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Q9XZ43

- 5NTD_LUTLO

UniProt

Q9XZ43 - 5NTD_LUTLO

Protein

Protein 5NUC

Gene

5NUC

Organism
Lutzomyia longipalpis (Sand fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell.By similarity

    Catalytic activityi

    UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.
    A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.

    Cofactori

    Zinc.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi39 – 391Zinc 1By similarity
    Metal bindingi41 – 411Zinc 1By similarity
    Metal bindingi93 – 931Zinc 1By similarity
    Metal bindingi93 – 931Zinc 2By similarity
    Metal bindingi125 – 1251Zinc 2By similarity
    Sitei126 – 1261Transition state stabilizerBy similarity
    Sitei129 – 1291Transition state stabilizerBy similarity
    Metal bindingi227 – 2271Zinc 2By similarity
    Metal bindingi250 – 2501Zinc 2By similarity
    Binding sitei361 – 3611SubstrateBy similarity
    Binding sitei399 – 3991SubstrateBy similarity
    Binding sitei404 – 4041SubstrateBy similarity
    Binding sitei427 – 4271SubstrateBy similarity

    GO - Molecular functioni

    1. 5'-nucleotidase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW
    3. nucleotide binding Source: UniProtKB-KW
    4. UDP-sugar diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. nucleotide catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein 5NUC
    Including the following 2 domains:
    UDP-sugar hydrolase (EC:3.6.1.45)
    Alternative name(s):
    UDP-sugar diphosphatase
    UDP-sugar pyrophosphatase
    5'-nucleotidase (EC:3.1.3.5)
    Short name:
    5'-NT
    Gene namesi
    Name:5NUC
    OrganismiLutzomyia longipalpis (Sand fly)
    Taxonomic identifieri7200 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraPsychodoideaPsychodidaeLutzomyiaLutzomyia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 572547Protein 5NUCPRO_0000000023Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi54 ↔ 64By similarity
    Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi360 ↔ 365By similarity
    Glycosylationi454 – 4541N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi488 ↔ 491By similarity
    Glycosylationi490 – 4901N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ9XZ43.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni512 – 5187Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the 5'-nucleotidase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    3.90.780.10. 1 hit.
    InterProiIPR008334. 5'-Nucleotdase_C.
    IPR006146. 5'-Nucleotdase_CS.
    IPR006179. 5_nucleotidase/apyrase.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PANTHERiPTHR11575. PTHR11575. 1 hit.
    PfamiPF02872. 5_nucleotid_C. 1 hit.
    PF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR01607. APYRASEFAMLY.
    SUPFAMiSSF55816. SSF55816. 1 hit.
    SSF56300. SSF56300. 1 hit.
    PROSITEiPS00785. 5_NUCLEOTIDASE_1. 1 hit.
    PS00786. 5_NUCLEOTIDASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9XZ43-1 [UniParc]FASTAAdd to Basket

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    MLFFLNFFVL VFSIELALLT ASAAAEDGSY EIIILHTNDM HARFDQTNAG    50
    SNKCQEKDKI ASKCYGGFAR VSTMVKKFRE ENGSSVLFLN AGDTYTGTPW 100
    FTLYKETIAT EMMNILRPDA ASLGNHEFDK GVEGLVPFLN GVTFPILTAN 150
    LDTSQEPTMT NAKNLKRSMI FTVSGHRVGV IGYLTPDTKF LSDVGKVNFI 200
    PEVEAINTEA QRLKKEENAE IIIVVGHSGL IKDREIAEKC PLVDIIVGGH 250
    SHTFLYTGSQ PDREVPVDVY PVVVTQSSGK KVPIVQAYCF TKYLGYFKVT 300
    INGKGNVVGW TGQPILLNNN IPQDQEVLTA LEKYRERVEN YGNRVIGVSR 350
    VILNGGHTEC RFHECNMGNL ITDAFVYANV ISTPMSTNAW TDASVVLYQS 400
    GGIRAPIDPR TAAGSITRLE LDNVLPFGNA LYVVKVPGNV LRKALEHSVH 450
    RYSNTSGWGE FPQVSGLKIR FNVNEEIGKR VKSVKVLCSN CSQPEYQPLR 500
    NKKTYNVIMD SFMKDGGDGY SMFKPLKIIK TLPLGDIETV EAYIEKMGPI 550
    FPAVEGRITV LGGLQKSDED WH 572
    Length:572
    Mass (Da):63,354
    Last modified:November 1, 1999 - v1
    Checksum:i69A652338C04536D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132510 mRNA. Translation: AAD32190.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132510 mRNA. Translation: AAD32190.1 .

    3D structure databases

    ProteinModelPortali Q9XZ43.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    3.90.780.10. 1 hit.
    InterProi IPR008334. 5'-Nucleotdase_C.
    IPR006146. 5'-Nucleotdase_CS.
    IPR006179. 5_nucleotidase/apyrase.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    PANTHERi PTHR11575. PTHR11575. 1 hit.
    Pfami PF02872. 5_nucleotid_C. 1 hit.
    PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR01607. APYRASEFAMLY.
    SUPFAMi SSF55816. SSF55816. 1 hit.
    SSF56300. SSF56300. 1 hit.
    PROSITEi PS00785. 5_NUCLEOTIDASE_1. 1 hit.
    PS00786. 5_NUCLEOTIDASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Toward an understanding of the biochemical and pharmacological complexity of the saliva of a hematophagous sand fly Lutzomyia longipalpis."
      Charlab R., Valenzuela J.G., Rowton E.D., Ribeiro J.M.
      Proc. Natl. Acad. Sci. U.S.A. 96:15155-15160(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Jacobina.
      Tissue: Salivary gland.
    2. "The salivary 5'-nucleotidase/phosphodiesterase of the hematophagus sand fly, Lutzomyia longipalpis."
      Ribeiro J.M.C., Rowton E.D., Charlab R.
      Insect Biochem. Mol. Biol. 30:279-285(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
      Tissue: Salivary gland.
    3. Erratum
      Ribeiro J.M.C., Rowton E.D., Charlab R.
      Insect Biochem. Mol. Biol. 30:609-609(2000)

    Entry informationi

    Entry namei5NTD_LUTLO
    AccessioniPrimary (citable) accession number: Q9XZ43
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3