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Protein

Protein 5NUC

Gene

5NUC

Organism
Lutzomyia longipalpis (Sand fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell.By similarity

Catalytic activityi

UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi39Zinc 1By similarity1
Metal bindingi41Zinc 1By similarity1
Metal bindingi93Zinc 1By similarity1
Metal bindingi93Zinc 2By similarity1
Metal bindingi125Zinc 2By similarity1
Sitei126Transition state stabilizerBy similarity1
Sitei129Transition state stabilizerBy similarity1
Metal bindingi227Zinc 2By similarity1
Metal bindingi250Zinc 2By similarity1
Binding sitei361SubstrateBy similarity1
Binding sitei399SubstrateBy similarity1
Binding sitei404SubstrateBy similarity1
Binding sitei427SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein 5NUC
Including the following 2 domains:
UDP-sugar hydrolase (EC:3.6.1.45)
Alternative name(s):
UDP-sugar diphosphatase
UDP-sugar pyrophosphatase
5'-nucleotidase (EC:3.1.3.5)
Short name:
5'-NT
Gene namesi
Name:5NUC
OrganismiLutzomyia longipalpis (Sand fly)
Taxonomic identifieri7200 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraPsychodoideaPsychodidaeLutzomyiaLutzomyia
Proteomesi
  • UP000092461 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000002326 – 572Protein 5NUCAdd BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 64By similarity
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi360 ↔ 365By similarity
Glycosylationi454N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi488 ↔ 491By similarity
Glycosylationi490N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ9XZ43
SMRiQ9XZ43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni512 – 518Substrate bindingBy similarity7

Sequence similaritiesi

Belongs to the 5'-nucleotidase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.60.21.10, 1 hit
3.90.780.10, 1 hit
InterProiView protein in InterPro
IPR008334 5'-Nucleotdase_C
IPR036907 5'-Nucleotdase_C_sf
IPR006146 5'-Nucleotdase_CS
IPR006179 5_nucleotidase/apyrase
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
PANTHERiPTHR11575 PTHR11575, 1 hit
PfamiView protein in Pfam
PF02872 5_nucleotid_C, 1 hit
PF00149 Metallophos, 1 hit
PRINTSiPR01607 APYRASEFAMLY
SUPFAMiSSF55816 SSF55816, 1 hit
PROSITEiView protein in PROSITE
PS00785 5_NUCLEOTIDASE_1, 1 hit
PS00786 5_NUCLEOTIDASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XZ43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFFLNFFVL VFSIELALLT ASAAAEDGSY EIIILHTNDM HARFDQTNAG
60 70 80 90 100
SNKCQEKDKI ASKCYGGFAR VSTMVKKFRE ENGSSVLFLN AGDTYTGTPW
110 120 130 140 150
FTLYKETIAT EMMNILRPDA ASLGNHEFDK GVEGLVPFLN GVTFPILTAN
160 170 180 190 200
LDTSQEPTMT NAKNLKRSMI FTVSGHRVGV IGYLTPDTKF LSDVGKVNFI
210 220 230 240 250
PEVEAINTEA QRLKKEENAE IIIVVGHSGL IKDREIAEKC PLVDIIVGGH
260 270 280 290 300
SHTFLYTGSQ PDREVPVDVY PVVVTQSSGK KVPIVQAYCF TKYLGYFKVT
310 320 330 340 350
INGKGNVVGW TGQPILLNNN IPQDQEVLTA LEKYRERVEN YGNRVIGVSR
360 370 380 390 400
VILNGGHTEC RFHECNMGNL ITDAFVYANV ISTPMSTNAW TDASVVLYQS
410 420 430 440 450
GGIRAPIDPR TAAGSITRLE LDNVLPFGNA LYVVKVPGNV LRKALEHSVH
460 470 480 490 500
RYSNTSGWGE FPQVSGLKIR FNVNEEIGKR VKSVKVLCSN CSQPEYQPLR
510 520 530 540 550
NKKTYNVIMD SFMKDGGDGY SMFKPLKIIK TLPLGDIETV EAYIEKMGPI
560 570
FPAVEGRITV LGGLQKSDED WH
Length:572
Mass (Da):63,354
Last modified:November 1, 1999 - v1
Checksum:i69A652338C04536D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132510 mRNA Translation: AAD32190.1

Similar proteinsi

Entry informationi

Entry namei5NTD_LUTLO
AccessioniPrimary (citable) accession number: Q9XZ43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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