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Q9Y041 (HGD_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homogentisate 1,2-dioxygenase

EC=1.13.11.5
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene names
Name:hgo-1
ORF Names:W06D4.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length437 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Homogentisate + O2 = 4-maleylacetoacetate.

Cofactor

Iron.

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself1EBI-320396,EBI-320396

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 437437Homogentisate 1,2-dioxygenase
PRO_0000220243

Sites

Metal binding3361Iron By similarity
Metal binding3421Iron By similarity
Metal binding3721Iron By similarity

Experimental info

Sequence conflict1561D → N in AAD00776. Ref.2
Sequence conflict1761L → P in AAD00776. Ref.2
Sequence conflict1931V → G in AAD00776. Ref.2
Sequence conflict2421V → G in AAD00776. Ref.2
Sequence conflict2651D → E in AAD00776. Ref.2
Sequence conflict4331F → Y in AAD00776. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9Y041 [UniParc].

Last modified April 27, 2001. Version 2.
Checksum: C14E7077C7CF9703

FASTA43749,239
        10         20         30         40         50         60 
MSEFDELKYL TGFGNEHATS DPRVPDALPV GQNSPQKCSH GLYAEQLSGT AFTAPRSQNQ 

        70         80         90        100        110        120 
RSWLYRIRPS VIHRPFEAMK ENDQHWTNNF SSIPPNPNQY RWNPFPLPTK EGVTFVDNLY 

       130        140        150        160        170        180 
TVCGGGDVIS RTGLAIHQFS CNASMEHTAM YNSDGDFLIV PQQGALEITT EFGRLLVNPQ 

       190        200        210        220        230        240 
EIAVIPQGIR FSVAVRGPSR GYILEVYGTH FQLPDLGPIG ANGLANPRDF EAPVAWFEDL 

       250        260        270        280        290        300 
DVEFTIINKY QGSWFQAKQG HSPFDVVGWH GNYVPYKYDL KKFMVINTVS FDHCDPSIFT 

       310        320        330        340        350        360 
VLTAPSVKHG TAIADFVIFP PRWGCADNTF RPPYYHRNCM SEYMGLITGC YEAKEGGFKP 

       370        380        390        400        410        420 
GGGSLHSMMT PHGPDFNCFE MASNADLKPQ RVAEGTMSFM FESSLNMAIT NWAVYQNVDK 

       430 
DYYKDWQPLK KHFTMPK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of the homogentisate 1,2-dioxygenase gene in A. thaliana and C. elegans."
Schmidt S.R., Werner E., Mueller C.R., Kress W.
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Bristol N2.
[2]"Sequence homology of HGO genes in eukaryotic organisms."
Schmidt S.R., Werner E., Mueller C.R., Kress W.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Bristol N2.
Tissue: Embryo.
[3]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF136150 Genomic DNA. Translation: AAF61419.1.
U95181 mRNA. Translation: AAD00776.1.
AL034364, Z93778 Genomic DNA. Translation: CAA22255.4.
PIRT19626.
T37469.
RefSeqNP_492433.1. NM_060032.6.
UniGeneCel.19613.

3D structure databases

ProteinModelPortalQ9Y041.
SMRQ9Y041. Positions 6-434.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid38158. 2 interactions.
MINTMINT-1040379.

Proteomic databases

PaxDbQ9Y041.
PRIDEQ9Y041.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaW06D4.1; W06D4.1; WBGene00001843.
GeneID172726.
KEGGcel:CELE_W06D4.1.
UCSCW06D4.1. c. elegans.

Organism-specific databases

CTD172726.
WormBaseW06D4.1; CE29602; WBGene00001843; hgo-1.

Phylogenomic databases

eggNOGCOG3508.
GeneTreeENSGT00390000004601.
HOGENOMHOG000139824.
InParanoidQ9Y041.
KOK00451.
OMARCFYNSD.
OrthoDBEOG7PP58Z.
PhylomeDBQ9Y041.

Enzyme and pathway databases

UniPathwayUPA00139; UER00339.

Family and domain databases

Gene3D2.60.120.10. 2 hits.
InterProIPR005708. Homogentis_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR11056. PTHR11056. 1 hit.
PfamPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR01015. hmgA. 1 hit.
ProtoNetSearch...

Other

NextBio876753.
PROQ9Y041.

Entry information

Entry nameHGD_CAEEL
AccessionPrimary (citable) accession number: Q9Y041
Secondary accession number(s): O62087, Q9NJP3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 27, 2001
Last modified: June 11, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase