Q9XYR0 (Q9XYR0_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
LD20987p EMBL AAM11145.1

Submitted name:
TNF-receptor-associated factor 1 EMBL AAD34346.1
Submitted name:
TNF-receptor-associated factor 4, isoform A EMBL AAF51024.1

Gene names

Name:	Traf4 FlyBase FBgn0026319
Synonyms:	TRAF1 EMBL AAD34346.1, Traf1 FlyBase FBgn0026319 EMBL AAM11145.1
ORF Names:	CG3048 FlyBase FBgn0026319, Dmel_CG3048 EMBL AAF51024.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	486 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 MATH domain. RuleBase RU004402

Ontologies

Keywords
Domain	Zinc-finger SAAS SAAS013323
Ligand	Metal-binding Zinc
Molecular function	Receptor EMBL AAF51024.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	Toll signaling pathway Non-traceable author statement. Source: FlyBase asymmetric protein localization involved in cell fate determination Inferred from mutant phenotype. Source: FlyBase dorsal closure Traceable author statement. Source: FlyBase eye development Inferred from mutant phenotype. Source: FlyBase imaginal disc fusion, thorax closure Inferred from genetic interaction. Source: FlyBase instar larval development Inferred from expression pattern. Source: FlyBase phagocytosis, engulfment Inferred from mutant phenotype. Source: FlyBase positive regulation of JNK cascade Inferred from genetic interaction. Source: FlyBase positive regulation of apoptotic process Inferred from mutant phenotype. Source: FlyBase salivary gland cell autophagic cell death Inferred from expression pattern. Source: FlyBase
Cellular component	apical cortex Inferred from direct assay. Source: FlyBase
Molecular function	protein binding Inferred from physical interaction. Source: FlyBase receptor activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin-protein ligase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9XYR0 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 41474B5E014A99D5	FASTA	486	53,665
	10 20 30 40 50 60 MVRSLAQWTK TLSFPSRLSP NRNSKDCSTL ASPVPPPTPP RNKTTSGSGN CATSRSSSST 70 80 90 100 110 120 VSSSHSSSHS SPTPGNNNNN MPITELEQII YPGPDPKHIM GSLVFCIHHK QGCKWSDELR 130 140 150 160 170 180 KLKGHLNACK HDATQCPNKC GAQIPRIMMT DHLQYTCTMR RTRCEFCQSE FSGAGLEEHN 190 200 210 220 230 240 GSCGQEPVYC EAKCGQRILR GRMTLHKSKD CAKRLRRCAH CQREFSADTL PLHAAQCPRA 250 260 270 280 290 300 PLACPQRCDA GPIPRGELEA HLRDECQSLA VSCSFKEAGC RFKGPRQMLE AHLESNAAAH 310 320 330 340 350 360 LSLMVALSSR QGQQIQMLKS AVSKLSINYT GTLLWKITDW SAKMAEARGK DGLELVSPPF 370 380 390 400 410 420 YTSQYGYKLQ ASMFLNGNGP GENTHVSVYI KVLPGEYDAL LKWPFSHSIT FTLFEQGAQS 430 440 450 460 470 480 GQGGVAESFV PDPTWENFQR PSNEPDQLGF GFPRFISHEL LHSRPFIKGD TVFLRVKVDP SKIVAV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"A Drosophila TNF-receptor-associated factor (TRAF) binds the ste20 kinase Misshapen and activates Jun kinase." Liu H., Su Y.C., Becker E., Treisman J., Skolnik E.Y. Curr. Biol. 9:101-104(1999) [PubMed: 10021364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[4]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A. , Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAM11145.1.
[5]	Skolnik E.S., Liu H., Su Y.-C., Becker E., Treisman J. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF119794 mRNA. Translation: AAD34346.1. AE014134 Genomic DNA. Translation: AAF51024.1. AY094792 mRNA. Translation: AAM11145.1.
RefSeq	NP_477416.1. NM_058068.3.
UniGene	Dm.3100.
3D structure databases
HSSP	HSSP built from PDB template 1L0A based on UniProtKB Q13114.
ProteinModelPortal	Q9XYR0.
SMR	Q9XYR0. Positions 61-97, 120-271, 301-485.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-19614N.
IntAct	Q9XYR0. 2 interactions.
MINT	MINT-941576.
STRING	Q9XYR0.
Proteomic databases
PRIDE	Q9XYR0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0077429; FBpp0077119; FBgn0026319.
GeneID	33638.
KEGG	dme:Dmel_CG3048.
UCSC	CG3048-RA. d. melanogaster.
Organism-specific databases
CTD	9618.
FlyBase	FBgn0026319. Traf4.
Phylogenomic databases
GeneTree	EMGT00050000009273.
InParanoid	Q9XYR0.
OMA	HEGMCPQ.
PhylomeDB	Q9XYR0.
Gene expression databases
ArrayExpress	Q9XYR0.
Bgee	Q9XYR0.
Family and domain databases
InterPro	IPR002083. MATH. IPR013323. SIAH-type. IPR012227. TNF_rcpt--assoc_TRAF. IPR008974. TRAF-like. IPR013322. TRAF-type. IPR001293. Znf_TRAF. [Graphical view]
Gene3D	G3DSA:3.90.890.10. SIAH-type. 1 hit. G3DSA:2.60.210.10. TRAF-type. 1 hit.
KO	K09848.
Pfam	PF00917. MATH. 1 hit. [Graphical view]
PIRSF	PIRSF015614. TRAF. 1 hit.
SMART	SM00061. MATH. 1 hit. [Graphical view]
SUPFAM	SSF49599. Traf_like. 3 hits.
PROSITE	PS50144. MATH. 1 hit. PS50145. ZF_TRAF. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	784548.

Entry information

Entry name

Q9XYR0_DROME

Accession

Primary (citable) accession number: Q9XYR0

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	January 25, 2012
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)