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Q9Y041

- HGD_CAEEL

UniProt

Q9Y041 - HGD_CAEEL

Protein

Homogentisate 1,2-dioxygenase

Gene

hgo-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Homogentisate + O2 = 4-maleylacetoacetate.

    Cofactori

    Iron.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi336 – 3361IronBy similarity
    Metal bindingi342 – 3421IronBy similarity
    Metal bindingi372 – 3721IronBy similarity

    GO - Molecular functioni

    1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. L-phenylalanine catabolic process Source: UniProtKB-UniPathway
    2. tyrosine catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Phenylalanine catabolism, Tyrosine catabolism

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00139; UER00339.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
    Alternative name(s):
    Homogentisate oxygenase
    Homogentisic acid oxidase
    Homogentisicase
    Gene namesi
    Name:hgo-1
    ORF Names:W06D4.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiW06D4.1; CE29602; WBGene00001843; hgo-1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: WormBase
    2. striated muscle dense body Source: WormBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 437437Homogentisate 1,2-dioxygenasePRO_0000220243Add
    BLAST

    Proteomic databases

    PaxDbiQ9Y041.
    PRIDEiQ9Y041.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself1EBI-320396,EBI-320396

    Protein-protein interaction databases

    BioGridi38158. 2 interactions.
    MINTiMINT-1040379.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y041.
    SMRiQ9Y041. Positions 6-434.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the homogentisate dioxygenase family.Curated

    Phylogenomic databases

    eggNOGiCOG3508.
    GeneTreeiENSGT00390000004601.
    HOGENOMiHOG000139824.
    InParanoidiQ9Y041.
    KOiK00451.
    OMAiRCFYNSD.
    OrthoDBiEOG7PP58Z.
    PhylomeDBiQ9Y041.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    InterProiIPR005708. Homogentis_dOase.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR11056. PTHR11056. 1 hit.
    PfamiPF04209. HgmA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR01015. hmgA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Y041-1 [UniParc]FASTAAdd to Basket

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    MSEFDELKYL TGFGNEHATS DPRVPDALPV GQNSPQKCSH GLYAEQLSGT    50
    AFTAPRSQNQ RSWLYRIRPS VIHRPFEAMK ENDQHWTNNF SSIPPNPNQY 100
    RWNPFPLPTK EGVTFVDNLY TVCGGGDVIS RTGLAIHQFS CNASMEHTAM 150
    YNSDGDFLIV PQQGALEITT EFGRLLVNPQ EIAVIPQGIR FSVAVRGPSR 200
    GYILEVYGTH FQLPDLGPIG ANGLANPRDF EAPVAWFEDL DVEFTIINKY 250
    QGSWFQAKQG HSPFDVVGWH GNYVPYKYDL KKFMVINTVS FDHCDPSIFT 300
    VLTAPSVKHG TAIADFVIFP PRWGCADNTF RPPYYHRNCM SEYMGLITGC 350
    YEAKEGGFKP GGGSLHSMMT PHGPDFNCFE MASNADLKPQ RVAEGTMSFM 400
    FESSLNMAIT NWAVYQNVDK DYYKDWQPLK KHFTMPK 437
    Length:437
    Mass (Da):49,239
    Last modified:April 27, 2001 - v2
    Checksum:iC14E7077C7CF9703
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti156 – 1561D → N in AAD00776. 1 PublicationCurated
    Sequence conflicti176 – 1761L → P in AAD00776. 1 PublicationCurated
    Sequence conflicti193 – 1931V → G in AAD00776. 1 PublicationCurated
    Sequence conflicti242 – 2421V → G in AAD00776. 1 PublicationCurated
    Sequence conflicti265 – 2651D → E in AAD00776. 1 PublicationCurated
    Sequence conflicti433 – 4331F → Y in AAD00776. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF136150 Genomic DNA. Translation: AAF61419.1.
    U95181 mRNA. Translation: AAD00776.1.
    AL034364, Z93778 Genomic DNA. Translation: CAA22255.4.
    PIRiT19626.
    T37469.
    RefSeqiNP_492433.1. NM_060032.6.
    UniGeneiCel.19613.

    Genome annotation databases

    EnsemblMetazoaiW06D4.1; W06D4.1; WBGene00001843.
    GeneIDi172726.
    KEGGicel:CELE_W06D4.1.
    UCSCiW06D4.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF136150 Genomic DNA. Translation: AAF61419.1 .
    U95181 mRNA. Translation: AAD00776.1 .
    AL034364 , Z93778 Genomic DNA. Translation: CAA22255.4 .
    PIRi T19626.
    T37469.
    RefSeqi NP_492433.1. NM_060032.6.
    UniGenei Cel.19613.

    3D structure databases

    ProteinModelPortali Q9Y041.
    SMRi Q9Y041. Positions 6-434.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 38158. 2 interactions.
    MINTi MINT-1040379.

    Proteomic databases

    PaxDbi Q9Y041.
    PRIDEi Q9Y041.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai W06D4.1 ; W06D4.1 ; WBGene00001843 .
    GeneIDi 172726.
    KEGGi cel:CELE_W06D4.1.
    UCSCi W06D4.1. c. elegans.

    Organism-specific databases

    CTDi 172726.
    WormBasei W06D4.1 ; CE29602 ; WBGene00001843 ; hgo-1.

    Phylogenomic databases

    eggNOGi COG3508.
    GeneTreei ENSGT00390000004601.
    HOGENOMi HOG000139824.
    InParanoidi Q9Y041.
    KOi K00451.
    OMAi RCFYNSD.
    OrthoDBi EOG7PP58Z.
    PhylomeDBi Q9Y041.

    Enzyme and pathway databases

    UniPathwayi UPA00139 ; UER00339 .

    Miscellaneous databases

    NextBioi 876753.
    PROi Q9Y041.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    InterProi IPR005708. Homogentis_dOase.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR11056. PTHR11056. 1 hit.
    Pfami PF04209. HgmA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR01015. hmgA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the homogentisate 1,2-dioxygenase gene in A. thaliana and C. elegans."
      Schmidt S.R., Werner E., Mueller C.R., Kress W.
      Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Bristol N2.
    2. "Sequence homology of HGO genes in eukaryotic organisms."
      Schmidt S.R., Werner E., Mueller C.R., Kress W.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Bristol N2.
      Tissue: Embryo.
    3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiHGD_CAEEL
    AccessioniPrimary (citable) accession number: Q9Y041
    Secondary accession number(s): O62087, Q9NJP3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3