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Protein

Proteasome subunit alpha type-5

Gene
N/A
Organism
Trypanosoma brucei brucei
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

BRENDAi3.4.25.1 6519

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-5 (EC:3.4.25.1)
Alternative name(s):
20S proteasome subunit alpha-5
OrganismiTrypanosoma brucei brucei
Taxonomic identifieri5702 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001241231 – 246Proteasome subunit alpha type-5Add BLAST246

Proteomic databases

PRIDEiQ9XZG5

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9XZG5
SMRiQ9XZG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Family and domain databases

CDDicd03753 proteasome_alpha_type_5, 1 hit
Gene3Di3.60.20.101 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR033812 Proteasome_alpha_type_5
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9XZG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSSKTEYDR GVNTFSPEGR IFQIEYAIEA IKLGSTSLGI QTPDAVIIAA
60 70 80 90 100
EKRVPSTLVD PSSVNKILEI DHHIGTVLSG MVADARILVD HARVEAQNHR
110 120 130 140 150
FTYDEPMSVE SCALATCDLS VQFGESGGRK KLMSRPFGVS LLIAGVDENG
160 170 180 190 200
PQLWQTDPSG TYTRYDAQAI GGGAEAAQTV FSERYHRNMT VEEAENLTVQ
210 220 230 240
ILRQVMEEKL TKTSVEIAIV PVSTGRLQIY DQEQIQRIID RQAEEN
Length:246
Mass (Da):27,177
Last modified:November 1, 1999 - v1
Checksum:iDAA6D211F5350A2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140353 Genomic DNA Translation: AAD31877.1

Genome annotation databases

GeneDBiTb927.10.230:pep

Similar proteinsi

Entry informationi

Entry nameiPSA5_TRYBB
AccessioniPrimary (citable) accession number: Q9XZG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: November 1, 1999
Last modified: April 25, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)