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Q9XYR5

- CONG_CONGE

UniProt

Q9XYR5 - CONG_CONGE

Protein

Contulakin-G

Gene
N/A
Organism
Conus geographus (Geography cone) (Nubecula geographus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Acts as an agonist of neurotensin receptors. It binds to human neurotensin type 1 receptor (NTSR1), rat neurotensin types 1 and 2 receptors (NTSR1/NTSR2) and mouse neurotensin type 3 receptor (SORT1).1 Publication

    Keywords - Molecular functioni

    G-protein coupled receptor impairing toxin, Neurotoxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Contulakin-G
    Alternative name(s):
    CGX-1160
    OrganismiConus geographus (Geography cone) (Nubecula geographus)
    Taxonomic identifieri6491 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

    Organism-specific databases

    ConoServeri1263. contulakin-G precursor.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Pharmaceutical usei

    Is under phase II clinical trials under the name CGX-1160 by Cognetix Inc. It is efficacious in a wide range of preclinical pain models (acute, post-surgical, inflammatory, and neuropathic), and is particularly efficacious in models of chronic pain.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Propeptidei23 – 50281 PublicationPRO_0000035083Add
    BLAST
    Peptidei51 – 6616Contulakin-GPRO_0000035084Add
    BLAST
    Propeptidei67 – 7610PRO_0000035085

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei51 – 511Pyrrolidone carboxylic acid1 Publication
    Glycosylationi60 – 601O-linked (GalNAc...)CAR_000164

    Post-translational modificationi

    O-glycosylated. The glycosylation seems to enhance the affinity to the neurotensin receptors.

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein, Pyrrolidone carboxylic acid

    PTM databases

    UniCarbKBiQ9XYR5.

    Expressioni

    Tissue specificityi

    Expressed by the venom duct.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the conotoxin C superfamily.Curated

    Keywords - Domaini

    Signal

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9XYR5-1 [UniParc]FASTAAdd to Basket

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    MQTAYWVMVM MMVWIAAPLS EGGKLNDVIR GLVPDDITPQ LILGSLISRR   50
    QSEEGGSNAT KKPYILRASD QVASGP 76
    Length:76
    Mass (Da):8,261
    Last modified:November 1, 1999 - v1
    Checksum:iD8094EB30C6AAFD4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF121108 mRNA. Translation: AAD30031.1.
    PIRiA59043.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF121108 mRNA. Translation: AAD30031.1 .
    PIRi A59043.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    UniCarbKBi Q9XYR5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    ConoServeri 1263. contulakin-G precursor.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 51-66, FUNCTION, TOXIN TARGET.
      Tissue: Venom.
    2. "Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T."
      Malmberg A.B., Gilbert H., McCabe R.T., Basbaum A.I.
      Pain 101:109-116(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHARMACEUTICAL.

    Entry informationi

    Entry nameiCONG_CONGE
    AccessioniPrimary (citable) accession number: Q9XYR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Miscellaneous

    The mature peptide does not contain cysteine residue.

    Keywords - Technical termi

    Direct protein sequencing, Pharmaceutical

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3