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Q9XZJ4

- PSA6_DROME

UniProt

Q9XZJ4 - PSA6_DROME

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Protein
Proteasome subunit alpha type-6
Gene
Prosalpha1, Prosalpha6, CG18495
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: FlyBase
  2. proteasome-mediated ubiquitin-dependent protein catabolic process Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Protein family/group databases

MEROPSiT01.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-6 (EC:3.4.25.1)
Alternative name(s):
20S proteasome subunit alpha-1
Gene namesi
Name:Prosalpha1
Synonyms:Prosalpha6
ORF Names:CG18495
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0263121. Prosalpha1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
  3. proteasome core complex Source: FlyBase
  4. proteasome core complex, alpha-subunit complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244Proteasome subunit alpha type-6
PRO_0000124134Add
BLAST

Proteomic databases

PaxDbiQ9XZJ4.
PRIDEiQ9XZJ4.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity. Interacts with PI31.1 Publication

Protein-protein interaction databases

BioGridi69878. 48 interactions.
IntActiQ9XZJ4. 1 interaction.
MINTiMINT-1330620.
STRINGi7227.FBpp0087968.

Structurei

3D structure databases

ProteinModelPortaliQ9XZJ4.
SMRiQ9XZJ4. Positions 2-243.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.

Phylogenomic databases

eggNOGiCOG0638.
GeneTreeiENSGT00550000074807.
InParanoidiQ9XZJ4.
KOiK02730.
OMAiMSRTSYD.
OrthoDBiEOG70PBZH.
PhylomeDBiQ9XZJ4.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XZJ4-1 [UniParc]FASTAAdd to Basket

« Hide

MSRGSSAGFD RHITIFSPEG RLYQVEYAFK AIAQENITTV ALKSGDCAVV    50
ATQKKVTEKN IVPETVTHLF RITKDIGCAM TGRIADSRSQ VQKARYEAAN 100
FRYKYGYEMP VDVLCRRIAD INQVYTQNAE MRPLGCSMVL IAYDNEIGPS 150
VYKTDPAGYF SGFKACSVGA KTLEANSYLE KKYKPNLSEE KAIQLAISCL 200
SSVLAIDFKP NGIEIGVVSK SDPTFRILDE REIEEHLTKI AEKD 244
Length:244
Mass (Da):27,162
Last modified:December 8, 2000 - v2
Checksum:iD217B272CA339D05
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941A → G in AAD33944. 1 Publication
Sequence conflicti122 – 1221N → T in AAD33944. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF144749 mRNA. Translation: AAD33944.1.
AE013599 Genomic DNA. Translation: AAF59183.1.
AY118637 mRNA. Translation: AAM50006.1.
RefSeqiNP_001163078.1. NM_001169607.1.
NP_524837.2. NM_080098.3.
NP_724614.1. NM_165565.2.
NP_724616.1. NM_165567.3.
UniGeneiDm.20810.
Dm.36589.

Genome annotation databases

EnsemblMetazoaiFBtr0088894; FBpp0087968; FBgn0050382.
FBtr0088895; FBpp0087969; FBgn0263121.
FBtr0088896; FBpp0087970; FBgn0263121.
FBtr0302223; FBpp0291433; FBgn0050382.
GeneIDi246582.
45780.
KEGGidme:Dmel_CG18495.
dme:Dmel_CG30382.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF144749 mRNA. Translation: AAD33944.1 .
AE013599 Genomic DNA. Translation: AAF59183.1 .
AY118637 mRNA. Translation: AAM50006.1 .
RefSeqi NP_001163078.1. NM_001169607.1.
NP_524837.2. NM_080098.3.
NP_724614.1. NM_165565.2.
NP_724616.1. NM_165567.3.
UniGenei Dm.20810.
Dm.36589.

3D structure databases

ProteinModelPortali Q9XZJ4.
SMRi Q9XZJ4. Positions 2-243.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 69878. 48 interactions.
IntActi Q9XZJ4. 1 interaction.
MINTi MINT-1330620.
STRINGi 7227.FBpp0087968.

Protein family/group databases

MEROPSi T01.971.

Proteomic databases

PaxDbi Q9XZJ4.
PRIDEi Q9XZJ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0088894 ; FBpp0087968 ; FBgn0050382 .
FBtr0088895 ; FBpp0087969 ; FBgn0263121 .
FBtr0088896 ; FBpp0087970 ; FBgn0263121 .
FBtr0302223 ; FBpp0291433 ; FBgn0050382 .
GeneIDi 246582.
45780.
KEGGi dme:Dmel_CG18495.
dme:Dmel_CG30382.

Organism-specific databases

CTDi 45780.
FlyBasei FBgn0263121. Prosalpha1.

Phylogenomic databases

eggNOGi COG0638.
GeneTreei ENSGT00550000074807.
InParanoidi Q9XZJ4.
KOi K02730.
OMAi MSRTSYD.
OrthoDBi EOG70PBZH.
PhylomeDBi Q9XZJ4.

Miscellaneous databases

NextBioi 843091.
PROi Q9XZJ4.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view ]
SMARTi SM00948. Proteasome_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Drosophila melanogaster 20S proteasome subunit alpha1 cDNA."
    Belote J.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  5. "Proteasome regulation by ADP-ribosylation."
    Cho-Park P.F., Steller H.
    Cell 153:614-627(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PI31.

Entry informationi

Entry nameiPSA6_DROME
AccessioniPrimary (citable) accession number: Q9XZJ4
Secondary accession number(s): Q0E9G1, Q9V324
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: December 8, 2000
Last modified: July 9, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi