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Q9XZ43

- 5NTD_LUTLO

UniProt

Q9XZ43 - 5NTD_LUTLO

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Protein
Protein 5NUC
Gene
5NUC
Organism
Lutzomyia longipalpis (Sand fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell By similarity.

Catalytic activityi

UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.

Cofactori

Zinc By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi39 – 391Zinc 1 By similarity
Metal bindingi41 – 411Zinc 1 By similarity
Metal bindingi93 – 931Zinc 1 By similarity
Metal bindingi93 – 931Zinc 2 By similarity
Metal bindingi125 – 1251Zinc 2 By similarity
Sitei126 – 1261Transition state stabilizer By similarity
Sitei129 – 1291Transition state stabilizer By similarity
Metal bindingi227 – 2271Zinc 2 By similarity
Metal bindingi250 – 2501Zinc 2 By similarity
Binding sitei361 – 3611Substrate By similarity
Binding sitei399 – 3991Substrate By similarity
Binding sitei404 – 4041Substrate By similarity
Binding sitei427 – 4271Substrate By similarity

GO - Molecular functioni

  1. 5'-nucleotidase activity Source: UniProtKB-EC
  2. UDP-sugar diphosphatase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
  4. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. nucleotide catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein 5NUC
Including the following 2 domains:
UDP-sugar hydrolase (EC:3.6.1.45)
Alternative name(s):
UDP-sugar diphosphatase
UDP-sugar pyrophosphatase
5'-nucleotidase (EC:3.1.3.5)
Short name:
5'-NT
Gene namesi
Name:5NUC
OrganismiLutzomyia longipalpis (Sand fly)
Taxonomic identifieri7200 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraPsychodoideaPsychodidaeLutzomyiaLutzomyia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 572547Protein 5NUC
PRO_0000000023Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 64 By similarity
Glycosylationi82 – 821N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi360 ↔ 365 By similarity
Glycosylationi454 – 4541N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi488 ↔ 491 By similarity
Glycosylationi490 – 4901N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ9XZ43.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni512 – 5187Substrate binding By similarity

Sequence similaritiesi

Belongs to the 5'-nucleotidase family.

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
3.90.780.10. 1 hit.
InterProiIPR008334. 5'-Nucleotdase_C.
IPR006146. 5'-Nucleotdase_CS.
IPR006179. 5_nucleotidase/apyrase.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR11575. PTHR11575. 1 hit.
PfamiPF02872. 5_nucleotid_C. 1 hit.
PF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR01607. APYRASEFAMLY.
SUPFAMiSSF55816. SSF55816. 1 hit.
SSF56300. SSF56300. 1 hit.
PROSITEiPS00785. 5_NUCLEOTIDASE_1. 1 hit.
PS00786. 5_NUCLEOTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XZ43-1 [UniParc]FASTAAdd to Basket

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MLFFLNFFVL VFSIELALLT ASAAAEDGSY EIIILHTNDM HARFDQTNAG    50
SNKCQEKDKI ASKCYGGFAR VSTMVKKFRE ENGSSVLFLN AGDTYTGTPW 100
FTLYKETIAT EMMNILRPDA ASLGNHEFDK GVEGLVPFLN GVTFPILTAN 150
LDTSQEPTMT NAKNLKRSMI FTVSGHRVGV IGYLTPDTKF LSDVGKVNFI 200
PEVEAINTEA QRLKKEENAE IIIVVGHSGL IKDREIAEKC PLVDIIVGGH 250
SHTFLYTGSQ PDREVPVDVY PVVVTQSSGK KVPIVQAYCF TKYLGYFKVT 300
INGKGNVVGW TGQPILLNNN IPQDQEVLTA LEKYRERVEN YGNRVIGVSR 350
VILNGGHTEC RFHECNMGNL ITDAFVYANV ISTPMSTNAW TDASVVLYQS 400
GGIRAPIDPR TAAGSITRLE LDNVLPFGNA LYVVKVPGNV LRKALEHSVH 450
RYSNTSGWGE FPQVSGLKIR FNVNEEIGKR VKSVKVLCSN CSQPEYQPLR 500
NKKTYNVIMD SFMKDGGDGY SMFKPLKIIK TLPLGDIETV EAYIEKMGPI 550
FPAVEGRITV LGGLQKSDED WH 572
Length:572
Mass (Da):63,354
Last modified:November 1, 1999 - v1
Checksum:i69A652338C04536D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF132510 mRNA. Translation: AAD32190.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF132510 mRNA. Translation: AAD32190.1 .

3D structure databases

ProteinModelPortali Q9XZ43.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
3.90.780.10. 1 hit.
InterProi IPR008334. 5'-Nucleotdase_C.
IPR006146. 5'-Nucleotdase_CS.
IPR006179. 5_nucleotidase/apyrase.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
PANTHERi PTHR11575. PTHR11575. 1 hit.
Pfami PF02872. 5_nucleotid_C. 1 hit.
PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR01607. APYRASEFAMLY.
SUPFAMi SSF55816. SSF55816. 1 hit.
SSF56300. SSF56300. 1 hit.
PROSITEi PS00785. 5_NUCLEOTIDASE_1. 1 hit.
PS00786. 5_NUCLEOTIDASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Toward an understanding of the biochemical and pharmacological complexity of the saliva of a hematophagous sand fly Lutzomyia longipalpis."
    Charlab R., Valenzuela J.G., Rowton E.D., Ribeiro J.M.
    Proc. Natl. Acad. Sci. U.S.A. 96:15155-15160(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Jacobina.
    Tissue: Salivary gland.
  2. "The salivary 5'-nucleotidase/phosphodiesterase of the hematophagus sand fly, Lutzomyia longipalpis."
    Ribeiro J.M.C., Rowton E.D., Charlab R.
    Insect Biochem. Mol. Biol. 30:279-285(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Tissue: Salivary gland.
  3. Erratum
    Ribeiro J.M.C., Rowton E.D., Charlab R.
    Insect Biochem. Mol. Biol. 30:609-609(2000)

Entry informationi

Entry namei5NTD_LUTLO
AccessioniPrimary (citable) accession number: Q9XZ43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: June 11, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3