Q9XYP3 (IF6_TRYCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Eukaryotic translation initiation factor 6 Short name=eIF-6
Organism	Trypanosoma cruzi
Taxonomic identifier	5693 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma › Schizotrypanum

Protein attributes

Sequence length	114 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis By similarity. HAMAP-Rule MF_03132
Subunit structure	Monomer. Associates with the 60S ribosomal subunit By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus › nucleolus By similarity. Note: Shuttles between cytoplasm and nucleus/nucleolus By similarity.
Sequence similarities	Belongs to the eIF-6 family.

Ontologies

Keywords
Biological process	Protein biosynthesis Ribosome biogenesis
Cellular component	Cytoplasm Nucleus
Molecular function	Initiation factor
Gene Ontology (GO)
Biological_process	mature ribosome assembly Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ribosome binding Inferred from electronic annotation. Source: InterPro translation initiation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 114	›114	Eukaryotic translation initiation factor 6 HAMAP-Rule MF_03132		PRO_0000153738
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q9XYP3 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 63671F07F6C532B3	FASTA	114	12,083
	10 20 30 40 50 60 GTTFRTSIAE NALVGSYAVV NNKGCMVHPK TPAQDMDEIA SLLQVPVVAG TINRGNAAIG 70 80 90 100 110 SGLVVNDWAA FCGLNTTATE ITVVERIFQL RRDLGGGRAN LLQQLRDTLV DELA

References

[1]	"T. cruzi SZ5 locus DNA." Lorenzi H., Catalani M., Levin M.J. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Tulahuen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF117890 Genomic DNA. Translation: AAD24769.1.
3D structure databases
ProteinModelPortal	Q9XYP3.
SMR	Q9XYP3. Positions 3-90.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_00032. eIF-6.
InterPro	IPR002769. eIF6. [Graphical view]
PANTHER	PTHR10784. PTHR10784. 1 hit.
Pfam	PF01912. eIF-6. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IF6_TRYCR

Accession

Primary (citable) accession number: Q9XYP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	October 3, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)