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Protein
Submitted name:

PTEN2

Gene

Pten

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • actin binding Source: FlyBase
  • non-membrane spanning protein tyrosine phosphatase activity Source: FlyBase
  • phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity Source: FlyBase
  • phosphoprotein phosphatase activity Source: FlyBase
  • protein serine/threonine phosphatase activity Source: FlyBase
  • protein tyrosine/serine/threonine phosphatase activity Source: FlyBase

GO - Biological processi

  • actin cytoskeleton organization Source: FlyBase
  • animal organ morphogenesis Source: FlyBase
  • apoptotic process Source: FlyBase
  • autophagy Source: FlyBase
  • basement membrane organization Source: FlyBase
  • cell competition in a multicellular organism Source: FlyBase
  • cell proliferation Source: FlyBase
  • cellular process Source: FlyBase
  • cellular protein localization Source: FlyBase
  • cytoskeleton organization Source: FlyBase
  • dendrite regeneration Source: FlyBase
  • epithelial cell fate determination, open tracheal system Source: FlyBase
  • insulin receptor signaling pathway Source: FlyBase
  • larval development Source: FlyBase
  • larval midgut histolysis Source: FlyBase
  • larval salivary gland morphogenesis Source: FlyBase
  • lipid homeostasis Source: FlyBase
  • melanotic encapsulation of foreign target Source: FlyBase
  • metamorphosis Source: FlyBase
  • negative regulation of axon regeneration Source: FlyBase
  • negative regulation of cell cycle Source: FlyBase
  • negative regulation of cell growth Source: FlyBase
  • negative regulation of cell size Source: FlyBase
  • negative regulation of growth Source: FlyBase
  • negative regulation of insulin receptor signaling pathway Source: FlyBase
  • negative regulation of multicellular organism growth Source: FlyBase
  • negative regulation of organ growth Source: FlyBase
  • neuron remodeling Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • phosphatidylinositol dephosphorylation Source: FlyBase
  • protein dephosphorylation Source: FlyBase
  • regulation of autophagy Source: FlyBase
  • regulation of cell cycle Source: FlyBase
  • regulation of cell junction assembly Source: FlyBase
  • regulation of cell shape Source: FlyBase
  • regulation of cell size Source: FlyBase
  • regulation of dendrite development Source: FlyBase
  • regulation of establishment of planar polarity Source: FlyBase
  • regulation of hemocyte proliferation Source: FlyBase
  • regulation of multicellular organism growth Source: FlyBase
  • regulation of organ growth Source: FlyBase
  • response to starvation Source: FlyBase
  • rhabdomere development Source: FlyBase
  • somatic muscle development Source: FlyBase
  • tissue development Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-1660499. Synthesis of PIPs at the plasma membrane.
R-DME-1855204. Synthesis of IP3 and IP4 in the cytosol.
R-DME-199418. Negative regulation of the PI3K/AKT network.
R-DME-202424. Downstream TCR signaling.
R-DME-5689880. Ub-specific processing proteases.
R-DME-8948747. Regulation of PTEN localization.
R-DME-8948751. Regulation of PTEN stability and activity.

Names & Taxonomyi

Protein namesi
Submitted name:
PTEN2Imported
Gene namesi
Name:PtenImported
Synonyms:PTENImported
ORF Names:CG5671Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0026379. Pten.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ9Y0B5.

Expressioni

Gene expression databases

BgeeiFBgn0026379.
ExpressionAtlasiQ9Y0B5. differential.

Interactioni

GO - Molecular functioni

  • actin binding Source: FlyBase

Structurei

3D structure databases

ProteinModelPortaliQ9Y0B5.
SMRiQ9Y0B5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 193Phosphatase tensin-typeInterPro annotationAdd BLAST173
Domaini181 – 337C2 tensin-typeInterPro annotationAdd BLAST157

Phylogenomic databases

eggNOGiKOG2283. Eukaryota.
COG2453. LUCA.
OrthoDBiEOG091G09VG.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_phosphatase.
IPR016130. Tyr_Pase_AS.
PfamiView protein in Pfam
PF00782. DSPc. 1 hit.
PF10409. PTEN_C2. 1 hit.
SMARTiView protein in SMART
SM01326. PTEN_C2. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y0B5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANTISLMSN VIRNVVSKKR IRYKEKGYDL DLTYINDNII AMGYPAPDKL
60 70 80 90 100
EGLFRNRLED VFKLLEENHA QHYKIYNLCS ERSYDVAKFR GRVAVYPFDD
110 120 130 140 150
HNPPTIELIQ RFCSDVDMWL KEDSSNVVAV HCKAGKGRTG TMICAYLVFS
160 170 180 190 200
GIKKSADEAL AWYDEKRTKD RKGVTIPSQR RYVQYFSKLV CSSVPYSKVS
210 220 230 240 250
LNVCEIRFSE SSCVQNLGMV ECSISVLHDS ATENAKPDRL KTLPIDFQKS
260 270 280 290 300
FVLTIKPSIP VSGDVKFELT KKSPDKIICH FWLNTFFVRN YSPCESDGTV
310 320 330 340 350
NKYIHTLSKS EIDDVHKDSE HKRFSEEFKI SIVFEAENFS NDVQAEASEK
360 370 380 390 400
ERNENVLNFE RSDYDSLSPN CYAEKKVLTA IVNDNTTKSQ TIETLDHKDI
410 420 430 440 450
VTKIQYDTST NSKNTSTACK RKQPNSKTLL PSLNDSTKEE IKRNHIFNQP
460 470 480 490 500
SIKKTDLIKW QNSEVHITRS INENKNINYN SYITCKQSSP KFNCGTEDGE
510
EDWESGESTY L
Length:511
Mass (Da):58,650
Last modified:November 1, 1999 - v1
Checksum:i10AB4A19D3DC04D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161258 mRNA. Translation: AAD45363.1.

Similar proteinsi

Entry informationi

Entry nameiQ9Y0B5_DROME
AccessioniPrimary (citable) accession number: Q9Y0B5
Secondary accession number(s): Q9U469
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)