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Protein

Delta-conotoxin SVIE

Gene

SO6

Organism
Conus striatus (Striated cone)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process (By similarity). However, this toxin interacts with a conserved hydrophobic triad (YFV) in the domain-4 voltage sensor of sodium channels.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-conotoxin SVIE
Short name:
Delta-SVIE
Alternative name(s):
Omega-conotoxin SO-6
Short name:
Omega-conotoxin SO6
Omega-conotoxin-4
Gene namesi
Name:SO6
OrganismiConus striatus (Striated cone)
Taxonomic identifieri6493 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri867. SVIE precursor.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 51291 PublicationPRO_0000034938Add
BLAST
Peptidei52 – 8231Delta-conotoxin SVIEPRO_0000034939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 69By similarity
Disulfide bondi61 ↔ 73By similarity
Modified residuei65 – 6514-hydroxyproline1 Publication
Disulfide bondi68 ↔ 77By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity
The cysteine framework is VI/VII (C-C-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin O1 superfamily.Curated

Keywords - Domaini

Knottin, Signal

Family and domain databases

InterProiIPR004214. Conotoxin.
IPR012322. Conotoxin_d-typ_CS.
IPR012321. Conotoxin_omega-typ_CS.
[Graphical view]
PfamiPF02950. Conotoxin. 1 hit.
[Graphical view]
PROSITEiPS60005. DELTA_CONOTOXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XZK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLTCVMIVA VLFLTTWTFV TADDSRYGLK NLFPKARHEM KNPEASKLNK
60 70 80
RDGCSSGGTF CGIHPGLCCS EFCFLWCITF ID
Length:82
Mass (Da):9,217
Last modified:November 1, 1999 - v1
Checksum:iF88996FC3C54C05D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61V → M in CAH64847 (PubMed:15652641).Curated

Mass spectrometryi

Molecular mass is 3320 Da from positions 52 - 82. Determined by ESI. Sequence shown.1 Publication
Molecular mass is 3343 Da from positions 52 - 82. Determined by ESI. Variant Glu-52.1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti52 – 521D → E Minor.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146351 mRNA. Translation: AAD31911.1.
AJ851174 mRNA. Translation: CAH64847.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146351 mRNA. Translation: AAD31911.1.
AJ851174 mRNA. Translation: CAH64847.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri867. SVIE precursor.

Family and domain databases

InterProiIPR004214. Conotoxin.
IPR012322. Conotoxin_d-typ_CS.
IPR012321. Conotoxin_omega-typ_CS.
[Graphical view]
PfamiPF02950. Conotoxin. 1 hit.
[Graphical view]
PROSITEiPS60005. DELTA_CONOTOXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCO16E_CONST
AccessioniPrimary (citable) accession number: Q9XZK5
Secondary accession number(s): Q5K0D4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: November 1, 1999
Last modified: July 22, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.