Reviewed,
UniProtKB/Swiss-Prot Q9Y048 (DTN1_CAEEL)
Last modified
June 16, 2009.
Version 55.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dystrobrevin-1 | ||||
| Gene names |
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| Organism | Caenorhabditis elegans [Complete proteome] | ||||
| Taxonomic identifier | 6239 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 590 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Plays a role in cholinergic transmission and as a functional partner of dystrophin (dys-1), necessary for muscle maintenance. Ref.1 Ref.4 Ref.5 Ref.6 Ref.7 |
| Subunit structure | Component of the dystrophin glycoprotein complex (DGC). Interacts with dys-1 and syntrophin (stn-1) to form the DGC. Ref.5 Ref.7 Ref.3 |
| Subcellular location | Cytoplasm By similarity. UniProtKB Q9D2N4 |
| Tissue specificity | From late embryogenesis to adulthood, expressed in neurons and muscles; particularly strong in the ventral nerve cord and in muscles of the body wall, head pharyngeal, and vulva; weaker in the intestinal muscle (at protein level). Ref.4 |
| Domain | The coiled-coil domain mediates the specific interaction with dys-1. Ref.5 |
| Disruption phenotype | Mutants synergistically exhibit progressive myopathy. In dyb-1;hlh-1 double mutants there is an uncoordinated phenotype associated with some muscle degeneration. Overexpression of dyb-1 in dys-1;hlh-1 double mutants delays, but does not prevent the onset and progression of myopathy. Ref.1 |
| Sequence similarities | Belongs to the dystrophin family. Dystrobrevin subfamily. Ref.1 Contains 1 ZZ-type zinc finger. |
Ontologies
Binary interactions
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Dystrobrevin- and dystrophin-like mutants display similar phenotypes in the nematode Caenorhabditis elegans." Gieseler K., Bessou C., Segalat L. Neurogenetics 2:87-90(1999) [PubMed: 10369883] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE. Strain: Bristol N2. |
| [2] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
| [3] | "In vitro interactions of Caenorhabditis elegans dystrophin with dystrobrevin and syntrophin." Gieseler K., Abdel-Dayem M., Segalat L. FEBS Lett. 461:59-62(1999) [PubMed: 10561496] [Abstract] Cited for: INTERACTION WITH STN-1 AND DYS-1. |
| [4] | "Molecular, genetic and physiological characterisation of dystrobrevin-like (dyb-1) mutants of Caenorhabditis elegans." Gieseler K., Mariol M.-C., Bessou C., Migaud M., Franks C.J., Holden-Dye L., Segalat L. J. Mol. Biol. 307:107-117(2001) [PubMed: 11243807] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY. |
| [5] | "Dystrobrevin requires a dystrophin-binding domain to function in Caenorhabditis elegans." Grisoni K., Gieseler K., Segalat L. Eur. J. Biochem. 269:1607-1612(2002) [PubMed: 11895430] [Abstract] Cited for: FUNCTION, INTERACTION WITH DYS-1. |
| [6] | "Overexpression of dystrobrevin delays locomotion defects and muscle degeneration in a dystrophin-deficient Caenorhabditis elegans." Gieseler K., Grisoni K., Mariol M.-C., Segalat L. Neuromuscul. Disord. 12:371-377(2002) [PubMed: 12062255] [Abstract] Cited for: FUNCTION. |
| [7] | "The stn-1 syntrophin gene of C.elegans is functionally related to dystrophin and dystrobrevin." Grisoni K., Gieseler K., Mariol M.-C., Martin E., Carre-Pierrat M., Moulder G., Barstead R., Segalat L. J. Mol. Biol. 332:1037-1046(2003) [PubMed: 14499607] [Abstract] Cited for: FUNCTION, INTERACTION WITH STN-1. |
Cross-references
Sequence databases | |
|---|---|
| AJ131742 mRNA. Translation: CAA10498.1. AF098989 Genomic DNA. Translation: AAK18956.2. | |
| RefSeq | NP_490860.1. |
| UniGene | Cel.19602 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:25663N. |
| IntAct | Q9Y048. 35 interactions. |
Genome annotation databases | |
| Ensembl | F47G6.1. Caenorhabditis elegans. [Contig view] |
| GeneID | 171715. |
| KEGG | cel:F47G6.1. |
| NMPDR | fig|6239.3.peg.240. |
Organism-specific databases | |
| WormBase | WBGene00001115. dyb-1. |
| WormPep | F47G6.1. CE26812. [WorfDB] |
Phylogenomic databases | |
| OMA | Q9Y048. NTLDHTT. |
Gene expression databases | |
| ArrayExpress | Q9Y048. |
Family and domain databases | |
| InterPro | IPR017432. Distrobrevin. IPR015153. EF-hand_regn-1. IPR015154. EF-hand_regn-2. IPR011992. EF-Hand_type. IPR000433. Znf_ZZ. [Graphical view] |
| Gene3D | G3DSA:1.10.238.10. EF-Hand_type. 2 hits. |
| Pfam | PF09068. efhand_1. 1 hit. PF09069. efhand_2. 1 hit. PF00569. ZZ. 1 hit. [Graphical view] |
| PIRSF | PIRSF038204. Distrobrevin. 1 hit. |
| SMART | SM00291. ZnF_ZZ. 1 hit. [Graphical view] |
| PROSITE | PS01357. ZF_ZZ_1. 1 hit. PS50135. ZF_ZZ_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 872407. |
Entry information
| Entry name | DTN1_CAEEL | ||||||||
| Accession | Primary (citable) accession number: Q9Y048 Secondary accession number(s): Q9TZI6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| SIMILARITY comments Index of protein domains and families |

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