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Protein

Homogentisate 1,2-dioxygenase

Gene

hgo-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.

Cofactori

Pathwayi: L-phenylalanine degradation

This protein is involved in step 4 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Probable phenylalanine-4-hydroxylase 1 (pah-1)
  2. no protein annotated in this organism
  3. 4-hydroxyphenylpyruvate dioxygenase (hpd-1)
  4. Homogentisate 1,2-dioxygenase (hgo-1)
  5. Probable maleylacetoacetate isomerase (gst-42)
  6. no protein annotated in this organism
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi336IronBy similarity1
Metal bindingi342IronBy similarity1
Metal bindingi372IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processPhenylalanine catabolism, Tyrosine catabolism
LigandIron, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-71182. Phenylalanine and tyrosine catabolism.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene namesi
Name:hgo-1
ORF Names:W06D4.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiW06D4.1; CE29602; WBGene00001843; hgo-1.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002202431 – 437Homogentisate 1,2-dioxygenaseAdd BLAST437

Proteomic databases

EPDiQ9Y041.
PaxDbiQ9Y041.
PeptideAtlasiQ9Y041.
PRIDEiQ9Y041.

PTM databases

iPTMnetiQ9Y041.

Expressioni

Gene expression databases

BgeeiWBGene00001843.

Interactioni

Protein-protein interaction databases

BioGridi38158. 2 interactors.
MINTiMINT-1040379.
STRINGi6239.W06D4.1.

Structurei

3D structure databases

ProteinModelPortaliQ9Y041.
SMRiQ9Y041.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.Curated

Phylogenomic databases

eggNOGiKOG1417. Eukaryota.
COG3508. LUCA.
GeneTreeiENSGT00390000004601.
HOGENOMiHOG000139824.
InParanoidiQ9Y041.
KOiK00451.
OMAiHGNYTPY.
OrthoDBiEOG091G11CO.
PhylomeDBiQ9Y041.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiView protein in InterPro
IPR005708. Homogentis_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin_sf.
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiView protein in Pfam
PF04209. HgmA. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y041-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEFDELKYL TGFGNEHATS DPRVPDALPV GQNSPQKCSH GLYAEQLSGT
60 70 80 90 100
AFTAPRSQNQ RSWLYRIRPS VIHRPFEAMK ENDQHWTNNF SSIPPNPNQY
110 120 130 140 150
RWNPFPLPTK EGVTFVDNLY TVCGGGDVIS RTGLAIHQFS CNASMEHTAM
160 170 180 190 200
YNSDGDFLIV PQQGALEITT EFGRLLVNPQ EIAVIPQGIR FSVAVRGPSR
210 220 230 240 250
GYILEVYGTH FQLPDLGPIG ANGLANPRDF EAPVAWFEDL DVEFTIINKY
260 270 280 290 300
QGSWFQAKQG HSPFDVVGWH GNYVPYKYDL KKFMVINTVS FDHCDPSIFT
310 320 330 340 350
VLTAPSVKHG TAIADFVIFP PRWGCADNTF RPPYYHRNCM SEYMGLITGC
360 370 380 390 400
YEAKEGGFKP GGGSLHSMMT PHGPDFNCFE MASNADLKPQ RVAEGTMSFM
410 420 430
FESSLNMAIT NWAVYQNVDK DYYKDWQPLK KHFTMPK
Length:437
Mass (Da):49,239
Last modified:April 27, 2001 - v2
Checksum:iC14E7077C7CF9703
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156D → N in AAD00776 (Ref. 2) Curated1
Sequence conflicti176L → P in AAD00776 (Ref. 2) Curated1
Sequence conflicti193V → G in AAD00776 (Ref. 2) Curated1
Sequence conflicti242V → G in AAD00776 (Ref. 2) Curated1
Sequence conflicti265D → E in AAD00776 (Ref. 2) Curated1
Sequence conflicti433F → Y in AAD00776 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136150 Genomic DNA. Translation: AAF61419.1.
U95181 mRNA. Translation: AAD00776.1.
AL034364, Z93778 Genomic DNA. Translation: CAA22255.4.
PIRiT19626.
T37469.
RefSeqiNP_492433.1. NM_060032.6.
UniGeneiCel.19613.

Genome annotation databases

EnsemblMetazoaiW06D4.1; W06D4.1; WBGene00001843.
GeneIDi172726.
KEGGicel:CELE_W06D4.1.
UCSCiW06D4.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiHGD_CAEEL
AccessioniPrimary (citable) accession number: Q9Y041
Secondary accession number(s): O62087, Q9NJP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 27, 2001
Last modified: November 22, 2017
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families