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Q9Y041

- HGD_CAEEL

UniProt

Q9Y041 - HGD_CAEEL

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Protein

Homogentisate 1,2-dioxygenase

Gene

hgo-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.

Cofactori

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi336 – 3361IronBy similarity
Metal bindingi342 – 3421IronBy similarity
Metal bindingi372 – 3721IronBy similarity

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-UniPathway
  2. tyrosine catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_233526. Phenylalanine and tyrosine catabolism.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene namesi
Name:hgo-1
ORF Names:W06D4.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiW06D4.1; CE29602; WBGene00001843; hgo-1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: WormBase
  2. striated muscle dense body Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Homogentisate 1,2-dioxygenasePRO_0000220243Add
BLAST

Proteomic databases

PaxDbiQ9Y041.
PRIDEiQ9Y041.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself1EBI-320396,EBI-320396

Protein-protein interaction databases

BioGridi38158. 2 interactions.
MINTiMINT-1040379.

Structurei

3D structure databases

ProteinModelPortaliQ9Y041.
SMRiQ9Y041. Positions 6-434.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.Curated

Phylogenomic databases

eggNOGiCOG3508.
GeneTreeiENSGT00390000004601.
HOGENOMiHOG000139824.
InParanoidiQ9Y041.
KOiK00451.
OMAiRCFYNSD.
OrthoDBiEOG7PP58Z.
PhylomeDBiQ9Y041.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR005708. Homogentis_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y041-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEFDELKYL TGFGNEHATS DPRVPDALPV GQNSPQKCSH GLYAEQLSGT
60 70 80 90 100
AFTAPRSQNQ RSWLYRIRPS VIHRPFEAMK ENDQHWTNNF SSIPPNPNQY
110 120 130 140 150
RWNPFPLPTK EGVTFVDNLY TVCGGGDVIS RTGLAIHQFS CNASMEHTAM
160 170 180 190 200
YNSDGDFLIV PQQGALEITT EFGRLLVNPQ EIAVIPQGIR FSVAVRGPSR
210 220 230 240 250
GYILEVYGTH FQLPDLGPIG ANGLANPRDF EAPVAWFEDL DVEFTIINKY
260 270 280 290 300
QGSWFQAKQG HSPFDVVGWH GNYVPYKYDL KKFMVINTVS FDHCDPSIFT
310 320 330 340 350
VLTAPSVKHG TAIADFVIFP PRWGCADNTF RPPYYHRNCM SEYMGLITGC
360 370 380 390 400
YEAKEGGFKP GGGSLHSMMT PHGPDFNCFE MASNADLKPQ RVAEGTMSFM
410 420 430
FESSLNMAIT NWAVYQNVDK DYYKDWQPLK KHFTMPK
Length:437
Mass (Da):49,239
Last modified:April 27, 2001 - v2
Checksum:iC14E7077C7CF9703
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561D → N in AAD00776. 1 PublicationCurated
Sequence conflicti176 – 1761L → P in AAD00776. 1 PublicationCurated
Sequence conflicti193 – 1931V → G in AAD00776. 1 PublicationCurated
Sequence conflicti242 – 2421V → G in AAD00776. 1 PublicationCurated
Sequence conflicti265 – 2651D → E in AAD00776. 1 PublicationCurated
Sequence conflicti433 – 4331F → Y in AAD00776. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136150 Genomic DNA. Translation: AAF61419.1.
U95181 mRNA. Translation: AAD00776.1.
AL034364, Z93778 Genomic DNA. Translation: CAA22255.4.
PIRiT19626.
T37469.
RefSeqiNP_492433.1. NM_060032.6.
UniGeneiCel.19613.

Genome annotation databases

EnsemblMetazoaiW06D4.1; W06D4.1; WBGene00001843.
GeneIDi172726.
KEGGicel:CELE_W06D4.1.
UCSCiW06D4.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136150 Genomic DNA. Translation: AAF61419.1 .
U95181 mRNA. Translation: AAD00776.1 .
AL034364 , Z93778 Genomic DNA. Translation: CAA22255.4 .
PIRi T19626.
T37469.
RefSeqi NP_492433.1. NM_060032.6.
UniGenei Cel.19613.

3D structure databases

ProteinModelPortali Q9Y041.
SMRi Q9Y041. Positions 6-434.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 38158. 2 interactions.
MINTi MINT-1040379.

Proteomic databases

PaxDbi Q9Y041.
PRIDEi Q9Y041.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai W06D4.1 ; W06D4.1 ; WBGene00001843 .
GeneIDi 172726.
KEGGi cel:CELE_W06D4.1.
UCSCi W06D4.1. c. elegans.

Organism-specific databases

CTDi 172726.
WormBasei W06D4.1 ; CE29602 ; WBGene00001843 ; hgo-1.

Phylogenomic databases

eggNOGi COG3508.
GeneTreei ENSGT00390000004601.
HOGENOMi HOG000139824.
InParanoidi Q9Y041.
KOi K00451.
OMAi RCFYNSD.
OrthoDBi EOG7PP58Z.
PhylomeDBi Q9Y041.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .
Reactomei REACT_233526. Phenylalanine and tyrosine catabolism.

Miscellaneous databases

NextBioi 876753.
PROi Q9Y041.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
InterProi IPR005708. Homogentis_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the homogentisate 1,2-dioxygenase gene in A. thaliana and C. elegans."
    Schmidt S.R., Werner E., Mueller C.R., Kress W.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Bristol N2.
  2. "Sequence homology of HGO genes in eukaryotic organisms."
    Schmidt S.R., Werner E., Mueller C.R., Kress W.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
    Tissue: Embryo.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiHGD_CAEEL
AccessioniPrimary (citable) accession number: Q9Y041
Secondary accession number(s): O62087, Q9NJP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 27, 2001
Last modified: November 26, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3