Q9XZ56 (Q9XZ56_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
4E-binding protein THOR EMBL AAF82476.1

Submitted name:
HL08053p EMBL AAD27856.1
Submitted name:
Thor EMBL AAF51100.1

Gene names

Name:	Thor FlyBase FBgn0261560 FlyBase FBgn0022073 EMBL AAD27856.1
ORF Names:	CG8846 FlyBase FBgn0022073, Dmel_CG8846 EMBL AAF51100.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	antibacterial humoral response Inferred from mutant phenotype Ref.2. Source: FlyBase determination of adult lifespan Inferred from direct assay. Source: FlyBase negative regulation of cell size Inferred from mutant phenotype. Source: FlyBase negative regulation of translational initiation Inferred from electronic annotation. Source: InterPro regulation of cell growth Inferred from mutant phenotype. Source: FlyBase regulation of mitochondrial translation Inferred from direct assay. Source: FlyBase response to oxidative stress Inferred from mutant phenotype. Source: FlyBase response to starvation Inferred from direct assay. Source: FlyBase triglyceride metabolic process Inferred from mutant phenotype. Source: FlyBase
Cellular component	cytosol Traceable author statement. Source: Reactome
Molecular function	eukaryotic initiation factor 4E binding Inferred from direct assay. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9XZ56 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 8A2CD2D318124CA0	FASTA	117	12,876
	10 20 30 40 50 60 MSASPTARQA ITQALPMITR KVVISDPIQM PEVYSSTPGG TLYSTTPGGT KLIYERAFMK 70 80 90 100 110 NLRGSPLSQT PPSNVPSCLL RGTPRTPFRK CVPVPTELIK QTKSLKIEDQ EQFQLDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity." Bernal A., Kimbrell D.A. Proc. Natl. Acad. Sci. U.S.A. 97:6019-6024(2000) [PubMed: 10811906] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[4]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A. , Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAD27856.1.
[5]	Tsang G., Brokstein P., Frise E., Harvey D., Evans-Holm M., Lewis S.E., Suh C., Rubin G.M. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAD27856.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF132557 mRNA. Translation: AAD27856.1. AE014134 Genomic DNA. Translation: AAF51100.1. AF244353 Genomic DNA. Translation: AAF82476.1.
RefSeq	NP_477295.1. NM_057947.4.
UniGene	Dm.3228.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9XZ56. 3 interactions.
MINT	MINT-848552.
STRING	Q9XZ56.
Proteomic databases
PRIDE	Q9XZ56.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0077524; FBpp0077213; FBgn0261560.
GeneID	33569.
KEGG	dme:Dmel_CG8846.
NMPDR	fig|7227.3.peg.596.
UCSC	CG8846-RA. d. melanogaster.
Organism-specific databases
CTD	33569.
FlyBase	FBgn0261560. Thor.
Phylogenomic databases
eggNOG	inNOG11359.
GeneTree	EMGT00050000016370.
InParanoid	Q9XZ56.
OMA	SQTPPSN.
OrthoDB	EOG4SQVD4.
PhylomeDB	Q9XZ56.
Enzyme and pathway databases
Reactome	REACT_115106. Signal Transduction. REACT_6313. Insulin receptor mediated signaling.
Gene expression databases
ArrayExpress	Q9XZ56.
Bgee	Q9XZ56.
Family and domain databases
InterPro	IPR008606. EIF4EBP. [Graphical view]
PANTHER	PTHR12669. EIF4EBP. 1 hit.
Pfam	PF05456. eIF_4EBP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	784239.

Entry information

Entry name

Q9XZ56_DROME

Accession

Primary (citable) accession number: Q9XZ56

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	January 25, 2012
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)