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Protein

Serine/threonine-protein phosphatase 4 catalytic subunit

Gene

ppp4c

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for development, chemotaxis and the expression of numerous genes.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52Manganese 1By similarity1
Metal bindingi54Manganese 1By similarity1
Metal bindingi80Manganese 1By similarity1
Metal bindingi80Manganese 2By similarity1
Metal bindingi112Manganese 2By similarity1
Active sitei113Proton donorBy similarity1
Metal bindingi162Manganese 2By similarity1
Metal bindingi236Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: dictyBase

GO - Biological processi

  • regulation of chemotaxis Source: dictyBase
  • regulation of sorocarp development Source: dictyBase

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit (EC:3.1.3.16)
Short name:
PP4C
Gene namesi
Name:ppp4c
Synonyms:pppC
ORF Names:DDB_G0272116
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0272116 ppp4c

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: dictyBase
  • nucleus Source: UniProtKB-SubCell
  • protein phosphatase 4 complex Source: dictyBase

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003278471 – 305Serine/threonine-protein phosphatase 4 catalytic subunitAdd BLAST305

Proteomic databases

PaxDbiQ9Y0B7
PRIDEiQ9Y0B7

Interactioni

Subunit structurei

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Probably part of a PP4 complex containing ppp4c and ppp4r2. Interacts with smkA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
smkAQ54I182EBI-2015876,EBI-2015890

Protein-protein interaction databases

IntActiQ9Y0B7, 1 interactor
STRINGi44689.DDB0185222

Structurei

3D structure databases

ProteinModelPortaliQ9Y0B7
SMRiQ9Y0B7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0372 Eukaryota
COG0639 LUCA
InParanoidiQ9Y0B7
KOiK15423
OMAiPDRMTLI
PhylomeDBiQ9Y0B7

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y0B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDLDRQIE QLKRCEIIKE SEVRALCSKA REILLEEGNV QRVDSPVTIC
60 70 80 90 100
GDIHGQFYDL KELFKVGGDC PQTNYLFMGD FVDRGFYSVE TFLLLLALKV
110 120 130 140 150
RYPDRITLIR GNHESRQITQ VYGFYEECVR KYGSVTVWKY CTEIFDYLSL
160 170 180 190 200
SALVDGKIFC VHGGLSPSIN TLDQIRAIDR KQEVPHEGPM CDLMWSDPED
210 220 230 240 250
IPGWNGSPRG AGFLFGEDVV QKFNHDNNLE FICRAHQLVM EGFKYMFNET
260 270 280 290 300
LVTVWSAPNY CYRCGNVAAI LQLDENLKKN FAIFEAAPQE SRGAPAKKPA

PEYFL
Length:305
Mass (Da):34,862
Last modified:November 1, 1999 - v1
Checksum:iC0903104ADA93D41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161253 mRNA Translation: AAD43137.1
AAFI02000008 Genomic DNA Translation: EAL71210.1
RefSeqiXP_645186.1, XM_640094.1

Genome annotation databases

EnsemblProtistsiEAL71210; EAL71210; DDB_G0272116
GeneIDi8618358
KEGGiddi:DDB_G0272116

Similar proteinsi

Entry informationi

Entry nameiPP4C_DICDI
AccessioniPrimary (citable) accession number: Q9Y0B7
Secondary accession number(s): Q559Z8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 1, 1999
Last modified: April 25, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health