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Q9XYR5

- CONG_CONGE

UniProt

Q9XYR5 - CONG_CONGE

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Protein

Contulakin-G

Gene
N/A
Organism
Conus geographus (Geography cone) (Nubecula geographus)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as an agonist of neurotensin receptors. It binds to human neurotensin type 1 receptor (NTSR1), rat neurotensin types 1 and 2 receptors (NTSR1/NTSR2) and mouse neurotensin type 3 receptor (SORT1).1 Publication

Keywords - Molecular functioni

G-protein coupled receptor impairing toxin, Neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Contulakin-G
Alternative name(s):
CGX-1160
OrganismiConus geographus (Geography cone) (Nubecula geographus)
Taxonomic identifieri6491 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri1263. contulakin-G precursor.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Is under phase II clinical trials under the name CGX-1160 by Cognetix Inc. It is efficacious in a wide range of preclinical pain models (acute, post-surgical, inflammatory, and neuropathic), and is particularly efficacious in models of chronic pain.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Propeptidei23 – 5028PRO_0000035083Add
BLAST
Peptidei51 – 6616Contulakin-G1 PublicationPRO_0000035084Add
BLAST
Propeptidei67 – 7610PRO_0000035085

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511Pyrrolidone carboxylic acid1 Publication
Glycosylationi60 – 601O-linked (GalNAc...)CAR_000164

Post-translational modificationi

O-glycosylated. The glycosylation seems to enhance the affinity to the neurotensin receptors.

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Pyrrolidone carboxylic acid

PTM databases

UniCarbKBiQ9XYR5.

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Sequence similaritiesi

Belongs to the conotoxin C superfamily.

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XYR5-1 [UniParc]FASTAAdd to Basket

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MQTAYWVMVM MMVWIAAPLS EGGKLNDVIR GLVPDDITPQ LILGSLISRR   50
QSEEGGSNAT KKPYILRASD QVASGP 76
Length:76
Mass (Da):8,261
Last modified:November 1, 1999 - v1
Checksum:iD8094EB30C6AAFD4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF121108 mRNA. Translation: AAD30031.1.
PIRiA59043.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF121108 mRNA. Translation: AAD30031.1 .
PIRi A59043.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

UniCarbKBi Q9XYR5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ConoServeri 1263. contulakin-G precursor.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 51-66, FUNCTION, TOXIN TARGET.
    Tissue: Venom.
  2. "Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T."
    Malmberg A.B., Gilbert H., McCabe R.T., Basbaum A.I.
    Pain 101:109-116(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHARMACEUTICAL.

Entry informationi

Entry nameiCONG_CONGE
AccessioniPrimary (citable) accession number: Q9XYR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: July 24, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

The mature peptide does not contain cysteine residue.

Keywords - Technical termi

Direct protein sequencing, Pharmaceutical

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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