Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9XZJ4

- PSA6_DROME

UniProt

Q9XZJ4 - PSA6_DROME

Protein

Proteasome subunit alpha type-6

Gene

Prosalpha1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (08 Dec 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.By similarity

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

    GO - Molecular functioni

    1. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. cellular response to DNA damage stimulus Source: FlyBase
    2. proteasome-mediated ubiquitin-dependent protein catabolic process Source: FlyBase

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Protein family/group databases

    MEROPSiT01.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit alpha type-6 (EC:3.4.25.1)
    Alternative name(s):
    20S proteasome subunit alpha-1
    Gene namesi
    Name:Prosalpha1
    Synonyms:Prosalpha6
    ORF Names:CG18495
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0263121. Prosalpha1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. proteasome core complex Source: FlyBase
    4. proteasome core complex, alpha-subunit complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 244244Proteasome subunit alpha type-6PRO_0000124134Add
    BLAST

    Proteomic databases

    PaxDbiQ9XZJ4.
    PRIDEiQ9XZJ4.

    Interactioni

    Subunit structurei

    The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity. Interacts with PI31.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi69878. 48 interactions.
    IntActiQ9XZJ4. 1 interaction.
    MINTiMINT-1330620.
    STRINGi7227.FBpp0087968.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9XZJ4.
    SMRiQ9XZJ4. Positions 2-243.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1A family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0638.
    GeneTreeiENSGT00550000074807.
    InParanoidiQ9XZJ4.
    KOiK02730.
    OMAiMSRTSYD.
    OrthoDBiEOG70PBZH.
    PhylomeDBiQ9XZJ4.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view]
    SMARTiSM00948. Proteasome_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9XZJ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRGSSAGFD RHITIFSPEG RLYQVEYAFK AIAQENITTV ALKSGDCAVV    50
    ATQKKVTEKN IVPETVTHLF RITKDIGCAM TGRIADSRSQ VQKARYEAAN 100
    FRYKYGYEMP VDVLCRRIAD INQVYTQNAE MRPLGCSMVL IAYDNEIGPS 150
    VYKTDPAGYF SGFKACSVGA KTLEANSYLE KKYKPNLSEE KAIQLAISCL 200
    SSVLAIDFKP NGIEIGVVSK SDPTFRILDE REIEEHLTKI AEKD 244
    Length:244
    Mass (Da):27,162
    Last modified:December 8, 2000 - v2
    Checksum:iD217B272CA339D05
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti94 – 941A → G in AAD33944. 1 PublicationCurated
    Sequence conflicti122 – 1221N → T in AAD33944. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF144749 mRNA. Translation: AAD33944.1.
    AE013599 Genomic DNA. Translation: AAF59183.1.
    AY118637 mRNA. Translation: AAM50006.1.
    RefSeqiNP_001163078.1. NM_001169607.1.
    NP_524837.2. NM_080098.3.
    NP_724614.1. NM_165565.2.
    NP_724616.1. NM_165567.3.
    UniGeneiDm.20810.
    Dm.36589.

    Genome annotation databases

    EnsemblMetazoaiFBtr0088894; FBpp0087968; FBgn0050382.
    FBtr0088895; FBpp0087969; FBgn0263121.
    FBtr0088896; FBpp0087970; FBgn0263121.
    FBtr0302223; FBpp0291433; FBgn0050382.
    GeneIDi246582.
    45780.
    KEGGidme:Dmel_CG18495.
    dme:Dmel_CG30382.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF144749 mRNA. Translation: AAD33944.1 .
    AE013599 Genomic DNA. Translation: AAF59183.1 .
    AY118637 mRNA. Translation: AAM50006.1 .
    RefSeqi NP_001163078.1. NM_001169607.1.
    NP_524837.2. NM_080098.3.
    NP_724614.1. NM_165565.2.
    NP_724616.1. NM_165567.3.
    UniGenei Dm.20810.
    Dm.36589.

    3D structure databases

    ProteinModelPortali Q9XZJ4.
    SMRi Q9XZJ4. Positions 2-243.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 69878. 48 interactions.
    IntActi Q9XZJ4. 1 interaction.
    MINTi MINT-1330620.
    STRINGi 7227.FBpp0087968.

    Protein family/group databases

    MEROPSi T01.971.

    Proteomic databases

    PaxDbi Q9XZJ4.
    PRIDEi Q9XZJ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0088894 ; FBpp0087968 ; FBgn0050382 .
    FBtr0088895 ; FBpp0087969 ; FBgn0263121 .
    FBtr0088896 ; FBpp0087970 ; FBgn0263121 .
    FBtr0302223 ; FBpp0291433 ; FBgn0050382 .
    GeneIDi 246582.
    45780.
    KEGGi dme:Dmel_CG18495.
    dme:Dmel_CG30382.

    Organism-specific databases

    CTDi 45780.
    FlyBasei FBgn0263121. Prosalpha1.

    Phylogenomic databases

    eggNOGi COG0638.
    GeneTreei ENSGT00550000074807.
    InParanoidi Q9XZJ4.
    KOi K02730.
    OMAi MSRTSYD.
    OrthoDBi EOG70PBZH.
    PhylomeDBi Q9XZJ4.

    Miscellaneous databases

    NextBioi 843091.
    PROi Q9XZJ4.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SMARTi SM00948. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Drosophila melanogaster 20S proteasome subunit alpha1 cDNA."
      Belote J.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.
    5. "Proteasome regulation by ADP-ribosylation."
      Cho-Park P.F., Steller H.
      Cell 153:614-627(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PI31.

    Entry informationi

    Entry nameiPSA6_DROME
    AccessioniPrimary (citable) accession number: Q9XZJ4
    Secondary accession number(s): Q0E9G1, Q9V324
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 8, 2000
    Last sequence update: December 8, 2000
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3