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Q9XZD6 (CDC2H_PLAVI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division control protein 2 homolog

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Pvcrk2
Gene names
Name:CRK2
OrganismPlasmodium vivax
Taxonomic identifier5855 [NCBI]
Taxonomic lineageEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Plasmodium)

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulation

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-158 activates it By similarity.

Subunit structure

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Cell division control protein 2 homolog
PRO_0000232671

Regions

Domain4 – 284281Protein kinase
Nucleotide binding10 – 189ATP By similarity

Sites

Active site1251Proton acceptor By similarity
Binding site321ATP By similarity

Amino acid modifications

Modified residue141Phosphothreonine By similarity
Modified residue151Phosphotyrosine By similarity
Modified residue1581Phosphothreonine; by CAK By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9XZD6 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 16A484C4B6CD313C

FASTA28833,094
        10         20         30         40         50         60 
MEKYHGLEKI GEGTYGVVYK AQNNYGETFA LKKIRLEKED EGIPSTAIRE ISILKELKHS 

        70         80         90        100        110        120 
NIVKLYDVIH TKKRLILVFE HLDQDLKKLL DVCDGGLESV TAKSFLLQLL SGIAYCHEHR 

       130        140        150        160        170        180 
VLHRDLKPQN LLINREGELK IADFGLARAF GIPVRKYTHE VVTLWYRAPD ILMGSKKYST 

       190        200        210        220        230        240 
PIDMWSVGCI FAEMVNGRPL FPGVSETDQL MRIFRILGTP NSENWPNVTE LPKYDPDFMV 

       250        260        270        280 
YEPLPWETFL KGLDDTGIDL LSKMLRLDPN QRITAKQALE HAYFKESN 

« Hide

References

[1]"Primary structure of the Plasmodium vivax crk2 gene and interference of the yeast cell cycle upon its conditional expression."
Speranca M.A., Vinkenoog R., Ocampos M., Fischer K., Janse C.J., Waters A.P., del Portillo H.A.
Exp. Parasitol. 97:119-128(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF136377 Genomic DNA. Translation: AAD29423.1.

3D structure databases

ProteinModelPortalQ9XZD6.
SMRQ9XZD6. Positions 1-286.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0515.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDC2H_PLAVI
AccessionPrimary (citable) accession number: Q9XZD6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families