0020510
ORF Names:	CG9749 FlyBase FBgn0020510, Dmel_CG9749 EMBL AAF55021.1

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 1 SH3 domain. RuleBase RU003338V3

Ontologies

Keywords
Domain	SH3 domain RuleBase RU003338V3
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	bristle development Inferred from mutant phenotype. Source: FlyBase cell adhesion Inferred from mutant phenotype. Source: FlyBase cortical actin cytoskeleton organization Inferred from mutant phenotype. Source: FlyBase lamellipodium assembly Inferred from mutant phenotype. Source: FlyBase muscle attachment Inferred from mutant phenotype. Source: FlyBase phagocytosis, engulfment Inferred from mutant phenotype. Source: FlyBase positive regulation of protein kinase activity Inferred from direct assay. Source: FlyBase regulation of cell shape Inferred from mutant phenotype. Source: FlyBase
Cellular component	lamellipodium membrane Inferred from direct assay. Source: FlyBase perinuclear region of cytoplasm Inferred from direct assay. Source: FlyBase
Molecular function	kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9Y0S9-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 5C60813E4100252E	FASTA	473	51,925
	10 20 30 40 50 60 MLTETPMASE NIMDELASLI RTEIPDGRQS LRDSYTNLER VADYCEDTYY RADNKKAALE 70 80 90 100 110 120 ATKNYTTQSL ASVAYQINTL AYSYMQLLEL QAQQLGEMES QMNHIAQTVH IHKEKVARRE 130 140 150 160 170 180 IGVLTANKVS SRQFKIVAPI NPEKPIKYVR KPIDYSMLDE IGHGINSAQH SQVRQKHRGS 190 200 210 220 230 240 SHGSVQSLLP PSVGPPPTTK PPTPPQMSRA GNTGTLGKSV SNTGTLGKSS REYRTPPVVN 250 260 270 280 290 300 PPQVPSHYAP NYPIGHPKRM STASSTMTTT TTGGGAAGNE RAAGYSALPM PPSQQIATHV 310 320 330 340 350 360 NLPSAGMMQS LPPPPPTTYD DRSSMPPAPP SPLTVSQHEM TEQSHIGMHT LGRNINRNHF 370 380 390 400 410 420 SLNFARPGSQ SPPLPPPPPP EDEHQDFGRP RTSTGPQLAP IVPEDQNLPG WVPKNFIEKV 430 440 450 460 470 VAIYDYYADK DDELSFQESS VLYVLKKNDD GWWEGVMDGV TGLFPGNYVE PCV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[4]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J. , Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAK93301.1.
[5]	"Drosophila Abelson interacting protein (dAbi) is a positive regulator of Abelson tyrosine kinase activity." Juang J.-L., Hoffmann F.M. Oncogene 0:0-0(1999) Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF151115 mRNA. Translation: AAD38382.1. AE014297 Genomic DNA. Translation: AAF55021.1. AY051877 mRNA. Translation: AAK93301.1. AE014297 Genomic DNA. Translation: ABW08669.1.
RefSeq	NP_001097785.1. NP_477263.1.
UniGene	Dm.3181
3D structure databases
HSSP	HSSP built from PDB template 1UGV based on UniProtKB Q9UNA1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y0S9. 11 interactions.
Proteomic databases
PRIDE	Q9Y0S9.
Genome annotation databases
Ensembl	FBgn0020510. Drosophila melanogaster. [Contig view]
GeneID	41718.
KEGG	dme:Dmel_CG9749.
NMPDR	fig|7227.3.peg.12713.
Organism-specific databases
FlyBase	FBgn0020510. Abi.
Phylogenomic databases
HOGENOM	Q9Y0S9.
OMA	Q9Y0S9. NIMDELA.
Gene expression databases
ArrayExpress	Q9Y0S9.
Family and domain databases
InterPro	IPR012849. Abl-interactor_HHR. IPR000108. Neu_cyt_fact_2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF07815. Abi_HHR. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view]
PRINTS	PR00499. P67PHOX.
ProDom	PD000066. SH3. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00326. SH3. 1 hit. [Graphical view]
PROSITE	PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	825216.

Entry information

Entry name

Q9Y0S9_DROME

Accession

Primary (citable) accession number: Q9Y0S9

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	June 16, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)