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Reviewed, UniProtKB/Swiss-Prot Q9Y048 (DTN1_CAEEL)

Last modified June 16, 2009. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Dystrobrevin-1
Gene names
Name: dyb-1
ORF Names: F47G6.1
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

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Protein attributes

Sequence length590 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Plays a role in cholinergic transmission and as a functional partner of dystrophin (dys-1), necessary for muscle maintenance. Ref.1 Ref.4 Ref.5 Ref.6 Ref.7

Subunit structure

Component of the dystrophin glycoprotein complex (DGC). Interacts with dys-1 and syntrophin (stn-1) to form the DGC. Ref.5 Ref.7 Ref.3

Subcellular location

Cytoplasm By similarity. UniProtKB Q9D2N4

Tissue specificity

From late embryogenesis to adulthood, expressed in neurons and muscles; particularly strong in the ventral nerve cord and in muscles of the body wall, head pharyngeal, and vulva; weaker in the intestinal muscle (at protein level). Ref.4

Domain

The coiled-coil domain mediates the specific interaction with dys-1. Ref.5

Disruption phenotype

Mutants synergistically exhibit progressive myopathy. In dyb-1;hlh-1 double mutants there is an uncoordinated phenotype associated with some muscle degeneration. Overexpression of dyb-1 in dys-1;hlh-1 double mutants delays, but does not prevent the onset and progression of myopathy. Ref.1

Sequence similarities

Belongs to the dystrophin family. Dystrobrevin subfamily. Ref.1

Contains 1 ZZ-type zinc finger.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 590590Dystrobrevin-1
PRO_0000080035

Regions

Zinc finger258 – 30548ZZ-type
Region484 – 4907Essential for interaction with dys-1
Coiled coil434 – 50875 Potential

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Sequences

Sequence LengthMass (Da)Tools
Q9Y048-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: CA0ACD6D54AEBB2A

FASTA59065,427
        10         20         30         40         50         60 
MLWSNGGGGP REPSSAPSPD HHRAMHSVPP IVASEMQQLI DEMRLQDFDS IRFATYRAAC 

        70         80         90        100        110        120 
KLRFIQQKTK VHLVDIWNMI EAFRENGLNA LPLHTVIKTS RAELLLTTVF HNLNKRLVAS 

       130        140        150        160        170        180 
QHVDTDVSIS LLLAFLLGAY DKQNTGRLTV FSIKVALATL CAGKLVDKLR YIFSQIADSN 

       190        200        210        220        230        240 
GLMDHIKFTD FLQQILSLTT AVFEAPTFGF SENAVNQCFH KDEKVSLNVF LDTFLSDPCP 

       250        260        270        280        290        300 
PCIMWLPLLH RMASVSNVYH PVVCDACQVR SFTGFRYKCQ RCANYQLCQS CFWRGRTSQN 

       310        320        330        340        350        360 
HSNEHEMKEY SSYKSPTKQL VHSIHKSLQC IPATSTVGDA NIDIFNAKIG GPVSSKPARP 

       370        380        390        400        410        420 
LNLNNIVPAT PTTIRRQHAA TSSADWPTSP VLLPGQASHG GVIDDEHKLI ARYAAKLSGR 

       430        440        450        460        470        480 
ADYPLSNGRS MNSSMVGDER TLIAQLEEEN SMMVREMARL ESQTTSDDGL AGLRDRKMEL 

       490        500        510        520        530        540 
EEKMFEMQQR RRELMMQLEH LMAQLNTGPQ PSGGVSSASL SQLPFTASDQ QLTGVNSTVA 

       550        560        570        580        590 
NAFRAGSLPA TSLQGDLLHA ADQITTNMSD LVRQLDLAQS DENGVTINGF

« Hide

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References

« Hide 'large scale' references
[1]"Dystrobrevin- and dystrophin-like mutants display similar phenotypes in the nematode Caenorhabditis elegans."
Gieseler K., Bessou C., Segalat L.
Neurogenetics 2:87-90(1999) [PubMed: 10369883] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE.
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[3]"In vitro interactions of Caenorhabditis elegans dystrophin with dystrobrevin and syntrophin."
Gieseler K., Abdel-Dayem M., Segalat L.
FEBS Lett. 461:59-62(1999) [PubMed: 10561496] [Abstract]
Cited for: INTERACTION WITH STN-1 AND DYS-1.
[4]"Molecular, genetic and physiological characterisation of dystrobrevin-like (dyb-1) mutants of Caenorhabditis elegans."
Gieseler K., Mariol M.-C., Bessou C., Migaud M., Franks C.J., Holden-Dye L., Segalat L.
J. Mol. Biol. 307:107-117(2001) [PubMed: 11243807] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[5]"Dystrobrevin requires a dystrophin-binding domain to function in Caenorhabditis elegans."
Grisoni K., Gieseler K., Segalat L.
Eur. J. Biochem. 269:1607-1612(2002) [PubMed: 11895430] [Abstract]
Cited for: FUNCTION, INTERACTION WITH DYS-1.
[6]"Overexpression of dystrobrevin delays locomotion defects and muscle degeneration in a dystrophin-deficient Caenorhabditis elegans."
Gieseler K., Grisoni K., Mariol M.-C., Segalat L.
Neuromuscul. Disord. 12:371-377(2002) [PubMed: 12062255] [Abstract]
Cited for: FUNCTION.
[7]"The stn-1 syntrophin gene of C.elegans is functionally related to dystrophin and dystrobrevin."
Grisoni K., Gieseler K., Mariol M.-C., Martin E., Carre-Pierrat M., Moulder G., Barstead R., Segalat L.
J. Mol. Biol. 332:1037-1046(2003) [PubMed: 14499607] [Abstract]
Cited for: FUNCTION, INTERACTION WITH STN-1.

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Cross-references

Sequence databases

AJ131742 mRNA. Translation: CAA10498.1.
AF098989 Genomic DNA. Translation: AAK18956.2.
RefSeqNP_490860.1.
UniGeneCel.19602

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:25663N.
IntActQ9Y048. 35 interactions.

Genome annotation databases

EnsemblF47G6.1. Caenorhabditis elegans. [Contig view]
GeneID171715.
KEGGcel:F47G6.1.
NMPDRfig|6239.3.peg.240.

Organism-specific databases

WormBaseWBGene00001115. dyb-1.
WormPepF47G6.1. CE26812. [WorfDB]

Phylogenomic databases

OMAQ9Y048. NTLDHTT.

Gene expression databases

ArrayExpressQ9Y048.

Family and domain databases

InterProIPR017432. Distrobrevin.
IPR015153. EF-hand_regn-1.
IPR015154. EF-hand_regn-2.
IPR011992. EF-Hand_type.
IPR000433. Znf_ZZ.
[Graphical view]
Gene3DG3DSA:1.10.238.10. EF-Hand_type. 2 hits.
PfamPF09068. efhand_1. 1 hit.
PF09069. efhand_2. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
PIRSFPIRSF038204. Distrobrevin. 1 hit.
SMARTSM00291. ZnF_ZZ. 1 hit.
[Graphical view]
PROSITEPS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio872407.

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Entry information

Entry nameDTN1_CAEEL
AccessionPrimary (citable) accession number: Q9Y048
Secondary accession number(s): Q9TZI6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 1, 1999
Last modified: June 16, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

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Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents