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Q9XYR5 (CONG_CONGE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 24, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Contulakin-G
Alternative name(s):
CGX-1160
OrganismConus geographus (Geography cone) (Nubecula geographus)
Taxonomic identifier6491 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Protein attributes

Sequence length76 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as an agonist of neurotensin receptors. It binds to human neurotensin type 1 receptor (NTSR1), rat neurotensin types 1 and 2 receptors (NTSR1/NTSR2) and mouse neurotensin type 3 receptor (SORT1). Ref.1

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom duct.

Post-translational modification

O-glycosylated. The glycosylation seems to enhance the affinity to the neurotensin receptors.

Pharmaceutical use

Is under phase II clinical trials under the name CGX-1160 by Cognetix Inc. It is efficacious in a wide range of preclinical pain models (acute, post-surgical, inflammatory, and neuropathic), and is particularly efficacious in models of chronic pain.

Miscellaneous

The mature peptide does not contain cysteine residue.

Sequence similarities

Belongs to the conotoxin C superfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Propeptide23 – 5028
PRO_0000035083
Peptide51 – 6616Contulakin-G Ref.1
PRO_0000035084
Propeptide67 – 7610
PRO_0000035085

Amino acid modifications

Modified residue511Pyrrolidone carboxylic acid Ref.1
Glycosylation601O-linked (GalNAc...)
CAR_000164

Sequences

Sequence LengthMass (Da)Tools
Q9XYR5 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: D8094EB30C6AAFD4

FASTA768,261
        10         20         30         40         50         60 
MQTAYWVMVM MMVWIAAPLS EGGKLNDVIR GLVPDDITPQ LILGSLISRR QSEEGGSNAT 

        70 
KKPYILRASD QVASGP 

« Hide

References

[1]"Contulakin-G, an O-glycosylated invertebrate neurotensin."
Craig A.G., Norberg T., Griffin D., Hoeger C., Akhtar M., Schmidt K., Low W., Dykert J., Richelson E., Navarro V., Mazella J., Watkins M., Hillyard D.R., Imperial J., Cruz L.J., Olivera B.M.
J. Biol. Chem. 274:13752-13759(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 51-66, FUNCTION, TOXIN TARGET.
Tissue: Venom.
[2]"Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T."
Malmberg A.B., Gilbert H., McCabe R.T., Basbaum A.I.
Pain 101:109-116(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PHARMACEUTICAL.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF121108 mRNA. Translation: AAD30031.1.
PIRA59043.

3D structure databases

ModBaseSearch...
MobiDBSearch...

PTM databases

UniCarbKBQ9XYR5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ConoServer1263. contulakin-G precursor.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameCONG_CONGE
AccessionPrimary (citable) accession number: Q9XYR5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: July 24, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families