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Protein

Eukaryotic translation initiation factor 6

Gene
N/A
Organism
Trypanosoma cruzi
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis, Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6
Short name:
eIF-6
OrganismiTrypanosoma cruzi
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleusnucleolus By similarity

  • Note: Shuttles between cytoplasm and nucleus/nucleolus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 114›114Eukaryotic translation initiation factor 6PRO_0000153738Add
BLAST

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit (By similarity).By similarity

Protein-protein interaction databases

STRINGi353153.XP_820032.1.

Structurei

3D structure databases

ProteinModelPortaliQ9XYP3.
SMRiQ9XYP3. Positions 3-90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.Curated

Family and domain databases

InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9XYP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GTTFRTSIAE NALVGSYAVV NNKGCMVHPK TPAQDMDEIA SLLQVPVVAG
60 70 80 90 100
TINRGNAAIG SGLVVNDWAA FCGLNTTATE ITVVERIFQL RRDLGGGRAN
110
LLQQLRDTLV DELA
Length:114
Mass (Da):12,083
Last modified:November 1, 1999 - v1
Checksum:i63671F07F6C532B3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117890 Genomic DNA. Translation: AAD24769.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117890 Genomic DNA. Translation: AAD24769.1.

3D structure databases

ProteinModelPortaliQ9XYP3.
SMRiQ9XYP3. Positions 3-90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi353153.XP_820032.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "T. cruzi SZ5 locus DNA."
    Lorenzi H., Catalani M., Levin M.J.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Tulahuen.

Entry informationi

Entry nameiIF6_TRYCR
AccessioniPrimary (citable) accession number: Q9XYP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: June 24, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.