Q9Y0S9 (Q9Y0S9_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Abelson interacting protein, isoform A EMBL AAF55021.1

Submitted name:
Abelson interacting protein, isoform B EMBL ABW08669.1
Submitted name:
Abl tyrosine kinase-interacting protein EMBL AAD38382.1
Submitted name:
LD37010p EMBL AAK93301.1

Gene names

Name:	Abi EMBL AAF55021.1 FlyBase FBgn0020510
ORF Names:	CG9749 FlyBase FBgn0020510, Dmel_CG9749 EMBL AAF55021.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 SH3 domain. RuleBase RU003338

Ontologies

Keywords
Domain	SH3 domain RuleBase RU003338
Molecular function	Kinase EMBL AAD38382.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	Golgi organization Inferred from mutant phenotype. Source: FlyBase cell adhesion Inferred from mutant phenotype. Source: FlyBase central nervous system neuron axonogenesis Inferred from mutant phenotype. Source: FlyBase chaeta development Inferred from mutant phenotype. Source: FlyBase cortical actin cytoskeleton organization Inferred from mutant phenotype. Source: FlyBase lamellipodium assembly Inferred from mutant phenotype. Source: FlyBase muscle attachment Inferred from mutant phenotype. Source: FlyBase neuromuscular junction development Inferred from genetic interaction. Source: FlyBase phagocytosis, engulfment Inferred from mutant phenotype. Source: FlyBase positive regulation of protein kinase activity Inferred from direct assay. Source: FlyBase regulation of cell shape Inferred from mutant phenotype. Source: FlyBase
Cellular component	lamellipodium membrane Inferred from direct assay. Source: FlyBase perinuclear region of cytoplasm Inferred from direct assay. Source: FlyBase
Molecular function	kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9Y0S9 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 5C60813E4100252E	FASTA	473	51,925
	10 20 30 40 50 60 MLTETPMASE NIMDELASLI RTEIPDGRQS LRDSYTNLER VADYCEDTYY RADNKKAALE 70 80 90 100 110 120 ATKNYTTQSL ASVAYQINTL AYSYMQLLEL QAQQLGEMES QMNHIAQTVH IHKEKVARRE 130 140 150 160 170 180 IGVLTANKVS SRQFKIVAPI NPEKPIKYVR KPIDYSMLDE IGHGINSAQH SQVRQKHRGS 190 200 210 220 230 240 SHGSVQSLLP PSVGPPPTTK PPTPPQMSRA GNTGTLGKSV SNTGTLGKSS REYRTPPVVN 250 260 270 280 290 300 PPQVPSHYAP NYPIGHPKRM STASSTMTTT TTGGGAAGNE RAAGYSALPM PPSQQIATHV 310 320 330 340 350 360 NLPSAGMMQS LPPPPPTTYD DRSSMPPAPP SPLTVSQHEM TEQSHIGMHT LGRNINRNHF 370 380 390 400 410 420 SLNFARPGSQ SPPLPPPPPP EDEHQDFGRP RTSTGPQLAP IVPEDQNLPG WVPKNFIEKV 430 440 450 460 470 VAIYDYYADK DDELSFQESS VLYVLKKNDD GWWEGVMDGV TGLFPGNYVE PCV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Drosophila Abelson interacting protein (dAbi) is a positive regulator of Abelson tyrosine kinase activity." Juang J.-L., Hoffmann F.M. Oncogene 0:0-0(1999) Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[4]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J. , Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAK93301.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF151115 mRNA. Translation: AAD38382.1. AE014297 Genomic DNA. Translation: AAF55021.1. AY051877 mRNA. Translation: AAK93301.1. AE014297 Genomic DNA. Translation: ABW08669.1.
RefSeq	NP_001097785.1. NM_001104315.1. NP_477263.1. NM_057915.4.
UniGene	Dm.3181.
3D structure databases
HSSP	HSSP built from PDB template 1UGV based on UniProtKB Q9UNA1.
ProteinModelPortal	Q9Y0S9.
SMR	Q9Y0S9. Positions 13-165, 409-470.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-35544N.
IntAct	Q9Y0S9. 5 interactions.
MINT	MINT-1577245.
STRING	Q9Y0S9.
Proteomic databases
PRIDE	Q9Y0S9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0082910; FBpp0082371; FBgn0020510. FBtr0112896; FBpp0111809; FBgn0020510.
GeneID	41718.
KEGG	dme:Dmel_CG9749.
NMPDR	fig|7227.3.peg.12713.
UCSC	CG9749-RA. d. melanogaster.
Organism-specific databases
CTD	41718.
FlyBase	FBgn0020510. Abi.
Phylogenomic databases
eggNOG	inNOG07022.
GeneTree	EMGT00050000006647.
InParanoid	Q9Y0S9.
OMA	TEQSHIG.
OrthoDB	EOG4N2Z47.
PhylomeDB	Q9Y0S9.
Gene expression databases
ArrayExpress	Q9Y0S9.
Bgee	Q9Y0S9.
Family and domain databases
InterPro	IPR012849. Abl-interactor_HHR_dom. IPR000108. p67phox. IPR001452. SH3_domain. [Graphical view]
Pfam	PF07815. Abi_HHR. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view]
PRINTS	PR00499. P67PHOX. PR00452. SH3DOMAIN.
SMART	SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50044. SH3. 1 hit.
PROSITE	PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	825216.

Entry information

Entry name

Q9Y0S9_DROME

Accession

Primary (citable) accession number: Q9Y0S9

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	January 25, 2012
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)