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Q9Y0B7

- PP4C_DICDI

UniProt

Q9Y0B7 - PP4C_DICDI

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Protein

Serine/threonine-protein phosphatase 4 catalytic subunit

Gene
ppp4c, pppC, DDB_G0272116
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for development, chemotaxis and the expression of numerous genes.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi52 – 521Manganese 1 By similarity
Metal bindingi54 – 541Manganese 1 By similarity
Metal bindingi80 – 801Manganese 1 By similarity
Metal bindingi80 – 801Manganese 2 By similarity
Metal bindingi112 – 1121Manganese 2 By similarity
Active sitei113 – 1131Proton donor By similarity
Metal bindingi162 – 1621Manganese 2 By similarity
Metal bindingi236 – 2361Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. protein serine/threonine phosphatase activity Source: dictyBase

GO - Biological processi

  1. dephosphorylation Source: GOC
  2. regulation of chemotaxis Source: dictyBase
  3. regulation of sorocarp development Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit (EC:3.1.3.16)
Short name:
PP4C
Gene namesi
Name:ppp4c
Synonyms:pppC
ORF Names:DDB_G0272116
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0272116. ppp4c.

Subcellular locationi

Cytoplasm. Nucleus
Note: Translocated to the nucleus in aggregation-competent cells, probably by smkA.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: dictyBase
  2. nucleus Source: UniProtKB-SubCell
  3. protein phosphatase 4 complex Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Serine/threonine-protein phosphatase 4 catalytic subunitPRO_0000327847Add
BLAST

Proteomic databases

PRIDEiQ9Y0B7.

Interactioni

Subunit structurei

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Probably part of a PP4 complex containing ppp4c and ppp4r2. Interacts with smkA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
smkAQ54I182EBI-2015876,EBI-2015890

Protein-protein interaction databases

IntActiQ9Y0B7. 1 interaction.
STRINGi44689.DDB_0185222.

Structurei

3D structure databases

ProteinModelPortaliQ9Y0B7.
SMRiQ9Y0B7. Positions 2-305.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
KOiK15423.
OMAiGSNAGPN.
PhylomeDBiQ9Y0B7.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y0B7-1 [UniParc]FASTAAdd to Basket

« Hide

MSSDLDRQIE QLKRCEIIKE SEVRALCSKA REILLEEGNV QRVDSPVTIC    50
GDIHGQFYDL KELFKVGGDC PQTNYLFMGD FVDRGFYSVE TFLLLLALKV 100
RYPDRITLIR GNHESRQITQ VYGFYEECVR KYGSVTVWKY CTEIFDYLSL 150
SALVDGKIFC VHGGLSPSIN TLDQIRAIDR KQEVPHEGPM CDLMWSDPED 200
IPGWNGSPRG AGFLFGEDVV QKFNHDNNLE FICRAHQLVM EGFKYMFNET 250
LVTVWSAPNY CYRCGNVAAI LQLDENLKKN FAIFEAAPQE SRGAPAKKPA 300
PEYFL 305
Length:305
Mass (Da):34,862
Last modified:November 1, 1999 - v1
Checksum:iC0903104ADA93D41
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF161253 mRNA. Translation: AAD43137.1.
AAFI02000008 Genomic DNA. Translation: EAL71210.1.
RefSeqiXP_645186.1. XM_640094.1.

Genome annotation databases

EnsemblProtistsiDDB0185222; DDB0185222; DDB_G0272116.
GeneIDi8618358.
KEGGiddi:DDB_G0272116.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF161253 mRNA. Translation: AAD43137.1 .
AAFI02000008 Genomic DNA. Translation: EAL71210.1 .
RefSeqi XP_645186.1. XM_640094.1.

3D structure databases

ProteinModelPortali Q9Y0B7.
SMRi Q9Y0B7. Positions 2-305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9Y0B7. 1 interaction.
STRINGi 44689.DDB_0185222.

Proteomic databases

PRIDEi Q9Y0B7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0185222 ; DDB0185222 ; DDB_G0272116 .
GeneIDi 8618358.
KEGGi ddi:DDB_G0272116.

Organism-specific databases

dictyBasei DDB_G0272116. ppp4c.

Phylogenomic databases

eggNOGi COG0639.
KOi K15423.
OMAi GSNAGPN.
PhylomeDBi Q9Y0B7.

Miscellaneous databases

PROi Q9Y0B7.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: AX4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  3. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  4. "MEK1 and protein phosphatase 4 coordinate Dictyostelium development and chemotaxis."
    Mendoza M.C., Booth E.O., Shaulsky G., Firtel R.A.
    Mol. Cell. Biol. 27:3817-3827(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SMKA AND PPP4R2.

Entry informationi

Entry nameiPP4C_DICDI
AccessioniPrimary (citable) accession number: Q9Y0B7
Secondary accession number(s): Q559Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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